-
2
-
-
0027281373
-
A novel protein domain required for apoptosis. Mutational analysis of human Fas antigen
-
Itoh N, Nagata S. A novel protein domain required for apoptosis. Mutational analysis of human Fas antigen. J Biol Chem. 268:1993;10932-10937.
-
(1993)
J Biol Chem
, vol.268
, pp. 10932-10937
-
-
Itoh, N.1
Nagata, S.2
-
3
-
-
0032602774
-
The death receptors
-
Kumar S. Heidelberg: Springer
-
Peter ME, Scaffidi C, Medema JP, Kischkel F, Krammer PH. The death receptors. Kumar S. Apoptosis, Problems and Diseases. 1998;25-63 Springer, Heidelberg.
-
(1998)
Apoptosis, Problems and Diseases
, pp. 25-63
-
-
Peter, M.E.1
Scaffidi, C.2
Medema, J.P.3
Kischkel, F.4
Krammer, P.H.5
-
4
-
-
0030868999
-
Ultraviolet radiation-induced apoptosis is mediated by activation of CD-95 (Fas/APO-1)
-
Rehemtulla A, Hamilton CA, Chinnaiyan AM, Dixit VM. Ultraviolet radiation-induced apoptosis is mediated by activation of CD-95 (Fas/APO-1). J Biol Chem. 272:1997;25783-25786.
-
(1997)
J Biol Chem
, vol.272
, pp. 25783-25786
-
-
Rehemtulla, A.1
Hamilton, C.A.2
Chinnaiyan, A.M.3
Dixit, V.M.4
-
5
-
-
0031943921
-
Ultraviolet light induces apoptosis via direct activation of CD95(Fas/APO-1) independently of its ligand CD95L
-
Aragane Y, Kulms D, Metze D, Wilkes G, Poppelmann B, Luger TA, Schwarz T. Ultraviolet light induces apoptosis via direct activation of CD95(Fas/APO-1) independently of its ligand CD95L. J Cell Biol. 140:1998;171-182.
-
(1998)
J Cell Biol
, vol.140
, pp. 171-182
-
-
Aragane, Y.1
Kulms, D.2
Metze, D.3
Wilkes, G.4
Poppelmann, B.5
Luger, T.A.6
Schwarz, T.7
-
6
-
-
0032579414
-
Sphingosine 1-phosphate inhibits activation of caspases that cleave poly(ADP-ribose) polymerase and lamins during Fas- And ceramide-mediated apoptosis in Jurkat T lymphocytes
-
Cuvillier O, Rosenthal DS, Smulson ME, Spiegel S. Sphingosine 1-phosphate inhibits activation of caspases that cleave poly(ADP-ribose) polymerase and lamins during Fas- and ceramide-mediated apoptosis in Jurkat T lymphocytes. J Biol Chem. 273:1998;2910-2916.
-
(1998)
J Biol Chem
, vol.273
, pp. 2910-2916
-
-
Cuvillier, O.1
Rosenthal, D.S.2
Smulson, M.E.3
Spiegel, S.4
-
7
-
-
0030863670
-
Requirement for GD3 ganglioside in CD95- And ceramide-induced apoptosis
-
De Maria R, Lenti L, Malisan F, d'Agostino F, Tomassini B, Zeuner A, Rippo MR, Testi R. Requirement for GD3 ganglioside in CD95- and ceramide-induced apoptosis. Science. 277:1997;1652-1655.
-
(1997)
Science
, vol.277
, pp. 1652-1655
-
-
De Maria, R.1
Lenti, L.2
Malisan, F.3
D'Agostino, F.4
Tomassini, B.5
Zeuner, A.6
Rippo, M.R.7
Testi, R.8
-
8
-
-
0032536876
-
Acidic sphingomyelinase (ASM) is necessary for fas-induced GD3 ganglioside accumulation and efficient apoptosis of lymphoid cells
-
De Maria R, Rippo MR, Schuchman EH, Testi R. Acidic sphingomyelinase (ASM) is necessary for fas-induced GD3 ganglioside accumulation and efficient apoptosis of lymphoid cells. J Exp Med. 187:1998;897-902.
-
(1998)
J Exp Med
, vol.187
, pp. 897-902
-
-
De Maria, R.1
Rippo, M.R.2
Schuchman, E.H.3
Testi, R.4
-
9
-
-
0030670626
-
Activation of CD95 (APO-1/Fas) signaling by ceramide mediates cancer therapy-induced apoptosis
-
Herr I, Wilhelm D, Bohler T, Angel P, Debatin KM. Activation of CD95 (APO-1/Fas) signaling by ceramide mediates cancer therapy-induced apoptosis. EMBO J. 16:1997;6200-6208.
-
(1997)
EMBO J
, vol.16
, pp. 6200-6208
-
-
Herr, I.1
Wilhelm, D.2
Bohler, T.3
Angel, P.4
Debatin, K.M.5
-
10
-
-
0030774818
-
CD95/Fas-induced ceramide formation proceeds with slow kinetics and is not blocked by caspase-3/CPP32 inhibition
-
Tepper AD, Boesen de Cock JG, de Vries E, Borst J, van Blitterswijk WJ. CD95/Fas-induced ceramide formation proceeds with slow kinetics and is not blocked by caspase-3/CPP32 inhibition. J Biol Chem. 272:1998;24308-24312.
-
(1998)
J Biol Chem
, vol.272
, pp. 24308-24312
-
-
Tepper, A.D.1
Boesen De Cock, J.G.2
De Vries, E.3
Borst, J.4
Van Blitterswijk, W.J.5
-
11
-
-
0030844273
-
Fas-induced apoptosis of T cells occurs independently of ceramide generation
-
Watts JD, Gu M, Polverino AJ, Patterson SD, Aebersold R. Fas-induced apoptosis of T cells occurs independently of ceramide generation. Proc Natl Acad Sci USA. 94:1997;7292-7296.
-
(1997)
Proc Natl Acad Sci USA
, vol.94
, pp. 7292-7296
-
-
Watts, J.D.1
Gu, M.2
Polverino, A.J.3
Patterson, S.D.4
Aebersold, R.5
-
12
-
-
0031817917
-
Caspases are the main executioners of Fas-mediated apoptosis, irrespective of the ceramide signalling pathway
-
Gamen S, Anel A, Pieiro A, Naval J. Caspases are the main executioners of Fas-mediated apoptosis, irrespective of the ceramide signalling pathway. Cell Death Different. 5:1998;241-249.
-
(1998)
Cell Death Different
, vol.5
, pp. 241-249
-
-
Gamen, S.1
Anel, A.2
Pieiro, A.3
Naval, J.4
-
13
-
-
16044364385
-
Acid sphingomyelinase-deficient human lymphoblasts and mice are defective in radiation-induced apoptosis
-
Santana P, Pena LA, Haimovitz-Friedman A, Martin S, Green D, McLoughlin M, Cordon-Cardo C, Schuchman EH, Fuks Z, Kolesnick R. Acid sphingomyelinase-deficient human lymphoblasts and mice are defective in radiation-induced apoptosis. Cell. 86:1996;189-199.
-
(1996)
Cell
, vol.86
, pp. 189-199
-
-
Santana, P.1
Pena, L.A.2
Haimovitz-Friedman, A.3
Martin, S.4
Green, D.5
McLoughlin, M.6
Cordon-Cardo, C.7
Schuchman, E.H.8
Fuks, Z.9
Kolesnick, R.10
-
14
-
-
0032571251
-
CD95 (Fas/APO-1) induces ceramide formation and apoptosis in the absence of a functional acid sphingomyelinase
-
Boesen-de Cock JG, Tepper AD, de Vries E, van Blitterswijk WJ, Borst J. CD95 (Fas/APO-1) induces ceramide formation and apoptosis in the absence of a functional acid sphingomyelinase. J Biol Chem. 273:1998;7560-7565.
-
(1998)
J Biol Chem
, vol.273
, pp. 7560-7565
-
-
Boesen-De Cock, J.G.1
Tepper, A.D.2
De Vries, E.3
Van Blitterswijk, W.J.4
Borst, J.5
-
15
-
-
0032584153
-
Cloned mammalian neutral sphingomyelinase: Functions in sphingolipid signaling?
-
Tomiuk S, Hofmann K, Nix M, Zumbansen M, Stoffel W. Cloned mammalian neutral sphingomyelinase: functions in sphingolipid signaling? Proc Natl Acad Sci USA. 95:1998;3638-3643.
-
(1998)
Proc Natl Acad Sci USA
, vol.95
, pp. 3638-3643
-
-
Tomiuk, S.1
Hofmann, K.2
Nix, M.3
Zumbansen, M.4
Stoffel, W.5
-
16
-
-
0030478659
-
Apoptosis: Does stress kill?
-
Cosulich S, Clarke P. Apoptosis: does stress kill? Curr Biol. 6:1996;1586-1588.
-
(1996)
Curr Biol
, vol.6
, pp. 1586-1588
-
-
Cosulich, S.1
Clarke, P.2
-
17
-
-
0028883850
-
Cytotoxicity-dependent APO-1(Fas/CD95)-associated Proteins Form a Death-inducing Signalling Complex (DISC) with the Receptor
-
Kischkel FC, Hellbardt S, Behrmann I, Germer M, Pawlita M, Krammer PH, Peter ME. Cytotoxicity-dependent APO-1(Fas/CD95)-associated Proteins Form a Death-inducing Signalling Complex (DISC) with the Receptor. EMBO J. 14:1995;5579-5588.
-
(1995)
EMBO J
, vol.14
, pp. 5579-5588
-
-
Kischkel, F.C.1
Hellbardt, S.2
Behrmann, I.3
Germer, M.4
Pawlita, M.5
Krammer, P.H.6
Peter, M.E.7
-
18
-
-
0028913550
-
A novel protein that interacts with the death domain of Fas/APO1 contains a sequence motif related to the death domain
-
Boldin MP, Varfolomeev EE, Pancer Z, Mett IL, Camonis JH, Wallach D. A novel protein that interacts with the death domain of Fas/APO1 contains a sequence motif related to the death domain. J Biol Chem. 270:1995;7795-7798.
-
(1995)
J Biol Chem
, vol.270
, pp. 7795-7798
-
-
Boldin, M.P.1
Varfolomeev, E.E.2
Pancer, Z.3
Mett, I.L.4
Camonis, J.H.5
Wallach, D.6
-
19
-
-
0029026548
-
FADD, a novel death domain-containing protein, interacts with the death domain of Fas and initiates apoptosis
-
Chinnaiyan AM, O'Rourke K, Tewari M, Dixit VM. FADD, a novel death domain-containing protein, interacts with the death domain of Fas and initiates apoptosis. Cell. 81:1995;505-512.
-
(1995)
Cell
, vol.81
, pp. 505-512
-
-
Chinnaiyan, A.M.1
O'Rourke, K.2
Tewari, M.3
Dixit, V.M.4
-
20
-
-
15844412409
-
FLICE, a novel FADD-homologous ICE/CED-3-like protease, Is recruited to the CD95 (Fas/APO-1) Death-Inducing Signaling Complex (DISC)
-
Muzio M, Chinnaiyan AM, Kischkel FC, O'Rourke K, Shevchenko A, Scaffidi C, Zhang M, Ni J, Gentz R, Mann M, et al. FLICE, a novel FADD-homologous ICE/CED-3-like protease, Is recruited to the CD95 (Fas/APO-1) Death-Inducing Signaling Complex (DISC). Cell. 85:1996;817-827.
-
(1996)
Cell
, vol.85
, pp. 817-827
-
-
Muzio, M.1
Chinnaiyan, A.M.2
Kischkel, F.C.3
O'Rourke, K.4
Shevchenko, A.5
Scaffidi, C.6
Zhang, M.7
Ni, J.8
Gentz, R.9
Mann, M.10
-
21
-
-
0030826338
-
Two FLICE Isoforms, Caspase 8/a and Caspase 8/b, are recruited and activated by the CD95 Death-inducing Signaling Complex (DISC)
-
Scaffidi C, Medema JP, Krammer PH, Peter ME. Two FLICE Isoforms, Caspase 8/a and Caspase 8/b, are recruited and activated by the CD95 Death-inducing Signaling Complex (DISC). J Biol Chem. 272:1997;26953-26958.
-
(1997)
J Biol Chem
, vol.272
, pp. 26953-26958
-
-
Scaffidi, C.1
Medema, J.P.2
Krammer, P.H.3
Peter, M.E.4
-
22
-
-
0030011398
-
Involvement of MACH, a novel MORT1/FADD-interacting protease, in Fas/APO-1- And TNF receptor-induced cell death
-
Boldin MP, Goncharov TM, Goltsev YV, Wallach D. Involvement of MACH, a novel MORT1/FADD-interacting protease, in Fas/APO-1- and TNF receptor-induced cell death. Cell. 85:1996;803-815.
-
(1996)
Cell
, vol.85
, pp. 803-815
-
-
Boldin, M.P.1
Goncharov, T.M.2
Goltsev, Y.V.3
Wallach, D.4
-
23
-
-
0344053451
-
In vitro activation of CPP32 and Mch3 by Mch4, a novel human apoptotic cysteine protease containing two FADD-like domains
-
Fernandes-Alnemri T, Armstrong RC, Krebs J, Srinivasula SM, Wang L, Bullrich F, Fritz LC, Trapani JA, Tomaselli KJ, Litwack G, Alnemri ES. In vitro activation of CPP32 and Mch3 by Mch4, a novel human apoptotic cysteine protease containing two FADD-like domains. Proc Natl Acad Sci USA. 93:1996;7464-7469.
-
(1996)
Proc Natl Acad Sci USA
, vol.93
, pp. 7464-7469
-
-
Fernandes-Alnemri, T.1
Armstrong, R.C.2
Krebs, J.3
Srinivasula, S.M.4
Wang, L.5
Bullrich, F.6
Fritz, L.C.7
Trapani, J.A.8
Tomaselli, K.J.9
Litwack, G.10
Alnemri, E.S.11
-
24
-
-
0030925774
-
FLICE is activated by association with the CD95 Death-inducing Signaling Complex (DISC)
-
of special interest. This provides a detailed biochemical analysis of the activation of caspase-8 in vivo.
-
Medema JP, Scaffidi C, Kischkel FC, Shevchenko A, Mann M, Krammer PH, Peter ME. FLICE is activated by association with the CD95 Death-inducing Signaling Complex (DISC). of special interest EMBO J. 16:1997;2794-2804 This provides a detailed biochemical analysis of the activation of caspase-8 in vivo.
-
(1997)
EMBO J
, vol.16
, pp. 2794-2804
-
-
Medema, J.P.1
Scaffidi, C.2
Kischkel, F.C.3
Shevchenko, A.4
Mann, M.5
Krammer, P.H.6
Peter, M.E.7
-
25
-
-
0029054725
-
RIP: A novel protein containing a death domain that interacts with Fas/APO-1 (CD95) in yeast and causes cell death
-
Stanger BZ, Leder P, Lee TH, Kim E, Seed B. RIP: a novel protein containing a death domain that interacts with Fas/APO-1 (CD95) in yeast and causes cell death. Cell. 81:1995;513-523.
-
(1995)
Cell
, vol.81
, pp. 513-523
-
-
Stanger, B.Z.1
Leder, P.2
Lee, T.H.3
Kim, E.4
Seed, B.5
-
26
-
-
0032033132
-
The death domain kinase RIP mediates the TNF-induced NF-kappaB signal
-
of special interest. This reports the characterization of RIP (receptor-interacting protein)-knockout mice demontrating that RIP is essential for activation of the transcription factor NF-κB activation that is mediated by the TNF receptor.
-
Kelliher MA, Grimm S, Ishida Y, Kuo F, Stanger BZ, Leder P. The death domain kinase RIP mediates the TNF-induced NF-kappaB signal. of special interest Immunity. 8:1998;297-303 This reports the characterization of RIP (receptor-interacting protein)-knockout mice demontrating that RIP is essential for activation of the transcription factor NF-κB activation that is mediated by the TNF receptor.
-
(1998)
Immunity
, vol.8
, pp. 297-303
-
-
Kelliher, M.A.1
Grimm, S.2
Ishida, Y.3
Kuo, F.4
Stanger, B.Z.5
Leder, P.6
-
27
-
-
0029066512
-
FAP-1: A protein tyrosine phosphatase that associates with Fas
-
Sato T, Irie S, Kitada S, Reed JC. FAP-1: a protein tyrosine phosphatase that associates with Fas. Science. 268:1995;411-415.
-
(1995)
Science
, vol.268
, pp. 411-415
-
-
Sato, T.1
Irie, S.2
Kitada, S.3
Reed, J.C.4
-
28
-
-
0030772973
-
Characterization of the interactions between PDZ domains of the protein-tyrosine phosphatase PTPL1 and the carboxyl-terminal tail of Fas
-
Saras J, Engstrom U, Gonez LJ, Heldin CH. Characterization of the interactions between PDZ domains of the protein-tyrosine phosphatase PTPL1 and the carboxyl-terminal tail of Fas. J Biol Chem. 272:1997;20979-20981.
-
(1997)
J Biol Chem
, vol.272
, pp. 20979-20981
-
-
Saras, J.1
Engstrom, U.2
Gonez, L.J.3
Heldin, C.H.4
-
29
-
-
0030778437
-
No evidence for involvement of mouse protein-tyrosine phosphatase-BAS-like Fas-associated phosphatase-1 in Fas-mediated apoptosis
-
Cuppen E, Nagata S, Wieringa B, Hendriks W. No evidence for involvement of mouse protein-tyrosine phosphatase-BAS-like Fas-associated phosphatase-1 in Fas-mediated apoptosis. J Biol Chem. 272:1997;30215-30220.
-
(1997)
J Biol Chem
, vol.272
, pp. 30215-30220
-
-
Cuppen, E.1
Nagata, S.2
Wieringa, B.3
Hendriks, W.4
-
30
-
-
0031587883
-
Daxx, a novel Fas-binding protein that activates JNK and apoptosis
-
Yang X, Khosravi-Far R, Chang HY, Baltimore D. Daxx, a novel Fas-binding protein that activates JNK and apoptosis. Cell. 89:1997;1067-1076.
-
(1997)
Cell
, vol.89
, pp. 1067-1076
-
-
Yang, X.1
Khosravi-Far, R.2
Chang, H.Y.3
Baltimore, D.4
-
31
-
-
7144263731
-
FADD: Essential for embryo development and signaling from some, but not all, inducers of apoptosis
-
of outstanding interest. This reports the characterization of FADD (Fas-associated death domain)-knockout mice and describes that FADD is essential for CD95-mediated apoptosis and is required for proper heart formation.
-
Yeh WC, Pompa JL, McCurrach ME, Shu HB, Elia AJ, Shahinian A, Ng M, Wakeham A, Khoo W, Mitchell K, et al. FADD: essential for embryo development and signaling from some, but not all, inducers of apoptosis. of outstanding interest Science. 279:1998;1954-1958 This reports the characterization of FADD (Fas-associated death domain)-knockout mice and describes that FADD is essential for CD95-mediated apoptosis and is required for proper heart formation.
-
(1998)
Science
, vol.279
, pp. 1954-1958
-
-
Yeh, W.C.1
Pompa, J.L.2
McCurrach, M.E.3
Shu, H.B.4
Elia, A.J.5
Shahinian, A.6
Ng, M.7
Wakeham, A.8
Khoo, W.9
Mitchell, K.10
-
32
-
-
0032546387
-
Fas-mediated apoptosis and activation-induced T-cell proliferation are defective in mice lacking FADD/Mort1
-
of outstanding interest. In addition to the findings in [31] the authors elegantly show the importance of FADD (Fas-associated death domain) for T cell proliferation.
-
Zhang J, Cado D, Chen A, Kabra NH, Winoto A. Fas-mediated apoptosis and activation-induced T-cell proliferation are defective in mice lacking FADD/Mort1. of outstanding interest Nature. 392:1998;296-300 In addition to the findings in [31] the authors elegantly show the importance of FADD (Fas-associated death domain) for T cell proliferation.
-
(1998)
Nature
, vol.392
, pp. 296-300
-
-
Zhang, J.1
Cado, D.2
Chen, A.3
Kabra, N.H.4
Winoto, A.5
-
33
-
-
0029821787
-
CD95 (APO-1/Fas) induces activation of SAP kinases downstream of ICE-like proteases
-
Cahill MA, Peter ME, Kischkel FC, Chinnayian AM, Dixit VM, Krammer PH, Nordheim A. CD95 (APO-1/Fas) induces activation of SAP kinases downstream of ICE-like proteases. Oncogene. 13:1996;2087-2096.
-
(1996)
Oncogene
, vol.13
, pp. 2087-2096
-
-
Cahill, M.A.1
Peter, M.E.2
Kischkel, F.C.3
Chinnayian, A.M.4
Dixit, V.M.5
Krammer, P.H.6
Nordheim, A.7
-
34
-
-
0032518446
-
Dominant-negative FADD inhibits TNFR60-, Fas/Apo1- And TRAIL-R/Apo2-mediated cell death but not gene induction
-
Wajant H, Johannes FJ, Haas E, Siemienski K, Schwenzer R, Schubert G, Weiss T, Grell M, Scheurich P. Dominant-negative FADD inhibits TNFR60-, Fas/Apo1- and TRAIL-R/Apo2-mediated cell death but not gene induction. Curr Biol. 8:1998;113-116.
-
(1998)
Curr Biol
, vol.8
, pp. 113-116
-
-
Wajant, H.1
Johannes, F.J.2
Haas, E.3
Siemienski, K.4
Schwenzer, R.5
Schubert, G.6
Weiss, T.7
Grell, M.8
Scheurich, P.9
-
35
-
-
0032472916
-
A dominant interfering mutant of FADD/MORT1 enhances deletion of autoreactive thymocytes and inhibits proliferation of mature T lymphocytes
-
of outstanding interest. This describes findings using a transgenic system that were essentially consistent with the conclusions described in annotation [32].
-
Newton K, Harris AW, Bath ML, Smith KGC, Strasser A. A dominant interfering mutant of FADD/MORT1 enhances deletion of autoreactive thymocytes and inhibits proliferation of mature T lymphocytes. of outstanding interest EMBO J. 17:1998;706-718 This describes findings using a transgenic system that were essentially consistent with the conclusions described in annotation [32].
-
(1998)
EMBO J
, vol.17
, pp. 706-718
-
-
Newton, K.1
Harris, A.W.2
Bath, M.L.3
Smith, K.G.C.4
Strasser, A.5
-
36
-
-
0032499138
-
P53-dependent impairment of T-cell proliferation in FADD dominant-negative transgenic mice
-
of outstanding interest. of outstanding interest. See annotation to [35].
-
of outstanding interest Zornig M, Hueber AO, Evan G. p53-dependent impairment of T-cell proliferation in FADD dominant-negative transgenic mice. of outstanding interest Curr Biol. 8:1998;467-470 See annotation to [35].
-
(1998)
Curr Biol
, vol.8
, pp. 467-470
-
-
Zornig, M.1
Hueber, A.O.2
Evan, G.3
-
37
-
-
0032055344
-
A role for FADD in T cell activation and development
-
of special interest. of outstanding interest. See annotation to [35].
-
of special interest Walsh CM, Wen BG, Chinnaiyan AM, O'Rourke K, Dixit VM, Hedrick SM. A role for FADD in T cell activation and development. of outstanding interest Immunity. 8:1998;439-449 See annotation to [35].
-
(1998)
Immunity
, vol.8
, pp. 439-449
-
-
Walsh, C.M.1
Wen, B.G.2
Chinnaiyan, A.M.3
O'Rourke, K.4
Dixit, V.M.5
Hedrick, S.M.6
-
38
-
-
0029906828
-
BAX-induced cell death may not require interleukin 1 beta-converting enzyme-like proteases
-
Xiang J, Chao DT, Korsmeyer SJ. BAX-induced cell death may not require interleukin 1 beta-converting enzyme-like proteases. Proc Natl Acad Sci USA. 93:1996;14559-14563.
-
(1996)
Proc Natl Acad Sci USA
, vol.93
, pp. 14559-14563
-
-
Xiang, J.1
Chao, D.T.2
Korsmeyer, S.J.3
-
39
-
-
0031033274
-
Inhibition of Ced-3/ICE-related proteases does not prevent cell death induced by oncogenes, DNA damage, or the Bcl-2 homologue Bak
-
McCarthy NJ, Whyte MK, Gilbert CS, Evan GI. Inhibition of Ced-3/ICE-related proteases does not prevent cell death induced by oncogenes, DNA damage, or the Bcl-2 homologue Bak. J Cell Biol. 136:1997;215-227.
-
(1997)
J Cell Biol
, vol.136
, pp. 215-227
-
-
McCarthy, N.J.1
Whyte, M.K.2
Gilbert, C.S.3
Evan, G.I.4
-
40
-
-
0009530192
-
Human ICE/CED-3 protease nomenclature
-
Alnemri ES, Livingston DJ, Nicholson DW, Salvesen G, Thornberry NA, Wong WW, Yuan J. Human ICE/CED-3 protease nomenclature. Cell. 87:1996;171.
-
(1996)
Cell
, vol.87
, pp. 171
-
-
Alnemri, E.S.1
Livingston, D.J.2
Nicholson, D.W.3
Salvesen, G.4
Thornberry, N.A.5
Wong, W.W.6
Yuan, J.7
-
41
-
-
0030849093
-
A combinatorial approach defines specificities of members of the caspase family and granzyme B. Functional relationships established for key mediators of apoptosis
-
of outstanding interest. This is a very comprehensive in vitro analysis of caspase specifities using a peptide library.
-
Thornberry NA, Rano TA, Peterson EP, Rasper DM, Timkey T, Garcia Calvo M, Houtzager VM, Nordstrom PA, Roy S, Vaillancourt JP, et al. A combinatorial approach defines specificities of members of the caspase family and granzyme B. Functional relationships established for key mediators of apoptosis. of outstanding interest J Biol Chem. 272:1997;17907-17911 This is a very comprehensive in vitro analysis of caspase specifities using a peptide library.
-
(1997)
J Biol Chem
, vol.272
, pp. 17907-17911
-
-
Thornberry, N.A.1
Rano, T.A.2
Peterson, E.P.3
Rasper, D.M.4
Timkey, T.5
Garcia Calvo, M.6
Houtzager, V.M.7
Nordstrom, P.A.8
Roy, S.9
Vaillancourt, J.P.10
-
42
-
-
0032579490
-
An induced proximity model for caspase-8 activation
-
of special interest. This work demonstrates that activation of caspase-8 does not depend on the activity of any other caspase and that caspase-8 activation can fully acount for all apoptotic features found during CD95-mediated apoptosis.
-
Muzio M, Stockwell BR, Stennicke HR, Salvesen GS, Dixit VM. An induced proximity model for caspase-8 activation. of special interest J Biol Chem. 273:1998;2926-2930 This work demonstrates that activation of caspase-8 does not depend on the activity of any other caspase and that caspase-8 activation can fully acount for all apoptotic features found during CD95-mediated apoptosis.
-
(1998)
J Biol Chem
, vol.273
, pp. 2926-2930
-
-
Muzio, M.1
Stockwell, B.R.2
Stennicke, H.R.3
Salvesen, G.S.4
Dixit, V.M.5
-
43
-
-
0032548842
-
Membrane oligomerization and cleavage activates the caspase-8 (FLICE/MACHalpha1) death signal
-
of special interest. See annotation to [42].
-
Martin DA, Siegel RM, Zheng L, Lenardo MJ. Membrane oligomerization and cleavage activates the caspase-8 (FLICE/MACHalpha1) death signal. of special interest J Biol Chem. 273:1998;4345-4349 See annotation to [42].
-
(1998)
J Biol Chem
, vol.273
, pp. 4345-4349
-
-
Martin, D.A.1
Siegel, R.M.2
Zheng, L.3
Lenardo, M.J.4
-
44
-
-
0031615875
-
Autoproteolytic Activation of Pro Caspases by Oligomerization
-
of special interest. See annotation to [42].
-
Yang X, Chang HY, Baltimore D. Autoproteolytic Activation of Pro Caspases by Oligomerization. of special interest Molec Cell. 1:1998;319-325 See annotation to [42].
-
(1998)
Molec Cell
, vol.1
, pp. 319-325
-
-
Yang, X.1
Chang, H.Y.2
Baltimore, D.3
-
45
-
-
0032014706
-
Apoptosis induced by a chimeric Fas/FLICE receptor: Lack of requirement for Fas- Or FADD-binding proteins
-
of special interest. See annotation to [42].
-
Memon SA, Hou J, Moreno MB, Zacharchuk CM. Apoptosis induced by a chimeric Fas/FLICE receptor: lack of requirement for Fas- or FADD-binding proteins. of special interest J Immunol. 160:1998;2046-2049 See annotation to [42].
-
(1998)
J Immunol
, vol.160
, pp. 2046-2049
-
-
Memon, S.A.1
Hou, J.2
Moreno, M.B.3
Zacharchuk, C.M.4
-
46
-
-
0032536519
-
Caspases are activated in a branched protease cascade and control distinct downstream processes in Fas-induced apoptosis
-
Hirata H, Takahashi A, Kobayashi S, Yonehara S, Sawai H, Okazaki T, Yamamoto K, Sasada M. Caspases are activated in a branched protease cascade and control distinct downstream processes in Fas-induced apoptosis. J Exp Med. 187:1998;587-600.
-
(1998)
J Exp Med
, vol.187
, pp. 587-600
-
-
Hirata, H.1
Takahashi, A.2
Kobayashi, S.3
Yonehara, S.4
Sawai, H.5
Okazaki, T.6
Yamamoto, K.7
Sasada, M.8
-
47
-
-
0031459164
-
Cleavage of FLICE by granzyme B during cytotoxic T lymphocyte-induced apoptosis
-
of special interest. This is the first in vivo demonstration that granzyme B activates the apoptosis pathway in CTL targets by using primarily caspase-8 cleavage as the entry point.
-
Medema JP, Toes REM, Scaffidi C, Zheng TS, Flavell RA, Melief CJM, Peter ME, Offringa R, Krammer PH. Cleavage of FLICE by granzyme B during cytotoxic T lymphocyte-induced apoptosis. of special interest Eur J Immunol. 27:1997;3492-3498 This is the first in vivo demonstration that granzyme B activates the apoptosis pathway in CTL targets by using primarily caspase-8 cleavage as the entry point.
-
(1997)
Eur J Immunol
, vol.27
, pp. 3492-3498
-
-
Medema, J.P.1
Toes, R.E.M.2
Scaffidi, C.3
Zheng, T.S.4
Flavell, R.A.5
Melief, C.J.M.6
Peter, M.E.7
Offringa, R.8
Krammer, P.H.9
-
48
-
-
0030815250
-
Betulinic acid triggers CD95 (APO-1/Fas)- And p53-independent apoptosis via activation of caspases in neuroectodermal tumors
-
of special interest. This is the first demonstration of an anticancer drug that induces apoptosis by direct activation of mitochondria without requirement of the CD95 death receptor/ligand system.
-
Fulda S, Friesen C, Los M, Scaffidi C, Mier W, Benedict M, Nuñez G, Krammer PH, Peter ME, Debatin KM. Betulinic acid triggers CD95 (APO-1/Fas)- and p53-independent apoptosis via activation of caspases in neuroectodermal tumors. of special interest Cancer Res. 57:1997;4956-4964 This is the first demonstration of an anticancer drug that induces apoptosis by direct activation of mitochondria without requirement of the CD95 death receptor/ligand system.
-
(1997)
Cancer Res
, vol.57
, pp. 4956-4964
-
-
Fulda, S.1
Friesen, C.2
Los, M.3
Scaffidi, C.4
Mier, W.5
Benedict, M.6
Nuñez, G.7
Krammer, P.H.8
Peter, M.E.9
Debatin, K.M.10
-
49
-
-
2342625486
-
The anti-cancer drug etoposide can induce caspase-8 processing and apoptosis in the absence of CD95 receptor-ligand interaction
-
Boesen-de Cock JG, de Vries JR, Williams GT, Borst J. The anti-cancer drug etoposide can induce caspase-8 processing and apoptosis in the absence of CD95 receptor-ligand interaction. Apoptosis. 3:1998;17-25.
-
(1998)
Apoptosis
, vol.3
, pp. 17-25
-
-
Boesen-De Cock, J.G.1
De Vries, J.R.2
Williams, G.T.3
Borst, J.4
-
50
-
-
0029125701
-
Protease activation during apoptosis: Death by a thousand cuts?
-
Martin SJ, Green DR. Protease activation during apoptosis: death by a thousand cuts? Cell. 82:1995;349-352.
-
(1995)
Cell
, vol.82
, pp. 349-352
-
-
Martin, S.J.1
Green, D.R.2
-
51
-
-
0032031417
-
The caspase-RB connection in cell death
-
of special interest. This provides an excellent and comprehensive overview on various caspase substrates.
-
Tan X, Wang YJ. The caspase-RB connection in cell death. of special interest Trends Cell Biol. 8:1998;116-120 This provides an excellent and comprehensive overview on various caspase substrates.
-
(1998)
Trends Cell Biol
, vol.8
, pp. 116-120
-
-
Tan, X.1
Wang, Y.J.2
-
52
-
-
0032549670
-
Caspase-dependent cleavage of signaling proteins during apoptosis. A turn-off mechanism for anti-apoptotic signals
-
Widmann C, Gibson S, Johnson GL. Caspase-dependent cleavage of signaling proteins during apoptosis. A turn-off mechanism for anti-apoptotic signals. J Biol Chem. 273:1998;7141-7147.
-
(1998)
J Biol Chem
, vol.273
, pp. 7141-7147
-
-
Widmann, C.1
Gibson, S.2
Johnson, G.L.3
-
53
-
-
0030820875
-
Caspase-3-generated fragment of gelsolin: Effector of morphological change in apoptosis
-
Kothakota S, Azuma T, Reinhard C, Klippel A, Tang J, Chu K, McGarry TJ, Kirschner MW, Koths K, Kwiatkowski DJ, Williams LT. Caspase-3-generated fragment of gelsolin: effector of morphological change in apoptosis. Science. 278:1997;294-298.
-
(1997)
Science
, vol.278
, pp. 294-298
-
-
Kothakota, S.1
Azuma, T.2
Reinhard, C.3
Klippel, A.4
Tang, J.5
Chu, K.6
McGarry, T.J.7
Kirschner, M.W.8
Koths, K.9
Kwiatkowski, D.J.10
Williams, L.T.11
-
54
-
-
0030770449
-
Caspase cleavage of keratin 18 and reorganization of intermediate filaments during epithelial cell apoptosis
-
of special interest. This provides a good summary on cleavage of various members of the intermediate filament protein family by caspases.
-
Caul'n C, Salvesen GS, Oshima RG. Caspase cleavage of keratin 18 and reorganization of intermediate filaments during epithelial cell apoptosis. of special interest J Cell Biol. 138:1997;1379-1394 This provides a good summary on cleavage of various members of the intermediate filament protein family by caspases.
-
(1997)
J Cell Biol
, vol.138
, pp. 1379-1394
-
-
Caul'N, C.1
Salvesen, G.S.2
Oshima, R.G.3
-
55
-
-
0030918572
-
Membrane and morphological changes in apoptotic cells regulated by caspase-mediated activation of PAK2
-
of special interest. This demonstrates a correlation between activation of the signaling molecule PAK2 (p21-activated kinase 2) and the ability of apoptosing cells to form apoptotic bodies.
-
Rudel T, Bokoch GM. Membrane and morphological changes in apoptotic cells regulated by caspase-mediated activation of PAK2. of special interest Science. 276:1997;1571-1574 This demonstrates a correlation between activation of the signaling molecule PAK2 (p21-activated kinase 2) and the ability of apoptosing cells to form apoptotic bodies.
-
(1997)
Science
, vol.276
, pp. 1571-1574
-
-
Rudel, T.1
Bokoch, G.M.2
-
56
-
-
0031443641
-
Activation of hPAK65 by caspase cleavage induces some of the morphological and biochemical changes of apoptosis
-
of special interest. See annotation to [55].
-
Lee N, MacDonald H, Reinhard C, Halenbeck R, Roulston A, Shi T, Williams LT. Activation of hPAK65 by caspase cleavage induces some of the morphological and biochemical changes of apoptosis. of special interest Proc Natl Acad Sci USA. 94:1997;13642-13647 See annotation to [55].
-
(1997)
Proc Natl Acad Sci USA
, vol.94
, pp. 13642-13647
-
-
Lee, N.1
MacDonald, H.2
Reinhard, C.3
Halenbeck, R.4
Roulston, A.5
Shi, T.6
Williams, L.T.7
-
57
-
-
0032522704
-
Caspase-mediated activation and induction of apoptosis by the mammalian Ste20-like kinase Mst1
-
Graves JD, Gotoh Y, Draves KE, Ambrose D, Han DKM, Wright M, Chernoff J, Clark EA, Krebs EG. Caspase-mediated activation and induction of apoptosis by the mammalian Ste20-like kinase Mst1. EMBO J. 17:1998;2224-2234.
-
(1998)
EMBO J
, vol.17
, pp. 2224-2234
-
-
Graves, J.D.1
Gotoh, Y.2
Draves, K.E.3
Ambrose, D.4
Han, D.K.M.5
Wright, M.6
Chernoff, J.7
Clark, E.A.8
Krebs, E.G.9
-
59
-
-
0030867842
-
Cleavage of focal adhesion kinase by caspases during apoptosis
-
Wen LP, Fahrni JA, Troie S, Guan JL, Orth K, Rosen GD. Cleavage of focal adhesion kinase by caspases during apoptosis. J Biol Chem. 272:1997;26056-26061.
-
(1997)
J Biol Chem
, vol.272
, pp. 26056-26061
-
-
Wen, L.P.1
Fahrni, J.A.2
Troie, S.3
Guan, J.L.4
Orth, K.5
Rosen, G.D.6
-
60
-
-
0030743898
-
The large subunit of the DNA replication complex C (DSEB/RF-C140) cleaved and inactivated by caspase-3 (CPP32/YAMA) during Fas-induced apoptosis
-
Ubeda M, Habener JF. The large subunit of the DNA replication complex C (DSEB/RF-C140) cleaved and inactivated by caspase-3 (CPP32/YAMA) during Fas-induced apoptosis. J Biol Chem. 272:1997;19562-19568.
-
(1997)
J Biol Chem
, vol.272
, pp. 19562-19568
-
-
Ubeda, M.1
Habener, J.F.2
-
61
-
-
0343306746
-
The large subunit of replication factor C is a substrate for caspase-3 in vitro and is cleaved by a caspase 3-like protease during Fas-mediated apoptosis
-
Rheaume E, Cohen LY, Uhlmann F, Lazure C, Alam A, Hurwitz J, Sekaly RP, Denis F. The large subunit of replication factor C is a substrate for caspase-3 in vitro and is cleaved by a caspase 3-like protease during Fas-mediated apoptosis. EMBO J. 16:1997;6346-6354.
-
(1997)
EMBO J
, vol.16
, pp. 6346-6354
-
-
Rheaume, E.1
Cohen, L.Y.2
Uhlmann, F.3
Lazure, C.4
Alam, A.5
Hurwitz, J.6
Sekaly, R.P.7
Denis, F.8
-
62
-
-
0031888955
-
A caspase-activated DNase that degrades DNA during apoptosis, and its inhibitor ICAD
-
of outstanding interest. This is an elegant biochemical identification and characterization of an endonuclease involved in oligosomal DNA degradation during apoptosis.
-
Enari M, Sakahira H, Yokoyama H, Okawa K, Iwamatsu A, Nagata S. A caspase-activated DNase that degrades DNA during apoptosis, and its inhibitor ICAD. of outstanding interest Nature. 391:1998;43-50 This is an elegant biochemical identification and characterization of an endonuclease involved in oligosomal DNA degradation during apoptosis.
-
(1998)
Nature
, vol.391
, pp. 43-50
-
-
Enari, M.1
Sakahira, H.2
Yokoyama, H.3
Okawa, K.4
Iwamatsu, A.5
Nagata, S.6
-
63
-
-
0032560073
-
CPAN, a human nuclease regulated by the caspase-sensitive inhibitor DFF-45
-
of special interest. of outstanding interest. This reports the cloning of the human homolog of the endonuclease, caspase-activated DNase (see annotation to [62]).
-
of special interest Halenbeck R, MacDonald H, Roulston A, Chen TT, Conroy L, Williams LT. CPAN, a human nuclease regulated by the caspase-sensitive inhibitor DFF-45. of outstanding interest Curr Biol. 8:1998;537-540 This reports the cloning of the human homolog of the endonuclease, caspase-activated DNase (see annotation to [62]).
-
(1998)
Curr Biol
, vol.8
, pp. 537-540
-
-
Halenbeck, R.1
MacDonald, H.2
Roulston, A.3
Chen, T.T.4
Conroy, L.5
Williams, L.T.6
-
64
-
-
0031889132
-
Cleavage of CAD inhibitor in CAD activation and DNA degradation during apoptosis
-
of outstanding interest. This reports the cloning and biochemical charterization of a protein, cleavage of which facilitates translocation of an endonuclease - caspase-activated DNase - into the nucleus.
-
Sakahira H, Enari M, Nagata S. Cleavage of CAD inhibitor in CAD activation and DNA degradation during apoptosis. of outstanding interest Nature. 391:1998;96-99 This reports the cloning and biochemical charterization of a protein, cleavage of which facilitates translocation of an endonuclease - caspase-activated DNase - into the nucleus.
-
(1998)
Nature
, vol.391
, pp. 96-99
-
-
Sakahira, H.1
Enari, M.2
Nagata, S.3
-
65
-
-
0032080022
-
CIDE, a novel family of cell death activators with homology to the 45 kDa subunit of the DNA fragmentation factor
-
Inohara N, Koseki T, Chen S, Wu X, Nuñez G. CIDE, a novel family of cell death activators with homology to the 45 kDa subunit of the DNA fragmentation factor. EMBO J. 17:1998;2526-2533.
-
(1998)
EMBO J
, vol.17
, pp. 2526-2533
-
-
Inohara, N.1
Koseki, T.2
Chen, S.3
Wu, X.4
Nuñez, G.5
-
66
-
-
0030916417
-
DFF, a heterodimeric protein that functions downstream of caspase-3 to trigger DNA fragmentation during apoptosis
-
of special interest. of outstanding interest. This provides characterization of a protein DFF-45 (identical to the inhibitor of caspase-activated DNase; see annotation to [62]) required for activation of a DNA-cleaving activity.
-
of special interest Liu X, Zou H, Slaughter C, Wang X. DFF, a heterodimeric protein that functions downstream of caspase-3 to trigger DNA fragmentation during apoptosis. of outstanding interest Cell. 89:1997;175-184 This provides characterization of a protein DFF-45 (identical to the inhibitor of caspase-activated DNase; see annotation to [62]) required for activation of a DNA-cleaving activity.
-
(1997)
Cell
, vol.89
, pp. 175-184
-
-
Liu, X.1
Zou, H.2
Slaughter, C.3
Wang, X.4
-
67
-
-
0030785790
-
The central executioner of apoptosis: Multiple connections between protease activation and mitochondria in Fas/APO-1/CD95- And ceramide-induced apoptosis
-
of special interest. This is a demonstration of the importance of mitochondria for CD95-mediated apoptosis.
-
Susin SA, Zamzami N, Castedo M, Daugas E, Wang HG, Geley S, Fassy F, Reed JC, Kroemer G. The central executioner of apoptosis: multiple connections between protease activation and mitochondria in Fas/APO-1/CD95- and ceramide-induced apoptosis. of special interest J Exp Med. 186:1997;25-37 This is a demonstration of the importance of mitochondria for CD95-mediated apoptosis.
-
(1997)
J Exp Med
, vol.186
, pp. 25-37
-
-
Susin, S.A.1
Zamzami, N.2
Castedo, M.3
Daugas, E.4
Wang, H.G.5
Geley, S.6
Fassy, F.7
Reed, J.C.8
Kroemer, G.9
-
68
-
-
0030745646
-
Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome c-dependent activation of caspase-3
-
of outstanding interest. This reports the identification and elegant characterization of the long-sought-after human homolog of the Caenorhabditis elegans death-promoting-protein CED-4.
-
Zou H, Henzel WJ, Liu X, Lutschg A, Wang X. Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome c-dependent activation of caspase-3. of outstanding interest Cell. 90:1997;405-413 This reports the identification and elegant characterization of the long-sought-after human homolog of the Caenorhabditis elegans death-promoting-protein CED-4.
-
(1997)
Cell
, vol.90
, pp. 405-413
-
-
Zou, H.1
Henzel, W.J.2
Liu, X.3
Lutschg, A.4
Wang, X.5
-
69
-
-
0030715323
-
Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade
-
of special interest. This is a characterization and functional analysis of caspase-9 - previously described as Apaf-3.
-
Li P, Nijhawan D, Budihardjo I, Srinivasula SM, Ahmad M, Alnemri ES, Wang X. Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade. of special interest Cell. 91:1997;479-489 This is a characterization and functional analysis of caspase-9 - previously described as Apaf-3.
-
(1997)
Cell
, vol.91
, pp. 479-489
-
-
Li, P.1
Nijhawan, D.2
Budihardjo, I.3
Srinivasula, S.M.4
Ahmad, M.5
Alnemri, E.S.6
Wang, X.7
-
70
-
-
0032472329
-
Mitochondrial cytochrome c release in apoptosis occurs upstream of DEVD-specific caspase activation and independently of mitochondrial transmembrane depolarization
-
Bossy-Wetzel E, Newmeyer DD, Green DR. Mitochondrial cytochrome c release in apoptosis occurs upstream of DEVD-specific caspase activation and independently of mitochondrial transmembrane depolarization. EMBO J. 17:1998;37-49.
-
(1998)
EMBO J
, vol.17
, pp. 37-49
-
-
Bossy-Wetzel, E.1
Newmeyer, D.D.2
Green, D.R.3
-
71
-
-
0032574761
-
Bax directly induces release of cytochrome c from isolated mitochondria
-
Jürgensmeier JM, Xie Z, Deveraux Q, Ellerby L, Bredesen D, Reed JC. Bax directly induces release of cytochrome c from isolated mitochondria. Proc Natl Acad Sci USA. 95:1998;4997-5002.
-
(1998)
Proc Natl Acad Sci USA
, vol.95
, pp. 4997-5002
-
-
Jürgensmeier, J.M.1
Xie, Z.2
Deveraux, Q.3
Ellerby, L.4
Bredesen, D.5
Reed, J.C.6
-
72
-
-
0030613796
-
Bcl-xL regulates the membrane potential and volume homeostasis of mitochondria
-
Van der Heiden MG, Chandel NS, Williamson EK, Schumacker PT, Thompson CB. Bcl-xL regulates the membrane potential and volume homeostasis of mitochondria. Cell. 91:1997;627-637.
-
(1997)
Cell
, vol.91
, pp. 627-637
-
-
Van Der Heiden, M.G.1
Chandel, N.S.2
Williamson, E.K.3
Schumacker, P.T.4
Thompson, C.B.5
-
73
-
-
0032576692
-
Bcl-2 prolongs cell survival after Bax-induced release of cytochrome c
-
Rosse T, Olivier R, Monney L, Rager M, Conus S, Fellay I, Jansen B, Borner C. Bcl-2 prolongs cell survival after Bax-induced release of cytochrome c. Nature. 391:1998;496-499.
-
(1998)
Nature
, vol.391
, pp. 496-499
-
-
Rosse, T.1
Olivier, R.2
Monney, L.3
Rager, M.4
Conus, S.5
Fellay, I.6
Jansen, B.7
Borner, C.8
-
74
-
-
0030803271
-
Bcl-2 and the outer mitochondrial membrane in the inactivation of cytochrome c during Fas-mediated apoptosis
-
Adachi S, Cross AR, Babior BM, Gottlieb RA. Bcl-2 and the outer mitochondrial membrane in the inactivation of cytochrome c during Fas-mediated apoptosis. J Biol Chem. 272:1997;21878-21882.
-
(1997)
J Biol Chem
, vol.272
, pp. 21878-21882
-
-
Adachi, S.1
Cross, A.R.2
Babior, B.M.3
Gottlieb, R.A.4
-
75
-
-
0032539673
-
Bcl-2 prevents apoptotic mitochondrial dysfunction by regulating proton flux
-
Shimizu S, Eguchi Y, Kamiike W, Funahashi Y, Mignon A, Lacronique V, Matsuda H, Tsujimoto Y. Bcl-2 prevents apoptotic mitochondrial dysfunction by regulating proton flux. Proc Natl Acad Sci USA. 95:1998;1455-1459.
-
(1998)
Proc Natl Acad Sci USA
, vol.95
, pp. 1455-1459
-
-
Shimizu, S.1
Eguchi, Y.2
Kamiike, W.3
Funahashi, Y.4
Mignon, A.5
Lacronique, V.6
Matsuda, H.7
Tsujimoto, Y.8
-
76
-
-
0032536771
-
Two CD95 (APO-1/Fas) signaling pathways
-
of outstanding interest. This reports the identification of two apoptosis signaling types that differ in their dependence on apoptogenic activities of mitochondria, providing an explanation for the differential ability of Bcl-2 or Bcl-xL to inhibit CD95-mediated apoptosis.
-
Scaffidi C, Fulda S, Srinivasan A, Friesen C, Li F, Tomaselli KJ, Debatin KM, Krammer PH, Peter ME. Two CD95 (APO-1/Fas) signaling pathways. of outstanding interest EMBO J. 17:1998;1675-1687 This reports the identification of two apoptosis signaling types that differ in their dependence on apoptogenic activities of mitochondria, providing an explanation for the differential ability of Bcl-2 or Bcl-xL to inhibit CD95-mediated apoptosis.
-
(1998)
EMBO J
, vol.17
, pp. 1675-1687
-
-
Scaffidi, C.1
Fulda, S.2
Srinivasan, A.3
Friesen, C.4
Li, F.5
Tomaselli, K.J.6
Debatin, K.M.7
Krammer, P.H.8
Peter, M.E.9
-
77
-
-
0032550363
-
The permeability transition pore complex: A target for apoptosis regulation by caspases and Bcl-2-related proteins
-
of special interest. This demonstrates the reconstitution of the permeability pore complex in liposomes.
-
Marzo I, Brenner C, Zamzami N, Susin SA, Beutner G, Brdiczka D, Remy R, Xie ZH, Reed JC, Kroemer G. The permeability transition pore complex: a target for apoptosis regulation by caspases and Bcl-2-related proteins. of special interest J Exp Med. 187:1998;1261-1271 This demonstrates the reconstitution of the permeability pore complex in liposomes.
-
(1998)
J Exp Med
, vol.187
, pp. 1261-1271
-
-
Marzo, I.1
Brenner, C.2
Zamzami, N.3
Susin, S.A.4
Beutner, G.5
Brdiczka, D.6
Remy, R.7
Xie, Z.H.8
Reed, J.C.9
Kroemer, G.10
-
78
-
-
0030767421
-
Involvement of caspase-4(-like) protease in Fas-mediated apoptotic pathway
-
Kamada S, Washida M, Hasegawa J, Kusano H, Funahashi Y, Tsujimoto Y. Involvement of caspase-4(-like) protease in Fas-mediated apoptotic pathway. Oncogene. 15:1997;285-290.
-
(1997)
Oncogene
, vol.15
, pp. 285-290
-
-
Kamada, S.1
Washida, M.2
Hasegawa, J.3
Kusano, H.4
Funahashi, Y.5
Tsujimoto, Y.6
-
79
-
-
0001509625
-
Caspase-4 and caspase-5, members of the ICE/CED-3 family of cysteine proteases, are CrmA-inhibitable proteases
-
Kamada S, Funahashi Y, Tsujimoto Y. Caspase-4 and caspase-5, members of the ICE/CED-3 family of cysteine proteases, are CrmA-inhibitable proteases. Cell Death Different. 4:1997;473-478.
-
(1997)
Cell Death Different
, vol.4
, pp. 473-478
-
-
Kamada, S.1
Funahashi, Y.2
Tsujimoto, Y.3
-
80
-
-
0032488664
-
L acts downstream of caspase-8 activation by the CD95 death-inducing signaling complex
-
L acts downstream of caspase-8 activation by the CD95 death-inducing signaling complex. J Biol Chem. 273:1998;3388-3393.
-
(1998)
J Biol Chem
, vol.273
, pp. 3388-3393
-
-
Medema, J.P.1
Scaffidi, C.2
Krammer, P.H.3
Peter, M.E.4
-
81
-
-
0032548502
-
L functions downstream of caspase-8 to inhibit Fas- And tumor necrosis factor receptor 1-induced apoptosis of MCF7 breast carcinoma cells
-
L functions downstream of caspase-8 to inhibit Fas- and tumor necrosis factor receptor 1-induced apoptosis of MCF7 breast carcinoma cells. J Biol Chem. 273:1998;4523-4529.
-
(1998)
J Biol Chem
, vol.273
, pp. 4523-4529
-
-
Srinivasan, A.1
Li, F.2
Wong, A.3
Kodandapani, L.4
Smidt R., Jr.5
Krebs, J.F.6
Fritz, L.C.7
Wu, J.C.8
Tomaselli, K.J.9
-
82
-
-
0032518787
-
Bim: A novel member of the Bcl-2 family that promotes apoptosis
-
O'Connor L, Strasser A, O'Reilly LA, Hausmann G, Adams JM, Cory S, Huang DC. Bim: a novel member of the Bcl-2 family that promotes apoptosis. EMBO J. 17:1998;384-395.
-
(1998)
EMBO J
, vol.17
, pp. 384-395
-
-
O'Connor, L.1
Strasser, A.2
O'Reilly, L.A.3
Hausmann, G.4
Adams, J.M.5
Cory, S.6
Huang, D.C.7
-
84
-
-
0032502776
-
Mtd, a Novel Bcl-2 Family Member Activates Apoptosis in the Absence of Heterodimerization with Bcl-2 and Bcl-XL
-
Inohara N, Ekhterae D, Garcia I, Carrio R, Merino J, Merry A, Chen S, Nuñez G. Mtd, a Novel Bcl-2 Family Member Activates Apoptosis in the Absence of Heterodimerization with Bcl-2 and Bcl-XL. J Biol Chem. 273:1998;8705-8710.
-
(1998)
J Biol Chem
, vol.273
, pp. 8705-8710
-
-
Inohara, N.1
Ekhterae, D.2
Garcia, I.3
Carrio, R.4
Merino, J.5
Merry, A.6
Chen, S.7
Nuñez, G.8
-
86
-
-
0032515874
-
Bcl-XL interacts with Apaf-1 and inhibits Apaf-1-dependent caspase-9 activation
-
Hu Y, Benedict MA, Wu D, Inohara N, Nuñuz G. Bcl-XL interacts with Apaf-1 and inhibits Apaf-1-dependent caspase-9 activation. Proc Natl Acad Sci USA. 95:1998;4386-4391.
-
(1998)
Proc Natl Acad Sci USA
, vol.95
, pp. 4386-4391
-
-
Hu, Y.1
Benedict, M.A.2
Wu, D.3
Inohara, N.4
Nuñuz, G.5
-
88
-
-
0031452949
-
Membrane Fas ligand kills human peripheral blood T lymphocytes, and soluble Fas ligand blocks the killing
-
Suda T, Hashimoto H, Tanaka M, Ochi T, Nagata S. Membrane Fas ligand kills human peripheral blood T lymphocytes, and soluble Fas ligand blocks the killing. J Exp Med. 186:1997;2045-2050.
-
(1997)
J Exp Med
, vol.186
, pp. 2045-2050
-
-
Suda, T.1
Hashimoto, H.2
Tanaka, M.3
Ochi, T.4
Nagata, S.5
-
90
-
-
0029609086
-
Bcl-2 and Fas/APO-1 regulate distinct pathways to lymphocyte apoptosis
-
Strasser A, Harris AW, Huang DC, Krammer PH, Cory S. Bcl-2 and Fas/APO-1 regulate distinct pathways to lymphocyte apoptosis. EMBO J. 14:1995;6136-6147.
-
(1995)
EMBO J
, vol.14
, pp. 6136-6147
-
-
Strasser, A.1
Harris, A.W.2
Huang, D.C.3
Krammer, P.H.4
Cory, S.5
-
91
-
-
0031573211
-
Bcl-x protects primary B cells against Fas-mediated apoptosis
-
Schneider TJ, Grillot D, Foote LC, Nuñez GE, Rothstein TL. Bcl-x protects primary B cells against Fas-mediated apoptosis. J Immunol. 159:1997;4834-4839.
-
(1997)
J Immunol
, vol.159
, pp. 4834-4839
-
-
Schneider, T.J.1
Grillot, D.2
Foote, L.C.3
Nuñez, G.E.4
Rothstein, T.L.5
-
92
-
-
13344279418
-
Bcl-2 protects from lethal hepatic apoptosis induced by an anti-Fas antibody in mice
-
Lacronique V, Mignon A, Fabre M, Viollet B, Rouquet N, Molina T, Porteu A, Henrion A, Bouscary D, Varlet P, et al. Bcl-2 protects from lethal hepatic apoptosis induced by an anti-Fas antibody in mice. Nat Med. 2:1996;80-86.
-
(1996)
Nat Med
, vol.2
, pp. 80-86
-
-
Lacronique, V.1
Mignon, A.2
Fabre, M.3
Viollet, B.4
Rouquet, N.5
Molina, T.6
Porteu, A.7
Henrion, A.8
Bouscary, D.9
Varlet, P.10
-
93
-
-
0029976410
-
A bcl-2 transgene expressed in hepatocytes protects mice from fulminant liver destruction but not from rapid death induced by anti-Fas antibody injection
-
Rodriguez I, Matsuura K, Khatib K, Reed JC, Nagata S, Vassalli P. A bcl-2 transgene expressed in hepatocytes protects mice from fulminant liver destruction but not from rapid death induced by anti-Fas antibody injection. J Exp Med. 83:1996;1031-1036.
-
(1996)
J Exp Med
, vol.83
, pp. 1031-1036
-
-
Rodriguez, I.1
Matsuura, K.2
Khatib, K.3
Reed, J.C.4
Nagata, S.5
Vassalli, P.6
-
95
-
-
0032521027
-
Suppression of Fas/APO-1-mediated apoptosis by mitogen-activated kinase signaling
-
Holmstrom TH, Chow SC, Elo I, Coffey ET, Orrenius S, Sistonen L, Eriksson JE. Suppression of Fas/APO-1-mediated apoptosis by mitogen-activated kinase signaling. J Immunol. 160:1998;2626-2636.
-
(1998)
J Immunol
, vol.160
, pp. 2626-2636
-
-
Holmstrom, T.H.1
Chow, S.C.2
Elo, I.3
Coffey, E.T.4
Orrenius, S.5
Sistonen, L.6
Eriksson, J.E.7
-
96
-
-
0039058167
-
Protection of CD95-mediated apoptosis by activation of phosphatidylinositide 3-kinase and protein kinase B
-
Häusler P, Papoff G, Eramo A, Reif K, Cantrell DA, Ruberti G. Protection of CD95-mediated apoptosis by activation of phosphatidylinositide 3-kinase and protein kinase B. Eur J Immunol. 28:1998;57-69.
-
(1998)
Eur J Immunol
, vol.28
, pp. 57-69
-
-
Häusler, P.1
Papoff, G.2
Eramo, A.3
Reif, K.4
Cantrell, D.A.5
Ruberti, G.6
-
97
-
-
0030970013
-
Viral FLICE-inhibitory proteins (FLIPs) prevent apoptosis induced by death receptors
-
of outstanding interest. This provides a description of a new class of viral proteins, containing death-effector domains, that inhibit CD95-mediated apoptosis at the death-inducing signaling complex.
-
Thome M, Schneider P, Hofmann K, Fickenscher H, Meinl E, Neipel F, Mattmann C, Burns K, Bodmer JL, Schroter M, Scaffidi C, et al. Viral FLICE-inhibitory proteins (FLIPs) prevent apoptosis induced by death receptors. of outstanding interest Nature. 386:1997;517-521 This provides a description of a new class of viral proteins, containing death-effector domains, that inhibit CD95-mediated apoptosis at the death-inducing signaling complex.
-
(1997)
Nature
, vol.386
, pp. 517-521
-
-
Thome, M.1
Schneider, P.2
Hofmann, K.3
Fickenscher, H.4
Meinl, E.5
Neipel, F.6
Mattmann, C.7
Burns, K.8
Bodmer, J.L.9
Schroter, M.10
Scaffidi, C.11
-
98
-
-
0031937494
-
The fight of viruses against apoptosis
-
of special interest. This is an excellent overview of apoptosis-modulating gene products found in certain classes of viruses.
-
Tschopp J, Thome M, Hofmann K, Meinl E. The fight of viruses against apoptosis. of special interest Curr Opin Genet Dev. 8:1998;82-87 This is an excellent overview of apoptosis-modulating gene products found in certain classes of viruses.
-
(1998)
Curr Opin Genet Dev
, vol.8
, pp. 82-87
-
-
Tschopp, J.1
Thome, M.2
Hofmann, K.3
Meinl, E.4
|