Long-term and rapid regulation of ob mRNA levels in adipose tissue from normal (Sprague Dawley rats) and obese (db/db mice, fa/fa rats) rodents

Diabetologia

Volumn 39, Issue 7, 1996, Pages 758-765

  Igel, M ^a   Kainulainen, H ^b   Brauers, A ^a   Becker, W ^a   Herberg, L ^a   Joost, H G ^a,c  

^a RWTH AACHEN UNIVERSITY   (Germany)

^b UNIVERSITY OF TAMPERE   (Finland)

^c RWTH AACHEN UNIVERSITY   (Germany)

Author keywords

Gene expression; Insulin resistance; Leptin; Ob gene; Obesity

Indexed keywords

INSULIN; MESSENGER RNA;

ADIPOSE TISSUE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; FEMALE; INSULIN RESISTANCE; MALE; MOUSE; NONHUMAN; OBESITY; PRIORITY JOURNAL; RAT;

ADIPOSE TISSUE; AGE FACTORS; ANIMALS; BLOTTING, NORTHERN; BODY WEIGHT; DIABETES MELLITUS, EXPERIMENTAL; FASTING; GENE EXPRESSION REGULATION; INSULIN; INSULIN RESISTANCE; LEPTIN; MALE; MICE; MICE, INBRED C57BL; OBESITY; PROTEIN BIOSYNTHESIS; PROTEINS; RATS; RATS, SPRAGUE-DAWLEY; RATS, ZUCKER; RNA, MESSENGER; TIME FACTORS;

EID: 0029999753     PISSN: 0012186X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s001250050508     Document Type: Article

References (21)

1. Friedman JM, Leibel RL (1992) Tackling a weighty problem. Cell 69: 217-220
2. Zhang Y, Proenca R, Maffei M, Barone M, Leopols L, Friedman JM (1994) Positional cloning of the mouse obese gene and its human homologue. Nature 372: 425-432
3. Pelleymounter MA, Cullen MJ, Baker MB et al. (1995) Effects of the obese gene product on body weight regulation in ob/ob mice. Science 269: 540-543
4. Halaas JL, Gajiwala KS, Maffei M et al. (1995) Weight-reducing effects of the plasma protein encoded by the obese gene. Science 269: 543-546
5. Campfield LA, Smith FJ, Guisez Y, Devos R, Burn P (1995) Recombinant mouse ob protein: evidence for a peripheral signal linking adiposity and central neural networks. Science 269: 546-549
6. Considine RV, Considine EL, Williams CJ et al. (1995) Evidence against either a premature stop codon or the absence of obese gene mRNA in human obesity. J Clin Invest 95: 2986-2988
7. Murakami T, Shima K (1995) Cloning of rat obese cDNA and its expression in obese rats. Biochim Biophys Res Commun 209: 944-952
8. Coleman DL (1973) Effects of parabiosis of obese with diabetic and normal mice. Diabetologia 9: 294-298
9. Maffei M, Fei H, Lee GH et al. (1995) Increased expression in adipocytes of ob RNA in mice with lesions of the hypothalamus and with mutations at the db locus. Proc Natl Acad Sci USA 92: 6957-6960
10. Saladin R, De Vos P, Guerre-Millo M et al. (1995) Transient increase in obese gene expression after food intake or insulin administration. Nature 377: 527-529
11. MacDougald AO, Hwang CS, Fan H, Lane MD (1995) Regulated expression of the obese gene product (leptin) in white adipose tissue and 3T3-L1 adipocytes. Proc Natl Acad Sci USA 92: 9034-9037
12. Kainulainen H, Breiner M, Schürmann A, Marttinen A, Virjo A, Joost HG (1994) In vivo glucose uptake and glucose transporter proteins GLUT1 and GLUT4 in heart and various types of skeletal muscle from streptozotocin-diabetic rats. Biochim Biophys Acta 1225: 275-282
13. Schürmann A, Breiner M, Becker W et al. (1994) Cloning of two novel ADP-ribosylation factor-like proteins and characterization of their differential expression in 3T3-L1 cells. J Biol Chem 269: 15683-15688
14. Feinberg AP, Vogelstein B (1983) A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity. Anal Biochem 132: 6-13
15. Coleman DI, Hummel KP (1967) Studies with the mutation, diabetes, in the mouse. Diabetologia 3: 238-248
16. Bach A, Schirardin H, Bauer M, Schaeffer A, Weryha A (1981) Age-related changes in biological parameters in Zucker rats. Lipids 16: 841-848
17. Hissin PJ, Foley JF, Wardzala LJ et al. (1982) Mechanism of insulin-resistant glucose transport activity in the enlarged adipose cell of the aged, obese rat. Relative depletion of intracellular glucose transport systems. J Clin Invest 70: 780-790
18. Herberg L, Coleman DL (1977) Laboratory animals exhibiting obesity and diabetes syndromes. Metabolism 26: 59-99
19. Zaninetti D, Crettaz M, Jeanrenaud B (1983) Dysregulation of glucose transport in hearts of genetically obese fa/ fa rats. Diabetologia 25: 525-529
20. Galante P, Maerker E, Scholz R et al. (1994) Insulin-induced translocation of GLUT4 in skeletal muscle of insulin-resistant Zucker rats. Diabetologia 37: 3-9
21. Truett GE, Bahary N, Friedman JM, Leibel RL (1991) Rat obesity gene fatty (fa) maps to chromosome 5: evidence for homology with the mouse gene diabetes (db). Proc Natl Acad Sci USA 88: 7806-7809