Peroxisome proliferator-activated receptor modulators as potential chemopreventive agents

Molecular Cancer Therapeutics

Volumn 1, Issue 5, 2002, Pages 357-363

  Kopelovich, Levy ^a   Fay, Judith R ^a   Glazer, Robert I ^b   Crowell, James A ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b GEORGETOWN UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; CELL RECEPTOR; LIGAND; TRANSCRIPTION FACTOR;

CHEMICAL MODEL; METABOLISM; NEOPLASM; REVIEW;

ANTICARCINOGENIC AGENTS; LIGANDS; MODELS, CHEMICAL; NEOPLASMS; RECEPTORS, CYTOPLASMIC AND NUCLEAR; TRANSCRIPTION FACTORS;

EID: 0001295227     PISSN: 15357163     EISSN: 15388514     Source Type: Journal    
DOI: None     Document Type: Short Survey

References (84)

1. Michalik, L., and Wahli, W. Peroxisome proliferator-activated receptors: Three isotypes for a multitude of functions. Curr. Opin. Biotechnol., 10: 564-570, 1999.
2. Willson, T. M., Brown, P. J., Sternbach, D. D., and Henke, B. R. The PPARs: From orphan receptors to drug discovery. J. Med. Chem., 43: 527-550, 2000. (Pubitemid 30127149)
3. Peters, J. M., Lee, S. S. T., Li, W., Ward, J. M., Gavrilova, O., Everett, C., Reitman, M. L., Hudson, L. D., and Gonzalez, F. J. Growth, adipose, brain, and skin alterations resulting from targeted disruption of the mouse peroxisome proliferator-activated receptor β(δ). Mol. Cell. Biol., 20: 5119-5128, 2000. (Pubitemid 30431565)
4. Lim, H., Gupta, R. A., Ma, W-G., Paria, B. C., Moller, D. E., Morrow, J. D., DuBois, R. N., Trzaskos, J. M., and Dey, S. K. Cyclo-oxygenase-2-derived prostacyclin mediates embryo implantation in the mouse via PPARδ. Genes Dev., 13: 1561-1574, 1999. (Pubitemid 29297924)
5. Gonzalez, F. J., Peters, J. M., and Cattley, R. C. Mechanism of action of the nongenotoxic peroxisome proliferators: role of the peroxisome proliferator-activated receptor α. J. Natl. Cancer Inst. (Bethesda), 90: 1702-1709, 1998. (Pubitemid 28539089)
6. Tontonoz, P., Hu, E., and Spiegelman, B. M. Stimulation of adipogenesis in fibroblasts by PPARγ2, a lipid-activated transcription factor. Cell, 79: 1147-1156, 1994.
7. Fajas, L., Auboeuf, D., Raspe, E., Schoonjans, K., Lefebvre, A-M., Saladin, R., Najib, J., Laville, M., Fruchart, J-C., Deeb, S., Vidal-Puig, A., Flier, J., Briggs, M. R., Staels, B., Vidal, H., and Auwerx, J. The organization, promoter analysis, and expression of the human PPARγ gene. J. Biol. Chem., 272: 18779-18789, 1997. (Pubitemid 27318225)
8. Sarraf, P., Mueller, E., Jones, D., King, F. J., DeAngelo, D. J., Partridge, J. B., Holden, S. A., Chen, L. B., Singer, S., Fletcher, C., and Spiegelman, B. M. Differentiation and reversal of malignant changes in colon cancer through PPARγ. Nat. Med., 4: 1046-1052, 1998. (Pubitemid 28417337)
9. Brockman, J. A., Gupta, R. A., and DuBois, R. N. Activation of PPARγ leads to inhibition of anchorage-independent growth of human colorectal cancer cells. Gastroenterology, 115: 1049-1055, 1998. (Pubitemid 28485592)
10. Tanaka, T., Kohno, H., Yoshitani, S-I., Takashima, S., Okumura, A., Murakami, A., and Hosokawa, M. Ligands for peroxisome proliferator-activated receptors α and γ inhibit chemically induced colitis and formation of aberrant crypt foci in rats. Cancer Res., 61: 2424-2428, 2001. (Pubitemid 32685818)
11. Sarraf, P., Mueller, E., Smith, W. M., Wright, H. M., Kum, J. B., Aaltonen, L. A., de la Chapelle, A., Spiegelman, B. M., and Eng, C. Loss-of-function mutations in PPARγ associated with human colon cancer. Mol. Cell, 3: 799-804, 1999. (Pubitemid 29323058)
12. Ricote, M., Li, A. C., Willson, T. M., Kelly, C. J., and Glass, C. K. The peroxisome proliferator-activated receptor-γ is a negative regulator of macrophage activation. Nature (Lond.), 391: 79-82, 1998. (Pubitemid 28079218)
13. Jiang, C., Ting, A. T., and Seed, B. PPAR-γ agonists inhibit production of monocyte inflammatory cytokines. Nature (Lond.), 391: 82-86, 1998. (Pubitemid 28079219)
14. Su, C. G., Wen, X., Bailey, S. T., Jiang, W., Rangwala, S. M., Keilbaugh, S. A., Flanigan, A., Murthy, S., Lazar, M. A., and Wu, G. D. A novel therapy for colitis utilizing PPAR-γ ligands to inhibit the epithelial inflammatory response. J. Clin. Investig., 104: 383-389, 1999. (Pubitemid 29534322)
15. Levin, B. Ulcerative colitis and colon cancer: Biology and surveillance. J. Cell. Biochem. Suppl., 16G: 47-50, 1992.
16. Cottrell, S., Bicknell, D., Kaklamanis, L., and Bodmer, W. F. Molecular analysis of APC mutations in familial adenomatous polyposis and sporadic colon carcinomas. Lancet, 340: 626-630, 1992.
17. Saez, E., Tontonoz, P., Nelson, M. C., Alvarez, J. G., Ming, U. T., Baird, S. M., Thomazy, V. A., and Evans, R. M. Activators of the nuclear receptor PPARγ enhance colon polyp formation. Nat. Med., 4: 1058-1061, 1998. (Pubitemid 28417339)
18. Lefebvre, A-M., Chen, I., Desreumaux, P., Najib, J., Fruchart, J-C., Geboes, K., Briggs, M., Heyman, R., and Auwerx, J. Activation of the peroxisome proliferator-activated receptor γ promotes the development of colon tumors in C57BL/6J-APC(Min)/+ mice. Nat. Med., 4: 1053-1057, 1998. (Pubitemid 28417338)
19. Mueller, E., Sarraf, P., Tontonoz, P., Evans, R. M., Martin, K. J., Zhang, M., Fletcher, C., Singer, S., and Spiegelman, B. M. Terminal differentiation of human breast cancer through PPAR. Mol. Cell, 1: 465-470, 1998. (Pubitemid 128378895)
20. Elstner, E., Muller, C., Koshizuka, K., Williamson, E. A., Park, D., Asou, H., Shintaku, P., Said, J. W., Heber, D., and Koeffler, H. P. Ligands for peroxisome proliferator-activated receptor γ and retinoic acid receptor inhibit growth and induce apoptosis of human breast cancer cells in vitro and in BNX mice. Proc. Natl. Acad. Sci. USA, 95: 8806-8811, 1998.
21. Suh, N., Wang, Y., Williams, C. R., Risingsong, R., Gilmer, T., Willson, T. M., and Sporn, M. B. A new ligand for the peroxisome proliferator-activated receptor-γ (PPAR-γ), GW7845, inhibits rat mammary carcinogenesis. Cancer Res., 59: 5671-5673, 1999.
22. Mehta, R. G., Williamson, E., Patel, M. K., and Koeffler, H. P. A ligand of peroxisome proliferator-activated receptor γ, retinoids, and prevention of preneoplastic mammary lesions. J. Natl. Cancer Inst. (Bethesda), 92: 418-423, 2000. (Pubitemid 30154824)
23. Rubin, G. L., Zhao, Y., Kalus, A. M., and Simpson, E. R. Peroxisome proliferator-activated receptor γ ligands inhibit estrogen biosynthesis in human breast adipose tissue: Possible implications for breast cancer therapy. Cancer Res., 60: 1604-1608, 2000. (Pubitemid 30183431)
24. Kubota, T., Koshizuka, K., Williamson, E. A., Asou, H., Said, J. W., Holden, S., Miyoshi, I., and Koeffler, H. P. Ligand for peroxisome proliferator-activated receptor γ (troglitazone) has potent antitumor effect against human prostate cancer both in vitro and in vivo. Cancer Res., 58: 3344-3352, 1998. (Pubitemid 28371075)
25. Mueller, E., Smith, M., Sarraf, P., Kroll, T., Aiyer, A., Kaufman, D. S., Oh, W., Demetri, G., Figg, W. D., Zhou, X-P., Eng, C., Spiegelman, B. M., and Kantoff, P. W. Effects of ligand activation of peroxisome proliferator-activated receptor γ in human prostate cancer. Proc. Natl. Acad. Sci. USA, 97: 10990-10995, 2000.
26. Butler, R., Mitchell, S. H., Tindall, D. J., and Young, C. Y. F. Non-apoptotic cell death associated with S-phase arrest of prostate cancer cells via the peroxisome proliferator-activated receptor γ ligand, 15-deoxy-δ (12,14)-prostaglandin J(2). Cell Growth Differ., 11: 49-61, 2000. (Pubitemid 30078666)
27. Hisatake, J-I., Ikezoe, T., Carey, M., Holden, S., Tomoyasu, S., and Koeffler, H. P. Down-regulation of prostate-specific antigen expression by ligands for peroxisome proliferator-activated receptor γ in human prostate cancer. Cancer Res., 60: 5494-5498, 2000.
28. Kelloff, G. J. Perspectives on cancer chemoprevention research and drug development. Adv. Cancer Res., 78: 199-334, 2000.
29. Demetri, G. D., Fletcher, C. D. M., Mueller, E., Sarraf, P., Naujoks, R., Campbell, N., Spiegelman, B. M., and Singer, S. Induction of solid tumor differentiation by the peroxisome proliferator-activated receptor-γ ligand troglitazone in patients with liposarcoma. Proc. Natl. Acad. Sci. USA, 96: 3951-3956, 1999. (Pubitemid 29169017)
30. Nelson, A. R., Fingleton, B., Rothenberg, M. L., and Matrisian, L. M. Matrix metalloproteinases: biologic activity and clinical implications. J. Clin. Oncol., 18: 1135-1149, 2000. (Pubitemid 30123793)
31. Chang, T-H., and Szabo, E. Induction of differentiation and apoptosis by ligands of peroxisome proliferator-activated receptor γ in non-small cell lung cancer. Cancer Res. 60: 1129-1138, 2000. (Pubitemid 30129556)
32. Xin, X., Yang, S., Kowalski, J., and Gerritsen, M. E. Peroxisome proliferator-activated receptor γ ligands are potent inhibitors of angiogenesis in vitro and in vivo. J. Biol. Chem. 274: 9116-9121, 1999. (Pubitemid 29164719)
33. Bishop-Bailey, D., and Hla, T. Endothelial cell apoptosis induced by the peroxisome proliferator-activated receptor (PPAR) ligand 15-deoxy-δ(12,14) -prostaglandin J(2). J. Biol. Chem., 274: 17042-17048, 1999.
34. Kroll, T. G., Sarraf, P., Pecciarini, L., Chen, C-J., Mueller, E., Spiegelman, B. M., and Fletcher, J. A. PAX8-PPARγ1 fusion in oncogene human thyroid carcinoma. Science (Wash. DC), 289: 1357-1360, 2000. (Pubitemid 30656054)
35. Kitamura, S., Miyazaki, Y., Shinomura, Y., Kondo, S., Kanayama, S., and Matsuzawa, Y. Peroxisome proliferator-activated receptor γ induces growth arrest and differentiation markers of human colon cancer cells. Jpn. J. Cancer Res., 90: 75-80, 1999. (Pubitemid 29084314)
36. Motomura, W., Okumara, T., Takahashi, N., Obara, T., and Kohgo, Y. Activation of peroxisome proliferator-activated receptor γ by troglitazone inhibits cell growth through the increase of p27(Kip1) in human pancreatic carcinoma cells. Cancer Res., 60: 5558-5564, 2000.
37. Altiok, S., Xu, M., and Spiegelman, B. M. PPARγ induces cell cycle withdrawal: inhibition of E2F/DP DNA-binding activity via down-regulation of PP2A. Genes Dev., 11: 1987-1998, 1997. (Pubitemid 27332985)
38. Morrison, R. F., and Farmer, S. R. Role of PPARγ in regulating a cascade expression of cyclin-dependent kinase inhibitors, p18(INK4c) and p21(Waf1/Cip1), during adipogenesis. J. Biol. Chem., 274: 17088-17097, 1999.
39. Guan, Y-F., Zhang, Y-H., Breyer, R. M., Davis, L., and Breyer, M. D. Expression of peroxisome proliferator-activated receptor γ (PPARγ) in human transitional bladder cancer and its role in inducing cell death. Neoplasia, 1: 330-339, 1999.
40. Wang, C., Fu, M., D'Amico, M., Albanese, C., Zhou, J-N., Brownlee, M., Lisanti, M. P., Chatterjee, V. K. K., Lazar, M. A., and Pestell, R. G. Inhibition of cellular proliferation through IκB kinase-independent and peroxisome proliferator-activated receptor γ-dependent repression of cyclin D1. Mol. Cell. Biol., 21: 3057-3070, 2001. (Pubitemid 32298373)
41. Patel, L., Pass, I., Coxon, P., Downes, C. P., Smith, S. A., and Macphee, C. H. Tumor suppressor and anti-inflammatory actions of PPARγ agonists are mediated via upregulation of PTEN. Curr. Biol., 11: 764-768, 2001. (Pubitemid 32442793)
42. Hanley, K., Jiang, Y., He, S. S., Friedman, M., Elias, P. M., Bikle, D. D., Williams, M. L., and Feingold, K. R. Keratinocyte differentiation is stimulated by activators of the nuclear hormone receptor PPARα. J. Investig. Dermatol., 110: 368-375, 1998. (Pubitemid 28158652)
43. Komuves, L. G., Hanley, K., Lefebvre, A-M., Man, M-Q., Ng, D. C., Bikle, D. D., Williams, M. L., Elias, P. M., Auwerx, J., and Feingold, K. R. Stimulation of PPARα promotes epidermal keratinocyte differentiation in vivo. J. Investig. Dermatol., 115: 353-360, 2000.
44. Komuves, L. G., Hanley, K., Man, M-Q., Elias, P. M., Williams, M. L., and Feingold, K. R. Keratinocyte differentiation in hyperproliferative epidermis: topical application of PPARα activators restores tissue homeostasis. J. Investig. Dermatol., 115: 361-367, 2000.
45. Hanley, K., Komuves, L. G., Ng, D. C., Schoonjans, K., He, S. S., Lau, P., Bikle, D. D., Williams, M. L., Elias, P. M., Auwerx, J., and Feingold, K. R. Farnesol stimulates differentiation in epidermal keratinocytes via PPARα. J. Biol. Chem., 275: 11484-11491, 2000. (Pubitemid 30212804)
46. Thuillier, P., Anchiraico, G. J., Nickel, K. P., Maldve, R. E., Gimenez-Conti, I., Muga, S. J., Liu, K-L., Fischer, S. M., and Belury, M. A. Activators of peroxisome proliferator-activated receptor-α partially inhibit mouse skin tumor promotion. Mol. Carcinog., 29: 134-142, 2000.
47. Collett, G. P., Betts, A. M., Johnson, M. I., Pulimood, A. B., Cook, S., Neal, D. E., and Robson, C. N. Peroxisome proliferator-activated receptor α is an androgen-responsive gene in human prostate and is highly expressed in prostatic adenocarcinoma. Clin. Cancer Res., 6: 3241-3248, 2000. (Pubitemid 30637754)
48. Pineau, T., Hudgins, W. R., Liu, L., Chen, L-C., Sher, T., Gonzalez, F. J., and Samid, D. Activation of a human peroxisome proliferator-activated receptor by the antitumor agent phenylacetate and its analogs. Biochem. Pharmacol., 52: 659-667, 1996. (Pubitemid 126689788)
49. Samid, D., Wells, M., Greene, M. E., Shen, W., Palmer, C. N. A., and Thibault, A. Peroxisome proliferator-activated receptor γ as a novel target in cancer therapy: binding and activation by an aromatic fatty acid with clinical antitumor activity. Clin. Cancer Res., 6: 933-941, 2000. (Pubitemid 30159351)
50. Devchand, P. R., Keller, H., Peters, J. M., Vazquez, M., Gonzalez, F. J., and Wahli, W. The PPARα-leukotriene B4 pathway to inflammation control. Nature (Lond.), 384: 39-43, 1996.
51. Spencer, N. F. L., Poynter, M. E., Im, S-Y., and Daynes, R. A. Constitutive activation of NF-κB in an animal model of aging. Int. Immunol., 9: 1581-1588, 1997. (Pubitemid 27434691)
52. Hill, M. R., Clarke, S., Rodgers, K., Thornhill, B., Peters, J. M., Gonzalez, F. J., and Gimble, J. M. Effect of peroxisome proliferator-activated receptor α activators on tumor necrosis factor expression in mice during endotoxemia. Infect. Immun., 67: 3488-3493, 1999. (Pubitemid 29291520)
53. Delerive, P., De Bossche, K., Besnard, S., Berghe, W. V., Peters, J. M., Gonzalez, F. J., Fruchart, J-C., Tedgui, A., Haegeman, G., and Staels, B. Peroxisome proliferator-activated receptor α negatively regulates the vascular inflammatory gene response by negative cross-talk with transcription factors NF-κB and AP-1. J. Biol. Chem., 274: 32048-32054, 1999.
54. Staels, B., Koenig, W., Habib, A., Merval, R., Lebret, M., Torra, I. P., Delerive, P., Fadel, A., Chinetti, G., Fruchart, J-C., Najib, J., Maclouf, J., and Tedgui, A. Activation of human aortic smooth-muscle cells is inhibited by PPARα but not by PPARγ activators. Nature (Lond.), 393: 790-793, 1998. (Pubitemid 28299490)
55. Meade, E. A., McIntyre, T. M., Zimmerman, G. A., and Prescott, S. M. Peroxisome proliferators enhance cyclooxygenase-2 expression in epithelial cells. J. Biol. Chem., 274: 8328-8334, 1999.
56. Mates, J. M., Perez-Gomez, C., and Nunez de Castro, I. Antioxidant enzymes and human diseases. Clin. Biochem., 32: 595-603, 1999. (Pubitemid 30039087)
57. Poynter, M. E., and Daynes, R. A. Peroxisome proliferator-activated receptor α activation modulates cellular redox status, represses nuclear factor-κB signaling, and reduces inflammatory cytokine production in aging. J. Biol. Chem., 273: 32833-32841, 1998. (Pubitemid 28557672)
58. He, T-C., Chan, T. A., Vogelstein, B., and Kinzler, K. W. PPARδ is an APC-regulated target of nonsteroidal anti-inflammatory drugs. Cell, 99: 335-345, 1999. (Pubitemid 29519912)
59. Park, B. H., Vogelstein, B., and Kinzler, K. W. Genetic disruption of PPARδ decreases the tumorigenicity of human colon cancer cells. Proc. Natl. Acad. Sci. USA, 98: 2598-2603, 2001. (Pubitemid 32209528)
60. Gupta, R. A., Tan, J., Krause, W. F., Geraci, M. W., Willson, T. M., Dey, S. K., and DuBois, R. N. Prostacyclin-mediated activation of peroxisome proliferator-activated receptor δ in colorectal cancer. Proc. Natl. Acad. Sci. USA, 97: 13275-13280, 2000.
61. Roy, H. K., Karolski, W. J., and Ratashak, A. Distal bowel selectivity in the chemoprevention of experimental colon carcinogenesis by the non-steroidal anti-inflammatory drug nabumetone. Int. J. Cancer, 92: 609-615, 2001. (Pubitemid 32327956)
62. Forman, B. M., Tontonoz, P., Chen, J., Brun, R. P., Spiegelman, B. M., and Evans, R. M. 15-deoxy-δ 12, 14-prostaglandin J2 is a ligand for the adipocyte determination factor PPARγ. Cell, 83: 803-812, 1995. (Pubitemid 3006324)
63. Lehmann, J. M., Moore, L. B., Smith-Oliver, T. A., Wilkison, W. O., Willson, T. M., and Kliewer, S. A. An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator-activated receptor γ (PPARγ). J. Biol. Chem. 270: 12953-12956, 1995.
64. Henke, B. R., Blanchard, S. G., Brackeen, M. F., Brown, K. K., Cobb, J. E., Collins, J. L., Harrington, W. W., Jr., Hashim, M. A., Hull-Ryde, E. A., Kaldor, I., Kliewer, S. A., Lake, D. H., Leesnitzer, L. M., Lehmann, J. M., Lenhard, J. M., Orband-Miller, L. A., Miller, J. F., Mook, R. A., Jr., Noble, S. A., Oliver, W., Jr., Parks, D. J., Plunket, K. D., Szewczyk, J. R., and Willson, T. M. N-(2-benzoylphenyl)-L-tyrosine PPARγ agonists. 1. Discovery of a novel series of potent antihyperglycemic and antihyperlipidemic agents. J. Med. Chem., 41: 5020-5036, 1998. (Pubitemid 28555461)
65. Cobb, J. E., Blanchard, S. G., Boswell, E. G., Brown, K. K., Charifson, P. S., Cooper, J. P., Collins, J. L., Dezube, M., Henke, B. R., Hull-Ryde, E. A., Lake, D. H., Lenhard, J. M., Oliver, W., Jr., Oplinger, J., Pentti, M., Parks, D. J., Plunket, K. D., and Tong, W. N-(2-benzoylphenyl)-L-tyrosine PPARγ agonists. 3. Structure-activity relationship and optimization of the N-aryl substituent. J. Med. Chem., 41: 5055-5069, 1998. (Pubitemid 28555463)
66. Henke, B. R., Adkison, K. K., Blanchard, S. G., Leesnitzer, L. M., Mook, R. A., Jr., Plunket, K. D., Ray, J. A., Roberson, C., Unwalla, R., and Willson, T. M. Synthesis and biological activity of a novel series of indole-derived PPARγ agonists. Bioorg. Med. Chem. Lett., 9: 3329-3334, 1999.
67. Brown, P. J., Winegar, D. A., Plunket, K. D., Moore, L. B., Lewis, M. C., Wilson, J. G., Sundseth, S. S., Koble, C. S., Wu, Z., Chapman, J. M., Lehmann, J. M., Kliewer, S. A., and Willson, T. M. A ureido-thioisobutyric acid (GW9578) is a subtype-selective PPARα agonist with potent lipid-lowering activity. J. Med. Chem., 42: 3785-3788, 1999. (Pubitemid 29453459)
68. Murakami, K., Tobe, K., Ide, T., Mochizuki, T., Ohashi, M., Akanuma, Y., Yazaki, Y., and Kadowaki, T. A novel insulin sensitizer acts as a coligand for peroxisome proliferator-activated receptor-α (PPAR-α) and PPAR-γ: Effect of PPAR-α activation on abnormal lipid metabolism in liver of Zucker fatty rats. Diabetes, 47: 1841-1847, 1998. (Pubitemid 28549189)
69. Shibata, T., Matsui, K., Nagao, K., Shinkai, H., Yonemori, F., and Wakitani, K. Pharmacological profiles of a novel oral antidiabetic agent, JTT-501, an isoxazolidinedione derivative. Eur. J. Pharmacol., 364: 211-219, 1999. (Pubitemid 29065273)
70. Reginato, M. J., Bailey, S. T., Krakow, S. L., Minami, C., Ishii, S., Tanaka, H., and Lazar, M. A. A potent antidiabetic thiazolidinedione with unique peroxisome proliferator-activated receptor γ-activating properties. J. Biol. Chem., 273: 32679-32684, 1998. (Pubitemid 28557651)
71. Elbrecht, A., Chen, Y., Adams, A., Berger, J., Griffin, P., Klatt, T., Zhang, B., Menke, J., Zhou, G., Smith, R. G., and Moller, D. E. L-764406 is a partial agonist of human peroxisome proliferator-activated receptor γ. J. Biol. Chem., 274: 7913-7922, 1999.
72. Oberfield, J. L., Collins, J. L., Holmes, C. P., Goreham, D. M., Cooper, J. P., Cobb, J. E., Lenhard, J. M., Hull-Ryde, E. A., Mohr, C. P., Blanchard, S. G., Parks, D. J., Moore, L. B., Lehmann, J. M., Plunket, K., Miller, A. B., Milburn, M. V., Kliewer, S. A., and Willson, T. M. A peroxisome proliferator-activated receptor γ ligand inhibits adipocyte differentiation. Proc. Natl. Acad. Sci. USA, 96: 6102-6106, 1999. (Pubitemid 29256626)
73. Schoonjans, K., and Auwerx, J. Thiazolidinediones. An update. Lancet, 355: 1008-1010, 2000.
74. Xu, H. E., Lambert, M. H., Montana, V. G., Parks, D. J., Blanchard, S. G., Brown, P. J., Sternbach, S. G., Lehmann, J. M., Wisely, G. B., Willson, T. M., Kliewer, S. A., and Milburn, M. V. Molecular recognition of fatty acids by peroxisome proliferator-activated receptors. Mol. Cell, 3: 397-403, 1999. (Pubitemid 29290680)
75. Krey, G., Braissant, O., L'Horset, F., Kalkhoven, E., Perroud, M., Parker, M. G., and Wahli, W. Fatty acids, eicosanoids, and hypolipidemic agents identified as ligands of peroxisome proliferator-activated receptors by coactivator-dependent receptor ligand assay. Mol. Endocrinol., 11: 779-791, 1997. (Pubitemid 27225305)
76. Willett, W. C., and MacMahon, B. Diet and cancer-an overview. N. Engl. J. Med., 310: 697-703, 1984.
77. Sporn, M. B., Suh, N., and Mangelsdorf, D. J. Prospects for prevention and treatment of cancer with selective PPARγ modulators (SPARMs). Trends Mol. Med., 7: 395-400, 2001. (Pubitemid 32823988)
78. Tsubouchi, Y., Sano, H., Kawahito, Y., Mukai, S., Yamada, R., Kohno, M., Inoue, K-I., Hla, T., and Kondo, M. Inhibition of human lung cancer cell growth by the peroxisome proliferator-activated receptor-γ agonists through induction of apoptosis. Biochem. Biophys. Res. Commun., 270: 400-405, 2000. (Pubitemid 30446848)
79. Fujimura, S., Suzumiya, J., Nakamura, K., and Ono, J. Effects of troglitazone on the growth and differentiation of hematopoietic cell lines. Int. J. Oncol., 13: 1263-1267, 1998. (Pubitemid 28551554)
80. Takahashi, N., Okumura, T., Motomura, W., Fujimoto, Y., Kawabata, I., and Kohgo, Y. Activation of PPARγ inhibits cell growth and induces apoptosis in human gastric cancer cells. FEBS Lett., 455: 135-139, 1999. (Pubitemid 29322796)
81. Shappell, S. B., Gupta, R. A., Manning, S. Whitehead, R., Boeglin, W. E., Schneider, C., Case, T., Price, J., Jack, G. S., Wheeler, T. M., Matusik, R. J., Brash, A. R., and DuBois, R. N. 15S-Hydroxyeicosatetraenoic acid activates peroxisome proliferator-activated receptor γ and inhibits proliferation in PC3 prostate carcinoma cells. Cancer Res., 61: 497-503, 2001. (Pubitemid 32128606)
82. Tontonoz, P., Singer, S., Forman, B. M., Sarraf, P., Fletcher, J. A., Fletcher, C. D. M., Brun, R. P., Mueller, E., Altiok, S., Oppenheim, H., Evans, R. M., and Spiegelman, B. M. Terminal differentiation of human liposarcoma cells induced by ligands for peroxisome proliferator-activated receptor γ and the retinoid X receptor. Proc. Natl. Acad. Sci. USA, 94: 237-241, 1997. (Pubitemid 27027193)
83. Han, S. W., Greene, M. E., Pitts, J., Wada, R. K., and Sidell, N. Novel expression and function of peroxisome proliferator-activated receptor γ (PPARγ) in human neuroblastoma cells. Clin. Cancer Res., 7: 98-104, 2001. (Pubitemid 32110211)
84. Clay, C. E., Namen, A., Atsumi, G-I., Willingham, M. C., High, K. P., Kute, T. E., Trimboli, A. J., Fonteh, A. N., Dawson, P. A., and Chilton, F. H. Influence of J series prostaglandins on apoptosis and tumorigenesis of breast cancer cells. Carcinogenesis (Lond.), 20: 1905-1911, 1999. (Pubitemid 29476115)