메뉴 건너뛰기




Volumn 92, Issue 2-3, 1996, Pages 195-209

Perforins in human cytolytic cells: The effect of age

Author keywords

Ageing; Cytolytic cells; Cytoplasm perforin; Flow cytometry; Lytic activity

Indexed keywords

CD8 ANTIGEN; PERFORIN;

EID: 0030595983     PISSN: 00476374     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0047-6374(96)01829-5     Document Type: Article
Times cited : (44)

References (44)
  • 1
    • 0022466528 scopus 로고
    • The expanded null cell compartment in ageing: Increase in the number of NK cells, changes in T-cell and NK cell subsets in human blood
    • [1] G.J. Ligthart, P.C. Van Vlohoven, H.R.E. Schuit and W. Hijmans, The expanded null cell compartment in ageing: increase in the number of NK cells, changes in T-cell and NK cell subsets in human blood. Immunology, 59 (1986) 353-357.
    • (1986) Immunology , vol.59 , pp. 353-357
    • Ligthart, G.J.1    Van Vlohoven, P.C.2    Schuit, H.R.E.3    Hijmans, W.4
  • 2
    • 0023225697 scopus 로고
    • Increased number of circulating Leu11 + (CD 16) large granular lymphocytes and decreased NK activity during human ageing
    • [2] A. Facchini, E. Mariani, A.R. Mariani, S. Papa, M. Vitale and F.A. Manzoli, Increased number of circulating Leu11 + (CD 16) large granular lymphocytes and decreased NK activity during human ageing. Clin. Exp. Immunol., 68 (1987) 340-347.
    • (1987) Clin. Exp. Immunol. , vol.68 , pp. 340-347
    • Facchini, A.1    Mariani, E.2    Mariani, A.R.3    Papa, S.4    Vitale, M.5    Manzoli, F.A.6
  • 3
    • 0023918758 scopus 로고
    • Age-associated alterations in human natural killer cells. 2: Increased frequency of selective NK subsets
    • [3] R. Krishnaraj and G. Blandford, Age-associated alterations in human natural killer cells. 2: increased frequency of selective NK subsets. Cell. Immunol., 114 (1988) 137-148.
    • (1988) Cell. Immunol. , vol.114 , pp. 137-148
    • Krishnaraj, R.1    Blandford, G.2
  • 5
    • 0026492479 scopus 로고
    • The impairment of natural killer function in the healthy aged is due to a postbinding deficient mechanism
    • [5] M. Vitale, L. Zamai, L.M. Neri, A. Galanzi, A. Facchini, R. Rana, A. Cataldi and S. Papa, The impairment of natural killer function in the healthy aged is due to a postbinding deficient mechanism. Cell. Immunol., 745 (1992) 1-10.
    • (1992) Cell. Immunol. , vol.745 , pp. 1-10
    • Vitale, M.1    Zamai, L.2    Neri, L.M.3    Galanzi, A.4    Facchini, A.5    Rana, R.6    Cataldi, A.7    Papa, S.8
  • 7
    • 0022308091 scopus 로고
    • Mechanism of lymphocyte-mediated cytotoxicity
    • [7] P.A. Henkart, Mechanism of lymphocyte-mediated cytotoxicity. Annu. Rev. Immunol., 3 (1985) 31-58.
    • (1985) Annu. Rev. Immunol. , vol.3 , pp. 31-58
    • Henkart, P.A.1
  • 8
    • 0025182959 scopus 로고
    • Adhesion receptors of the immune system
    • [8] T.A. Springer, Adhesion receptors of the immune system. Nature, 343 (1990) 425-434.
    • (1990) Nature , vol.343 , pp. 425-434
    • Springer, T.A.1
  • 9
    • 0028294895 scopus 로고
    • The binding and lysis of target cells by cytotoxic lymphocytes: Molecular and cellular aspects
    • [9] G. Berke, The binding and lysis of target cells by cytotoxic lymphocytes: molecular and cellular aspects. Annu. Rev. Immunol., 12 (1994) 735-773.
    • (1994) Annu. Rev. Immunol. , vol.12 , pp. 735-773
    • Berke, G.1
  • 10
    • 0022494081 scopus 로고
    • Properties of a purified pore-forming protein (perforin 1) isolated from H-2-restricted cytotoxic T-cells granules
    • [10] J.D.E. Young, E.R. Podack and Z.A. Cohn, Properties of a purified pore-forming protein (perforin 1) isolated from H-2-restricted cytotoxic T-cells granules. J. Exp. Med., 164 (1986) 144-135.
    • (1986) J. Exp. Med. , vol.164 , pp. 144-1135
    • Young, J.D.E.1    Podack, E.R.2    Cohn, Z.A.3
  • 11
    • 0023645045 scopus 로고
    • A family of serine esterases in lytic granules of cytolytic T lymphocytes
    • [11] D. Masson and J. Tschopp, A family of serine esterases in lytic granules of cytolytic T lymphocytes. Cell, 49 (1987) 679-685.
    • (1987) Cell , vol.49 , pp. 679-685
    • Masson, D.1    Tschopp, J.2
  • 12
    • 0025230476 scopus 로고
    • Perforin-mediated target cell lysis by cytolytic T lymphocytes
    • [12] J. Tschopp and M. Nabholz, Perforin-mediated target cell lysis by cytolytic T lymphocytes. Annu. Rev. Immunol., 8 (1990) 279-302.
    • (1990) Annu. Rev. Immunol. , vol.8 , pp. 279-302
    • Tschopp, J.1    Nabholz, M.2
  • 13
    • 0027507325 scopus 로고
    • The calcium-binding protein calreticulin is a major constituent of lytic granules in cytolytic T lymphocytes
    • [13] M. Dupuis, E. Schaerer, K.H. Krause and J. Tschopp, The calcium-binding protein calreticulin is a major constituent of lytic granules in cytolytic T lymphocytes. J. Exp. Med., 177 (1993) 1-7.
    • (1993) J. Exp. Med. , vol.177 , pp. 1-7
    • Dupuis, M.1    Schaerer, E.2    Krause, K.H.3    Tschopp, J.4
  • 15
    • 0001041396 scopus 로고
    • Isolation and biochemical and functional characterization of perforin 1 from cytolytic T-cell granules
    • [15] E.R. Podack, J.D.E. Young and Z.A. Cohn, Isolation and biochemical and functional characterization of perforin 1 from cytolytic T-cell granules. Proc. Natl. Acad. Sci. USA, 82 (1985) 8629-8633.
    • (1985) Proc. Natl. Acad. Sci. USA , vol.82 , pp. 8629-8633
    • Podack, E.R.1    Young, J.D.E.2    Cohn, Z.A.3
  • 16
    • 0025032026 scopus 로고
    • Involvement of granule proteins in T-cell-mediated cytolysis
    • [16] O. Krähenbühl and J. Tschopp, Involvement of granule proteins in T-cell-mediated cytolysis. Nat. Immun. Cell Growth Regul., 9 (1990) 274-282.
    • (1990) Nat. Immun. Cell Growth Regul. , vol.9 , pp. 274-282
    • Krähenbühl, O.1    Tschopp, J.2
  • 18
  • 19
    • 0024592017 scopus 로고
    • Killing of target cells by lymphocytes: A mechanistic view
    • [19] J.D.E. Young, Killing of target cells by lymphocytes: a mechanistic view. Physiol. Rev., 69 (1989) 250-314.
    • (1989) Physiol. Rev. , vol.69 , pp. 250-314
    • Young, J.D.E.1
  • 21
    • 0028990670 scopus 로고
    • Lymphocyte-mediated cytotoxicity in vitro and in vivo: Mechanisms and significance
    • [21] D. Kägi, B. Ledermann, K. Bürki, R.M. Zinkernagel and H. Hengartner, Lymphocyte-mediated cytotoxicity in vitro and in vivo: mechanisms and significance. Immunol. Rev., 146 (1995) 95-115.
    • (1995) Immunol. Rev. , vol.146 , pp. 95-115
    • Kägi, D.1    Ledermann, B.2    Bürki, K.3    Zinkernagel, R.M.4    Hengartner, H.5
  • 23
    • 0025336034 scopus 로고
    • Necessity of the assessment of health status in human immunogerontological studies: Evaluation of the SENIEUR protocol
    • [23] G.J. Ligthart, J.X. Corberand, H.G.M. Geertzen, A.E. Meinders, D.L. Knook and W. Hijmans, Necessity of the assessment of health status in human immunogerontological studies: evaluation of the SENIEUR protocol. Mech. Ageing Dev., 55 (1990) 89-105.
    • (1990) Mech. Ageing Dev. , vol.55 , pp. 89-105
    • Ligthart, G.J.1    Corberand, J.X.2    Geertzen, H.G.M.3    Meinders, A.E.4    Knook, D.L.5    Hijmans, W.6
  • 24
    • 0026061995 scopus 로고
    • A gentle fixation and permeabilization method for combined cell surface and intracellular staining with improved precision in DNA quantification
    • [24] I. Schmid, H. Uittenbogaart and J.V. Giorgi, A gentle fixation and permeabilization method for combined cell surface and intracellular staining with improved precision in DNA quantification. Cytometry, 12 (1991) 279-285.
    • (1991) Cytometry , vol.12 , pp. 279-285
    • Schmid, I.1    Uittenbogaart, H.2    Giorgi, J.V.3
  • 25
    • 0021267291 scopus 로고
    • Analysis with OKT monoclonal antibodies of T-lymphocyte subsets present in blood and liver of patients with chronic active hepatitis
    • [25] E. Mariani, A. Facchini, F. Miglio, G.F. Stefanini, M. Mazzetti, T. Leupers, G. Gasbarrini, G. Labo and A. Astaldi, Analysis with OKT monoclonal antibodies of T-lymphocyte subsets present in blood and liver of patients with chronic active hepatitis. Liver, 4 (1984) 22-28.
    • (1984) Liver , vol.4 , pp. 22-28
    • Mariani, E.1    Facchini, A.2    Miglio, F.3    Stefanini, G.F.4    Mazzetti, M.5    Leupers, T.6    Gasbarrini, G.7    Labo, G.8    Astaldi, A.9
  • 26
    • 0023124839 scopus 로고
    • Use of polygonal windows for physical discrimination among mononuclear subpopulations in flow cytometry
    • [26] M. Vitale, S. Papa, A.R. Mariani, A. Facchini, R. Rizzoli and F.A. Manzoli, Use of polygonal windows for physical discrimination among mononuclear subpopulations in flow cytometry. J. Immunol. Methods, 96 (1987) 63-68.
    • (1987) J. Immunol. Methods , vol.96 , pp. 63-68
    • Vitale, M.1    Papa, S.2    Mariani, A.R.3    Facchini, A.4    Rizzoli, R.5    Manzoli, F.A.6
  • 27
    • 0024672318 scopus 로고
    • Model system evaluating fluorescein-labelled microbeads as internal standards to calibrate fluorescence intensity on flow cytometers
    • [27] R.F. Vogt, G.D. Cross, L.O. Henderson and D.L. Phillips, Model system evaluating fluorescein-labelled microbeads as internal standards to calibrate fluorescence intensity on flow cytometers. Cytometry, 10 (1989) 294-302.
    • (1989) Cytometry , vol.10 , pp. 294-302
    • Vogt, R.F.1    Cross, G.D.2    Henderson, L.O.3    Phillips, D.L.4
  • 28
    • 0002659795 scopus 로고
    • Calibration of fluorescent intensity microbead standards and assignment of effective fluorescein/protein ratios to the fluorescein isothiocyanate (FITC)-conjugated secondary antibodies used in the Fifth Workshop
    • S.F. Schlossman, L. Boumsell, W. Gilks, J.M. Harlan, T. Kishimoto, C. Morimoto, J. Ritz, S. Shaw, R. Silverstein, T. Springer, T.F. Tedder and R.F. Todd (eds.), Oxford University Press, Oxford
    • [28] R.Y.M. Poon, R. Johnson, T. Stanton, E. Fernandez-Repollet and A. Schwartz, Calibration of fluorescent intensity microbead standards and assignment of effective fluorescein/protein ratios to the fluorescein isothiocyanate (FITC)-conjugated secondary antibodies used in the Fifth Workshop. In S.F. Schlossman, L. Boumsell, W. Gilks, J.M. Harlan, T. Kishimoto, C. Morimoto, J. Ritz, S. Shaw, R. Silverstein, T. Springer, T.F. Tedder and R.F. Todd (eds.), Leucocyte Typing V. White cell differentiation antigens, Oxford University Press, Oxford, 1995, pp. 13-16.
    • (1995) Leucocyte Typing V. White Cell Differentiation Antigens , pp. 13-16
    • Poon, R.Y.M.1    Johnson, R.2    Stanton, T.3    Fernandez-Repollet, E.4    Schwartz, A.5
  • 29
    • 0017759583 scopus 로고
    • Cytotoxic reactivity of human lymphocytes cultured in vitro
    • [29] J.R. Ortaldo, G.D. Bonnard and R.B. Herbermann, Cytotoxic reactivity of human lymphocytes cultured in vitro. J. Immunol., 119 (1977) 1351-1357.
    • (1977) J. Immunol. , vol.119 , pp. 1351-1357
    • Ortaldo, J.R.1    Bonnard, G.D.2    Herbermann, R.B.3
  • 31
    • 0028990676 scopus 로고
    • Perform and lymphocyte-mediated cytolysis
    • [31] C.C. Liu, P.M. Persechini and J.D.E. Young, Perform and lymphocyte-mediated cytolysis. Immunol Rev., 146 (1995) 145-175.
    • (1995) Immunol Rev. , vol.146 , pp. 145-175
    • Liu, C.C.1    Persechini, P.M.2    Young, J.D.E.3
  • 32
    • 0028990670 scopus 로고
    • Lymphocyte-mediated cytotoxicity in vitro and in vivo: Mechanisms and significance
    • [32] D. Kägi, B. Ledermann, K. Bürki, R.M. Zinkernagel and H. Hengartner, Lymphocyte-mediated cytotoxicity in vitro and in vivo: mechanisms and significance. Immunol. Rev., 146 (1995) 95-115.
    • (1995) Immunol. Rev. , vol.146 , pp. 95-115
    • Kägi, D.1    Ledermann, B.2    Bürki, K.3    Zinkernagel, R.M.4    Hengartner, H.5
  • 33
    • 0029162873 scopus 로고
    • Relative perforin-and Fas-mediated lysis in T1 and T2 CD8 effector populations
    • [33] L.L. Carter and R.W. Dutton, Relative perforin-and Fas-mediated lysis in T1 and T2 CD8 effector populations. J. Immunol., 755 (1995) 1028-1031.
    • (1995) J. Immunol. , vol.755 , pp. 1028-1031
    • Carter, L.L.1    Dutton, R.W.2
  • 34
    • 0029039291 scopus 로고
    • Loss of cytotoxic T-lymphocyte function in Chediak-Higashi syndrome arises from a secretory defect that prevents lytic granule exocytosis
    • [34] K. Baetz, S. Isaaz and G.M. Griffiths, Loss of cytotoxic T-lymphocyte function in Chediak-Higashi syndrome arises from a secretory defect that prevents lytic granule exocytosis. J. Immunol., 154 (1995) 6122-6131.
    • (1995) J. Immunol. , vol.154 , pp. 6122-6131
    • Baetz, K.1    Isaaz, S.2    Griffiths, G.M.3
  • 35
    • 0025000275 scopus 로고
    • Inhibition of lymphocyte mediated cytotoxicity by perforin antisense oligonucleotides
    • [35] H. Acha-Orbea, L. Scarpellino, S. Hertig, M. Dupuis and J. Tschopp, Inhibition of lymphocyte mediated cytotoxicity by perforin antisense oligonucleotides. EMBO J., 9 (1990) 3815-3819.
    • (1990) EMBO J. , vol.9 , pp. 3815-3819
    • Acha-Orbea, H.1    Scarpellino, L.2    Hertig, S.3    Dupuis, M.4    Tschopp, J.5
  • 36
    • 0029009394 scopus 로고
    • Requirement for Natural Killer cells in the induction of cytotoxic T-cells
    • [36] F.J. Kos and E.G. Engleman, Requirement for Natural Killer cells in the induction of cytotoxic T-cells. J. Immunol., 155 (1995) 578-584.
    • (1995) J. Immunol. , vol.155 , pp. 578-584
    • Kos, F.J.1    Engleman, E.G.2
  • 37
    • 0028909084 scopus 로고
    • Transgenic control of perforin gene expression. Functional evidence for two separate control regions
    • [37] M.G. Lichtenheld, E.R. Podack and R.B. Levy, Transgenic control of perforin gene expression. Functional evidence for two separate control regions. J. Immunol., 154 (1995) 2153-2163.
    • (1995) J. Immunol. , vol.154 , pp. 2153-2163
    • Lichtenheld, M.G.1    Podack, E.R.2    Levy, R.B.3
  • 38
    • 0026606906 scopus 로고
    • Perforin expression in human peripheral blood mononuclear cells. Definition of an IL-2-independent pathway of perforin induction in CD8 + T-cells
    • [38] P. Lu, J.A. Garcia-Sanz, M.G. Lichtenheld and E.R. Podack, Perforin expression in human peripheral blood mononuclear cells. Definition of an IL-2-independent pathway of perforin induction in CD8 + T-cells. J. Immunol., 148 (1992) 3354-3360.
    • (1992) J. Immunol. , vol.148 , pp. 3354-3360
    • Lu, P.1    Garcia-Sanz, J.A.2    Lichtenheld, M.G.3    Podack, E.R.4
  • 39
    • 0026531097 scopus 로고
    • Multiple cytolytic mechanisms displayed by activated human peripheral blood T-cell subsets
    • [39] M.J. Smyth, Y. Norihisa and J.R. Ortaldo, Multiple cytolytic mechanisms displayed by activated human peripheral blood T-cell subsets. J. Immunol., 148 (1992) 55-62.
    • (1992) J. Immunol. , vol.148 , pp. 55-62
    • Smyth, M.J.1    Norihisa, Y.2    Ortaldo, J.R.3
  • 40
    • 0027475735 scopus 로고
    • Expression of perforin and membrane-bound lymphotoxin (tumour necrosis factor-β) in virus-specific CD4 + human cytotoxic T-cell clones
    • [40] M. Yasukawa, Y. Yakusijin, H. Hasegawa, M. Muyake, Y. Hitsumoto, S. Kimura, N. Takeuchi and S. Fujita, Expression of perforin and membrane-bound lymphotoxin (tumour necrosis factor-β) in virus-specific CD4 + human cytotoxic T-cell clones. Blood, 81 (1993) 1527-1534.
    • (1993) Blood , vol.81 , pp. 1527-1534
    • Yasukawa, M.1    Yakusijin, Y.2    Hasegawa, H.3    Muyake, M.4    Hitsumoto, Y.5    Kimura, S.6    Takeuchi, N.7    Fujita, S.8
  • 41
    • 0028928464 scopus 로고
    • Cord blood T-lymphocytes lack constitutive perforin expression in contrast to adult peripheral blood T lymphocytes
    • [41] C. Berthou, S. Legros-Maïda, A. Souliè, A. Wargnier, J. Guillet, C. Rabian, E. Gluckman and M. Sasportes, Cord blood T-lymphocytes lack constitutive perforin expression in contrast to adult peripheral blood T lymphocytes. Blood, 85 (1995) 1540-1546.
    • (1995) Blood , vol.85 , pp. 1540-1546
    • Berthou, C.1    Legros-Maïda, S.2    Souliè, A.3    Wargnier, A.4    Guillet, J.5    Rabian, C.6    Gluckman, E.7    Sasportes, M.8
  • 42
    • 0025992313 scopus 로고
    • Rapid loss of perforin and serine protease RNA in cytotoxic lymphocytes exposed to sensitive targets
    • [42] A. Bajpai, B.S. Kwon and Z. Brahmi, Rapid loss of perforin and serine protease RNA in cytotoxic lymphocytes exposed to sensitive targets. Immunology, 74 (1991) 258-264.
    • (1991) Immunology , vol.74 , pp. 258-264
    • Bajpai, A.1    Kwon, B.S.2    Brahmi, Z.3
  • 43
    • 0027265549 scopus 로고
    • Modulation of perforin and granzyme messenger RNA expression in human natural killer cells
    • [43] T.W. Salcedo, L. Azzoni, S.F. Wolf and B. Perussia, Modulation of perforin and granzyme messenger RNA expression in human natural killer cells. J. Immunol., 151 (1993) 2511-2520.
    • (1993) J. Immunol. , vol.151 , pp. 2511-2520
    • Salcedo, T.W.1    Azzoni, L.2    Wolf, S.F.3    Perussia, B.4
  • 44
    • 0026801986 scopus 로고
    • Pore-forming protein in individual cytotoxic T lymphocytes: The effect of senescence provides a probe for understanding the lytic mechanism
    • [44] J.A. Horvath, H.S. Mostowski, K. Okumura and E.T. Bloom, Pore-forming protein in individual cytotoxic T lymphocytes: the effect of senescence provides a probe for understanding the lytic mechanism. Eur. J. Immunol., 22 (1992) 2694-2654.
    • (1992) Eur. J. Immunol. , vol.22 , pp. 2694-12654
    • Horvath, J.A.1    Mostowski, H.S.2    Okumura, K.3    Bloom, E.T.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.