Synthesis and characterization of bivalent peptide ligands targeted to G-protein-coupled receptors

Chemistry and Biology

Volumn 3, Issue 7, 1996, Pages 537-542

  Carrithers, Michael D ^a   Lerner, Michael R ^a,b  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

bombesin; melanocyte stimulating hormone; melanophore; peptide dimer

Indexed keywords

ANIMALIA; MELANOPHORA; XENOPUS LAEVIS;

EID: 0030198872     PISSN: 10745521     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1074-5521(96)90144-1     Document Type: Article

References (25)

1. Crothers, D.M. & Metzger, H. (1972). The influence of polyvalency on the binding properties of antibodies. Immunochemistry 9, 341-357.
2. Spike, C.G. & Parry, R.W. (1953). Thermodynamics of chelation. I. The statistical factor in chelate ring formation. J. Am. Chem. Soc. 75, 2726-2729.
3. Neri, D., Momo, M., Prospero, T. & Winter, G. (1995). High affinity antigen binding by chelating recombinant antibodies (CRAbs). J. Mol. Biol. 246, 367-373.
4. Page, M.I. & Jencks, W.P. (1971). Entropic contributions to rate accelerations in enzymic and intramolecular reactions and the chelate effect. Proc. Natl. Acad. Sci. USA 68, 1678-1683.
5. Delisi, C. & Crothers, D.M. (1971). Theory of the influence of oligonucleotide chain conformation on double helix stability. Biopolymers 10, 1809-1827.
6. v fragments with high avidity in Escherichia coli. Biochemistry 31, 1579-1584.
7. Holliger, P., Prospero, T. & Winter, G. (1993). "Diabodies": small bivalent and bispecific antibody fragments. Proc. Natl. Acad Sci. USA 90, 6444-6448.
8. Mallender, W.D. & Voss, E.W. (1994). Construction, expression, and activity of a bivalent bispecific single-chain antibody. J. Biol. Chem. 269, 199-206.
9. Lee, R.T., Lin, P. & Lee, Y.C. (1984). New synthetic cluster ligands for galactose/N-acetylgalactosamine-specific lectin of mammalian liver. Biochemistry 23, 4255-4261.
10. Duncan, R. & Spreafico, F. (1994). Polymer conjugates: pharmacokinetic considerations for design and development. Clin. Pharmacokinet. 27, 290-306.
11. Engel, M., Williams, R.W. & Erickson, B.W. (1991). Designed coiled-coil proteins: synthesis and spectroscopy of two 78-residue α-helical dimers. Biochemistry 30, 3161-3169.
12. Slate, C.A., Weninger, S.C., Church, F.C. & Erickson, B.W. (1995). Engineering of five 88-residue receptor-adhesive modular proteins containing a parallel α-helical coiled coil and two RGD ligand sites. Int. J. Peptide Protein Res. 45, 290-298.
13. Plank, C., Oberhauser, B., Mechtler, K., Koch, C. & Wagner, E. (1994). The influence of endosome-disruptive peptides on gene transfer using synthetic virus-like gene transfer systems. J. Biol. Chem. 269, 12918-12924.
14. Conn, P.M., Rogers, D.C. & McNeil, R. (1982). Potency enhancement of a GnRH agonist: GnRH-receptor microaggregation stimulates gonadotropin release. Endocrinology 111, 335-337.
15. Conn, P.M., Rogers, D.C., Stewart, J.M., Niedel, J. & Sheffield, T. (1982). Conversion of a gonadotropin-releasing hormone antagonist to an agonist. Nature 296, 653-654.
16. Jayawickreme, C.K., Quillan, J.M., Graminski, G.F. & Lerner, M.R. (1994). Discovery and structure-function analysis of α-melanocyte stimulating hormone antagonists. J. Biol. Chem. 269, 29846-29854.
17. s-protein-coupled receptors using a recombinant melanophore-based bioassay. Anal. Biochem. 206, 315-322.
18. Graminski, G.F., Jayawickreme, C.K., Potenza, M.N. & Lerner, M.R. (1993). Pigment dispersion in frog melanophores can be induced by a phorbol ester or stimulation of a recombinant receptor that activates phospholipase C. J. Biol. Chem. 268, 5957-5964.
19. Karne, S., Jayawickreme, C.K. & Lerner, M.R. (1993). Cloning and characterization of an endothelin-3 specific receptor from Xenopus laevis dermal melanophores. J. Biol. Chem. 268, 19126-19133.
20. Jayawickreme, C.K., Graminski, G.F., Quillan, J.M. & Lerner, M.R. (1994). Creation and functional screening of a multi-use peptide library. Proc. Natl. Acad. Sci. USA 91, 1614-1618.
21. Schertler, G.F.X., Villa, C. & Henderson, R. (1993). Projection structure of rhodopsin. Nature 362, 770-772.
22. Tam, J.P, Wu, C.R., Liu, W. & Zhang, J.W. (1991). Disulfide bond formation in peptides by dimethyl sulfoxide. Scope and applications. J. Am. Chem. Soc. 113, 6657-6662.
23. Maggio, R., Vogel, Z. & Wess, J. (1993). Coexpression studies with mutant muscarinic/adrenergic receptors provide evidence for intermolecular 'cross-talk' between G-protein-linked receptors. Proc. Natl. Acad. Sci. USA 90, 3103-3107.
24. Fuh, G., Cunningham, B.C., Fukunaga, R., Nagata, S., Goeddel, D.V. & Wells, J.A. (1992). Rational design of potent antagonists to the human growth hormone receptor. Science 256, 1677-1680.
25. Seed, B. (1994). Making agonists of antagonists. Chemistry & Biology 1, 125-129.