A method for quantitation of solid-phase synthesis using 19F NMR spectroscopy

Journal of Combinatorial Chemistry

Volumn 2, Issue 1, 2000, Pages 8-9

  Drew, Mark ^a   Orton, Edward ^b   Krolikowski, Paul ^b   Salvino, Joseph M ^a   Kumar, N Vasant ^b  

^a Department of Lead Discovery ^*  (United States)

^b SANOFI   (France)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 0002591763     PISSN: 15204766     EISSN: None     Source Type: Journal    
DOI: 10.1021/cc990057l     Document Type: Article

References (22)

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18. Arshady, A.; Ledwith, A. React. Polym. 1983, 1, 159-174 and references therein. See Supporting Information for a typical synthesis of resin 5. The polymer resin 5 used in this study was prepared by Polymer Laboratories Ltd., U.K.
19. For leading references on fluoride ion chromatography, see: Dorsey, J. G.; Cooper, W. T.; Sues, B. A.; Foley, J. P.; Barth, H. G. Anal. Chem. 1996, 68, 515R-568R. The fluoride ion chromatography analyses were performed by Quantitative Technologies Inc., NJ. The analysis was replicated five times on each of three different days.
20. 3. Typical samples consisted of 2-4 mg of resin swollen in DMF. The sample was spun at 1500-1700 Hz. We also showed the feasibility of using gel-phase samples in standard 5 mm probes at different field strengths (200, 300, and 500 MHz).
21. -1 resolution on a Nicolet model 460 FTIR interfaced to an InspectIR microscope with a Si ATR objective.
22. Refer to Supporting Information.