Functional consequences of 7TM receptor dimerization

European Journal of Pharmaceutical Sciences

Volumn 23, Issue 4-5, 2004, Pages 301-317

  Hansen, Jakob Lerche ^a   Sheikh, Søren P ^a  

^a Mental Health Services CPH   (Denmark)

Author keywords

7TM receptor; Dimerization; G protein; GPCR; Oligomerization

Indexed keywords

7TM RECEPTOR; ADENOSINE A2 RECEPTOR; ANTIBODY; DOPAMINE 2 RECEPTOR; LEUKOTRIENE B4 AGONIST; LEUKOTRIENE RECEPTOR STIMULATING AGENT; LIGAND; METABOTROPIC RECEPTOR 5; OPIATE AGONIST; OXYTOCIN; RECEPTOR; RECEPTOR ANTIBODY; SIGMA OPIATE RECEPTOR; UNCLASSIFIED DRUG;

AFFINITY LABELING; AMINO TERMINAL SEQUENCE; BIOLUMINESCENCE RESONANCE ENERGY TRANSFER; CROSS LINKING; DIMERIZATION; FLUORESCENCE; IMMUNOPRECIPITATION; LIGAND BINDING; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVIEW; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

ANIMALS; DIMERIZATION; HUMANS; RECEPTORS, G-PROTEIN-COUPLED;

EID: 9644263918     PISSN: 09280987     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejps.2004.08.004     Document Type: Review

References (159)

1. S. AbdAlla, H. Lother, A.M. Abdel-tawab, and U. Quitterer The angiotensin II AT2 receptor is an AT1 receptor antagonist J. Biol. Chem. 276 2001 39721 39726
2. S. AbdAlla, H. Lother, A. el Massiery, and U. Quitterer Increased AT(1) receptor heterodimers in preeclampsia mediate enhanced angiotensin II responsiveness Nat. Med. 7 2001 1003 1009
3. S. AbdAlla, H. Lother, and U. Quitterer AT1-receptor heterodimers show enhanced G-protein activation and altered receptor sequestration Nature 407 2000 94 98
4. S. AbdAlla, E. Zaki, H. Lother, and U. Quitterer Involvement of the amino terminus of the B(2) receptor in agonist-induced receptor dimerization J. Biol. Chem. 274 1999 26079 26084
5. J. Abe, H. Suzuki, M. Notoya, T. Yamamoto, and S. Hirose Ig-hepta, a novel member of the G protein-coupled hepta-helical receptor (GPCR) family that has immunoglobulin-like repeats in a long N-terminal extracellular domain and defines a new subfamily of GPCRs J. Biol. Chem. 274 1999 19957 19964
6. S. Angers, A. Salahpour, and M. Bouvier Dimerization: an emerging concept for G-protein-coupled receptor ontogeny and function Annu. Rev. Pharmacol. Toxicol. 42 2002 409 435
7. S. Angers, A. Salahpour, E. Joly, S. Hilairet, D. Chelsky, M. Dennis, and M. Bouvier Detection of beta 2-adrenergic receptor dimerization in living cells using bioluminescence resonance energy transfer (BRET) Proc. Natl. Acad. Sci. USA 97 2000 3684 3689
8. D. Armstrong, and P.G. Strange Dopamine D2 receptor dimer formation: evidence from ligand binding J. Biol. Chem. 276 2001 22621 22629
9. S. Avissar, G. Amitai, and M. Sokolovsky Oligomeric structure of muscarinic receptors is shown by photoaffinity labeling: subunit assembly may explain high- and low-affinity agonist states Proc. Natl. Acad. Sci. USA 80 1983 156 159
10. M.A. Ayoub, C. Couturier, E. Lucas-Meunier, S. Angers, P. Fossier, M. Bouvier, and R. Jockers Monitoring of ligand-independent dimerization and ligand-induced conformational changes of melatonin receptors in living cells by bioluminescence resonance energy transfer J. Biol. Chem. 277 2002 21522 21528
11. G.J. Babcock, M. Farzan, and J. Sodroski Ligand-independent dimerization of CXCR4, a principal HIV-1 coreceptor J. Biol. Chem. 278 2003 3378 3385
12. M. Bai Dimerization of G-protein-coupled receptors: roles in signal transduction Cell. Signal. 16 2004 175 186
13. M. Bai, S. Trivedi, and E.M. Brown Dimerization of the extracellular calcium-sensing receptor (CaR) on the cell surface of CaR-transfected HEK293 cells J. Biol. Chem. 273 1998 23605 23610
14. J.L. Baneres, and J. Parello Structure-based analysis of GPCR function: evidence for a novel pentameric assembly between the dimeric leukotriene B4 receptor BLT1 and the G-protein J. Mol. Biol. 329 2003 815 829
15. T.J. Baranski, P. Herzmark, O. Lichtarge, B.O. Gerber, J. Trueheart, E.C. Meng, T. Iiri, S.P. Sheikh, and H.R. Bourne C5a receptor activation. Genetic identification of critical residues in four transmembrane helices J. Biol. Chem. 274 1999 15757 15765
16. L. Barki-Harrington, L.M. Luttrell, and H.A. Rockman Dual inhibition of {beta}-Adrenergic and Angiotensin II receptors by a single antagonist: a functional role for receptor-receptor interaction in vivo Circulation 108 2003 1611 1618
17. M. Benkirane, D.Y. Jin, R.F. Chun, R.A. Koup, and K.T. Jeang Mechanism of transdominant inhibition of CCR5-mediated HIV-1 infection by ccr5delta32 J. Biol. Chem. 272 1997 30603 30606
18. M.M. Berglund, D.A. Schober, M.A. Esterman, and D.R. Gehlert Neuropeptide Y Y4 receptor homodimers dissociate upon agonist stimulation J. Pharmacol. Exp. Ther. 307 2003 1120 1126
19. C. Blanpain, J.M. Vanderwinden, J. Cihak, V. Wittamer, E. Le Poul, H. Issafras, M. Stangassinger, G. Vassart, S. Marullo, D. Schlndorff, M. Parmentier, and M. Mack Multiple active states and oligomerization of CCR5 revealed by functional properties of monoclonal antibodies Mol. Biol. Cell. 13 2002 723 737
20. A.E. Brady, and L.E. Limbird G-protein-coupled receptor interacting proteins: emerging roles in localization and signal transduction Cell. Signal. 14 2002 297 309
21. G.E. Breitwieser G-protein-coupled receptor oligomerization: implications for G protein activation and cell signaling Circ. Res. 94 2004 17 27
22. A.R. Calver, M.J. Robbins, C. Cosio, S.Q. Rice, A.J. Babbs, W.D. Hirst, I. Boyfield, M.D. Wood, R.B. Russell, G.W. Price, A. Couve, S.J. Moss, and M.N. Pangalos The C-terminal domains of the GABA(b) receptor subunits mediate intracellular trafficking but are not required for receptor signaling J. Neurosci. 21 2001 1203 1210
23. M. Canals, J. Burgueno, D. Marcellino, N. Cabello, E.I. Canela, J. Mallol, L. Agnati, S. Ferre, M. Bouvier, K. Fuxe, F. Ciruela, C. Lluis, and R. Franco Homodimerization of adenosine A2A receptors: qualitative and quantitative assessment by fluorescence and bioluminescence energy transfer J. Neurochem. 88 2004 726 734
24. M.D. Carrithers, and M.R. Lerner Synthesis and characterization of bivalent peptide ligands targeted to G-protein-coupled receptors Chem. Biol. 3 1996 537 542
25. M.C. Carson, C.M. Harper, A.J. Baukal, G. Aguilera, and K.J. Catt Physicochemical characterization of photoaffinity-labeled angiotensin II receptors Mol. Endocrinol. 1 1987 147 153
26. G.D. Chazenbalk, A. Kakinuma, J.C. Jaume, S.M. McLachlan, and B. Rapoport Evidence for negative cooperativity among human thyrotropin receptors overexpressed in mammalian cells Endocrinol. 137 1996 4586 4591
27. Z.J. Cheng, and L.J. Miller Agonist-dependent dissociation of oligomeric complexes of G-protein-coupled cholecystokinin receptors demonstrated in living cells using bioluminescence resonance energy transfer J. Biol. Chem. 276 2001 48040 48047
28. S.L. Chinault, M.C. Overton, and K.J. Blumer Subunits of a yeast G-protein-coupled receptor are activated independently by agonist but function in concert to activate G protein heterotrimers J. Biol. Chem. 2004
29. F. Ciruela, V. Casado, J. Mallol, E.I. Canela, C. Lluis, and R. Franco Immunological identification of A1 adenosine receptors in brain cortex J. Neurosci. Res. 42 1995 818 828
30. N.J. Colley, J.A. Cassill, E.K. Baker, and C.S. Zuker Defective intracellular transport is the molecular basis of rhodopsin-dependent dominant retinal degeneration Proc. Natl. Acad. Sci. USA 92 1995 3070 3074
31. P.M. Conn, D.C. Rogers, J.M. Stewart, J. Niedel, and T. Sheffield Conversion of a gonadotropin-releasing hormone antagonist to an agonist Nature 296 1982 653 655
32. A. Cornea, and P.M. Conn Measurement of changes in fluorescence resonance energy transfer between gonadotropin-releasing hormone receptors in response to agonists Methods 27 2002 333 339
33. A. Cornea, J.A. Janovick, G. Maya-Nunez, and P.M. Conn Gonadotropin-releasing hormone receptor microaggregation Rate monitored by fluorescence resonance energy transfer J. Biol. Chem. 276 2001 2153 2158
34. S. Cvejic, and L.A. Devi Dimerization of the delta opioid receptor: implication for a role in receptor internalization J. Biol. Chem. 272 1997 26959 26964
35. C.E. Dann, J.C. Hsieh, A. Rattner, D. Sharma, J. Nathans, and D.J. Leahy Insights into Wnt binding and signalling from the structures of two frizzled cysteine-rich domains Nature 412 2001 86 90
36. B. Duthey, S. Caudron, J. Perroy, B. Bettler, L. Fagni, J.P. Pin, and L. Prezeau A single subunit (GB2) is required for G-protein activation by the heterodimeric GABA(B) receptor J. Biol. Chem. 277 2002 3236 3241
37. L. Ellgaard, and A. Helenius Quality control in the endoplasmic reticulum Nat. Rev. Mol. Cell. Biol. 4 2003 181 191
38. S. Ferre, M. Karcz-Kubicha, B.T. Hope, P. Popoli, J. Burgueno, M.A. Gutierrez, V. Casado, K. Fuxe, S.R. Goldberg, C. Lluis, R. Franco, and F. Ciruela Synergistic interaction between adenosine A2A and glutamate mGlu5 receptors: implications for striatal neuronal function Proc. Natl. Acad. Sci. USA 99 2002 11940 11945
39. S. Filipek, K. Krysko, D. Fotiadis, Y. Liang, D.A. Saperstein, A. Engel, and K. Palczewski A concept for G protein activation by G-protein-coupled receptor dimers: the transducin/rhodopsin interface Photochem. Photobiol. Sci. 3 2004 1 12
40. M. Filizola, O. Olmea, and H. Weinstein Prediction of heterodimerization interfaces of G-protein-coupled receptors with a new subtractive correlated mutation method Protein Eng. 15 2002 881 885
41. M. Filizola, and H. Weinstein Structural models for dimerization of G-protein-coupled receptors: the opioid receptor homodimers Biopolymers 66 2002 317 325
42. D.H. Floyd, A. Geva, S.P. Bruinsma, M.C. Overton, K.J. Blumer, and T.J. Baranski C5a receptor oligomerization. II. Fluorescence resonance energy transfer studies of a human G-protein-coupled receptor expressed in yeast J. Biol. Chem. 278 2003 35354 35361
43. D. Fotiadis, Y. Liang, S. Filipek, D.A. Saperstein, A. Engel, and K. Palczewski Atomic-force microscopy: rhodopsin dimers in native disc membranes Nature 421 2003 127 128
44. D. Fotiadis, Y. Liang, S. Filipek, D.A. Saperstein, A. Engel, and K. Palczewski The G-protein-coupled receptor rhodopsin in native mambrane FEBS Lett. 564 2004 281 288
45. Y. Fukushima, T. Asano, T. Saitoh, M. Anai, M. Funaki, T. Ogihara, H. Katagiri, N. Matsuhashi, Y. Yazaki, and K. Sugano Oligomer formation of histamine H2 receptors expressed in Sf9 and COS7 cells FEBS Lett. 409 1997 283 286
46. T. Galvez, B. Duthey, J. Kniazeff, J. Blahos, G. Rovelli, B. Bettler, L. Prezeau, and J.P. Pin Allosteric interactions between GB1 and GB2 subunits are required for optimal GABA(B) receptor function EMBO J. 20 2001 2152 2159
47. S.R. George, T. Fan, Z. Xie, R. Tse, V. Tam, G. Varghese, and B.F. O'Dowd Oligomerization of mu- and delta-opioid receptors. Generation of novel functional properties J. Biol. Chem. 275 2000 26128 26135
48. S.R. George, S.P. Lee, G. Varghese, P.R. Zeman, P. Seeman, G.Y. Ng, and B.F. O'Dowd A transmembrane domain-derived peptide inhibits D1 dopamine receptor function without affecting receptor oligomerization J. Biol. Chem. 273 1998 30244 30248
49. S.R. George, B.F. O'Dowd, and S.P. Lee G-protein-coupled receptor oligomerization and its potential for drug discovery Nat. Rev. Drug Discov. 1 2002 808 820
50. A. Geva, T.B. Lassere, O. Lichtarge, S.K. Pollitt, and T.J. Baranski Genetic mapping of the human C5a receptor. Identification of transmembrane amino acids critical for receptor function J. Biol. Chem. 275 2000 35393 35401
51. S. Gines, J. Hillion, M. Torvinen, S. Le Crom, V. Casado, E.I. Canela, S. Rondin, J.Y. Lew, S. Watson, M. Zoli, L.F. Agnati, P. Verniera, C. Lluis, S. Ferre, K. Fuxe, and R. Franco Dopamine D1 and adenosine A1 receptors form functionally interacting heteromeric complexes Proc. Natl. Acad. Sci. USA 97 2000 8606 8611
52. I. Gomes, J. Filipovska, B.A. Jordan, and L.A. Devi Oligomerization of opioid receptors Methods 27 2002 358 365
53. I. Gomes, B.A. Jordan, A. Gupta, C. Rios, N. Trapaidze, and L.A. Devi G-protein-coupled receptor dimerization: implications in modulating receptor function J. Mol. Med. 79 2001 226 242
54. I. Gomes, B.A. Jordan, A. Gupta, N. Trapaidze, V. Nagy, and L.A. Devi Heterodimerization of mu and delta opioid receptors: a role in opiate synergy J. Neurosci. 20 2000 RC110
55. P.R. Gouldson, M.K. Dean, C.R. Snell, R.P. Bywater, G. Gkoutos, and C.A. Reynolds Lipid-facing correlated mutations and dimerization in G-protein-coupled receptors Protein Eng. 14 2001 759 767
56. P.R. Gouldson, C. Higgs, R.E. Smith, M.K. Dean, G.V. Gkoutos, and C.A. Reynolds Dimerization and domain swapping in G-protein-coupled receptors: a computational study Neuropsychopharmacology 23 2000 S60 S77
57. W. Guo, L. Shi, and J.A. Javitch The fourth transmembrane segment forms the interface of the dopamine D2 receptor homodimer J. Biol. Chem. 278 2003 4385 4388
58. S. Halazy, M. Perez, C. Fourrier, I. Pallard, P.J. Pauwels, C. Palmier, G.W. John, J.P. Valentin, R. Bonnafous, and J. Martinez Serotonin dimers: application of the bivalent ligand approach to the design of new potent and selective 5-HT (1B/1D) agonists J. Med. Chem. 39 1996 4920 4927
59. Hansen JL, J.T., Haunsø, S., Sheikh, S.P., 2004. Oligomerization of wild type and non-functional mutant Angiotensin II type I (AT1) receptors inhibits Gaq protein signaling but not ERK activation. JBC in press.
60. A.C. Hanyaloglu, R.M. Seeber, T.A. Kohout, R.J. Lefkowitz, and K.A. Eidne Homo- and hetero-oligomerization of thyrotropin-releasing hormone (TRH) receptor subtypes. Differential regulation of beta-arrestins 1 and 2 J. Biol. Chem. 277 2002 50422 50430
61. E. Hazum, K.J. Chang, H.J. Leighton, O.W. Lever Jr., and P. Cuatrecasas Increased biological activity of dimers of oxymorphone and enkephalin: possible role of receptor cross-linking Biochem. Biophys. Res. Commun. 104 1982 347 353
62. E. Hazum, and D. Keinan Gonadotropin releasing hormone activation is mediated by dimerization of occupied receptors Biochem. Biophys. Res. Commun. 133 1985 449 456
63. L. He, J. Fong, M. von Zastrow, and J.L. Whistler Regulation of opioid receptor trafficking and morphine tolerance by receptor oligomerization Cell 108 2002 271 282
64. T.E. Hebert, T.P. Loisel, L. Adam, N. Ethier, S.S. Onge, and M. Bouvier Functional rescue of a constitutively desensitized beta2AR through receptor dimerization Biochem. J. 330 Pt 1 1998 287 293
65. T.E. Hebert, S. Moffett, J.P. Morello, T.P. Loisel, D.G. Bichet, C. Barret, and M. Bouvier A peptide derived from a beta2-adrenergic receptor transmembrane domain inhibits both receptor dimerization and activation J. Biol. Chem. 271 1996 16384 16392
66. J.T. Herberg, J. Codina, K.A. Rich, F.J. Rojas, and R. Iyengar The hepatic glucagon receptor. Solubilization, characterization, and development of an affinity adsorption assay for the soluble receptor J. Biol. Chem. 259 1984 9285 9294
67. P. Hernanz-Falcon, J.M. Rodriguez-Frade, A. Serrano, D. Juan, A. del Sol, S.F. Soriano, F. Roncal, L. Gomez, A. Valencia, A.C. Martinez, and M. Mellado Identification of amino acid residues crucial for chemokine receptor dimerization Nat. Immunol. 5 2004 216 223
68. J. Hillion, M. Canals, M. Torvinen, V. Casado, R. Scott, A. Terasmaa, A. Hansson, S. Watson, M.E. Olah, J. Mallol, E.I. Canela, M. Zoli, L.F. Agnati, C.F. Ibanez, C. Lluis, R. Franco, S. Ferre, and K. Fuxe Coaggregation, cointernalization, and codesensitization of adenosine A2A receptors and dopamine D2 receptors J. Biol. Chem. 277 2002 18091 18097
69. R.D. Horvat, D.A. Roess, S.E. Nelson, B.G. Barisas, and C.M. Clay Binding of agonist but not antagonist leads to fluorescence resonance energy transfer between intrinsically fluorescent gonadotropin-releasing hormone receptors Mol. Endocrinol. 15 2001 695 703
70. S.M. Hurtley, and A. Helenius Protein oligomerization in the endoplasmic reticulum Annu. Rev. Cell. Biol. 5 1989 277 307
71. H. Issafras, S. Angers, S. Bulenger, C. Blanpain, M. Parmentier, C. Labbe-Jullie, M. Bouvier, and S. Marullo Constitutive agonist-independent CCR5 oligomerization and antibody- mediated clustering occurring at physiological levels of receptors J. Biol. Chem. 277 2002 34666 34673
72. A.A. Jensen, J.L. Hansen, S.P. Sheikh, and H. Brauner-Osborne Probing intermolecular protein-protein interactions in the calcium-sensing receptor homodimer using bioluminescence resonance energy transfer (BRET) Eur. J. Biochem. 269 2002 5076 5087
73. K.A. Jones, B. Borowsky, J.A. Tamm, D.A. Craig, M.M. Durkin, M. Dai, W.J. Yao, M. Johnson, C. Gunwaldsen, L.Y. Huang, C. Tang, Q. Shen, J.A. Salon, K. Morse, T. Laz, K.E. Smith, D. Nagarathnam, S.A. Noble, T.A. Branchek, and C. Gerald GABA(B) receptors function as a heteromeric assembly of the subunits GABA(B)R1 and GABA(B)R2 Nature 396 1998 674 679
74. B.A. Jordan, and L.A. Devi G-protein-coupled receptor heterodimerization modulates receptor function Nature 399 1999 697 700
75. B.A. Jordan, N. Trapaidze, I. Gomes, R. Nivarthi, and L.A. Devi Oligomerization of opioid receptors with beta 2-adrenergic receptors: a role in trafficking and mitogen-activated protein kinase activation Proc. Natl. Acad. Sci. USA 98 2001 343 348
76. K.D. Karpa, R. Lin, N. Kabbani, and R. Levenson The dopamine D3 receptor interacts with itself and the truncated D3 splice variant d3nf: D3-D3nf interaction causes mislocalization of D3 receptors Mol. Pharmacol. 58 2000 677 683
77. K. Kaupmann, B. Malitschek, V. Schuler, J. Heid, W. Froestl, P. Beck, J. Mosbacher, S. Bischoff, A. Kulik, R. Shigemoto, A. Karschin, and B. Bettler GABA(B)-receptor subtypes assemble into functional heteromeric complexes Nature 396 1998 683 687
78. A. Kaykas, J. Yang-Snyder, M. Heroux, K.V. Shah, M. Bouvier, and R.T. Moon Mutant frizzled 4 associated with vitreoretinopathy traps wild-type frizzled in the endoplasmic reticulum by oligomerization Nat. Cell. Biol. 6 2004 52 58
79. J.M. Klco, T.B. Lassere, and T.J. Baranski C5a receptor oligomerization. I. Disulfide trapping reveals oligomers and potential contact surfaces in a G-protein-coupled receptor J. Biol. Chem. 278 2003 35345 35353
80. K.M. Kroeger, A.C. Hanyaloglu, R.M. Seeber, L.E. Miles, and K.A. Eidne Constitutive and agonist-dependent homo-oligomerization of the thyrotropin-releasing hormone receptor. Detection in living cells using bioluminescence resonance energy transfer J. Biol. Chem. 276 2001 12736 12743
81. R. Kuner, G. Kohr, S. Grunewald, G. Eisenhardt, A. Bach, and H.C. Kornau Role of heteromer formation in GABAB receptor function Science 283 1999 74 77
82. N. Kunishima, Y. Shimada, Y. Tsuji, T. Sato, M. Yamamoto, T. Kumasaka, S. Nakanishi, H. Jingami, and K. Morikawa Structural basis of glutamate recognition by a dimeric metabotropic glutamate receptor Nature 407 2000 971 977
83. J.R. Larkowicz Principles of Fluorescence Spectroscopy 2nd Edition 1999 Kluwer Academic, Plenum Publishers New York
84. R. Latif, P. Graves, and T.F. Davies Oligomerization of the human thyrotropin receptor: fluorescent protein-tagged hTSHR reveals post-translational complexes J. Biol. Chem. 276 2001 45217 45224
85. R. Latif, P. Graves, and T.F. Davies Ligand-dependent inhibition of oligomerization at the human thyrotropin receptor J. Biol. Chem. 277 2002 45059 45067
86. C. Lavoie, and T.E. Hebert Pharmacological characterization of putative beta1-beta2-adrenergic receptor heterodimers Can. J. Physiol. Pharmacol. 81 2003 186 195
87. C. Lavoie, J.F. Mercier, A. Salahpour, D. Umapathy, A. Breit, L.R. Villeneuve, W.Z. Zhu, R.P. Xiao, E.G. Lakatta, M. Bouvier, and T.E. Hebert Beta 1/beta 2-adrenergic receptor heterodimerization regulates beta 2-adrenergic receptor internalization and ERK signaling efficacy J. Biol. Chem. 277 2002 35402 35410
88. C. Le Gouill, J.L. Parent, C.A. Caron, R. Gaudreau, L. Volkov, M. Rola-Pleszczynski, and J. Stankova Selective modulation of wild type receptor functions by mutants of G-protein-coupled receptors J. Biol. Chem. 274 1999 12548 12558
89. D. Lebesgue, G. Wallukat, A. Mijares, C. Granier, J. Argibay, and J. Hoebeke An agonist-like monoclonal antibody against the human beta2-adrenoceptor Eur. J. Pharmacol. 348 1998 123 133
90. S.P. Lee, B.F. O'Dowd, G.Y. Ng, G. Varghese, H. Akil, A. Mansour, T. Nguyen, and S.R. George Inhibition of cell surface expression by mutant receptors demonstrates that D2 dopamine receptors exist as oligomers in the cell Mol. Pharmacol. 58 2000 120 128
91. Y. Liang, D. Fotiadis, S. Filipek, D.A. Saperstein, K. Palczewski, and A. Engel Organization of the G-protein-coupled receptors rhodopsin and opsin in native membranes J. Biol. Chem. 278 2003 21655 21662
92. L.E. Limbird, and R.J. Lefkowitz Negative cooperativity among beta-adrenergic receptors in frog erythrocyte membranes J. Biol. Chem. 251 1976 5007 5014
93. L.E. Limbird, P.D. Meyts, and R.J. Lefkowitz Beta-adrenergic receptors: evidence for negative cooperativity Biochem. Biophys. Res. Commun. 64 1975 1160 1168
94. J. Liu, D. Maurel, S. Etzol, I. Brabet, H. Ansanay, J.P. Pin, and P. Rondard Molecular determinants involved in the allosteric control of agonist affinity in the GABAB receptor by the GABAB2 subunit J. Biol. Chem. 279 2004 15824 15830
95. R. Maggio, P. Barbier, A. Colelli, F. Salvadori, G. Demontis, and G.U. Corsini G protein-linked receptors: pharmacological evidence for the formation of heterodimers J. Pharmacol. Exp. Ther. 291 1999 251 257
96. M. Margeta-Mitrovic, Y.N. Jan, and L.Y. Jan A trafficking checkpoint controls GABA(B) receptor heterodimerization Neuron 27 2000 97 106
97. M. McVey, D. Ramsay, E. Kellett, S. Rees, S. Wilson, A.J. Pope, and G. Milligan Monitoring receptor oligomerization using time-resolved fluorescence resonance energy transfer and bioluminescence resonance energy transfer. The human delta -opioid receptor displays constitutive oligomerization at the cell surface, which is not regulated by receptor occupancy J. Biol. Chem. 276 2001 14092 14099
98. M. Mellado, J.M. Rodriguez-Frade, A.J. Vila-Coro, S. Fernandez, A. Martin de Ana, D.R. Jones, J.L. Toran, and A.C. Martinez Chemokine receptor homo- or heterodimerization activates distinct signaling pathways EMBO J. 20 2001 2497 2507
99. J.F. Mercier, A. Salahpour, S. Angers, A. Breit, and M. Bouvier Quantitative assessment of beta 1- and beta 2-adrenergic receptor homo- and heterodimerization by bioluminescence resonance energy transfer J. Biol. Chem. 277 2002 44925 44931
100. A. Mijares, D. Lebesgue, G. Wallukat, and J. Hoebeke From agonist to antagonist: fab fragments of an agonist-like monoclonal anti-beta (2)-adrenoceptor antibody behave as antagonists Mol. Pharmacol. 58 2000 373 379
101. C. Monnot, C. Bihoreau, S. Conchon, K.M. Curnow, P. Corvol, and E. Clauser Polar residues in the transmembrane domains of the type 1 angiotensin II receptor are required for binding and coupling. Reconstitution of the binding site by co-expression of two deficient mutants J. Biol. Chem. 271 1996 1507 1513
102. G. Nelson, J. Chandrashekar, M.A. Hoon, L. Feng, G. Zhao, N.J. Ryba, and C.S. Zuker An amino-acid taste receptor Nature 416 2002 199 202
103. G. Nelson, M.A. Hoon, J. Chandrashekar, Y. Zhang, N.J. Ryba, and C.S. Zuker Mammalian sweet taste receptors Cell 106 2001 381 390
104. G.Y. Ng, B.F. O'Dowd, S.P. Lee, H.T. Chung, M.R. Brann, P. Seeman, and S.R. George Dopamine D2 receptor dimers and receptor-blocking peptides Biochem. Biophys. Res. Commun. 227 1996 200 204
105. T. Nguyen, D.A. Shapiro, S.R. George, V. Setola, D.K. Lee, R. Cheng, L. Rauser, S.P. Lee, K.R. Lynch, B.L. Roth, and B.F. O'Dowd Discovery of a novel member of the histamine receptor family Mol. Pharmacol. 59 2001 427 433
106. E.A. Nimchinsky, P.R. Hof, W.G. Janssen, J.H. Morrison, and C. Schmauss Expression of dopamine D3 receptor dimers and tetramers in brain and in transfected cells J. Biol. Chem. 272 1997 29229 29237
107. F. Novi, M. Scarselli, G.U. Corsini, and R. Maggio The paired activation of the two components of the muscarinic M3 receptor dimer is required for induction of ERK1/2 phosphorylation J. Biol. Chem. 2003
108. M.C. Overton, and K.J. Blumer G-protein-coupled receptors function as oligomers in vivo Curr. Biol. 10 2000 341 344
109. M.C. Overton, and K.J. Blumer The extracellular N-terminal domain and transmembrane domains 1 and 2 mediate oligomerization of a yeast G-protein-coupled receptor J. Biol. Chem. 277 2002 41463 41472
110. M.C. Overton, S.L. Chinault, and K.J. Blumer Oligomerization, biogenesis, and signaling is promoted by a glycophorin A-like dimerization motif in transmembrane domain 1 of a yeast G-protein-coupled receptor J. Biol. Chem. 278 2003 49369 49377
111. A. Pagano, G. Rovelli, J. Mosbacher, T. Lohmann, B. Duthey, D. Stauffer, D. Ristig, V. Schuler, I. Meigel, C. Lampert, T. Stein, L. Prezeau, J. Blahos, J. Pin, W. Froestl, R. Kuhn, J. Heid, K. Kaupmann, and B. Bettler C-terminal interaction is essential for surface trafficking but not for heteromeric assembly of GABA(b) receptors J. Neurosci. 21 2001 1189 1202
112. S. Paglin, and J.D. Jamieson Covalent cross-linking of angiotensin II to its binding sites in rat adrenal membranes Proc. Natl. Acad. Sci. USA 79 1982 3739 3743
113. Y.X. Pan, E. Bolan, and G.W. Pasternak Dimerization of morphine and orphanin FQ/nociceptin receptors: generation of a novel opioid receptor subtype Biochem. Biophys. Res. Commun. 297 2002 659 663
114. P. Park, C.S. Sum, D.R. Hampson, H.H. Van Tol, and J.W. Wells Nature of the oligomers formed by muscarinic m2 acetylcholine receptors in Sf9 cells Eur. J. Pharmacol. 421 2001 11 22
115. P.S. Park, C.S. Sum, A.B. Pawagi, and J.W. Wells Cooperativity and oligomeric status of cardiac muscarinic cholinergic receptors Biochemistry 41 2002 5588 5604
116. R.C. Patel, U. Kumar, D.C. Lamb, J.S. Eid, M. Rocheville, M. Grant, A. Rani, T. Hazlett, S.C. Patel, E. Gratton, and Y.C. Patel Ligand binding to somatostatin receptors induces receptor-specific oligomer formation in live cells Proc. Natl. Acad. Sci. USA 99 2002 3294 3299
117. R.C. Patel, D.C. Lange, and Y.C. Patel Photobleaching fluorescence resonance energy transfer reveals ligand-induced oligomer formation of human somatostatin receptor subtypes Methods 27 2002 340 348
118. A. Perron, Z.G. Chen, D. Gingras, D.J. Dupre, J. Stankova, and M. Rola-Pleszczynski Agonist-independent desensitization and internalization of the human platelet-activating factor receptor by coumermycin-gyrase B-induced dimerization J. Biol. Chem. 278 2003 27956 27965
119. M. Perez, P.J. Pauwels, C. Fourrier, P. Chopin, J.P. Valentin, G.W. John, M. Marien, and S. Halazy Dimerization of sumatriptan as an efficient way to design a potent, centrally and orally active 5-HT1B agonist Bioorg. Med. Chem. Lett. 8 1998 675 680
120. U.E. Petaja-Repo, M. Hogue, A. Laperriere, S. Bhalla, P. Walker, and M. Bouvier Newly synthesized human delta opioid receptors retained in the endoplasmic reticulum are retrotranslocated to the cytosol, deglycosylated, ubiquitinated, and degraded by the proteasome J. Biol. Chem. 276 2001 4416 4423
121. U.E. Petaja-Repo, M. Hogue, A. Laperriere, P. Walker, and M. Bouvier Export from the endoplasmic reticulum represents the limiting step in the maturation and cell surface expression of the human delta opioid receptor J. Biol. Chem. 275 2000 13727 13736
122. G.L. Peterson, L.C. Rosenbaum, D.J. Broderick, and M.I. Schimerlik Physical properties of the purified cardiac muscarinic acetylcholine receptor Biochemistry 25 1986 3189 3202
123. M. Pfeiffer, T. Koch, H. Schroder, M. Klutzny, S. Kirscht, H.J. Kreienkamp, V. Hollt, and S. Schulz Homo- and heterodimerization of somatostatin receptor subtypes. Inactivation of sst(3) receptor function by heterodimerization with sst(2A) J. Biol. Chem. 276 2001 14027 14036
124. M. Pfeiffer, T. Koch, H. Schroder, M. Laugsch, V. Hollt, and S. Schulz Heterodimerization of somatostatin and opioid receptors cross-modulates phosphorylation, internalization, and desensitization J. Biol. Chem. 277 2002 19762 19772
125. D. Ramsay, E. Kellett, M. McVey, S. Rees, and G. Milligan Homo- and hetero-oligomeric interactions between G-protein-coupled receptors in living cells monitored by two variants of bioluminescence resonance energy transfer (BRET): hetero-oligomers between receptor subtypes form more efficiently than between less closely related sequences Biochem. J. 365 2002 429 440
126. K. Ray, B.C. Hauschild, P.J. Steinbach, P.K. Goldsmith, O. Hauache, and A.M. Spiegel Identification of the cysteine residues in the amino-terminal extracellular domain of the human Ca(2+) receptor critical for dimerization Implications for function of monomeric Ca(2+) receptor J. Biol. Chem. 274 1999 27642 27650
127. V.M. Rivera, X. Wang, S. Wardwell, N.L. Courage, A. Volchuk, T. Keenan, D.A. Holt, M. Gilman, L. Orci, F. Cerasoli Jr., J.E. Rothman, and T. Clackson Regulation of protein secretion through controlled aggregation in the endoplasmic reticulum Science 287 2000 826 830
128. M. Rocheville, D.C. Lange, U. Kumar, S.C. Patel, R.C. Patel, and Y.C. Patel Receptors for dopamine and somatostatin: formation of hetero-oligomers with enhanced functional activity Science 288 2000 154 157
129. M. Rocheville, D.C. Lange, U. Kumar, R. Sasi, R.C. Patel, and Y.C. Patel Subtypes of the somatostatin receptor assemble as functional homo- and heterodimers J. Biol. Chem. 275 2000 7862 7869
130. J.M. Rodriguez-Frade, G. Del Real, A. Serrano, P. Hernanz-Falcon, S.F. Soriano, A.J. Vila-Coro, A.M. De Ana, P. Lucas, I. Prieto, A.C. Martinez, and M. Mellado Blocking HIV-1 infection via CCR5 and CXCR4 receptors by acting in trans on the CCR2 chemokine receptor EMBO J. 23 2004 66 76
131. J.M. Rodriguez-Frade, A.J. Vila-Coro, A.M. de Ana, J.P. Albar, A.C. Martinez, and M. Mellado The chemokine monocyte chemoattractant protein-1 induces functional responses through dimerization of its receptor CCR2 Proc. Natl. Acad. Sci. USA 96 1999 3628 3633
132. T.B. Rogers High affinity angiotensin II receptors in myocardial sarcolemmal membranes. Characterization of receptors and covalent linkage of 125I-angiotensin II to a membrane component of 116,000 daltons. J. Biol. Chem. 259 1984 8106 8114
133. C. Romano, W.L. Yang, and K.L. O'Malley Metabotropic glutamate receptor 5 is a disulfide-linked dimer J. Biol. Chem. 271 1996 28612 28616
134. J.J. Rondeau, N. McNicoll, E. Escher, S. Meloche, H. Ong, and A. De Lean Hydrodynamic properties of the angiotensin II receptor from bovine adrenal zona glomerulosa Biochem. J. 268 1990 443 448
135. A. Salahpour, S. Angers, J.F. Mercier, M. Lagace, S. Marullo, and M. Bouvier Homodimerization of the beta 2-adrenergic receptor as a pre-requisite for cell surface targeting J. Biol. Chem. 2004
136. K. Salim, T. Fenton, J. Bacha, H. Urien-Rodriguez, T. Bonnert, H.A. Skynner, E. Watts, J. Kerby, A. Heald, M. Beer, G. McAllister, and P.C. Guest Oligomerization of G-protein-coupled receptors shown by selective co-immunoprecipitation J. Biol. Chem. 277 2002 15482 15485
137. M. Scarselli, F. Novi, G.U. Corsini, and R. Maggio Functional rescue of the inactive splice variant of the dopamine D3 receptor D3nf. Brain Res. 987 2003 244 247
138. A. Schulz, R. Grosse, G. Schultz, T. Gudermann, and T. Schoneberg Structural implication for receptor oligomerization from functional reconstitution studies of mutant V2 vasopressin receptors J. Biol. Chem. 275 2000 2381 2389
139. P.R. Selvin Fluorescence resonance energy transfer Methods Enzymol. 246 1995 300 334
140. I.R. Siemens, G.N. Swanson, S.J. Fluharty, and J.W. Harding Solubilization and partial characterization of angiotensin II receptors from rat brain J. Neurochem. 57 1991 690 700
141. S. Terrillon, C. Barberis, and M. Bouvier Heterodimerization of V1a and V2 vasopressin receptors determines the interaction with beta-arrestin and their trafficking patterns Proc. Natl. Acad. Sci. USA 101 2004 1548 1553
142. S. Terrillon, and M. Bouvier Roles of G-protein-coupled receptor dimerization EMBO Rep. 5 2004 30 34
143. S. Terrillon, T. Durroux, B. Mouillac, A. Breit, M.A. Ayoub, M. Taulan, R. Jockers, C. Barberis, and M. Bouvier Oxytocin and vasopressin V1a and V2 receptors form constitutive homo- and heterodimers during biosynthesis Mol. Endocrinol. 17 2003 677 691
144. Thormeyer, D., Ammerpohl, O., Larsson, O., Xu, Y., Asinger, A., Wahlestedt, C., Liang, Z., 2003. Characterization of lacZ complementation deletions using membrane receptor dimerization. Biotechniques 34, 346-350.
145. F. Trettel, S. Di Bartolomeo, C. Lauro, M. Catalano, M.T. Ciotti, and C. Limatola Ligand-independent CXCR2 dimerization J. Biol. Chem. 278 2003 40980 40988
146. Y. Tsuji, Y. Shimada, T. Takeshita, N. Kajimura, S. Nomura, N. Sekiyama, J. Otomo, J. Usukura, S. Nakanishi, and H. Jingami Cryptic dimer interface and domain organization of the extracellular region of metabotropic glutamate receptor subtype 1 J. Biol. Chem. 275 2000 28144 28151
147. J.R. Van Brocklyn, B. Behbahani, and N.H. Lee Homodimerization and heterodimerization of S1P/EDG sphingosine-1-phosphate receptors Biochim. Biophys. Acta 1582 2002 89 93
148. B. Van Der Meer, G. Coker, and SY. Chen Resonance Energy Transfer - Theory and Data 1994 VCH Publishers, Inc.
149. A.J. Vila-Coro, M. Mellado, A. Martin de Ana, P. Lucas, G. del Real, A.C. Martinez, and J.M. Rodriguez-Frade HIV-1 infection through the CCR5 receptor is blocked by receptor dimerization Proc. Natl. Acad. Sci. USA 97 2000 3388 3393
150. A.J. Vila-Coro, J.M. Rodriguez-Frade, A. Martin De Ana, M.C. Moreno-Ortiz, A.C. Martinez, and M. Mellado The chemokine SDF-1alpha triggers CXCR4 receptor dimerization and activates the JAK/STAT pathway Faseb J. 13 1999 1699 1710
151. J.H. White, A. Wise, M.J. Main, A. Green, N.J. Fraser, G.H. Disney, A.A. Barnes, P. Emson, S.M. Foord, and F.H. Marshall Heterodimerization is required for the formation of a functional GABA(B) receptor Nature 396 1998 679 682
152. K.A. Wreggett, and J.W. Wells Cooperativity manifest in the binding properties of purified cardiac muscarinic receptors J. Biol. Chem. 270 1995 22488 22499
153. Z. Xie, S.P. Lee, B.F. O'Dowd, and S.R. George Serotonin 5-HT1B and
154. Y. Xu, D.W. Piston, and C.H. Johnson A bioluminescence resonance energy transfer (BRET) system: application to interacting circadian clock proteins Proc. Natl. Acad. Sci. USA 96 1999 151 156
155. K. Yoshioka, O. Saitoh, and H. Nakata Heteromeric association creates a P2Y-like adenosine receptor Proc. Natl. Acad. Sci. USA 98 2001 7617 7622
156. K. Yoshioka, O. Saitoh, and H. Nakata Agonist-promoted heteromeric oligomerization between adenosine A(1) and P2Y(1) receptors in living cells FEBS Lett. 523 2002 147 151
157. P. Zawarynski, T. Tallerico, P. Seeman, S.P. Lee, B.F. O'Dowd, and S.R. George Dopamine D2 receptor dimers in human and rat brain FEBS Lett. 441 1998 383 386
158. F.Y. Zeng, and J. Wess Identification and molecular characterization of m3 muscarinic receptor dimers J. Biol. Chem. 274 1999 19487 19497
159. X. Zhu, and J. Wess Truncated V2 vasopressin receptors as negative regulators of wild-type V2 receptor function Biochemistry 37 1998 15773 15784