Solution phase combinatorial chemistry. Synthesis of novel linear pyridinopolyamine libraries with potent antibacterial activity

Journal of Organic Chemistry

Volumn 62, Issue 15, 1997, Pages 5156-5164

  An, H ^a   Haly, B D ^a   Fraser, A S ^a   Guinosso, C J ^a   Cook, P D ^a  

^a ISIS PHARMACEUTICALS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 [[2 [(2 NITROBENZENESULFONYL)[[6 (AMINOMETHYL) 2 PYRIDINYL]METHYL]AMINO]ETHYL](TERT BUTOXYCARBONYL)AMINO] 1 PROPANOL; 3 [[2 [(2 NITROBENZENESULFONYL)[[6 (PHTHALIMIDOMETHYL) 2 PYRIDINYL]METHYL]AMINO]ETHYL](TERT BUTOXYCARBONYL)AMINO] 1 PROPANOL; 3 [[2 [[[6 (AMINOMETHYL) 2 PYRIDINYL]METHYL]AMINO]ETHYL](TERT BUTOXYCARBONYL)AMINO] 1 PROPANOL; 3 [[2 [[[6 (AMINOMETHYL) 2 PYRIDINYL]METHYL]AMINO]ETHYL](TOSYL)AMINO] 1 PROPANOL; 3 [[2 [[[6 (AMINOMETHYL) 2 PYRIDINYL]METHYL]AMINO]ETHYL]AMINO] 1 PROPANOL; 3 [[2 [BENZYL[[6 [[DIBENZYLAMINO]METHYL] 2 PYRIDINYL]METHYL]AMINO]ETHYL]BENZYLAMINO] 1 PROPANOL; ANTIINFECTIVE AGENT; POLYAMINE DERIVATIVE; UNCLASSIFIED DRUG;

ANTIBACTERIAL ACTIVITY; ARTICLE; CYCLIZATION; DRUG SYNTHESIS; ESCHERICHIA COLI; MASS SPECTROMETRY; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PROTON NUCLEAR MAGNETIC RESONANCE; REDUCTION; STREPTOCOCCUS PYOGENES;

EID: 0030743265     PISSN: 00223263     EISSN: None     Source Type: Journal    
DOI: 10.1021/jo970535j     Document Type: Article

References (0)