Dimerization and domain swapping in G-protein-coupled receptors: A computational study

Neuropsychopharmacology

Volumn 23, Issue 4, 2000, Pages S60-S77

  Gouldson, Paul R ^a   Higgs, Christopher ^a   Smith, Richard E ^a   Dean, Mark K ^a   Gkoutos, George V ^a   Reynolds, Christopher A ^a  

^a UNIVERSITY OF ESSEX   (United Kingdom)

Author keywords

Activation; Adrenergic; Bioinformatics; Brownian dynamics; Correlated mutation analysis; Dimerization; Domain swapping; Domains; Evolutionary trace analysis; Functional rescue; G protein; G protein coupled receptors; GPCR; Molecular dynamics; Molecular modeling

Indexed keywords

4 AMINOBUTYRIC ACID B RECEPTOR; ADRENALIN; ADRENERGIC RECEPTOR; ALPHA 2 ADRENERGIC RECEPTOR; CHIMERIC PROTEIN; G PROTEIN COUPLED RECEPTOR; GUANINE NUCLEOTIDE BINDING PROTEIN; MEMBRANE PROTEIN; MUSCARINIC M3 RECEPTOR; MUSCARINIC RECEPTOR; NORADRENALIN; PINDOLOL; PROPRANOLOL; RECEPTOR SUBTYPE; RHODOPSIN RECEPTOR; TACHYKININ RECEPTOR; TRANSDUCIN; UNCLASSIFIED DRUG; VASOPRESSIN RECEPTOR;

BINDING SITE; CELL ACTIVATION; DIMERIZATION; DRUG RECEPTOR BINDING; HUMAN; MOLECULAR DYNAMICS; MOLECULAR EVOLUTION; NONHUMAN; OLIGOMERIZATION; PRIORITY JOURNAL; PROTEIN FAMILY; PROTEIN PROTEIN INTERACTION; PROTEIN SECONDARY STRUCTURE; REVIEW; SIGNAL TRANSDUCTION; SITE DIRECTED MUTAGENESIS; STRUCTURE ACTIVITY RELATION;

ANIMAL; BINDING SITES; DIMERIZATION; DNA MUTATIONAL ANALYSIS; EVOLUTION, MOLECULAR; GTP-BINDING PROTEINS; HELIX-LOOP-HELIX MOTIFS; HUMAN; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, CELL SURFACE; RECEPTORS, GABA-B; SUPPORT, U.S. GOV'T, P.H.S.;

EID: 0033806215     PISSN: 0893133X     EISSN: 1740634X     Source Type: Journal    
DOI: 10.1016/S0893-133X(00)00153-6     Document Type: Article

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