Solid phase synthesis of hydantoin library using a novel cyclization and traceless cleavage step

Tetrahedron Letters

Volumn 38, Issue 26, 1997, Pages 4603-4606

  Kim, Sang Woong ^a   Ahn, Sang Youl ^a   Koh, Jong Sung ^a   Lee, Jin Ho ^a   Ro, Seonggu ^a   Cho, Hae Yeon ^a  

^a LG Chemical Ltd   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

ALDEHYDE; AMINO ACID DERIVATIVE; HYDANTOIN DERIVATIVE; ISOCYANIC ACID DERIVATIVE;

ARTICLE; CYCLIZATION; DRUG SYNTHESIS;

EID: 0030976794     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4039(97)00986-6     Document Type: Article

References (22)

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18. (b) Wang resin (0.85mmol/g) was purchased from the novabiochem.
19. Kaiser test showed negative result.
20. We observed 89% ee by chiral HPLC after cleavage from resin.
21. No racemization was observed during the cyclization step.
22. Each compound showed single spot and one peak on TLC and HPLC, respectively.