Inhibitory effects of telomere-mimic phosphorothioate oligonucleotides on various human tumor cells in vitro

Anticancer Research

Volumn 17, Issue 4 A, 1997, Pages 2455-2458

  Ohnuma, Takao ^a   Li, Feng Li ^a   Holland, James F ^a  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

Inhibitory effects; Oligodeoxynucleotides; Telomere

Indexed keywords

OLIGODEOXYNUCLEOTIDE; PHOSPHOROTHIOIC ACID;

ANTINEOPLASTIC ACTIVITY; ARTICLE; BURKITT LYMPHOMA; CANCER CELL CULTURE; CELL GROWTH; CELL SUSPENSION; CHORIOCARCINOMA; CONTROLLED STUDY; DAUDI CELL; GROWTH INHIBITION; HUMAN; HUMAN CELL; LEUKEMIA; LEUKEMIA CELL LINE; LYMPHOMA; MELANOMA; MESOTHELIOMA; MONOLAYER CULTURE; OVARY CARCINOMA; PRIORITY JOURNAL; SQUAMOUS CELL CARCINOMA; TELOMERE;

GROWTH INHIBITORS; HUMANS; OLIGONUCLEOTIDES; TELOMERE; THIONUCLEOTIDES; TUMOR CELLS, CULTURED;

EID: 0030836393     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (34)

1. Blackburn EH: Structure and function of telomeres. Nature 350: 569-573, 1991.
2. Moyzis RK, Buckingham JM, Cram LS, Dani M, Deaven LL, Jones MD, Meyne J, Ratliff RL and Wu J-R: A highly conserved repetitive DNA sequence, (TTAGGG)n, present at the telomeres of human chromosomes. Proc Natl Acad Sci USA 85: 6622-6626, 1988.
3. n among vertebrates. Proc Natl Acad Sci USA 86: 7049-7053, 1989.
4. Blackburn EH and Szostak JW: The molecular structure of centromeres and telomeres. Annu Rev Biochem 53: 163-194, 1984.
5. Zakian VA: Structure and function of telomeres. Annu Rev Genet 23: 579-604, 1989.
6. Harley CB: Telomere loss: mitotic clock or genetic time bomb? Mutat Res 256: 271-282, 1991.
7. Watson JD: Origin of concatemeric T7 DNA. Nature New Biol 239: 197-201, 1972.
8. Olovnikov A: Theory of marginotomy: the incomplete copying of template margin in enzymatic synthesis of polynucleotides and biological significance of the phenomenon. J Theor Biol 41: 181-190, 1973.
9. Harley CB, Futcher AB and Grcider CW: Telomeres shorten during aging of human fibroblasls. Nalure 345: 458-460, 1990.
10. Allsopp RC, Vaziri H, Pattrerson C, Goldstein S, Younglai EV, Futcher AB, Greider CW and Harley CW: Telomere length predicts replicative capacity of human fibroblasts. Proc Natl Acad Sci USA 89: 10114-10118, 1992.
11. Vaziri H, Schächter F, Uchida I, Wei L, Zhu X, Effros R, Cohen D and Harley CB: Loss of tetomeric DNA during aging of normal and trisomy 21 human lymphocytes. Am J Hum Genet 52: 661-667, 1993.
12. Hastie ND, Dempster M, Dunlop MG, Thompson AM, Green DK and Allshire RC: Telomere reduction in human colorectal carcinoma and with ageing. Nature 346: 866-868, 1990.
13. Lindsey J, McGill NI, Lindsey LA, Green DK and Cooke HJ: In vivo loss of telomeric repeats with age in humans. Mutat Res 256: 45-48, 1991.
14. Wright WE and Shay JW: Telomere positional effects and the regulation of cellular senescence. Trends Genet 8: 193-197, 1992.
15. Counter CM, Avillon AA, LeFeuvre CE, Stewart NG, Greider CW, Harley CB and Bacchetti S: Telomere shortening associated with chromosome instability is arrested in immortal cells which express telomerase activity. EMBO J 11: 1921-1929, 1992.
16. Counter CM, Hirte HW, Bacchetti S and Harley CB: Telomerase activity in human ovarian carcinoma. Proc Natl Acad Sci USA 91: 2900-2904, 1994.
17. Counter CM, Botelho FM, Wang P, Harley CB and Bacchetti S: Stabilization of short telomeres and telomerase activity accompany immortalization of Epstein-Barr virus-transformed human B lymphocytes. J Virol 68: 3410-3414, 1994.
18. Greider CW and Blackburn EH: Identification of a specific telomere terminal transferase activity in tetrahymena extracts. Cell 43: 405-413 1985.
19. Greider CW and Blackburn EH: A telomeric sequence in the RNA of Tetrahymena telomerase required for telomere repeat synthesis. Nature 337: 331-337, 1989.
20. Yu G-L, Bradley JD, Attardi LD and Blackburn EH: In vivo alteration of telomere sequences and senescence caused by mutated Tetrahymena telomerase RNAs. Nature 344: 126-132, 1990.
21. Kim NW, Piatyszek MA, Prowse KR, Harley CB, West MD, Ho PLC, Coviello GM, Wright WE, Weinrich SL. and Shay JW: Specific association of human telomerase activity with immortal cells and cancer. Science 266: 2011-2015, 1994.
22. de Lange T: Activation of telomerase in human tumors. Proc Natl Acad Sci USA 91: 2882-2885, 1994.
23. Counter CM, Gupta J, Harley CB, Leber B and Bachetti S: Telomerase activity in normal leucocytes and in hematopoietic malignancies. Blood 85: 2315-2320, 1995.
24. Chen SF, Maine IP and Windle B; Effect of 3′-azidothymidine triphophate (AZTTP) and 3′-azidothymidine (AZT) on telomerase activity and telomere function. (Abstract 3302) Proc Am Assoc Cancer Res 56: 554, 1995.
25. Joshi SS, Palen BN, Mala JE and Iversen PL: Growth inhibitory effects of telomere mimic-oligonucleotides on human leukemia/ly- mphoma cells in vitro. (Abstract 2449) Proc Am Assoc Cancer Res 36: 411, 1995.
26. Fletcher TM and Chen SF: The effects of 7-Deaza-2′- deoxynucleoside triphosphate on telomeres and telomerase. (Abstract 3857) Proc Am Assoc Cancer Res 37: 562, 1996.
27. Piatyszek, MA, Norton JC, Wright WE, Shay JW and Corey DR: Inhibition of human telomerase activity by peptide nucleic acid oligomers. (Abstract 3833) Proc Am Assoc Cancer Res 37: 559, 1996.
28. Albanell J, Gunawardane R, Han W, Mellado B, Dmitorvsky E and Moore MAS: Telomerase activity downregulalion by differentiation agents in human malignant cell lines. (Abstract 3839) Proc Am Assoc Cancer Res 37: 560, 1996.
29. Mazumder A and Pommier Y: Telomerase inhibition by RNA-directed antibiotics. (Abstract 2702) Proc Am Assoc Cancer Res 37: 396, 1996.
30. Fearon KL, Stults JT, Bergot BJ. Christensen LM and Raible AM: Investigation of the 'n-1' impurity in phophorothioate oligodeoxynucleotides synthesized by the solid-phase β-cyanoethyl phosphoramidite method using stepwise sulfurization. Nucleic Acids Res 23: 2754-2761, 1995.
31. Minowada J, Ohnuma T and Moore GE: Rosette-forming human lymphoid cell lines. I. Establishment and evidence for origin of thymus-derived lymphocytes. J Natl Cancer Inst 49: 891-895, 1972.
32. Ohnuma T, Ohnoshi T, Tanaka T, Andrejczuk A, Holland JF and Wolman SR: Characterization and chemotherapeutic sensitivity of two malignant melanoma sublines derived from a patient. (Abstract 206) Proc Am Assoc Cancer Res and ASCO 22: 52, 1981.
33. Tibbets LM, Chu MY, Spremulli EN, Leduc EH and Calabresi P: Loss and restoration of tumorigenicity in a human mesothelioma cell line. (Abstract 176) Proc Am Assoc Cancer Res 25: 45, 1984.
34. Mosmann T: Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J Immunol Methods 65: 55-63, 1983.