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0003861336
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Solid-Supported Combinatorial and Parallel Synthesis of Small-Molecular-Weight Compound Libraries
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(a) Solid-Supported Combinatorial and Parallel Synthesis of Small-Molecular-Weight Compound Libraries; Tetrahedron Organic Chemistry Series, Volume 17; Obrecht, D.; Villalgordo, J. M., Eds.; Elsevier Science: Oxford, 1998.
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(b) Wilson, S. R.; Czarnik, A. W., Eds.; John Wiley: New York
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(b) Armstrong, R. W.; Brown, S. D.; Keating, T. A.; Tempest, P. A. In Combinatorial Chemistry. Synthesis and Application; Wilson, S. R.; Czarnik, A. W., Eds.; John Wiley: New York, 1997; pp. 153-190.
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Armstrong, R.W.1
Brown, S.D.2
Keating, T.A.3
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5
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©
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Endeavor
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Ugi, I.1
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6
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(a) Park, S.-J.; Keum, G.; Kang, S.-B.; Koh, H.-Y.; Kim, Y. Tetrahedron Lett. 1998, 39, 7109.
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7
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(b)
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(b) Bossio, R.; Marcaccini, S.; Paoli, P.; Pepino, R. Synthesis 1994, 672.
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Bossio, R.1
Marcaccini, S.2
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8
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Peptides. Chemistry and Biology
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15
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(d) Piercey, M. F.; Moon, M. W.; Blinn, J. R.; Dobry-Schreur, P. J. K. Brain Res. 1986, 385, 74.
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16
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0032582849
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(a)
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(a) Hulme, C.; Tang, S.-Y.; Burns, C. J.; Morize, I.; Labaudiniere, R. J. Org. Chem. 1998, 63, 8021. Keating, T. A.; Armstrong, R. W. J. Org. Chem. 1996, 61, 8935.
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Hulme, C.1
Tang, S.-Y.2
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Morize, I.4
Labaudiniere, R.5
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17
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0030443529
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(a) Hulme, C.; Tang, S.-Y.; Burns, C. J.; Morize, I.; Labaudiniere, R. J. Org. Chem. 1998, 63, 8021. Keating, T. A.; Armstrong, R. W. J. Org. Chem. 1996, 61, 8935.
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Keating, T.A.1
Armstrong, R.W.2
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18
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0032191453
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Note: The preparation of the safety-catch linker resin is reported by Elemental analysis indicated a loading of 0.8 mmol/g
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Note: The preparation of the safety-catch linker resin is reported by: Hulme, C.; Peng, J.; Morton, G.; Salvino, J. M.; Herpin, T.; Labaudiniere, R. Tetrahedron Lett. 1998, 39, 7227. Elemental analysis indicated a loading of 0.8 mmol/g.
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Tetrahedron Lett.
, vol.39
, pp. 7227
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Hulme, C.1
Peng, J.2
Morton, G.3
Salvino, J.M.4
Herpin, T.5
Labaudiniere, R.6
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19
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27844466269
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4. Please note that the stability of this aldehyde is limited and the use of freshly prepared batches is advised. See
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4. Please note that the stability of this aldehyde is limited and the use of freshly prepared batches is advised. See: Nahm, S.; Weinreb, S. M. Tetrahedron Lett. 1981, 22, 3815.
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(1981)
Tetrahedron Lett.
, vol.22
, pp. 3815
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Nahm, S.1
Weinreb, S.M.2
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20
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33845551642
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Flynn, D. L.; Zelle, R. E.; Grieco, P. A. J. Org. Chem. 1983, 48, 2424.
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Flynn, D.L.1
Zelle, R.E.2
Grieco, P.A.3
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21
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84992237321
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Note: Methyl ester formation is postulated to proceed via an intermediate N-acyliminium ion
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Note: Methyl ester formation is postulated to proceed via an intermediate N-acyliminium ion.
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22
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84992237323
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Purchased from Argonaut® technologies
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Purchased from Argonaut® technologies.
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23
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84992235319
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3CN to 100% over 5 min. HPLC was interfaced with APCI techniques
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3CN to 100% over 5 min. HPLC was interfaced with APCI techniques.
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24
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0343902739
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Org Poster 232
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The preparation of this resin was recently reported by workers at Amgen It is prepared in five steps from 4-(4-hydroxyphenyl)-cyclohexanone using Merrifield as the base resin. Loading in the 0.7-0.8 mmol/g range was achieved and reactions can be monitered by on-bead FTIR
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The preparation of this resin was recently reported by workers at Amgen: Piscopio, A. Org Poster 232, Las Vegas Am. Chem. Soc. Meeting, 1997. It is prepared in five steps from 4-(4-hydroxyphenyl)-cyclohexanone using Merrifield as the base resin. Loading in the 0.7-0.8 mmol/g range was achieved and reactions can be monitered by on-bead FTIR.
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(1997)
Las Vegas Am. Chem. Soc. Meeting
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Piscopio, A.1
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27
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0027322862
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(a) Note also that β-lactam formation was not investigated. Reaction of N-BOC-α-amino aldehydes in the Ugi MCR+acid treatment will predominantly produce imidazolines as reported in
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(a) Baldwin, J. E.; Hulme, C.; Schofield, C. J.; Edwards, A. J. J. Chem. Soc., Chem. Commun. 1993, 935. Note also that β-lactam formation was not investigated. Reaction of N-BOC-α-amino aldehydes in the Ugi MCR+acid treatment will predominantly produce imidazolines as reported in
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(1993)
J. Chem. Soc., Chem. Commun.
, pp. 935
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Baldwin, J.E.1
Hulme, C.2
Schofield, C.J.3
Edwards, A.J.4
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28
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0033527709
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(b)
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(b) Hulme, C.; Ma, L.; Romano, J.; Morrissette, M. Tetrahedron Lett. 1999, 40, 7925.
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(1999)
Tetrahedron Lett.
, vol.40
, pp. 7925
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Hulme, C.1
Ma, L.2
Romano, J.3
Morrissette, M.4
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29
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0032191453
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Hulme, C.; Peng, J.; Louridas, B.; Menard, P.; Krolikowski, P.; Kumar, N. V. Tetrahedron Lett. 1998, 39, 7227. Note: Mono-N-BOC diamines are available in three steps as reported by Krapcho, A. P.; Maresh, M. J.; Lunn, J. Synth. Comm. 1993, 23, 2443.
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(1998)
Tetrahedron Lett.
, vol.39
, pp. 7227
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Hulme, C.1
Peng, J.2
Louridas, B.3
Menard, P.4
Krolikowski, P.5
Kumar, N.V.6
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30
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0032191453
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Note: Mono-N-BOC diamines are available in three steps as reported by Krapcho
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Hulme, C.; Peng, J.; Louridas, B.; Menard, P.; Krolikowski, P.; Kumar, N. V. Tetrahedron Lett. 1998, 39, 7227. Note: Mono-N-BOC diamines are available in three steps as reported by Krapcho, A. P.; Maresh, M. J.; Lunn, J. Synth. Comm. 1993, 23, 2443.
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(1993)
Synth. Comm.
, vol.23
, pp. 2443
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Maresh, A.P.1
Lunn, M.J.2
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