Leptin sensitivity in nonobese glucagon-like peptide I receptor-/- mice

Diabetes

Volumn 46, Issue 12, 1997, Pages 2029-2034

  Scrocchi, Louise A ^a   Brown, Theodore J ^b   Drucker, Daniel J ^a,c  

^a UNIVERSITY OF TORONTO   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c TORONTO GENERAL HOSPITAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCAGON LIKE PEPTIDE 1; GLUCAGON RECEPTOR; LEPTIN;

ANIMAL EXPERIMENT; ARTICLE; BODY WEIGHT; DIABETES MELLITUS; FOOD INTAKE; GLUCOSE BLOOD LEVEL; INSULIN RELEASE; MOUSE; NONHUMAN; OBESITY; PRIORITY JOURNAL;

EID: 0030781057     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diab.46.12.2029     Document Type: Article

References (29)

1. Zhang Y, Proenca R, Maffei M, Barone M, Leopold L, Friedman JM: Positional cloning of the mouse obese gene and its human homologue. Nature 372:425-431, 1994
2. Tartaglia LA, Dembski M, Weng X, Deng N, Culpepper J, Devos R, Richards GJ, Campfield LA, Clark FT, Deeds J, Muir C, Sanker S, Moriarty A, Moore KJ, Smutko JS, Mays GG, Woolf EA, Monroe CA, Tepper RI: Identification and expression cloning of a leptin receptor, OB-R. Cell 83:1263-1271, 1995
3. Lee G-H, Proenca R, Montez JM, Carroll KM, Darvishzadeh JG, Lee JI, Friedman JM: Abnormal splicing of the leptin receptor in diabetic mice. Nature 379:632-635, 1996
4. Chua SC, Chung WK, Wu-Peng XS, Zhang Y, Lui SM, Tartaglia L, Leibel RL: Phenotypes of mouse diabetes and rat fatty due to mutation in the Ob (leptin) receptor. Science 271:994-996, 1996
5. Ingalls AM, Dickie MM, Snell GD: Obese, new mutation in house mouse. J Hered 41:317-318, 1950
6. Halaas JL, Gajiwala KS, Maffei M, Cohen SL, Chait BT, Rabinowitz D, Lallone RL, Burley SK, Friedman JM: Weight-reducing effects of the plasma protein encoded by the obese gene. Science 269:543-546, 1995
7. Pelleymounter MA, Cullen MJ, Baker MB, Hecht R, Winters D, Boone T, Collins F: Effects of the obese gene product on body weight regulation in ob/ob mice. Science 269:540-543, 1995
8. Campfield LA, Smith FJ, Guisez Y, Devos R, Burn P: Recombinant mouse OB protein: evidence for a peripheral signal linking adiposity and central neural networks. Science 269:546-549, 1995
9. Ahima RS, Prabakaran D, Mantzoros C, Qu D, Lowell B, Maratos-Flier E, Flier JS: Role of leptin in the neuroendocrine response to fasting. Nature 382:250-252, 1996
10. Schwartz MW, Baskin DG, Bukowski TR, Kuijper JL, Foster D, Lasser G, Prunkard DE, Porte Jr D, Woods SC, Seeley RJ, Weigle DS: Specificity of leptin action on elevated blood glucose levels and hypothalamic neuropeptide Y gene expression in ob/ob mice. Diabetes 45:531-535, 1996
11. Cohen B, Novick D, Rubinstein M: Modulation of insulin activities by leptin. Science 274:1185-1188, 1996
12. Emilsson V, Liu Y-L, Cawthorne MA, Morton NM, Davenport M: Expression of the functional leptin receptor mRNA in pancreatic islets and direct inhibitory action of leptin on insulin secretion. Diabetes 46:313-316, 1997
13. Mojsov S, Weir GC, Habener JF: Insulinotropin: glucagon-like peptide I (7-37) co-encoded in the glucagon gene is a potent stimulator of insulin release in the perfused rat pancreas. J Clin Invest 79:616-619, 1987
14. Kreymann B, Ghatei MA, Williams G, Bloom SR: Glucagon-like peptide-1 7-36: a physiological incretin in man. Lancet ii:1300-1304, 1987
15. Holst JJ, Orskov C, Nielsen OV, Schwartz TW: Truncated glucagon-like peptide I, an insulin-releasing hormone from the distal gut. FEBS Lett 211:169-174, 1987
16. Turton MD, O'Shea D, Gunn I, Beak SA, Edwards CMB, Meeran K, Choi SJ, Taylor GM, Heath MM, Lambert PD, Wilding JPH, Smith DM, Ghatei MA, Herbert J, Bloom SR: A role for glucagon-like peptide-1 in the central regulation of feeding. Nature 379:69-72, 1996
17. Scrocchi LA, Brown TJ, MacLusky N, Brubaker PL, Auerbach AB, Joyner AL, Drucker DJ: Glucose intolerance but normal satiety in mice with a null mutation in the glucagon-like peptide receptor gene. Nat Med 2:1254-1258, 1996
18. Van Dijk G, Thiele TE, Donahey JCK, Campfield LA, Smith FJ, Burn P, Bernstein IL, Woods SC, Seeley RJ: Central infusions of leptin and GLP-I-(7-36) amide differentially stimulate c-FLI in the rat brain. Am J Physiol 271:R1096-R1100, 1996
19. Kieffer TJ, Heller RS, Habener JF: Leptin receptors expressed on pancreatic b-cells. Biochem Biophys Res Commun 224:522-527, 1996
20. Drucker DJ, Brubaker PL: Proglucagon gene expression is regulated by a cyclic AMP-dependent pathway in rat intestine. Proc Natl Acad Sci USA 86:3953-3957, 1989
21. Considine RV, Sinha MK, Heiman ML, Kriauciunas A, Stephens TW, Nyce MR, Ohannesian JP, Marco CC, McKee LJ, Bauer TL, Caro JF: Serum immunoreactive-leptin concentrations in normal-weight and obese humans. N Engl J Med 334:292-295, 1996
22. Maffei M, Halaas J, Ravussin E, Pratley RE, Lee GH, Zhang Y, Fei H, Kim S, Lallone R, Ranganathan S, Kern PA, Friedman JM: Leptin levels in human and rodent: measurement of plasma leptin and ob RNA on obese and weight-reduced subjects. Nat Med 1:1155-1161, 1995
23. Caro JF, Sinha MK, Kolaczynski JW, Zhang PL, Considine RV: Leptin:the tale of an obesity gene. Diabetes 45:1455-1462, 1996
24. Segal KR, Landt M, Klein S, Ratcliffe JG: Relationship between insulin sensitivity and plasma leptin concentration in lean and obese men. Diabetes 45:988-991, 1996
25. Larsson H, Elmstahl S, Ahren B, Konishi J, Shigeno C: Plasma leptin levels correlate to islet function independently of body fat in postmenopausal women. Diabetes 45:1580-1584, 1996
26. D'alessio DA, Kahn SE, Leusner CR, Ensinck JW: Glucagon-like peptide 1 enhances glucose tolerance both by stimulation of insulin release and by increasing insulin-independent glucose disposal. J Clin Invest 93:2263-2266, 1994
27. D'alessio DA, Prigeon RL, Ensinck JW: Enterai enhancement of glucose disposition by both insulin-dependent and insulin-independent processes: a physiological role of glucagon-like peptide I. Diabetes 44:1433-1437, 1995
28. Toft-Nielsen M, Madsbad S, Holst JJ: The effect of glucagon-like peptide 1 (GLP-I) on glucose elimination in healthy subjects depends on the pancreatic glucoregulatory hormones. Diabetes 45:552-556, 1996
29. Erickson JC, Clegg KE, Palmiter RD: Sensitivity to leptin and susceptibility to seizures of mice lacking neuropeptide Y. Nature 381:415-418, 1996