Solution phase combinatorial chemistry. I. Synthesis of polyazacyclophane scaffolds and tertiary amine libraries

Tetrahedron Letters

Volumn 37, Issue 40, 1996, Pages 7233-7236

  An, Haoyun ^a   Cook, P Dan ^a  

^a ISIS PHARMACEUTICALS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINE; MACROCYCLIC COMPOUND;

ARTICLE; DRUG SYNTHESIS; REACTION ANALYSIS; TECHNIQUE;

EID: 0030607193     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/0040-4039(96)01627-9     Document Type: Article

References (33)

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31. 19. The column loaded with crude library was first eluted with less polar eluent to remove the excess electrophiles, and further eluted with more polar eluents to wash all possible compounds in library out of the column. All fractions containing library compounds were collected. The theoretical yield was calculated according to the average molecular weight. The yield was obtained by comparing the amount of isolated library with the theoretical yield.
32. 20. The PLC loaded with crude library was developed by selected solvents. The whole library band, which was wider than those of general single compounds, was collected to get pure library without electrophiles and other impurities.
33. 1H NMR spectra of libraries show the right ratio of various protons.