Protective effect of melatonin against hippocampal DNA damage induced by intraperitoneal administration of kainate to rats

Neuroscience

Volumn 73, Issue 3, 1996, Pages 631-636

  Uz, T ^a   Giusti, P ^c   Franceschini, D ^c   Kharlamov, A ^a   Manev, H ^a,b  

^a ALLEGHENY SINGER RESEARCH INSTITUTE   (United States)

^b Sterling Medical Office   (United States)

^c UNIVERSITY OF PADOVA   (Italy)

Author keywords

apoptosis; excitotoxicity; glutamate; melatonin; pineal gland

Indexed keywords

KAINIC ACID; MELATONIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL DAMAGE; CELL LOSS; CELL VIABILITY; DNA DAMAGE; DRUG EFFICACY; HIPPOCAMPUS; IMAGE ANALYSIS; INTRAPERITONEAL DRUG ADMINISTRATION; MALE; NEUROPROTECTION; NEUROTOXICITY; NISSL STAINING; NONHUMAN; PRIORITY JOURNAL; QUANTITATIVE ASSAY; RAT;

EID: 0030218902     PISSN: 03064522     EISSN: None     Source Type: Journal    
DOI: 10.1016/0306-4522(96)00155-8     Document Type: Article

References (19)

1. 1. Barlow-Waiden L., Reiter J. J., Abe M., Pablos M., Mendez-Pelaez A., Chen L. D. and Poeggeler B. (1995) Melatonin stimulates brain glutathione peroxidase activity. Neurochem Int. 26, 497-502.
2. 2. Cagnoli C. M., Atabay C., Kharlamov E. and Manev H. (1995) Melatonin protects neurons from singlet oxygen-induced apoptosis. J. Pineal Res. 18, 222-226.
3. 3. Champney T. H., Sanchez-Forte M., Munoz-Hoyos A., Molina-Carballo A., Moreno-Madrid F. and Acuna-Castroviejo D. (1995) Anticonvulsant effect of melatonin in humans: two case studies. Soc. Neurosci. Abstr. 21, 1964.
4. 4. Filipowski R. K., Hetman M., Kaminska B. and Kaczmarek L. (1994) DNA fragmentation in rat brain after intraperitoneal administration of kainate. NeuroReport 5, 1538-1540.
5. 5. Giusti P., Gusella M., Lipartiti M., Milani D., Zhu W., Vicini S. and Manev H. (1995) Melatonin protects primary cultures of cerebellar granule neurons from kainate but not from N-methyl-D-aspartate excitotoxicity. Expl Neurol. 131, 39-46.
6. 6. Giusti P., Lipartiti M., Fanceschini D., Schiavo N., Floreani M. and Manev H. (1996) Neuroprotection by melatonin from kainate-induced excitotoxicity in rats. Fedn Am. Socs exp. Biol. J. (in press).
7. 7. Hardeland R. and Rodriguez C. (1995) Versatile melatonin: a pervasive molecule serves various functions in signaling and protection. Chronobiol. Int. 12, 157-165.
8. 8. Ishimaru M., Der T. C., Tenkova T. I., Sesma M. A., Thurston J. H. and Olney J. W. (1995) Three types of excitotoxicity evaluated for apoptosissignals. Soc. Neurosci. Abstr. 21, 1584.
9. 9. Kharlamov A., Guidotti A., Costa E., Hayes R. and Armstrong D. (1993) Semisynthetic sphingolipids prevent protein kinase C translocation and neuronal damage in the perifocal area following a photochemically induced thrombotic brain cortical lesion. J. Neurosci. 13, 2483-2494.
10. 10. Manev H., Kharlamov A. and Armstrong D. M. (1994) Photochemical brain injury in rats triggers DNA fragmentation, p53 and HSP72. Neuro Report 5, 2661-2664.
11. 11. Melchiorri D., Reiter R. J., Sewerynek E., Chen L. D. and Nistico G. (1995) Melatonin reduces kainate-induced lipid peroxidation in homogenates of different brain regions. Fedn Am. Socs exp. Biol. J. 9, 1205-1210.
12. 12. Norlund J. J. and Lerner A. B. (1977) The effects of oral melatonin on skin color and on the release of pituitary hormones. J. clin. Endocr. Metab. 45, 768-774.
13. 13. Paxinos G. and Watson C. (1982) The Rat Brain in Stereotaxic Coordinates. Academic Press, Sydney.
14. 14. Pollard H., Charriaut-Marlangue C., Cantagrel S., Represa A., Robain O., Moreau J. and Ben-Ari Y. (1994) Kainate-induced apoptotic cell death in hippocampal neurons. Neuroscience 63, 7-18.
15. 15. Pozo D., Reiter R. J., Calvo J. R. and Guerrero J. M. (1994) Physiological concentrations of melatonin inhibit nitric oxide synthase in rat cerebellum. Life Sci. 55, PL455-PL460.
16. 16. Reiter R. J. (1995) Oxidative processes and antioxidative defense mechanisms in the aging brain. Fedn Am. Socs exp. Biol. J. 9, 526-533.
17. 17. Reppert S. M., Weaver D. R., Cassone V. M., Godson C. and Kolakowski L. E. Jr (1995) Melatonin receptors are for the birds: molecular analysis of two receptor subtypes differentially expressed in chick brain. Neuron 15, 1003-1015.
18. 18. Sakhi S., Brace A., Sun N., Tocco, G. and Baudry M. (1994) p53 induction is associated with neuronal damage in the central nervous system. Proc. natn. Acad. Sci. U.S.A. 91, 7525-7529.
19. 19. Sperk G. (1994) Kainic acid seizures in the rat. Prog. Neurobiol. 42, 1-32.