Inhibition of cellular proliferation through IκB kinase-independent and peroxisome proliferator-activated receptor γ-dependent repression of cyclin D1

Molecular and Cellular Biology

Volumn 21, Issue 9, 2001, Pages 3057-3070

  Wang, C ^a   Fu, M ^a   D'Amico, M ^a   Albanese, C ^a   Zhou, J N ^a   Brownlee, M ^a   Lisanti, M P ^a   Chatterjee, V K K ^a   Lazar, M A ^a   Pestell, R G ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARBONYL DERIVATIVE; CYCLIN D1; DELTA15 PROSTAGLANDIN J2; I KAPPA B; I KAPPA B KINASE; ICOSANOID; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PHOSPHOTRANSFERASE; PROSTAGLANDIN D2; PROSTAGLANDIN J2; PROSTAGLANDIN SYNTHASE INHIBITOR; PROTEIN C FOS; PROTEIN P300; PROTEIN SERINE THREONINE KINASE; ROSIGLITAZONE; TROGLITAZONE; UNCLASSIFIED DRUG;

ANTIINFLAMMATORY ACTIVITY; ARTICLE; AUTOREGULATION; CANCER INHIBITION; CELL DIFFERENTIATION; CONTROLLED STUDY; ENZYME ACTIVITY; GENE EXPRESSION REGULATION; GENE OVEREXPRESSION; GENE REPRESSION; GENE TARGETING; HUMAN; HUMAN CELL; IMMUNE RESPONSE; LIGAND BINDING; MACROPHAGE FUNCTION; MITOSIS INHIBITION; PRIORITY JOURNAL;

BINDING SITES; CELL DIVISION; CYCLIN D1; G1 PHASE; GENE EXPRESSION REGULATION; GROWTH INHIBITORS; HELA CELLS; HUMANS; I-KAPPA B KINASE; LIGANDS; MITOGEN-ACTIVATED PROTEIN KINASES; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE II; NUCLEAR PROTEINS; PROMOTER REGIONS (GENETICS); PROSTAGLANDIN D2; PROTEIN-SERINE-THREONINE KINASES; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RESPONSE ELEMENTS; TRANS-ACTIVATORS; TRANSCRIPTION FACTOR AP-1; TRANSCRIPTION FACTORS; TUMOR CELLS, CULTURED;

EID: 0035052916     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.21.9.3057-3070.2001     Document Type: Article

References (71)

1. Transcriptional activation by PPARγ is inhibited by phosphorylation at a consensus mitogen-activated protein kinase site
2. Amyloid β-peptide stimulates nitric oxide production in astrocytes through an NFκB-dependent mechanism
3. Activation of the cyclin D1 gene by the E1A-associated protein p300 through AP-1 inhibits cellular apoptosis
4. ras mutants and c-Ets-2 activate the cyclin D1 promoter through distinguishable regions
5. PPARgamma induces cell cycle withdrawal: Inhibition of E2F/DP DNA-binding activity via down-regulation of PP2A
6. Activation of cAMP and mitogen responsive genes relies on a common nuclear factor
7. Kip 1
8. Activation of PPARγ leads to inhibition of anchorage-independent growth of human colorectal cancer cells
9. Stat3 as an oncogene
10. Fos family members induce cell cycle entry by activating cyclin D1
11. Expression and amplification of cyclin genes in human breast cancer
12. Regulation of peroxisome proliferator-activated receptor γ activity by mitogen-activated protein kinase
13. 2 in activated murine macrophages
14. PPAR-γ dependent and independent effects on macrophage-gene expression in lipid metabolism
15. Activation of proliferator-activated receptors alpha and gamma induces apoptosis of human monocyte-derived macrophages
16. Epidermal growth factor induction of the c-jun promoter by a Rac pathway
17. Central role of peroxisome proliferator-activated receptors in the actions of peroxisome proliferators
18. Positive and negative regulation of IκB kinase activity through IKKβ subunit phosphorylation
19. Peroxisome proliferator-activated receptors: Nuclear control of metabolism
20. Ligands for peroxisome proliferator-activated receptor and retinoic acid receptor inhibit growth and induce apoptosis of human breast cancer cells in vitro and in BNX mice
21. BRCA1 inhibition of estrogen receptor signaling in transfected cells
22. Hypolipidemic drugs, polyunsaturated fatty acids, and eicosanoids are ligands for peroxisome proliferator-activated receptors α and δ
23. 15-Deoxy-delta12, 14-prostaglandin J2 is a ligand for the adipocyte determination factor PPAR gamma
24. p300 interacts with the N- and C-terminal part of PPARγ2 in a ligand-independent and -dependent manner, respectively
25. p300 and CBP: Partners for life and death
26. A dominant-negative peroxisome proliferator-activated receptor γ (PPARγ) mutant is a constitutive repressor and inhibits PPARγ-mediated adipogenesis
27. NF-κB controls cell growth and differentiation through the transcriptional regulation of cyclin D1
28. Inhibition of adipogenesis through MAP kinase-mediate phosphorylation of PPARγ
29. PPAR-γ agonists inhibit production of monocyte inflammatory cytokines
30. Integration of Rac-dependent regulation of cyclin D1 transcription through an NF-κB-dependent pathway
31. A CBP integrator complex mediates transcriptional activation and AP-1 inhibition by nuclear receptors
32. The IκB kinase (IKK) and NF-κB: Key elements of proinflammatory signalling
33. A prostaglandin J2 metabolite binds peroxisome proliferator-activated receptor γ and promotes adipocyte differentiation
34. Ligand-type specific interactions of peroxisome proliferator-activated receptor γ with transcriptional coactivators
35. Analysis of domains in the IKKα and IKKβ proteins that regulate their kinase activity
36. Cyclin D1 is required for transformation by activated Neu and is induced through an E2F-dependent signaling pathway
37. v-src signaling in breast cancer cells
38. Activation of the peroxisome proliferator-activated receptor gamma promotes the development of colon tumors in C57BL/6J-APCMin/+ mice
39. Peroxisome proliferator-activated receptor γ-dependent represion of the inducible nitric oxide synthase gene
40. 1 checkpoint
41. Peroxisome proliferator-activated receptor-γ activators inhibit IFN-γ-induced expression of the T cell-active CXC chemokines IP10, Mig, and I-TAC in human endothelial cells
42. Transcriptional regulation of cyclin D1 promoter by STAT5: Its involvement in cytokine-dependent growth of hematopoietic cells
43. Determinants of coactivator LXXLL motif specificity in nuclear receptor transcriptional activation
44. Terminal differentiation of human breast cancer through PPARγ
45. Ligand binding and co-activator assembly of the peroxisome proliferator-activated receptor-γ
46. The cyclins and cyclin-dependent kinase inhibitors in hormonal regulation of proliferation and differentiation
47. Hormone action II: Transcriptional regulation of endocrine genes by second messenger signalling pathways
48. 1/S phase transition by expression of cyclins D1 and E with an inducible system
49. The peroxisome proliferator-activated receptor γ is a negative regulator of macrophage activation
50. Transcriptional regulation of adipogenesis
51. Anti-inflammatory cyclopentenone prostaglandins are direct inhibitors of IκB kinase
52. Activators of the nuclear receptor PPARγ enhance colon polyp formation
53. Prostaglandins with antiproliferative activity induce the synthesis of a heat shock protein in human cells
54. Differentiation and reversal of malignant changes in colon cancer through PPARγ
55. Transactivation by retinoid X receptor-peroxisome proliferator-activated receptor γ (PPARγ) heterodimers: Intermolecular synergy requires only the PPARγ hormonedependent activation function
56. Interdomain communication regulating ligand binding by PPAR-γ
57. Hyperexpression of mitogen-activated protein kinase in human breast cancer
58. 2 inhibits multiple steps in the NF-κB signaling pathway
59. mPPARγ2: Tissue-specific regulator of an adipocyte enhancer
60. Stimulation of adipogenesis in fibroblasts by PPAR-γ2, a lipid-activated transcription factor
61. Distinct role for cyclin dependent kinases in cell cycle control
62. Inhibition of cyclin D1 kinase activity is associated with E2F-mediated inhibition of cyclin D1 promoter activity through E2F and Sp1
63. Induction of cyclin D1 by simian virus 40 small tumor antigen
64. Angiotensin II activation of cyclin D1-dependent kinase activity
65. Ligand-independent activation domain in the N-terminus of peroxisome proliferator-activated receptor γ (PPARγ)
66. Analysis with specific polyclonal antiserum indicates that the E1A- associated 300-kDa product is a stable nuclear phosphoprotein that undergoes cell cycle phase-specific modification
67. Discrete roles for peroxisome proliferator-activated receptor γ and retinoid X receptor in recruiting nuclear receptor coactivators
68. Differential activation of peroxisome-proliferator-activated receptors by eicosanoids
69. Ras regulation of cyclin dependent immunoprecipitation kinase assays. Regulators and effectors of small GTPases
70. Isolation and characterization of PBP, a protein that interacts with peroxisome proliferator-activated receptor