Numerical and functional characteristics of lymphocyte subsets in centenarians

Journal of Clinical Immunology

Volumn 17, Issue 5, 1997, Pages 420-429

  Miyaji, Chikako ^a   Watanabe, Hisami ^a   Minagawa, Masahiro ^a   Toma, Hiromu ^b   Kawamura, Toshihiko ^a   Nohara, Yumiko ^b   Nozaki, Hiroyuki ^b   Sato, Yoshiya ^b   Abo, Toru ^a  

^a NIIGATA UNIVERSITY   (Japan)

^b UNIVERSITY OF THE RYUKYUS   (Japan)

Author keywords

Age associated change; Centenarians; Immune system; Natural killer cells; NK1+ T cells

Indexed keywords

CD3 ANTIGEN; CD56 ANTIGEN; CD57 ANTIGEN;

AGED; AGING; ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; FEMALE; FLOW CYTOMETRY; HUMAN; HUMAN CELL; LYMPHOCYTE COUNT; LYMPHOCYTE PROLIFERATION; MAJOR CLINICAL STUDY; MALE; NATURAL KILLER CELL; PRIORITY JOURNAL; T LYMPHOCYTE SUBPOPULATION;

AGED; AGING; ANTIGENS, CD56; ANTIGENS, CD57; CD8-POSITIVE T-LYMPHOCYTES; CELL DIVISION; CELL SIZE; CYTOTOXICITY TESTS, IMMUNOLOGIC; FEMALE; FLOW CYTOMETRY; HUMANS; JAPAN; KILLER CELLS, NATURAL; LYMPHOCYTE COUNT; LYMPHOCYTE SUBSETS; MALE; MIDDLE AGED; T-LYMPHOCYTES;

EID: 0030749381     PISSN: 02719142     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1027324626199     Document Type: Article

References (31)

1. Sansoni P, Cossarizza A, Brianti V, Fagnoni F, Snelli G, Monti D, Marcato A, Passeri G, Ortolani C, Forti H, Fagiolo U, Passeri M, Franceschi C: Lymphocyte subsets and natural killer cell activity in healthy old people and centenarians. Blood 82:2767-2773, 1993
2. Murasko DM, Weiner P, Kaye D: Decline in mitogen induced proliferation of lymphocytes with increasing age. Clin Exp Immunol 70:440-448, 1987
3. Lehtonen L, Eskola J, Vainio O, Lehtonen A: Changes in lymphocyte subsets and immune competence in very advanced age. J Gerontol 45:M108-M112, 1990
4. Matour D, Melnicoff M, Kaye D, Murasko DM: The role of T cell phenotypes in decreased lymphoproliferation of the elderly. Clin Immunol Immunopathol 50:82-99, 1989
5. Kay MM, Makinodan T: Relationship between ageing and immune system. Prog Allergy 29:134-181, 1981
6. Goto M, Nishioka K: Age- and sex-related changes of the lymphocyte subsets in healthy individuals: An analysis by two-dimensional flow cytometry. J Gerontol 44:M51-M56, 1989
7. Abo T, Cooper MD, Balch CM: Postnatal expansion of the natural killer and killer cell population in humans identified by the monoclonal HNK-1 antibody. J Exp Med 155:321-326, 1982
8. Krishnaraj R, Blandford G: Age-associated alterations in human natural killer cells. I. Increased activity as per conventional and kinetic analysis. Clin Immunol Immunopathol 45:268-285, 1987
9. Sato K, Ohtsuka K, Hasegawa K, Yamagiwa S, Watanabe H, Asakura H, Abo T: Evidence for extrathymic generation of intermediate TCR cells in the liver revealed in thymectomized, irradiated mice subjected to bone marrow transplantation. J Exp Med 182:759-767, 1995
10. +T cells arc present within a population of intermediate TCR cells. J Immunol 155:2972-2983, 1995
11. + cells expressing intermediate levels of the T cell receptor in the liver and other immune organs. Eur J Immunol 25:2272-2278, 1995
12. Kawachi Y, Arai K, Moroda T, Kawamura T, Umezu H, Naito M, Ohtsuka K, Hasegawa K, Takahashi-Iwanaga H, Iwanaga T, Shults LD, Watanabe H, Abo T: Supportive cellular elements for hepatic T cell differentiation: T cells expressing intermediate levels of the T cell receptor are cytotoxic against syngeneic hepatoma, and are lost after hepatocyte damage. Eur J Immunol 25:3452-3459, 1995
13. + stem cells and thymocyte precursors in the livers of adult mice. J Exp Med 184:687-693, 1996
14. Moroda T, Iiai T, Kawachi Y, Kawamura T, Hatakeyama K, Abo T: Restricted appearance of sell-reactive clones into T cell receptor intermediate cells in neonatally thymectomized mice with autoimmune disease. Eur J Immunol 26:3084-3091, 1996
15. Iiai T, Watanabe H, Seki S, Sugiura K, Hirokawa K, Utsuyama M, Takahashi-Iwanaga H, Iwanaga T, Ohteki T, Abo T: Ontogeny and development of extrathymic T cells in mouse liver. Immunology 77:556-563, 1992
16. Ohtsuka K, Iiai T, Watanabe H, Tanaka T, Miyasaka M, Sato K, Asakura H, Abo T: Similarities and differences between extrathymic T cells residing in mouse liver and intestine. Cell Immunol 153:52-66, 1994
17. +T cells in patients with malignancy. Clin Exp Immunol 97:522-527, 1994
18. +T cells in humans: Their abundance in the liver and similarity to extrathymic T cells in mice. Biomed Res 16:1-9, 1995
19. +T cells which increase at tumour sites in patients with colorectal cancer. Clin Exp Immunol 102:159-166, 1995
20. - double negative lymphocytes by bacterial stimulation. Int Immunol 2:775-785, 1990
21. Seki S, Abo T, Masuda T, Ohteki T, Kanno A, Takeda K, Rikiishi H, Nagura H, Kumagai K: Identification of activated T cell receptor γδ lymphocytes in the liver of tumor-bearing hosts. J Clin Invest 86:409-415, 1990
22. + (Leu-7) human lymphocytes. II. Distinguishing phenotypic and functional properties of natural killer cells from activated NK-like cells. J Immunol 129:1758-1761, 1982
23. + (Leu-7) human lymphocytes. I. Two distinct phenotypes of human NK cells with different cytotoxic capability. J Immunol 129:1752-1757, 1982
24. + lymphocytes and T cell dysfunction in recipients of bone marrow transplantation. Clin Exp Immunol 82:145-150, 1990
25. Hilbe W, Eisterer W, Schmid C, Starz I, Silly H, Duba C, Ludescher C, Thaler J: Bone marrow lymphocyte subsets in myelodysplastic syndromes. J Clin Pathol 47:505-507, 1994
26. + T cells with restricted T-cell receptor β chain variability after bone marrow transplantation. Blood 83:587-595, 1994
27. + lymphocytes from bone marrow transplanted patients inhibits cell-mediated cytolysis. Blood 77:2237-2241, 1991
28. Tsuchida M, Iiai T, Watanabe H, Abo T: Relative resistance of intermediate TCR cells to anti-CD3 mAb in mice in vivo and their partial functional characterization. Cell Immunol 145:78-90, 1992
29. Watanabe H, Iiai T, Kimura M, Ohtsuka K, Tanaka T, Miyasaka M, Tsuchida M, Hanawa H, Abo T: Characterization of intermediate TCR cells in the liver of mice with respect to their unique IL-2R expression. Cell Immunol 149:331-342, 1993
30. Osman Y, Watanabe T, Kawachi Y, Sato K, Ohtsuka K, Watanabe H, Hashimoto S, Moriyama Y, Shibata A, Abo T: Intermediate TCR cells with self-reactive clones are effector cells which induce syngeneic graft-versus-host disease in mice. Cell Immunol 166: 172-186, 1995
31. Abo T, Watanabe H, Sato K, Iiai T, Moroda T, Takeda K, Seki S: Extrathymic T cells stand at an intermediate phylogenetic position between natural killer cells and thymus-derived T cells. Nat Immun 14:173-187, 1995