Blockade of HERG channels by the class III antiarrhythmic azimilide: Mode of action

British Journal of Pharmacology

Volumn 123, Issue 1, 1998, Pages 23-30

  Busch, A E ^a,b,e   Eigenberger, B ^a   Jurkiewicz, N K ^c   Salata, J J ^c   Pica, A ^d   Suessbrich, H ^a   Lang, F ^a  

^a UNIVERSITY OF TÜBINGEN   (Germany)

^b MAX PLANCK INSTITUTE OF EXPERIMENTAL MEDICINE   (Germany)

^c MERCK RESEARCH LABORATORIES   (United States)

^d SECOND UNIVERSITY OF NAPLES   (Italy)

^e SANOFI   (France)

Author keywords

Arrhythmia; Azimilide; HERG; I(K); I(Ks); I(sK) (minK); K+ channel; KvLQT1; Torsades de pointes

Indexed keywords

ANTIARRHYTHMIC AGENT; AZIMILIDE; PROTEIN SUBUNIT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG PROTEIN BINDING; FEMALE; GUINEA PIG; HEART CONDUCTION; HEART MUSCLE CELL; MOUSE; NONHUMAN; OOCYTE; PRIORITY JOURNAL; XENOPUS;

ANIMALS; ANTI-ARRHYTHMIA AGENTS; CATION TRANSPORT PROTEINS; CELL LINE; DNA-BINDING PROTEINS; ELECTRIC STIMULATION; ETHER-A-GO-GO POTASSIUM CHANNELS; GUINEA PIGS; IMIDAZOLES; IMIDAZOLIDINES; MEMBRANE POTENTIALS; OOCYTES; PATCH-CLAMP TECHNIQUES; PIPERAZINES; POTASSIUM; POTASSIUM CHANNEL BLOCKERS; POTASSIUM CHANNELS; POTASSIUM CHANNELS, VOLTAGE-GATED; RNA, MESSENGER; TRANS-ACTIVATORS; XENOPUS;

EID: 0031974336     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0701575     Document Type: Article

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