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Volumn 64, Issue 6, 1998, Pages 703-712

Impact of aging on innate immunity

Author keywords

Antigen presentation; Immunosenescence; Natural immunity

Indexed keywords

CYTOKINE; T LYMPHOCYTE RECEPTOR;

EID: 0031730549     PISSN: 07415400     EISSN: None     Source Type: Journal    
DOI: 10.1002/jlb.64.6.703     Document Type: Review
Times cited : (135)

References (128)
  • 1
    • 0029826636 scopus 로고    scopus 로고
    • Antigen-independent changes in naive CD4 T cells with aging
    • Linton, P. J., Haynes, L., Klinman, N. R., Swain, S. L. (1996) Antigen-independent changes in naive CD4 T cells with aging. J. Exp. Med. 184, 1891-1900.
    • (1996) J. Exp. Med. , vol.184 , pp. 1891-1900
    • Linton, P.J.1    Haynes, L.2    Klinman, N.R.3    Swain, S.L.4
  • 2
    • 0030823184 scopus 로고    scopus 로고
    • Replicative senescence of T lymphocytes: Does the Hayflick Limit lead to immune exhaustion?
    • Effros, R. B., Pawelec, G. (1997) Replicative senescence of T lymphocytes: does the Hayflick Limit lead to immune exhaustion? Immunol. Today 18, 450-454.
    • (1997) Immunol. Today , vol.18 , pp. 450-454
    • Effros, R.B.1    Pawelec, G.2
  • 3
    • 0031436582 scopus 로고    scopus 로고
    • Effect of age on humoral immunity, selection of the B-cell repertoire and B-cell development
    • LeMaoult, J., Szybo, P., Weksler, M. (1997) Effect of age on humoral immunity, selection of the B-cell repertoire and B-cell development. Immunol. Rev. 160, 115-126.
    • (1997) Immunol. Rev. , vol.160 , pp. 115-126
    • LeMaoult, J.1    Szybo, P.2    Weksler, M.3
  • 4
    • 0031435618 scopus 로고    scopus 로고
    • Age-related changes in antibody repertoire: Contribution from T cells
    • Song, H., Price, P. W., Cerny, J. (1997) Age-related changes in antibody repertoire: contribution from T cells. Immunol. Rev. 160, 55-62.
    • (1997) Immunol. Rev. , vol.160 , pp. 55-62
    • Song, H.1    Price, P.W.2    Cerny, J.3
  • 5
    • 0031050034 scopus 로고    scopus 로고
    • Innate immunity: Impact on the adaptive immune response
    • Medzhitov, R. M., Janeway, C. A. (1997) Innate immunity: impact on the adaptive immune response. Curr. Opin. Immunol. 9, 4-9.
    • (1997) Curr. Opin. Immunol. , vol.9 , pp. 4-9
    • Medzhitov, R.M.1    Janeway, C.A.2
  • 6
    • 0032523315 scopus 로고    scopus 로고
    • Molecular and cellular basis of immunosenescence
    • Solana, R., Pawelec, G. (1998) Molecular and cellular basis of immunosenescence. Mech. Ageing Dev. 102, 115-129.
    • (1998) Mech. Ageing Dev. , vol.102 , pp. 115-129
    • Solana, R.1    Pawelec, G.2
  • 7
    • 0031963448 scopus 로고    scopus 로고
    • Impaired natural killer cell function as a consequence of aging
    • Albright, J. W., Albright, J. F. (1998) Impaired natural killer cell function as a consequence of aging. Exp. Gerontol. 33, 13-25.
    • (1998) Exp. Gerontol. , vol.33 , pp. 13-25
    • Albright, J.W.1    Albright, J.F.2
  • 9
    • 0030319530 scopus 로고    scopus 로고
    • Effect of aging on the tumoricidal functions of murine peritoneal macrophages
    • Khare, V., Sodhi, A., Singh, S. M. (1997) Effect of aging on the tumoricidal functions of murine peritoneal macrophages. Nat. Immun. 15, 285-294.
    • (1997) Nat. Immun. , vol.15 , pp. 285-294
    • Khare, V.1    Sodhi, A.2    Singh, S.M.3
  • 10
    • 0028145440 scopus 로고
    • Effect of aging on murine macrophages - Diminished response to IFN-gamma for enhanced oxidative metabolism
    • Ding, A., Hwang, S., Schwab, R. (1994) Effect of aging on murine macrophages - Diminished response to IFN-gamma for enhanced oxidative metabolism. J. Immunol. 153, 2146-2152.
    • (1994) J. Immunol. , vol.153 , pp. 2146-2152
    • Ding, A.1    Hwang, S.2    Schwab, R.3
  • 15
    • 0030913257 scopus 로고    scopus 로고
    • - B cells: Possible involvement in age-associated cytokine disregulation
    • - B cells: possible involvement in age-associated cytokine disregulation. Int. Immunol. 9, 745-754.
    • (1997) Int. Immunol. , vol.9 , pp. 745-754
    • Spencer, N.F.L.1    Daynes, R.A.2
  • 16
    • 0030887804 scopus 로고    scopus 로고
    • Macrophage prostaglandin production contributes to the age-associated decrease in T cell function which is reversed by the dietary antioxidant vitamin E
    • Beharka, A. A., Wu, D. Y., Han, S. N., Meydani, S. N. (1997) Macrophage prostaglandin production contributes to the age-associated decrease in T cell function which is reversed by the dietary antioxidant vitamin E. Mech. Ageing Dev. 93, 59-77.
    • (1997) Mech. Ageing Dev. , vol.93 , pp. 59-77
    • Beharka, A.A.1    Wu, D.Y.2    Han, S.N.3    Meydani, S.N.4
  • 17
    • 0031915936 scopus 로고    scopus 로고
    • An increase in basal glucocorticoid concentration with age induces suppressor macrophages with high-density Fc gamma RII/III
    • Kizaki, T., Ookawara, T., Ohishi, S., Itoh, Y., Iwabuchi, K., Onoe, K., Day, N. K., Good, R. A., Ohno, H. (1998) An increase in basal glucocorticoid concentration with age induces suppressor macrophages with high-density Fc gamma RII/III. Immunol. 93, 409-414.
    • (1998) Immunol. , vol.93 , pp. 409-414
    • Kizaki, T.1    Ookawara, T.2    Ohishi, S.3    Itoh, Y.4    Iwabuchi, K.5    Onoe, K.6    Day, N.K.7    Good, R.A.8    Ohno, H.9
  • 18
    • 0032080187 scopus 로고    scopus 로고
    • Differential deactivation of human dendritic cells by endotoxin desensitization: Role of tumor necrosis factor-alpha and prostaglandin E2
    • Rieser, C., Papesh, C., Herold, M., Bock, G., Ramoner, R., Klocker, H., Bartsch, G., Thurnher, M. (1998) Differential deactivation of human dendritic cells by endotoxin desensitization: role of tumor necrosis factor-alpha and prostaglandin E2. Blood 91, 3112-3117.
    • (1998) Blood , vol.91 , pp. 3112-3117
    • Rieser, C.1    Papesh, C.2    Herold, M.3    Bock, G.4    Ramoner, R.5    Klocker, H.6    Bartsch, G.7    Thurnher, M.8
  • 19
    • 0018760821 scopus 로고
    • Sensitivity of lymphocytes to prostaglandin E2 increases in subjects over age 70
    • Goodwin, J. S., Messner, R. P. (1979) Sensitivity of lymphocytes to prostaglandin E2 increases in subjects over age 70. J. Clin. Invest. 64, 434-439.
    • (1979) J. Clin. Invest. , vol.64 , pp. 434-439
    • Goodwin, J.S.1    Messner, R.P.2
  • 20
    • 0028696340 scopus 로고
    • Age-associated changes of neutrophil responsiveness in a human healthy elderly population
    • Polignano, A., Tortorella, C., Venezia, A., Jirillo, E., Antonaci, S. (1994) Age-associated changes of neutrophil responsiveness in a human healthy elderly population. Cytobios. 80, 145-153.
    • (1994) Cytobios. , vol.80 , pp. 145-153
    • Polignano, A.1    Tortorella, C.2    Venezia, A.3    Jirillo, E.4    Antonaci, S.5
  • 21
    • 0027099807 scopus 로고
    • Effects of recombinant human granulocyte colony-stimulating factor on neutrophil functions in aged animals
    • Yoshino, T., Tamara, M., Kawabe, M., Nomura, H., Imai, N., Ono, M. (1992) Effects of recombinant human granulocyte colony-stimulating factor on neutrophil functions in aged animals. Br. J. Haematol. 82, 664-670.
    • (1992) Br. J. Haematol. , vol.82 , pp. 664-670
    • Yoshino, T.1    Tamara, M.2    Kawabe, M.3    Nomura, H.4    Imai, N.5    Ono, M.6
  • 22
    • 0027976232 scopus 로고
    • Reduction in superoxide anion secretion and bactericidal activity of neutrophils from aged rats: Reversal by the combination of gamma interferon and growth hormone
    • Fu, Y. K., Arkins, S., Li, Y. M., Dantzer, R., Kelley, K. W. (1994) Reduction in superoxide anion secretion and bactericidal activity of neutrophils from aged rats: reversal by the combination of gamma interferon and growth hormone. Infect. Immun. 62, 1-8.
    • (1994) Infect. Immun. , vol.62 , pp. 1-8
    • Fu, Y.K.1    Arkins, S.2    Li, Y.M.3    Dantzer, R.4    Kelley, K.W.5
  • 23
    • 0026795415 scopus 로고
    • Modulation of granulocyte survival and programmed cell death by cytokines and bacterial products
    • Colotta, F., Re, F., Polentarutti, N., Sozzani, S., Mantovani, A. (1992) Modulation of granulocyte survival and programmed cell death by cytokines and bacterial products. Blood 80, 2012-2020.
    • (1992) Blood , vol.80 , pp. 2012-2020
    • Colotta, F.1    Re, F.2    Polentarutti, N.3    Sozzani, S.4    Mantovani, A.5
  • 24
    • 0027484754 scopus 로고
    • Inhibition of apoptosis and prolongation of neutrophil longevity by inflammatory mediators
    • Lee, A., Whyte, M. K. B., Haslett, C. (1993) Inhibition of apoptosis and prolongation of neutrophil longevity by inflammatory mediators. J. Leukoc. Biol. 54, 283-288.
    • (1993) J. Leukoc. Biol. , vol.54 , pp. 283-288
    • Lee, A.1    Whyte, M.K.B.2    Haslett, C.3
  • 27
    • 0021850379 scopus 로고
    • Age-dependent alterations of Fc-gamma receptor-mediated effector functions of human polymorphonuclear leukocytes
    • Fülöp, T., Foris, G., Worum, I., Leovey, A. (1985) Age-dependent alterations of Fc-gamma receptor-mediated effector functions of human polymorphonuclear leukocytes. Clin. Exp. Immunol. 61, 425-432.
    • (1985) Clin. Exp. Immunol. , vol.61 , pp. 425-432
    • Fülöp, T.1    Foris, G.2    Worum, I.3    Leovey, A.4
  • 29
    • 0026006646 scopus 로고
    • Effects of age on second messenger generation in neutrophils
    • Lipschitz, D. A., Udupa, K. B., Indelicato, S. R., Das, M. (1991) Effects of age on second messenger generation in neutrophils. Blood 78, 1347.
    • (1991) Blood , vol.78 , pp. 1347
    • Lipschitz, D.A.1    Udupa, K.B.2    Indelicato, S.R.3    Das, M.4
  • 30
    • 0027360781 scopus 로고
    • Age-dependent changes in transmembrane signalling - Identification of G-proteins in human lymphocytes and polymorphonuclear leukocytes
    • Fülöp, T., Barabas, G., Varga, Z., Jozsef, C., Csabina, S., Szucs, S., Seres, I., Szikszay, E., Jeney, Z., Penyige, A. (1993) Age-dependent changes in transmembrane signalling - identification of G-proteins in human lymphocytes and polymorphonuclear leukocytes. Cell. Signal. 5, 593-603.
    • (1993) Cell. Signal. , vol.5 , pp. 593-603
    • Fülöp, T.1    Barabas, G.2    Varga, Z.3    Jozsef, C.4    Csabina, S.5    Szucs, S.6    Seres, I.7    Szikszay, E.8    Jeney, Z.9    Penyige, A.10
  • 31
    • 0026522376 scopus 로고
    • Intracellular nucleotides of lymphocytes and granulocytes from normal ageing subjects
    • Borzi, R. M., Dalmonte, P., Uguccioni, M., Meliconi, R., Facchini, A. (1992) Intracellular nucleotides of lymphocytes and granulocytes from normal ageing subjects. Mech. Ageing Dev. 64, 1-11.
    • (1992) Mech. Ageing Dev. , vol.64 , pp. 1-11
    • Borzi, R.M.1    Dalmonte, P.2    Uguccioni, M.3    Meliconi, R.4    Facchini, A.5
  • 33
    • 0014340640 scopus 로고
    • Free radical theory of aging: Effect of free radical reaction inhibitors on the mortality rate of male LAF mice
    • Harman, D. (1968) Free radical theory of aging: effect of free radical reaction inhibitors on the mortality rate of male LAF mice. J. Gerontol. 23, 476-482.
    • (1968) J. Gerontol. , vol.23 , pp. 476-482
    • Harman, D.1
  • 34
    • 0026047662 scopus 로고
    • The aging process - Major risk factor for disease and death
    • Harman, D. (1991) The aging process - major risk factor for disease and death. Proc. Natl. Acad. Sci. USA. 88, 5360-5363.
    • (1991) Proc. Natl. Acad. Sci. USA , vol.88 , pp. 5360-5363
    • Harman, D.1
  • 36
    • 0022466528 scopus 로고
    • The expanded null cell compartment in ageing: Increase in the number of natural killer cells and changes in T cell and NK cell subsets in human blood
    • Ligthart, G. J., Van Vlokhoven, P. C., Schuit, H. R. E., Hijmans, W. (1986) The expanded null cell compartment in ageing: increase in the number of natural killer cells and changes in T cell and NK cell subsets in human blood. Immunol. 59, 353-357.
    • (1986) Immunol. , vol.59 , pp. 353-357
    • Ligthart, G.J.1    Van Vlokhoven, P.C.2    Schuit, H.R.E.3    Hijmans, W.4
  • 40
    • 0024374054 scopus 로고
    • Natural killer cell function is not diminished in the healthy aged and is proportional to the number of NK cells in the peripheral blood
    • Ligthart, G. J., Schuit, H. R. E., Hijmans, W. (1989) Natural killer cell function is not diminished in the healthy aged and is proportional to the number of NK cells in the peripheral blood. Immunol. 68, 396-402.
    • (1989) Immunol. , vol.68 , pp. 396-402
    • Ligthart, G.J.1    Schuit, H.R.E.2    Hijmans, W.3
  • 41
    • 0026677147 scopus 로고
    • Preferential accumulation of mature NK-cells during human immunosenescence
    • Krishnaraj, R., Svanborg, A. (1992) Preferential accumulation of mature NK-cells during human immunosenescence. J. Cell. Biochem. 50, 386-391.
    • (1992) J. Cell. Biochem. , vol.50 , pp. 386-391
    • Krishnaraj, R.1    Svanborg, A.2
  • 42
  • 43
    • 0023205403 scopus 로고
    • Age-associated alterations in human natural killer cells. I. Increased activity as per conventional and kinetic analysis
    • Krishnaraj, R., Blandford, G. (1987) Age-associated alterations in human natural killer cells. I. Increased activity as per conventional and kinetic analysis. Clin. Immunol. Immunopathol. 45, 268-274.
    • (1987) Clin. Immunol. Immunopathol. , vol.45 , pp. 268-274
    • Krishnaraj, R.1    Blandford, G.2
  • 45
    • 0026492479 scopus 로고
    • The impairment of natural killer function in the healthy aged is due to a postbinding deficient mechanism
    • Vitale, M., Zamai, L., Neri, L. M., Galnzi, A., Facchini, A., Rana, R., Cataldi, A., Papa, S. (1992) The impairment of natural killer function in the healthy aged is due to a postbinding deficient mechanism. Cell. Immunol. 145, 1-10.
    • (1992) Cell. Immunol. , vol.145 , pp. 1-10
    • Vitale, M.1    Zamai, L.2    Neri, L.M.3    Galnzi, A.4    Facchini, A.5    Rana, R.6    Cataldi, A.7    Papa, S.8
  • 47
    • 0024792513 scopus 로고
    • Biology of natural killer cells
    • Trinchieri, G. (1989) Biology of natural killer cells. Adv. Immunol. 47, 187-376.
    • (1989) Adv. Immunol. , vol.47 , pp. 187-376
    • Trinchieri, G.1
  • 49
    • 0031842690 scopus 로고    scopus 로고
    • Age-dependent decreases of NK cell phosphoinositide turnover during spontaneous but not Fc-mediated cytolytic activity
    • Mariani, E., Mariani, A. R., Meneghetti, A., Tarozzi, A., Cocco, L., Facchini, A. (1998) Age-dependent decreases of NK cell phosphoinositide turnover during spontaneous but not Fc-mediated cytolytic activity. Int. Immunol. 10, 981-988.
    • (1998) Int. Immunol. , vol.10 , pp. 981-988
    • Mariani, E.1    Mariani, A.R.2    Meneghetti, A.3    Tarozzi, A.4    Cocco, L.5    Facchini, A.6
  • 51
    • 9244245804 scopus 로고    scopus 로고
    • CD31-triggered rearrangement of the actin cytoskeleton in human natural killer cells
    • Poggi, A., Panzeri, M. C., Moretta, L., Zocchi, M. R. (1996) CD31-triggered rearrangement of the actin cytoskeleton in human natural killer cells Eur. J. Immunol. 26, 817-824.
    • (1996) Eur. J. Immunol. , vol.26 , pp. 817-824
    • Poggi, A.1    Panzeri, M.C.2    Moretta, L.3    Zocchi, M.R.4
  • 52
    • 0030042385 scopus 로고    scopus 로고
    • Inhibitory MHC class I receptors on NK cells and T cells
    • Lanier, L. L., Phillips, J. H. (1996) Inhibitory MHC class I receptors on NK cells and T cells. Immunol. Today 17, 86-91.
    • (1996) Immunol. Today , vol.17 , pp. 86-91
    • Lanier, L.L.1    Phillips, J.H.2
  • 54
    • 3743111357 scopus 로고
    • Natural killer cell receptors: Activation and inhibition of NK cell-mediated cytotoxicity
    • R. Solana and J. Pena, eds., Austin, TX: R.D. Landes
    • Solana, R., Pena, J. (1994) Natural killer cell receptors: activation and inhibition of NK cell-mediated cytotoxicity. In Histocompatibility Antigens and Natural Killer Cell Recognition and Lysis (R. Solana and J. Pena, eds.), Austin, TX: R.D. Landes.
    • (1994) Histocompatibility Antigens and Natural Killer Cell Recognition and Lysis
    • Solana, R.1    Pena, J.2
  • 55
    • 3743144659 scopus 로고
    • Effect of target cell histocompatibility antigens in NK cell-mediated recognition and lysis
    • R. Solana and J. Pena, eds., Austin, TX: R.D. Landes
    • Pena, J., Solana, R. (1994) Effect of target cell histocompatibility antigens in NK cell-mediated recognition and lysis. In Histocompatibility Antigens and Natural Killer Cell Recognition and Lysis (R. Solana and J. Pena, eds.), Austin, TX: R.D. Landes.
    • (1994) Histocompatibility Antigens and Natural Killer Cell Recognition and Lysis
    • Pena, J.1    Solana, R.2
  • 56
    • 0342576231 scopus 로고    scopus 로고
    • NK-cell receptors and recognition of MHC class I molecules
    • Lopez Botet, M., Moretta, L., Strominger, J. (1996) NK-cell receptors and recognition of MHC class I molecules. Immunol. Today 17, 212-214.
    • (1996) Immunol. Today , vol.17 , pp. 212-214
    • Lopez Botet, M.1    Moretta, L.2    Strominger, J.3
  • 59
    • 0025827589 scopus 로고
    • CD69-mediated pathway of lymphocyte activation - Anti-CD69 monoclonal antibodies trigger the cytolytic activity of different lymphoid effector cells with the exception of cytolytic lymphocytes-T expressing T-cell receptor-alpha/beta
    • Moretta, A., Poggi, A., Pende, D., Tripodi, G., Orengo, A. M., Pella, N., Augugliaro, R., Bottino, C., Ciecone, E., Moretta, L. (1991) CD69-mediated pathway of lymphocyte activation - anti-CD69 monoclonal antibodies trigger the cytolytic activity of different lymphoid effector cells with the exception of cytolytic lymphocytes-T expressing T-cell receptor-alpha/beta. J. Exp. Med. 174, 1393-1398.
    • (1991) J. Exp. Med. , vol.174 , pp. 1393-1398
    • Moretta, A.1    Poggi, A.2    Pende, D.3    Tripodi, G.4    Orengo, A.M.5    Pella, N.6    Augugliaro, R.7    Bottino, C.8    Ciecone, E.9    Moretta, L.10
  • 60
    • 0027416708 scopus 로고
    • Regulation of CD69 expression on human natural killer cells: Differential involvement of protein kinase C and protein tyrosine kinases
    • Borrego, F., Pena, J., Solana, R. (1993) Regulation of CD69 expression on human natural killer cells: differential involvement of protein kinase C and protein tyrosine kinases. Eur. J. Immunol. 23, 1039-1043.
    • (1993) Eur. J. Immunol. , vol.23 , pp. 1039-1043
    • Borrego, F.1    Pena, J.2    Solana, R.3
  • 61
    • 0027966063 scopus 로고
    • Human NKR-PIA - A disulfide-linked homodimer of the C-type lectin superfamily expressed by a subset of NK and T lymphocytes
    • Lanier, L. L., Chang, C. W., Phillips, J. H. (1994) Human NKR-PIA - A disulfide-linked homodimer of the C-type lectin superfamily expressed by a subset of NK and T lymphocytes. J. Immunol. 153, 2417-2428.
    • (1994) J. Immunol. , vol.153 , pp. 2417-2428
    • Lanier, L.L.1    Chang, C.W.2    Phillips, J.H.3
  • 62
    • 0032526860 scopus 로고    scopus 로고
    • NKp44, a novel triggering surface molecule specifically expressed by activated natural killer cells, is involved in non-major histocompatibility complex-restricted tumor cell lysis
    • Vitale, M., Bottino, C., Sivori, S., San Severino, L., Castriconi, R., Marcenaro, E., Augugliaro, R., Morretta, L., Moretta, A. (1998) NKp44, a novel triggering surface molecule specifically expressed by activated natural killer cells, is involved in non-major histocompatibility complex-restricted tumor cell lysis. J. Exp. Med. 187, 2065-2070.
    • (1998) J. Exp. Med. , vol.187 , pp. 2065-2070
    • Vitale, M.1    Bottino, C.2    Sivori, S.3    San Severino, L.4    Castriconi, R.5    Marcenaro, E.6    Augugliaro, R.7    Morretta, L.8    Moretta, A.9
  • 63
    • 9444272188 scopus 로고    scopus 로고
    • A novel surface molecule homologous to the p58/p50 family of receptors is selectively expressed on a subset of human natural killer cells and induces both triggering of cell functions and proliferation
    • Bottino, C., Sivori, S., Vitale, M., Cantoni, C., Falco, R., Pende, D., Morelli, L., Augugliaro, R., Semenzato, G., Biassoni, R., Moretta, L., Moretta, A. (1996) A novel surface molecule homologous to the p58/p50 family of receptors is selectively expressed on a subset of human natural killer cells and induces both triggering of cell functions and proliferation. Eur. J. Immunol. 26, 1816-1824.
    • (1996) Eur. J. Immunol. , vol.26 , pp. 1816-1824
    • Bottino, C.1    Sivori, S.2    Vitale, M.3    Cantoni, C.4    Falco, R.5    Pende, D.6    Morelli, L.7    Augugliaro, R.8    Semenzato, G.9    Biassoni, R.10    Moretta, L.11    Moretta, A.12
  • 64
    • 0030039386 scopus 로고    scopus 로고
    • The human leukocyte antigen (HLA)-C-specific "activatory" or "inhibitory" natural killer cell receptors display highly homologous extracellular domains but differ in their transmembrane and intracytoplasmic portions
    • Biassoni, R., Cantoni, C., Falco, M., Verdiani, S., Bottino, C., Vitale, M., Conte, R., Poggi, A., Moretta, A., Moretta, L. (1996) The human leukocyte antigen (HLA)-C-specific "activatory" or "inhibitory" natural killer cell receptors display highly homologous extracellular domains but differ in their transmembrane and intracytoplasmic portions. J. Exp. Med. 183, 645-650.
    • (1996) J. Exp. Med. , vol.183 , pp. 645-650
    • Biassoni, R.1    Cantoni, C.2    Falco, M.3    Verdiani, S.4    Bottino, C.5    Vitale, M.6    Conte, R.7    Poggi, A.8    Moretta, A.9    Moretta, L.10
  • 65
    • 0029088483 scopus 로고
    • Existence of both inhibitory (p58) and activatory (p50) receptors for HLA-C molecules in human natural killer cells
    • Moretta, A., Sivori, S., Vitale, M., Pende, D., Morelli, L., Augugliaro, R., Bottino, C., Moretta, L. (1995) Existence of both inhibitory (p58) and activatory (p50) receptors for HLA-C molecules in human natural killer cells. J. Exp. Med. 182, 875-884.
    • (1995) J. Exp. Med. , vol.182 , pp. 875-884
    • Moretta, A.1    Sivori, S.2    Vitale, M.3    Pende, D.4    Morelli, L.5    Augugliaro, R.6    Bottino, C.7    Moretta, L.8
  • 68
    • 0031920023 scopus 로고    scopus 로고
    • T cell immunosenescence and its clinical relevance in man
    • Remarque, E., Pawelec, G. (1998) T cell immunosenescence and its clinical relevance in man. Rev. Clin. Gerontol. 8, 5-14.
    • (1998) Rev. Clin. Gerontol. , vol.8 , pp. 5-14
    • Remarque, E.1    Pawelec, G.2
  • 69
    • 0028299684 scopus 로고
    • Effects of aging on natural killer cell activity and activation by interleukin-2 and IFN-alpha
    • Kutza, J., Murasko, D. M. (1994) Effects of aging on natural killer cell activity and activation by interleukin-2 and IFN-alpha. Cell. Immunol. 155, 195-204.
    • (1994) Cell. Immunol. , vol.155 , pp. 195-204
    • Kutza, J.1    Murasko, D.M.2
  • 70
    • 0030607135 scopus 로고    scopus 로고
    • Age-associated decline in IL-2 and IL-12 induction of LAK cell activity of human PBMC samples
    • Kutza, J., Murasko, D. M. (1996) Age-associated decline in IL-2 and IL-12 induction of LAK cell activity of human PBMC samples. Mech. Ageing Dev. 90, 209-222.
    • (1996) Mech. Ageing Dev. , vol.90 , pp. 209-222
    • Kutza, J.1    Murasko, D.M.2
  • 71
    • 0021329243 scopus 로고
    • Cellular immunosenescence in F344 rats: Decreased natural killer (NK) cell activity involves changes in regulatory interactions between NK cells, interferon, prostaglandin and macrophages
    • Bash, J. A., Vogel, D. (1984) Cellular immunosenescence in F344 rats: decreased natural killer (NK) cell activity involves changes in regulatory interactions between NK cells, interferon, prostaglandin and macrophages. Mech. Ageing Dev. 24, 49-65.
    • (1984) Mech. Ageing Dev. , vol.24 , pp. 49-65
    • Bash, J.A.1    Vogel, D.2
  • 72
    • 0031563145 scopus 로고    scopus 로고
    • Activation of NK1.1(+) T cells in vitro and their possible role in age-associated changes in inducible IL-4 production
    • Poynter, M. E., Mu, H. H., Chen, X. P., Daynes, R. A. (1997) Activation of NK1.1(+) T cells in vitro and their possible role in age-associated changes in inducible IL-4 production. Cell. Immunol. 179, 22-29.
    • (1997) Cell. Immunol. , vol.179 , pp. 22-29
    • Poynter, M.E.1    Mu, H.H.2    Chen, X.P.3    Daynes, R.A.4
  • 78
    • 0031912158 scopus 로고    scopus 로고
    • Changes in natural killer cells, the CD57CD8 subset, and cytokines in healthy aging
    • McNerlan, S. E., Rea, I. M., Alexander, H. D., Morris, T. C. (1998) Changes in natural killer cells, the CD57CD8 subset, and cytokines in healthy aging. J. Clin. Immunol. 18, 31-38.
    • (1998) J. Clin. Immunol. , vol.18 , pp. 31-38
    • McNerlan, S.E.1    Rea, I.M.2    Alexander, H.D.3    Morris, T.C.4
  • 80
    • 0031593686 scopus 로고    scopus 로고
    • The gamma/delta T cell bridge: Linking innate and acquired immunity
    • Mak, T. W., Ferrick, D. A. (1998) The gamma/delta T cell bridge: linking innate and acquired immunity. Nature Med. 4, 764-765.
    • (1998) Nature Med. , vol.4 , pp. 764-765
    • Mak, T.W.1    Ferrick, D.A.2
  • 82
    • 0028980812 scopus 로고
    • Differential production of interferon-gamma and interleukin-4 in response to Th1- And Th2-stimulating pathogens by gamma delta T cells in vivo
    • Ferrick, D. A., Schrenzel, M. D., Mulvania, T., Hsieh, B., Ferlin, W. G., Lepper, W. (1995) Differential production of interferon-gamma and interleukin-4 in response to Th1-and Th2-stimulating pathogens by gamma delta T cells in vivo. Nature 373, 255-257.
    • (1995) Nature , vol.373 , pp. 255-257
    • Ferrick, D.A.1    Schrenzel, M.D.2    Mulvania, T.3    Hsieh, B.4    Ferlin, W.G.5    Lepper, W.6
  • 84
    • 0021845523 scopus 로고
    • Impaired antigen-presenting function of macrophages from aged mice
    • Vetricka, V., Tlaskalova-Hogenova, H., Pospisil, M. (1985) Impaired antigen-presenting function of macrophages from aged mice. Immunol. Invest. 14, 105-114.
    • (1985) Immunol. Invest. , vol.14 , pp. 105-114
    • Vetricka, V.1    Tlaskalova-Hogenova, H.2    Pospisil, M.3
  • 85
    • 0026580344 scopus 로고
    • Splenic and inguinal lymph node T-cells of aged mice respond differently to polyclonal and antigen-specific stimuli
    • Kirschmann, D. A., Murasko, D. M. (1992) Splenic and inguinal lymph node T-cells of aged mice respond differently to polyclonal and antigen-specific stimuli. Cell. Immunol. 139, 426-437.
    • (1992) Cell. Immunol. , vol.139 , pp. 426-437
    • Kirschmann, D.A.1    Murasko, D.M.2
  • 87
    • 0028661071 scopus 로고
    • Lack of B7-2 expression in the germinal centers of aged mice
    • Miller, C., Kelsoe, G., Han, S. (1994) Lack of B7-2 expression in the germinal centers of aged mice. Aging: Immunol. Infect. Dis. 5, 249-257.
    • (1994) Aging: Immunol. Infect. Dis. , vol.5 , pp. 249-257
    • Miller, C.1    Kelsoe, G.2    Han, S.3
  • 88
    • 0029822246 scopus 로고    scopus 로고
    • Morphologically and functionally intact dendritic cells can be derived from the peripheral blood of aged individuals
    • Steger, M. M., Maczek, C., Grubeckloebenstein, B. (1996) Morphologically and functionally intact dendritic cells can be derived from the peripheral blood of aged individuals. Clin. Exp. Immunol. 105, 544-550.
    • (1996) Clin. Exp. Immunol. , vol.105 , pp. 544-550
    • Steger, M.M.1    Maczek, C.2    Grubeckloebenstein, B.3
  • 89
    • 0030935315 scopus 로고    scopus 로고
    • Peripheral blood dendritic cells reinduce proliferation in in vitro aged T cell populations
    • Steger, M. M., Maczek, C., Grubeckloebenstein, B. (1997) Peripheral blood dendritic cells reinduce proliferation in in vitro aged T cell populations. Mech. Ageing Dev. 93, 125-130.
    • (1997) Mech. Ageing Dev. , vol.93 , pp. 125-130
    • Steger, M.M.1    Maczek, C.2    Grubeckloebenstein, B.3
  • 90
    • 0027190386 scopus 로고
    • Accessory function and properties of monocytes from healthy elderly humans for T-lymphocyte responses to mitogen and antigen
    • Rich, E. A., Mincek, M. A., Armitage, K. B., Duffy, E. G., Owen, D. C., Fayen, J. D., Hom, D. L., Ellner, J. J. (1993) Accessory function and properties of monocytes from healthy elderly humans for T-lymphocyte responses to mitogen and antigen. Gerontol. 39, 93-108.
    • (1993) Gerontol. , vol.39 , pp. 93-108
    • Rich, E.A.1    Mincek, M.A.2    Armitage, K.B.3    Duffy, E.G.4    Owen, D.C.5    Fayen, J.D.6    Hom, D.L.7    Ellner, J.J.8
  • 91
    • 0031448878 scopus 로고    scopus 로고
    • Primary and secondary alterations of immune reactivity in the elderly: Impact of dietary factors and disease
    • Wick, G., Grubeck-Loebenstein, B. (1997) Primary and secondary alterations of immune reactivity in the elderly: impact of dietary factors and disease. Immunol. Rev. 160, 171-184.
    • (1997) Immunol. Rev. , vol.160 , pp. 171-184
    • Wick, G.1    Grubeck-Loebenstein, B.2
  • 92
    • 0026969261 scopus 로고
    • The immunogenetics of immune senescence
    • Weksler, M. E., Schwab, R. (1992) The immunogenetics of immune senescence. Exp. Clin. Immunogenet. 9, 182-187.
    • (1992) Exp. Clin. Immunogenet. , vol.9 , pp. 182-187
    • Weksler, M.E.1    Schwab, R.2
  • 93
    • 0029987099 scopus 로고    scopus 로고
    • Impaired expression of hematopoietic growth factors: A candidate mechanism for the hematopoietic defect of aging
    • Buchanan, J. P., Peters, C. A., Rasmussen, C. J., Rothstein, G. (1996) Impaired expression of hematopoietic growth factors: A candidate mechanism for the hematopoietic defect of aging. Exp. Gerontol. 31, 135-144.
    • (1996) Exp. Gerontol. , vol.31 , pp. 135-144
    • Buchanan, J.P.1    Peters, C.A.2    Rasmussen, C.J.3    Rothstein, G.4
  • 94
    • 0030219954 scopus 로고    scopus 로고
    • Modulation of hemopoietic factor production in relation to endothelial cell aging by interleukin-1 induction
    • Fujii, T., Kumazaki, T., Nagasawa, T., Kobayashi, M., Abe, T., Mitsui, Y. (1996) Modulation of hemopoietic factor production in relation to endothelial cell aging by interleukin-1 induction. Exp. Cell Res. 226, 356-362.
    • (1996) Exp. Cell Res. , vol.226 , pp. 356-362
    • Fujii, T.1    Kumazaki, T.2    Nagasawa, T.3    Kobayashi, M.4    Abe, T.5    Mitsui, Y.6
  • 95
    • 0021260751 scopus 로고
    • The effect of age on antigen retention in lymphoid follicles and collagenous tissue of mice
    • Holmes, K. L., Schnizlein, C. T., Perkins, E. H., Tew, J. C. (1984) The effect of age on antigen retention in lymphoid follicles and collagenous tissue of mice. Mech. Ageing Dev. 25, 243-249.
    • (1984) Mech. Ageing Dev. , vol.25 , pp. 243-249
    • Holmes, K.L.1    Schnizlein, C.T.2    Perkins, E.H.3    Tew, J.C.4
  • 96
    • 0002047158 scopus 로고
    • Morphometry and kinetics of antigen transport and developing antigen retaining reticulum of follicular dendritic cells in lymph nodes of aging immune mice
    • Szakal, A. K., Taylor, J. K., Smith, J. P., Kosco, M. K., Burton, G. F., Tew, J. G. (1988) Morphometry and kinetics of antigen transport and developing antigen retaining reticulum of follicular dendritic cells in lymph nodes of aging immune mice. Aging: Immunol. Infect. Dis. 1, 7-22.
    • (1988) Aging: Immunol. Infect. Dis. , vol.1 , pp. 7-22
    • Szakal, A.K.1    Taylor, J.K.2    Smith, J.P.3    Kosco, M.K.4    Burton, G.F.5    Tew, J.G.6
  • 97
    • 0020073049 scopus 로고
    • Effect of chronological aging and ultraviolet irradiation on Langerhans cells in human epidermis
    • Gilchrest, B. A., Murphy, G. F., Soter, N. A. (1982) Effect of chronological aging and ultraviolet irradiation on Langerhans cells in human epidermis. J. Invest. Dermatol. 79, 85-88.
    • (1982) J. Invest. Dermatol. , vol.79 , pp. 85-88
    • Gilchrest, B.A.1    Murphy, G.F.2    Soter, N.A.3
  • 99
    • 0029988952 scopus 로고    scopus 로고
    • Age-associated changes in lymphoid and antigen-presenting cell functions in mice immunized with Trypanosoma cruzi antigens
    • Maletto, B. A., Gruppi, A., Moron, G., Pistoresipalencia, M. C. (1996) Age-associated changes in lymphoid and antigen-presenting cell functions in mice immunized with Trypanosoma cruzi antigens. Mech. Ageing Dev. 88, 39-47.
    • (1996) Mech. Ageing Dev. , vol.88 , pp. 39-47
    • Maletto, B.A.1    Gruppi, A.2    Moron, G.3    Pistoresipalencia, M.C.4
  • 100
    • 0029909142 scopus 로고    scopus 로고
    • Cellular basis of decreased immune responses to pneumococcal vaccines in aged mice
    • Garg, M., Luo, W., Kaplan, A. M., Bondada, S. (1996) Cellular basis of decreased immune responses to pneumococcal vaccines in aged mice. Infect. Immun. 64, 4456-4462.
    • (1996) Infect. Immun. , vol.64 , pp. 4456-4462
    • Garg, M.1    Luo, W.2    Kaplan, A.M.3    Bondada, S.4
  • 101
    • 0028597408 scopus 로고
    • Cytokine production and aging: Overproduction of IL-8 in elderly males in response to lipopolysaccharide
    • Clark, J. A., Peterson, T. C. (1994) Cytokine production and aging: Overproduction of IL-8 in elderly males in response to lipopolysaccharide. Mech. Ageing Dev. 77, 127-139.
    • (1994) Mech. Ageing Dev. , vol.77 , pp. 127-139
    • Clark, J.A.1    Peterson, T.C.2
  • 102
    • 0029737506 scopus 로고    scopus 로고
    • Lower serum concentrations of cytokines in elderly patients with pneumonia and the impaired production of cytokines by peripheral blood monocytes in the elderly
    • Gon, Y., Hashimoto, S., Hayashi, S., Koura, T., Matsumoto, K., Horie, T. (1996) Lower serum concentrations of cytokines in elderly patients with pneumonia and the impaired production of cytokines by peripheral blood monocytes in the elderly. Clin. Exp. Immunol. 106, 120-126.
    • (1996) Clin. Exp. Immunol. , vol.106 , pp. 120-126
    • Gon, Y.1    Hashimoto, S.2    Hayashi, S.3    Koura, T.4    Matsumoto, K.5    Horie, T.6
  • 106
    • 0025336034 scopus 로고
    • Necessity of the assessment of health status in human immunogerontological studies: Evaluation of the SENIEUR protocol
    • Ligthart, G. J., Corberand, J. X., Goertzen, H. G. M., Minders, A. E., Knook, D. L., Hijmans, W. (1990) Necessity of the assessment of health status in human immunogerontological studies: evaluation of the SENIEUR protocol. Mech. Ageing Dev. 55, 89-98.
    • (1990) Mech. Ageing Dev. , vol.55 , pp. 89-98
    • Ligthart, G.J.1    Corberand, J.X.2    Goertzen, H.G.M.3    Minders, A.E.4    Knook, D.L.5    Hijmans, W.6
  • 107
    • 0030845070 scopus 로고    scopus 로고
    • Zinc supplementation reconstitutes the production of interferon-alpha by leukocytes from elderly persons
    • Cakman, I., Kirchner, H., Rink, L. (1997) Zinc supplementation reconstitutes the production of interferon-alpha by leukocytes from elderly persons. J. Interferon Cytokine Res. 17, 469-472.
    • (1997) J. Interferon Cytokine Res. , vol.17 , pp. 469-472
    • Cakman, I.1    Kirchner, H.2    Rink, L.3
  • 108
    • 0024412048 scopus 로고
    • Nutritional regulation of immunity and risk of infection in old age
    • Chandra, R. K. (1989) Nutritional regulation of immunity and risk of infection in old age. Immunol. 67, 141-147.
    • (1989) Immunol. , vol.67 , pp. 141-147
    • Chandra, R.K.1
  • 109
    • 0030913726 scopus 로고    scopus 로고
    • Evidence of enhanced type 2 immune response and impaired upregulation of a type 1 response in frail elderly nursing home residents
    • Castle, S., Uyemura, K., Wong, W., Modlin, R., Effros, R. (1997) Evidence of enhanced type 2 immune response and impaired upregulation of a type 1 response in frail elderly nursing home residents. Mech. Ageing Dev. 94, 7-16.
    • (1997) Mech. Ageing Dev. , vol.94 , pp. 7-16
    • Castle, S.1    Uyemura, K.2    Wong, W.3    Modlin, R.4    Effros, R.5
  • 111
    • 0028839320 scopus 로고
    • Age-related enhancement of tumor necrosis factor (TNF) production in mice
    • Han, D., Hosokawa, T., Aoike, A., Kawai, K. (1995) Age-related enhancement of tumor necrosis factor (TNF) production in mice. Mech. Ageing Dev. 84, 39-54.
    • (1995) Mech. Ageing Dev. , vol.84 , pp. 39-54
    • Han, D.1    Hosokawa, T.2    Aoike, A.3    Kawai, K.4
  • 112
    • 0025827542 scopus 로고
    • Influence of age and caloric restriction on macrophage IL-6 and TNF production, lymphokine
    • Effros, R. B., Svoboda, K., Walford, R. L. (1991) Influence of age and caloric restriction on macrophage IL-6 and TNF production, lymphokine. Cytokine Res. 10, 347-351.
    • (1991) Cytokine Res. , vol.10 , pp. 347-351
    • Effros, R.B.1    Svoboda, K.2    Walford, R.L.3
  • 113
    • 0029558551 scopus 로고
    • Cytokine production and lymphocyte subpopulations in aged humans. An assessment during nocturnal sleep
    • Born, J., Uthgenannt, D., Dodt, C., Nunninghoff, D., Ringvolt, E., Wagner, T., Fehm, H. L. (1995) Cytokine production and lymphocyte subpopulations in aged humans. An assessment during nocturnal sleep. Mech. Ageing Dev. 84, 113-126.
    • (1995) Mech. Ageing Dev. , vol.84 , pp. 113-126
    • Born, J.1    Uthgenannt, D.2    Dodt, C.3    Nunninghoff, D.4    Ringvolt, E.5    Wagner, T.6    Fehm, H.L.7
  • 115
    • 0344269351 scopus 로고    scopus 로고
    • Increase of interleukin 6 and decrease of interleukin 2 production during the ageing process are influenced by the health status
    • Mysliwska, J., Bryl, E., Foerster, J., Mysliwski, A. (1998) Increase of interleukin 6 and decrease of interleukin 2 production during the ageing process are influenced by the health status. Mech. Ageing Dev. 100, 313-328.
    • (1998) Mech. Ageing Dev. , vol.100 , pp. 313-328
    • Mysliwska, J.1    Bryl, E.2    Foerster, J.3    Mysliwski, A.4
  • 118
    • 0030038103 scopus 로고    scopus 로고
    • Oxidative stress, caloric restriction, and aging
    • Sohal, R. S., Weindruch, R. (1996) Oxidative stress, caloric restriction, and aging. Science 273, 59-63.
    • (1996) Science , vol.273 , pp. 59-63
    • Sohal, R.S.1    Weindruch, R.2
  • 120
    • 0028308494 scopus 로고
    • Dietary restriction from middle age attenuates age-associated lymphoma development and IL 6 dysregulation in C57BL/6 mice
    • Volk, M. J., Pugh, T. D., Kim, M. J., Frith, C. H., Daynes, R. A., Ershler, W. B., Weindruch, R. (1993) Dietary restriction from middle age attenuates age-associated lymphoma development and IL 6 dysregulation in C57BL/6 mice. Cancer Res. 54, 3054-3063.
    • (1993) Cancer Res. , vol.54 , pp. 3054-3063
    • Volk, M.J.1    Pugh, T.D.2    Kim, M.J.3    Frith, C.H.4    Daynes, R.A.5    Ershler, W.B.6    Weindruch, R.7
  • 122
    • 0031732983 scopus 로고    scopus 로고
    • Serum dehydroepiandrosterone (DHEA) and DHEA sulfate are negatively correlated with serum interleukin 6 (IL 6) and DHEA inhibits IL 6 secretion from mononuclear cells in man in vitro: Possible link between endocrinosenescence and immunosenescence
    • Straub, R. H., Konecna, L., Hrach, S., Rothe, G., Kreutz, M., Scholmerich, J., Falk, W., Lang, B. (1998) Serum dehydroepiandrosterone (DHEA) and DHEA sulfate are negatively correlated with serum interleukin 6 (IL 6) and DHEA inhibits IL 6 secretion from mononuclear cells in man in vitro: possible link between endocrinosenescence and immunosenescence. J. Clin. Endocrinol. Metab. 83, 2012-2017.
    • (1998) J. Clin. Endocrinol. Metab. , vol.83 , pp. 2012-2017
    • Straub, R.H.1    Konecna, L.2    Hrach, S.3    Rothe, G.4    Kreutz, M.5    Scholmerich, J.6    Falk, W.7    Lang, B.8
  • 125
    • 0029655289 scopus 로고    scopus 로고
    • Synthesis of anti-acetylcholine receptor antibodies CD5 B cells from peripheral blood of myasthenia gravis patients
    • Heidenreich, F., Jovin, T. (1996) Synthesis of anti-acetylcholine receptor antibodies CD5 B cells from peripheral blood of myasthenia gravis patients. J. Neurol. 243, 57-62.
    • (1996) J. Neurol. , vol.243 , pp. 57-62
    • Heidenreich, F.1    Jovin, T.2
  • 126
    • 0029619435 scopus 로고
    • Effect of dietary high doses of vitamin e on the cell size of T and B lymphocyte subsets in young and old CBA mice
    • Brohee, D., Neve, P. (1995) Effect of dietary high doses of vitamin E on the cell size of T and B lymphocyte subsets in young and old CBA mice. Mech. Ageing Dev. 85, 147-159.
    • (1995) Mech. Ageing Dev. , vol.85 , pp. 147-159
    • Brohee, D.1    Neve, P.2
  • 127
    • 0029987839 scopus 로고    scopus 로고
    • Elements of immunity - The instructive role of innate immunity in the acquired immune response
    • Fearon, D. T., Locksley, R. M. (1996) Elements of immunity - The instructive role of innate immunity in the acquired immune response. Science 272, 50-54.
    • (1996) Science , vol.272 , pp. 50-54
    • Fearon, D.T.1    Locksley, R.M.2
  • 128
    • 0032006898 scopus 로고    scopus 로고
    • Linkages of innate and adaptive immunity
    • Carroll, M. C., Prodeus, A. P. (1998) Linkages of innate and adaptive immunity. Curr. Opin. Immunol. 10, 36-40.
    • (1998) Curr. Opin. Immunol. , vol.10 , pp. 36-40
    • Carroll, M.C.1    Prodeus, A.P.2


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