Engineering exosite peptides for complete inhibition of factor VIIa using a protease switch with substrate phage

Journal of Biological Chemistry

Volumn 278, Issue 24, 2003, Pages 21823-21830

  Maun, Henry R ^a,b   Eigenbrot, Charles ^a   Lazarus, Robert A ^a  

^a GENENTECH INC   (United States)

^b UNIVERSITY OF FREIBURG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CRYSTAL STRUCTURE; PH EFFECTS; PROTEINS; TISSUE;

ENZYMATIC ACTIVITY;

NITROGEN COMPOUNDS;

A 183; A 183X; ANTICOAGULANT AGENT; BLOOD CLOTTING FACTOR 7A; CYCLOPEPTIDE; GLUTAMYLGLUTAMYLTRYPTOPHYLGLUTAMYLVALYLLEUCYLCYSTEINYLTRYPTOPHYLTHREONYLTRY PTOPHYLGLUTAMYLTHREONYLCYSTEINYLGLUTAMYLARGININE; GLUTAMYLGLUTAMYLTRYPTOPHYLGLUTAMYLVALYLLEUCYLCYSTEINYLTRYPTOPHYLTHREONYLTRY PTOPHYLGLUTAMYLTHREONYLCYSTEINYLGLUTAMYLARGINYLGLYCYLGLUTAMYLGLYCYLVALYLGLUTAMYL GLUTAMYLGLUTAMYLLEUCYLTRYPTOPHYLGLUTAMYLTRYPTOPHYLARGININE; PEPTIDE; PROTEINASE; THROMBOPLASTIN; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ANTICOAGULATION; ARTICLE; BACTERIOPHAGE; BINDING SITE; CARBOXY TERMINAL SEQUENCE; CHIMERA; CRYSTAL STRUCTURE; ENZYME ACTIVITY; HUMAN; NONHUMAN; PH; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN ENGINEERING; PROTHROMBIN TIME;

AMINO ACID SEQUENCE; AMINO ACIDS; ANTICOAGULANTS; ARGININE; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; DNA; DOSE-RESPONSE RELATIONSHIP, DRUG; FACTOR VIIA; HUMANS; HYDROGEN-ION CONCENTRATION; INHIBITORY CONCENTRATION 50; MODELS, BIOLOGICAL; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PEPTIDE LIBRARY; PEPTIDES; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; PROTHROMBIN TIME; THROMBOPLASTIN;

EID: 0038498064     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M300951200     Document Type: Article

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