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Volumn 369, Issue , 2003, Pages 469-496

Library Generation via Postcondensation Modifications of Isocyanide-Based Multicomponent Reactions

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR BLOCKING AGENT; AMYLOID BETA PROTEIN; ANTICONVULSIVE AGENT; ANTIDEPRESSANT AGENT; BENZIMIDAZOLE DERIVATIVE; BENZODIAZEPINE DERIVATIVE; CHOLECYSTOKININ RECEPTOR BLOCKING AGENT; FIBRINOGEN RECEPTOR ANTAGONIST; HETEROCYCLIC COMPOUND; HYPNOTIC AGENT; IMIDAZOLINE DERIVATIVE; NEUROPEPTIDE Y RECEPTOR ANTAGONIST; PROTON PUMP INHIBITOR; QUINOXALINONE DERIVATIVE; RNA DIRECTED DNA POLYMERASE INHIBITOR; UNCLASSIFIED DRUG;

EID: 0013076055     PISSN: 00766879     EISSN: None     Source Type: Book Series    
DOI: 10.1016/S0076-6879(03)69024-5     Document Type: Article
Times cited : (47)

References (96)
  • 8
    • 0018942777 scopus 로고
    • For earlier syntheses of 1,4-benzodiazepines see (b) M. Gates, J. Org. Chem. 45, 1675 (1980).
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    • Gates, M.1
  • 17
    • 0027180339 scopus 로고    scopus 로고
    • note
    • N-Boc anthranilic acids are readily accessible in multigram quantities via the synthetic route shown in the scheme below from the corresponding anthranilic acid or isatin. N-Boc diamines are readily available as described in A. P. Krapcho, M. J. Maresh, and J. Lunn, Synthetic Commun. 23, 2443 (1993). The majority of available N-Boc anthranilic acids may be purchased from Anaspec AA. Diagram presented.
  • 20
    • 85030922523 scopus 로고    scopus 로고
    • note
    • (b) Note that MP-carbonate (Argonaut Technologies) was used to facilitate cyclization in the ketopiperazine series.
  • 26
    • 85030923514 scopus 로고    scopus 로고
    • note
    • PS-TsNHNH2 was purchased from Argonaut Technologies, Foster City, CA.
  • 53
    • 85030919078 scopus 로고    scopus 로고
    • note
    • PS-NCO was purchased from Argonaut Technologies, Foster City, California.
  • 63
  • 66
    • 85030928408 scopus 로고    scopus 로고
    • note
    • 3CN to 100% over 5 min.
  • 67
    • 0032580464 scopus 로고    scopus 로고
    • For an early application of the TMSN3-modified Ugi reaction producing fused tetrazoles see H. Bienayme, Tetrahedron Lett. 39, 2735 (1998).
    • (1998) Tetrahedron Lett. , vol.39 , pp. 2735
    • Bienayme, H.1
  • 79
    • 0033600274 scopus 로고    scopus 로고
    • (b) D. Selkoe, Nature 399A, 23 (1999).
    • (1999) Nature , vol.399 A , pp. 23
    • Selkoe, D.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.