The synthesis of hydantoin 4-imides on solid support

Tetrahedron Letters

Volumn 37, Issue 42, 1996, Pages 7489-7492

  Short, Kevin M ^a   Ching, Brett W ^a   Mjalli, Adnan M M ^a  

^a Ontogen Corporation   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HYDANTOIN DERIVATIVE;

ARTICLE; DRUG SYNTHESIS; REACTION ANALYSIS;

EID: 0030583515     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/0040-4039(96)01699-1     Document Type: Article

References (14)

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3. 3. (a):Zhang, C.; Moran, E.J.; Woiwode, T.F.; Short, K.M.; Mjalli, A.M.M. Tetrahedron Lett. 1996, 37, 751.
4. (b):Sarshar, S.; Siev, D.; Mjalli, A.M.M. Tetrahedron Lett. 1996, 37, 835.
5. 4. Mjalli, A.M.M.; Sarshar, S.; Baiga, T.J. Tetrahedron Lett. 1996, 37, 2943.
6. 5. Short, K.M.; Mjalli, A.M.M., Tet. Lett. 1996, 37, submitted.
7. 6. Roussel-Uclaf, United States Patent US 4873256.
8. 7. Boehringer Mannheim, Europian Patent EP 352652. Morrey, J.D. Antiviral Res. 1991, 15, 51.
9. 7. Boehringer Mannheim, European Patent EP 352652. Morrey, J.D. Antiviral Res. 1991, 15, 51.
10. 8. Ugi, I. Angew. Chem. Int. Ed. Engl. 1962, 1, 8.
11. 9. Cargill, J.F.; Maiefski, R.R.; Toyonaga, B.E. International Symposium on Laboratory Automation and Robotics Proceedings (ISLAR '95), Boston, MA, Zymark Corporation, 1996, 221.
12. 10. Wang, S.S. J. Am. Chem. Soc. 1973, 95, 1328.
13. 11. We found that HXCN could be conveniently generated in situ, by the addition of pyridine.HCl to KXCN (X=O,S).
14. 2 as before gave the required 2-thiohydantoin 4-imides (i) in low yields (6-11%). (formula presented)