-
1
-
-
0038795317
-
Hypoxia attenuates the p53 response to cellular damage
-
Achison M., Hupp T.R. Hypoxia attenuates the p53 response to cellular damage. Oncogene. 22:2003;3431-3440
-
(2003)
Oncogene
, vol.22
, pp. 3431-3440
-
-
Achison, M.1
Hupp, T.R.2
-
2
-
-
0036323284
-
2-dependent degradation domain of hypoxia inducible factor-1α (HIF-1α)
-
2-dependent degradation domain of hypoxia inducible factor-1α (HIF-1α). J Cancer Res Clin Oncol. 128:2002;358-362
-
(2002)
J Cancer Res Clin Oncol
, vol.128
, pp. 358-362
-
-
Anastasiadis, A.G.1
Ghafar, M.A.2
Salomon, L.3
Vacherot, F.4
Benedict, P.5
Chen -., M.W.6
Shabsigh, A.7
Burchardt, M.8
Chopin, D.K.9
Shabsigh, R.10
Buttyan, R.11
-
3
-
-
0034282518
-
Overexpression of hypoxia-inducible factor 1α is a marker for an unfavorable prognosis in early stage invasive cervical cancer
-
Birner P., Schindl M., Obermair A., Plank C., Breitenecker G., Oberhuber G. Overexpression of hypoxia-inducible factor 1α is a marker for an unfavorable prognosis in early stage invasive cervical cancer. Cancer Res. 60:2000;4693-4696
-
(2000)
Cancer Res
, vol.60
, pp. 4693-4696
-
-
Birner, P.1
Schindl, M.2
Obermair, A.3
Plank, C.4
Breitenecker, G.5
Oberhuber, G.6
-
4
-
-
0035925072
-
Levels of hypoxia-inducible factor-1 alpha during breast carcinogenesis
-
Bos R., Zhong H., Hanrahan C.F., Mommers E.C., Semenza G.L., Pinedo H.M., Abeloff M.D., Simons J.W., van Diest P.J., van der Wall E. Levels of hypoxia-inducible factor-1 alpha during breast carcinogenesis. J Natl Cancer Inst. 93:2001;309-314
-
(2001)
J Natl Cancer Inst
, vol.93
, pp. 309-314
-
-
Bos, R.1
Zhong, H.2
Hanrahan, C.F.3
Mommers, E.C.4
Semenza, G.L.5
Pinedo, H.M.6
Abeloff, M.D.7
Simons, J.W.8
Van Diest, P.J.9
Van Der Wall, E.10
-
5
-
-
0030022252
-
Tumor oxygenation predicts for the likelihood of distant metastasis in human soft tissue sarcoma
-
Brizel D.M., Scully S.P., Harrelson J.M., Layfield L.J., Bean J.M., Prosnitz L.R., Dewhirst M.W. Tumor oxygenation predicts for the likelihood of distant metastasis in human soft tissue sarcoma. Cancer Res. 56:1996;941-943
-
(1996)
Cancer Res
, vol.56
, pp. 941-943
-
-
Brizel, D.M.1
Scully, S.P.2
Harrelson, J.M.3
Layfield, L.J.4
Bean, J.M.5
Prosnitz, L.R.6
Dewhirst, M.W.7
-
6
-
-
9644268819
-
The potential therapeutic application of targeting HIF-1 using gene therapy or small molecule approaches
-
Brown L.M., Williams K.J., Cowen R.L., Melillo G., Sausville E., Stratford I.J. The potential therapeutic application of targeting HIF-1 using gene therapy or small molecule approaches. Proc AACR. 44:2003;4633
-
(2003)
Proc AACR
, vol.44
, pp. 4633
-
-
Brown, L.M.1
Williams, K.J.2
Cowen, R.L.3
Melillo, G.4
Sausville, E.5
Stratford, I.J.6
-
7
-
-
0034255036
-
Expression of the gene encoding the proapoptotic NIP3 protein is induced by hypoxia
-
Bruick R.K. Expression of the gene encoding the proapoptotic NIP3 protein is induced by hypoxia. Proc Natl Acad Sci USA. 97:2000;9082-9087
-
(2000)
Proc Natl Acad Sci USA
, vol.97
, pp. 9082-9087
-
-
Bruick, R.K.1
-
8
-
-
0032581277
-
Role of HIF-1α in hypoxia-mediated apoptosis, cell proliferation and tumor angiogenesis
-
Carmeliet P., Dor Y., Herbert J.-.M., Fukumura D., Brusselmans K., Dewerchin M., Neeman M., Bono F., Abramovitch R., Maxwell P., Koch C.J., Ratcliffe P.J., Moons L., Jain R.K., Collen D., Keshet E. Role of HIF-1α in hypoxia-mediated apoptosis, cell proliferation and tumor angiogenesis. Nature. 394:1998;485-490
-
(1998)
Nature
, vol.394
, pp. 485-490
-
-
Carmeliet, P.1
Dor, Y.2
Herbert -., J.M.3
Fukumura, D.4
Brusselmans, K.5
Dewerchin, M.6
Neeman, M.7
Bono, F.8
Abramovitch, R.9
Maxwell, P.10
Koch, C.J.11
Ratcliffe, P.J.12
Moons, L.13
Jain, R.K.14
Collen, D.15
Keshet, E.16
-
9
-
-
0035937715
-
Regulation of glut1 mRNA by hypoxia-inducible factor-1. Interaction between H-ras and hypoxia
-
Chen C., Pore N., Behrooz A., Ismail-Beigi F., Maity A. Regulation of glut1 mRNA by hypoxia-inducible factor-1. Interaction between H-ras and hypoxia. J Biol Chem. 276:2001;9519-9525
-
(2001)
J Biol Chem
, vol.276
, pp. 9519-9525
-
-
Chen, C.1
Pore, N.2
Behrooz, A.3
Ismail-Beigi, F.4
Maity, A.5
-
10
-
-
0344608877
-
Dominant-negative hypoxia-inducible factor 1 alpha reduces the tumorigenecity of pancreatic cancer cells through the suppression of glucose metabolism
-
Chen J., Zhao S., Nakada K., Kuge Y., Tamaki N., Okada F., Wang J., Shindo M., Higashino F., Takeda K., Asaka M., Katoh H., Sugiyama T., Hosokawa M., Kobayashi M. Dominant-negative hypoxia-inducible factor 1 alpha reduces the tumorigenecity of pancreatic cancer cells through the suppression of glucose metabolism. Am J Pathol. 162:2003;1283-1291
-
(2003)
Am J Pathol
, vol.162
, pp. 1283-1291
-
-
Chen, J.1
Zhao, S.2
Nakada, K.3
Kuge, Y.4
Tamaki, N.5
Okada, F.6
Wang, J.7
Shindo, M.8
Higashino, F.9
Takeda, K.10
Asaka, M.11
Katoh, H.12
Sugiyama, T.13
Hosokawa, M.14
Kobayashi, M.15
-
11
-
-
0037096732
-
Hypoxia-inducible factor-1-dependent regulation of the multidrug resistance (MDR1) gene
-
Comerford K.M., Wallace T.J., Karhausen J., Louis N.A., Montalto M.C., Colgan S.P. Hypoxia-inducible factor-1-dependent regulation of the multidrug resistance (MDR1) gene. Cancer Res. 62:2002;3387-3394
-
(2002)
Cancer Res
, vol.62
, pp. 3387-3394
-
-
Comerford, K.M.1
Wallace, T.J.2
Karhausen, J.3
Louis, N.A.4
Montalto, M.C.5
Colgan, S.P.6
-
12
-
-
9644268816
-
A novel human P450 reductase activated indolequinone prodrug for use in adenoviral mediated hypoxia selective gene therapy
-
Cowen R.L., Williams K.J., Jaffar M., Telfer B., Garvey D., Stratford I.J. A novel human P450 reductase activated indolequinone prodrug for use in adenoviral mediated hypoxia selective gene therapy. Eur J Cancer. 38(S7):2002;492
-
(2002)
Eur J Cancer
, vol.38
, Issue.S7
, pp. 492
-
-
Cowen, R.L.1
Williams, K.J.2
Jaffar, M.3
Telfer, B.4
Garvey, D.5
Stratford, I.J.6
-
13
-
-
0642379637
-
Viral delivery of P450 reductase recapitulates the ability of constitutive overexpression of reductase enzymes to potentiate the activity of Mitomycin C in human breast cancer xenografts
-
Cowen RL, Patterson AV, Telfer BA, Airley R, Hobbs S, Phillips RM, Jaffar M, Stratford IJ, Williams KJ. Viral delivery of P450 reductase recapitulates the ability of constitutive overexpression of reductase enzymes to potentiate the activity of Mitomycin C in human breast cancer xenografts. Mol Cancer Ther 2003;2:901-9.
-
(2003)
Mol Cancer Ther
, vol.2
, pp. 901-909
-
-
Cowen, R.L.1
Patterson, A.V.2
Telfer, B.A.3
Airley, R.4
Hobbs, S.5
Phillips, R.M.6
Jaffar, M.7
Stratford, I.J.8
Williams, K.J.9
-
14
-
-
1242271216
-
Hypoxia targeted gene therapy to increase the efficacy of tirapazamine as an adjuvant to radiotherapy: Reversing tumour radio-resistance and effecting cure
-
Cowen RL, Williams KJ, Chinje EC, Jaffar M, Sheppard F, Telfer BA, Wind NS, Stratford IJ. Hypoxia targeted gene therapy to increase the efficacy of tirapazamine as an adjuvant to radiotherapy: reversing tumour radio-resistance and effecting cure. Cancer Res 2004;64:1396-402.
-
(2004)
Cancer Res
, vol.64
, pp. 1396-1402
-
-
Cowen, R.L.1
Williams, K.J.2
Chinje, E.C.3
Jaffar, M.4
Sheppard, F.5
Telfer, B.A.6
Wind, N.S.7
Stratford, I.J.8
-
15
-
-
0030968939
-
Targeting gene expression to hypoxic tumor cells
-
Dachs G.U., Patterson A.V., Firth J.D., Ratcliffe P.J., Townsend K.M., Stratford I.J., Harris A.L. Targeting gene expression to hypoxic tumor cells. Nature Med. 3:1997;515-520
-
(1997)
Nature Med
, vol.3
, pp. 515-520
-
-
Dachs, G.U.1
Patterson, A.V.2
Firth, J.D.3
Ratcliffe, P.J.4
Townsend, K.M.5
Stratford, I.J.6
Harris, A.L.7
-
16
-
-
12144287046
-
Hypoxia mediated down regulation of Bid and Bax in tumours occurs via HIF-1 dependent and independent mechanisms and contributes to drug resistance
-
Erler J.T., Cawthorne C.J., Williams K.J., Koritzinksy M., Wouters B., Wilson C., Miller C., Demonacos C., Stratford I.J., Dive C. Hypoxia mediated down regulation of Bid and Bax in tumours occurs via HIF-1 dependent and independent mechanisms and contributes to drug resistance. Mol Cell Biol. 24:2004;2875-2889
-
(2004)
Mol Cell Biol
, vol.24
, pp. 2875-2889
-
-
Erler, J.T.1
Cawthorne, C.J.2
Williams, K.J.3
Koritzinksy, M.4
Wouters, B.5
Wilson, C.6
Miller, C.7
Demonacos, C.8
Stratford, I.J.9
Dive, C.10
-
17
-
-
0031716020
-
Oxygenation predicts radiation response in patients with cervix cancer
-
Fyles A.W., Milosevic M., Wong R., Kavanagh M.C., Pintilie M., Sun A., Chapman W., Levin W., Manchul L., Keane T.J., Hill R.P. Oxygenation predicts radiation response in patients with cervix cancer. Radiother Oncol. 48:1998;149-156
-
(1998)
Radiother Oncol
, vol.48
, pp. 149-156
-
-
Fyles, A.W.1
Milosevic, M.2
Wong, R.3
Kavanagh, M.C.4
Pintilie, M.5
Sun, A.6
Chapman, W.7
Levin, W.8
Manchul, L.9
Keane, T.J.10
Hill, R.P.11
-
18
-
-
0023932431
-
Oxygen distribution in squamous cell carcinoma metastases and its relationship to outcome of radiation therapy
-
Gatenby R.A., Kessler H.B., Rosenblum J.S., Coia L.R., Moldofsky P.J., Hartz W.H., Broder G.J. Oxygen distribution in squamous cell carcinoma metastases and its relationship to outcome of radiation therapy. Int J Radiat Oncol Biol Phys. 14:1988;831-838
-
(1988)
Int J Radiat Oncol Biol Phys
, vol.14
, pp. 831-838
-
-
Gatenby, R.A.1
Kessler, H.B.2
Rosenblum, J.S.3
Coia, L.R.4
Moldofsky, P.J.5
Hartz, W.H.6
Broder, G.J.7
-
19
-
-
0001952040
-
-
Vaupel and Kelleher, editors. Wissenschaftliche Verlagsgesellschaft mbH Stuttgart
-
Giaccia AJ, Koumenis C, Denko N. The influence of tumor hypoxia on malignant progression. Tumor hypoxia: Pathophysiology, clinical significance and therapeutic perspectives. Vaupel and Kelleher, editors. Wissenschaftliche Verlagsgesellschaft mbH Stuttgart, 1999. p. 115-24.
-
(1999)
The Influence of Tumor Hypoxia on Malignant Progression. Tumor Hypoxia: Pathophysiology, Clinical Significance and Therapeutic Perspectives
, pp. 115-124
-
-
Giaccia, A.J.1
Koumenis, C.2
Denko, N.3
-
20
-
-
0030025773
-
Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumors
-
Graeber T.G., Osmanian C., Jacks T., Housman D.E., Koch S.J., Lowe S.W., Giaccia A.J. Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumors. Nature. 379:1996;88-91
-
(1996)
Nature
, vol.379
, pp. 88-91
-
-
Graeber, T.G.1
Osmanian, C.2
Jacks, T.3
Housman, D.E.4
Koch, S.J.5
Lowe, S.W.6
Giaccia, A.J.7
-
21
-
-
0036468251
-
Metabolic changes detected by in vivo magnetic resonance studies of HEPA-1 wild-type tumors and tumors deficient in hypoxia-inducible factor-1β HIF- 1β 1: Evidence of an anabolic role for the HIF-1 pathway
-
Griffiths J.R., McSheehy P.M.J., Robinson S.P., Troy H., Chung Y.-.L., Leek R.D., Williams K.J., Stratford I.J., Harris A.L., Stubbs M. Metabolic changes detected by in vivo magnetic resonance studies of HEPA-1 wild-type tumors and tumors deficient in hypoxia-inducible factor-1β HIF- 1β 1. evidence of an anabolic role for the HIF-1 pathway Cancer Res. 62:2002;688-695
-
(2002)
Cancer Res
, vol.62
, pp. 688-695
-
-
Griffiths, J.R.1
McSheehy, P.M.J.2
Robinson, S.P.3
Troy, H.4
Chung -., Y.L.5
Leek, R.D.6
Williams, K.J.7
Stratford, I.J.8
Harris, A.L.9
Stubbs, M.10
-
22
-
-
0029775242
-
Association between tumor hypoxia and malignant progression in advanced cancer of the uterine cervix
-
Hockel M., Schlenger K., Aral B., Mitze M., Schaffer U., Vaupel P. Association between tumor hypoxia and malignant progression in advanced cancer of the uterine cervix. Cancer Res. 56:1996;4509-4515
-
(1996)
Cancer Res
, vol.56
, pp. 4509-4515
-
-
Hockel, M.1
Schlenger, K.2
Aral, B.3
Mitze, M.4
Schaffer, U.5
Vaupel, P.6
-
23
-
-
0037093107
-
Rescue of hypoxia-inducible factor-1α-deficient tumor growth by wild-type cells is independent of the vascular endothelial growth factor
-
Hopfl G., Wenger R.H., Ziegler U., Stallmach T., Gardelle O., Achermann R., Wergin M., Kaser-Hotz B., Saunders H.M., Williams K.J., Stratford I.J., Gassmann M., Desbailetts I. Rescue of hypoxia-inducible factor-1α- deficient tumor growth by wild-type cells is independent of the vascular endothelial growth factor. Cancer Res. 62:2002;2962-2970
-
(2002)
Cancer Res
, vol.62
, pp. 2962-2970
-
-
Hopfl, G.1
Wenger, R.H.2
Ziegler, U.3
Stallmach, T.4
Gardelle, O.5
Achermann, R.6
Wergin, M.7
Kaser-Hotz, B.8
Saunders, H.M.9
Williams, K.J.10
Stratford, I.J.11
Gassmann, M.12
Desbailetts, I.13
-
24
-
-
0035917313
-
2 sensing
-
2 sensing Science. 292:2001;464-468
-
(2001)
Science
, vol.292
, pp. 464-468
-
-
Ivan, M.1
Kondo, K.2
Yang, H.3
Kim, W.4
Valiando, J.5
Ohh, M.6
Salic, A.7
Asara, J.M.8
Lane, W.S.9
Kaelin Jr., W.G.10
-
25
-
-
0035917808
-
2-regulated prolyl hydroxylation
-
2-regulated prolyl hydroxylation. Science. 292:2001;468-472
-
(2001)
Science
, vol.292
, pp. 468-472
-
-
Jaakkola, P.1
Mole, D.R.2
Tian -., Y.M.3
Wilson, M.I.4
Geilbert, J.5
Gaskell, S.J.6
Von Kriegsheim, A.7
Hebestreit, H.F.8
Mukherji, M.9
Schofield, C.J.10
Maxwell, P.H.11
Pugh, C.W.12
Ratcliffe, P.J.13
-
26
-
-
0030659531
-
V-src induces expression of hypoxia-inducible factor 1 (HIF-1) and transcription of genes encoding VEGF and enolase 1: Involvement of HIF-1 in tumor progression
-
Jiang B.-.H., Agani F., Passaniti A., Semenza G.L. V-src induces expression of hypoxia-inducible factor 1 (HIF-1) and transcription of genes encoding VEGF and enolase 1. involvement of HIF-1 in tumor progression Cancer Res. 57:1997;5328-5335
-
(1997)
Cancer Res
, vol.57
, pp. 5328-5335
-
-
Jiang -., B.H.1
Agani, F.2
Passaniti, A.3
Semenza, G.L.4
-
27
-
-
0037374289
-
Regulation of colon carcinoma cell invasion by hypoxia-inducible factor 1
-
Krishnamachary B., Berg-Dixon S., Kelly B., Agani F., Feldser D., Ferreira G., Iyer N., LaRusch J., Pak B., Taghavi P., Semenza G.L. Regulation of colon carcinoma cell invasion by hypoxia-inducible factor 1. Cancer Res. 63:2003;1138-1143
-
(2003)
Cancer Res
, vol.63
, pp. 1138-1143
-
-
Krishnamachary, B.1
Berg-Dixon, S.2
Kelly, B.3
Agani, F.4
Feldser, D.5
Ferreira, G.6
Iyer, N.7
Larusch, J.8
Pak, B.9
Taghavi, P.10
Semenza, G.L.11
-
28
-
-
0034529914
-
Suppression of tumor growth through disruption of hypoxia-inducible transcription
-
Kung A.L., Wang S., Klco J.M., Kaelin W.G., Livingston D.M. Suppression of tumor growth through disruption of hypoxia-inducible transcription. Nature Med. 6:2000;1335-1340
-
(2000)
Nature Med
, vol.6
, pp. 1335-1340
-
-
Kung, A.L.1
Wang, S.2
Klco, J.M.3
Kaelin, W.G.4
Livingston, D.M.5
-
29
-
-
0037337763
-
Oxygen-dependent regulation of hypoxia-inducible factors by prolyl and asparaginyl hydroxylation
-
Lando D., Gorman J.J., Whitelaw M.L., Peet D.J. Oxygen-dependent regulation of hypoxia-inducible factors by prolyl and asparaginyl hydroxylation. Eur J Biochem. 270:2003;781-790
-
(2003)
Eur J Biochem
, vol.270
, pp. 781-790
-
-
Lando, D.1
Gorman, J.J.2
Whitelaw, M.L.3
Peet, D.J.4
-
30
-
-
0035012605
-
HER2 (neu) signaling increases the rate of hypoxia-inducible factor 1alpha (HIF-1alpha) synthesis: Novel mechanism for HIF-1-mediated vascular endothelial growth factor expression
-
Laughner E., Taghavi P., Chiles K., Mahon P.C., Semenza G.L. HER2 (neu) signaling increases the rate of hypoxia-inducible factor 1alpha (HIF-1alpha) synthesis. novel mechanism for HIF-1-mediated vascular endothelial growth factor expression Mol Cell Biol. 21:2001;3995-4004
-
(2001)
Mol Cell Biol
, vol.21
, pp. 3995-4004
-
-
Laughner, E.1
Taghavi, P.2
Chiles, K.3
Mahon, P.C.4
Semenza, G.L.5
-
31
-
-
0035887011
-
FIH-1: A novel protein that interacts with hif-1α and VHL to mediate repression of HIF-1 transcriptional activity
-
Mahon P.C., Hirota K., Semenza G.L. FIH-1. a novel protein that interacts with hif-1α and VHL to mediate repression of HIF-1 transcriptional activity Genes Dev. 15:2001;2675-2686
-
(2001)
Genes Dev
, vol.15
, pp. 2675-2686
-
-
Mahon, P.C.1
Hirota, K.2
Semenza, G.L.3
-
32
-
-
0030816109
-
Hypoxia-inducible factor-1 modulates gene expression in solid tumors and influences both angiogenesis and tumor growth
-
Maxwell P.H., Dachs G.U., Gleadle J.M., Nicholls L.G., Harris A.L., Stratford I.J., Hankinson O., Pugh C.W., Ratcliffe P.J. Hypoxia-inducible factor-1 modulates gene expression in solid tumors and influences both angiogenesis and tumor growth. Proc Natl Acad Sci USA. 94:1997;8104-8109
-
(1997)
Proc Natl Acad Sci USA
, vol.94
, pp. 8104-8109
-
-
Maxwell, P.H.1
Dachs, G.U.2
Gleadle, J.M.3
Nicholls, L.G.4
Harris, A.L.5
Stratford, I.J.6
Hankinson, O.7
Pugh, C.W.8
Ratcliffe, P.J.9
-
33
-
-
0033587146
-
The tumur suppressor protein VHL targets hypoxia inducible factors for oxygen-dependent proteolysis
-
Maxwell P.H., Wiesener M.S., Chang G.-.W., Clifford S.C., Vaux E.C., Cockman M.E., Wycoff C.C., Pugh C.W., Maher E.R., Ratcliffe P.J. The tumur suppressor protein VHL targets hypoxia inducible factors for oxygen-dependent proteolysis. Nature. 399:1999;271-275
-
(1999)
Nature
, vol.399
, pp. 271-275
-
-
Maxwell, P.H.1
Wiesener, M.S.2
Chang -., G.W.3
Clifford, S.C.4
Vaux, E.C.5
Cockman, M.E.6
Wycoff, C.C.7
Pugh, C.W.8
Maher, E.R.9
Ratcliffe, P.J.10
-
34
-
-
0035877163
-
Hypoxia-inducible factor 1-mediated inhibition of peroisome proliferator-activated receptor α expression during hypoxia
-
Narravula S., Colgan S.P. Hypoxia-inducible factor 1-mediated inhibition of peroisome proliferator-activated receptor α expression during hypoxia. J Immunol. 166:2001;7543-7548
-
(2001)
J Immunol
, vol.166
, pp. 7543-7548
-
-
Narravula, S.1
Colgan, S.P.2
-
35
-
-
0034307112
-
A confirmatory prognostic study on oxygenation status and regional control in advanced head and neck squamous cell carcinoma treated by radiation therapy
-
Nordsmark M., Overgaard J. A confirmatory prognostic study on oxygenation status and regional control in advanced head and neck squamous cell carcinoma treated by radiation therapy. Radiother Oncol. 57:2000;39-43
-
(2000)
Radiother Oncol
, vol.57
, pp. 39-43
-
-
Nordsmark, M.1
Overgaard, J.2
-
36
-
-
0027261178
-
Oxygen tension distributions are sufficient to explain the local response of human breast tumors treated with radiation alone
-
Okunieff P., Hoeckel M., Dunphy E.P., Schlenger K., Knoop C., Vaupel P. Oxygen tension distributions are sufficient to explain the local response of human breast tumors treated with radiation alone. Int J Radiat Oncol Biol Phys. 26:1993;631-636
-
(1993)
Int J Radiat Oncol Biol Phys
, vol.26
, pp. 631-636
-
-
Okunieff, P.1
Hoeckel, M.2
Dunphy, E.P.3
Schlenger, K.4
Knoop, C.5
Vaupel, P.6
-
37
-
-
0028867912
-
Importance of P450 reductase activity in determining sensitivity of breast tumor cells to the bioreductive drug, tirapazamine (SR 4233)
-
Patterson A.V., Barham H.M., Chinje E.C., Adams G.E., Harris A.L., Stratford I.J. Importance of P450 reductase activity in determining sensitivity of breast tumor cells to the bioreductive drug, tirapazamine (SR 4233). Br J Cancer. 72:1995;1144-1150
-
(1995)
Br J Cancer
, vol.72
, pp. 1144-1150
-
-
Patterson, A.V.1
Barham, H.M.2
Chinje, E.C.3
Adams, G.E.4
Harris, A.L.5
Stratford, I.J.6
-
38
-
-
0030692717
-
Overexpression of human NADPH: Cytochrome c (p450) reductase confers enhanced sensitivity to both tirapazamine (sr4233) and rsu1069
-
Patterson A.V., Saunders M., Chinje E.C., Talbot D.C., Harris A.L., Stratford I.J. Overexpression of human NADPH. cytochrome c (p450) reductase confers enhanced sensitivity to both tirapazamine (sr4233) and rsu1069 Br J Cancer. 76:1997;1338-1347
-
(1997)
Br J Cancer
, vol.76
, pp. 1338-1347
-
-
Patterson, A.V.1
Saunders, M.2
Chinje, E.C.3
Talbot, D.C.4
Harris, A.L.5
Stratford, I.J.6
-
39
-
-
0036328116
-
Oxygen-sensitive enzyme-prodrug gene therapy for the eradication of radiation-resistant solid tumors
-
Patterson A.V., Williams K.J., Cowen R.L., Jaffar M., Telfer B.A., Saunders M., Airley R., Honess D., van der Kogel A.J., Wolf C.R., Stratford I.J. Oxygen-sensitive enzyme-prodrug gene therapy for the eradication of radiation-resistant solid tumors. Gene Ther. 9:2002;946-954
-
(2002)
Gene Ther
, vol.9
, pp. 946-954
-
-
Patterson, A.V.1
Williams, K.J.2
Cowen, R.L.3
Jaffar, M.4
Telfer, B.A.5
Saunders, M.6
Airley, R.7
Honess, D.8
Van Der Kogel, A.J.9
Wolf, C.R.10
Stratford, I.J.11
-
40
-
-
0032801526
-
Comparisons among pimonidazole binding, oxygen electrode measurements, and radiation response in C3H mouse tumors
-
Raleigh J.A., Chou S.C., Arteel G.E., Horsman M.R. Comparisons among pimonidazole binding, oxygen electrode measurements, and radiation response in C3H mouse tumors. Radiat Res. 151:1999;580-589
-
(1999)
Radiat Res
, vol.151
, pp. 580-589
-
-
Raleigh, J.A.1
Chou, S.C.2
Arteel, G.E.3
Horsman, M.R.4
-
41
-
-
0036682284
-
Identification of small molecule inhibitors of hypoxia-inducible factor 1 transcriptional activation pathway
-
Rapisarda A., Uranchimeg B., Scudiero D.A., Selby M., Sausville E.A., Shoemaker R.H., Melillo G. Identification of small molecule inhibitors of hypoxia-inducible factor 1 transcriptional activation pathway. Cancer Res. 62:2002;4316-4324
-
(2002)
Cancer Res
, vol.62
, pp. 4316-4324
-
-
Rapisarda, A.1
Uranchimeg, B.2
Scudiero, D.A.3
Selby, M.4
Sausville, E.A.5
Shoemaker, R.H.6
Melillo, G.7
-
42
-
-
0033954247
-
Regulation of tumor angiogenesis by p53-induced degradation of hypoxia-inducible factor 1α
-
Ravi R., Mookerjee B., Bhujwalla Z.M., Hayes Sutter C., Artemov D., Zeng Q., Dillehay L.E., Madan A., Semenza G.L., Bedi A. Regulation of tumor angiogenesis by p53-induced degradation of hypoxia-inducible factor 1α Genes Dev. 14:2000;34-44
-
(2000)
Genes Dev
, vol.14
, pp. 34-44
-
-
Ravi, R.1
Mookerjee, B.2
Bhujwalla, Z.M.3
Hayes Sutter, C.4
Artemov, D.5
Zeng, Q.6
Dillehay, L.E.7
Madan, A.8
Semenza, G.L.9
Bedi, A.10
-
43
-
-
0032725554
-
P42/p44 mitogen-activated protein kinases phosphorylate hypoxia-inducible factor 1α (HIF-1α) and enhance the transcriptional activity of HIF-1
-
Richard D.E., Berra E., Gothie E., Roux D., Pouyssegur J. P42/p44 mitogen-activated protein kinases phosphorylate hypoxia-inducible factor 1α (HIF-1α) and enhance the transcriptional activity of HIF-1. J Biol Chem. 274:1999;32631-32637
-
(1999)
J Biol Chem
, vol.274
, pp. 32631-32637
-
-
Richard, D.E.1
Berra, E.2
Gothie, E.3
Roux, D.4
Pouyssegur, J.5
-
44
-
-
0032100732
-
HIF-1α is required for solid tumor formation and embryonic vascularisation
-
Ryan H.E., Lo J., Johnson R.S. HIF-1α is required for solid tumor formation and embryonic vascularisation. EMBO J. 17:1998;3005-3015
-
(1998)
EMBO J
, vol.17
, pp. 3005-3015
-
-
Ryan, H.E.1
Lo, J.2
Johnson, R.S.3
-
45
-
-
0033870727
-
Hypoxia-inducible factor-1alpha is a positive factor in solid tumor growth
-
Ryan H.E., Poloni M., McNulty W., Elson D., Gassmann M., Arbeit J.M., Johnson R.S. Hypoxia-inducible factor-1alpha is a positive factor in solid tumor growth. Cancer Res. 60:2000;4010-4015
-
(2000)
Cancer Res
, vol.60
, pp. 4010-4015
-
-
Ryan, H.E.1
Poloni, M.2
McNulty, W.3
Elson, D.4
Gassmann, M.5
Arbeit, J.M.6
Johnson, R.S.7
-
46
-
-
0037515549
-
Caro Jaime. MAPK signaling up-regulates the activity of hypoxia-inducible factors by its effects on p300
-
Sang N., Stiehl D.P., Bohensky J., Leshchinsky I., Srinivas V. Caro Jaime. MAPK signaling up-regulates the activity of hypoxia-inducible factors by its effects on p300. J Biol Chem. 278:2003;14013-14019
-
(2003)
J Biol Chem
, vol.278
, pp. 14013-14019
-
-
Sang, N.1
Stiehl, D.P.2
Bohensky, J.3
Leshchinsky, I.4
Srinivas, V.5
-
47
-
-
0030871773
-
Tirapazamine-induced cytotoxicity and DNA damage in transplanted tumors: Relationship to tumor hypoxia
-
Siim B., Menke D.R., Dorie M.J., Brown J.M. Tirapazamine-induced cytotoxicity and DNA damage in transplanted tumors. relationship to tumor hypoxia Cancer Res. 57:1997;2922-2928
-
(1997)
Cancer Res
, vol.57
, pp. 2922-2928
-
-
Siim, B.1
Menke, D.R.2
Dorie, M.J.3
Brown, J.M.4
-
48
-
-
0035884701
-
HIF-1 dependent regulation of hypoxic induction of the cell death factors BNIP3 and NIX in human tumors
-
Sowter H.M., Ratcliffe P.J., Watson P., Greenberg A.H., Harris A.L. HIF-1 dependent regulation of hypoxic induction of the cell death factors BNIP3 and NIX in human tumors. Cancer Res. 61:2001;6669-6673
-
(2001)
Cancer Res
, vol.61
, pp. 6669-6673
-
-
Sowter, H.M.1
Ratcliffe, P.J.2
Watson, P.3
Greenberg, A.H.4
Harris, A.L.5
-
49
-
-
0003874399
-
-
Vaupel and Kelleher editors. Wissenschaftliche Verlagsgesellschaft mbH Stuttgart.
-
Stratford IJ, Patterson AV, Dachs GU, Telfer B, Williams KJ. Hypoxia-mediated gene expression Tumor Hypoxia: Pathophysiology, clinical significance and therapeutic perspectives. Vaupel and Kelleher editors. Wissenschaftliche Verlagsgesellschaft mbH Stuttgart. 1999. p. 107-13.
-
(1999)
Hypoxia-mediated Gene Expression Tumor Hypoxia: Pathophysiology, Clinical Significance and Therapeutic Perspectives
, pp. 107-113
-
-
Stratford, I.J.1
Patterson, A.V.2
Dachs, G.U.3
Telfer, B.4
Williams, K.J.5
-
50
-
-
0035003528
-
Gene transfer of antisense hypoxia-inducible factor-1α enhances the therapeutic efficacy of cancer immunotherapy
-
Sun X., Kanwar J.R., Leung E., Lehnert K., Wang D., Krissansen G.W. Gene transfer of antisense hypoxia-inducible factor-1α enhances the therapeutic efficacy of cancer immunotherapy. Gene Ther. 8:2000;638-645
-
(2000)
Gene Ther
, vol.8
, pp. 638-645
-
-
Sun, X.1
Kanwar, J.R.2
Leung, E.3
Lehnert, K.4
Wang, D.5
Krissansen, G.W.6
-
51
-
-
0019349297
-
Classification of antineoplastic agents by their selective toxicities toward oxygenated and hypoxic tumor cells
-
Teicher B.A., Lazo J.S., Sartorelli A.C. Classification of antineoplastic agents by their selective toxicities toward oxygenated and hypoxic tumor cells. Cancer Res. 41:1981;73-81
-
(1981)
Cancer Res
, vol.41
, pp. 73-81
-
-
Teicher, B.A.1
Lazo, J.S.2
Sartorelli, A.C.3
-
52
-
-
0028307739
-
Hypoxia and drug resistance
-
Teicher B.A. Hypoxia and drug resistance. Cancer Metastasis Rev. 13:1994;39-68
-
(1994)
Cancer Metastasis Rev
, vol.13
, pp. 39-68
-
-
Teicher, B.A.1
-
53
-
-
0038282482
-
The hypoxia-inducible factor-1α is a negative factor for tumor therapy
-
Unruh A., Ressel A., Mohamed H.G., Johnson R.S., Nadrowitz R., Richter E., Katschinski D.M., Wenger R.H. The hypoxia-inducible factor-1α is a negative factor for tumor therapy. Oncogene. 22:2003;3213-3220
-
(2003)
Oncogene
, vol.22
, pp. 3213-3220
-
-
Unruh, A.1
Ressel, A.2
Mohamed, H.G.3
Johnson, R.S.4
Nadrowitz, R.5
Richter, E.6
Katschinski, D.M.7
Wenger, R.H.8
-
54
-
-
0037365537
-
Regulation of the multidrug resistance transporter P-glycoprotein in multicellular tumor spheroids by hypoxia-inducible factor (HIF-1) and reactive oxygen species
-
Wartenberg M., Ling F.C., Muschen M., Klein F., Acker H., Gassmann M., Petrat K., Putz V., Hescheler J., Sauer H. Regulation of the multidrug resistance transporter P-glycoprotein in multicellular tumor spheroids by hypoxia-inducible factor (HIF-1) and reactive oxygen species. FASEB. 17:2003;503-505
-
(2003)
FASEB
, vol.17
, pp. 503-505
-
-
Wartenberg, M.1
Ling, F.C.2
Muschen, M.3
Klein, F.4
Acker, H.5
Gassmann, M.6
Petrat, K.7
Putz, V.8
Hescheler, J.9
Sauer, H.10
-
55
-
-
0037050215
-
A protective role for HIF-1 in response to redox manipulation and glucose deprivation: Implications for tumorigenesis
-
Williams K.J., Telfer B.A., Airley R.E., Peters H.P., Sheridan M.R., van der Kogel A.J., Harris A.L., Stratford I.J. A protective role for HIF-1 in response to redox manipulation and glucose deprivation. implications for tumorigenesis Oncogene. 21:2002;282-290
-
(2002)
Oncogene
, vol.21
, pp. 282-290
-
-
Williams, K.J.1
Telfer, B.A.2
Airley, R.E.3
Peters, H.P.4
Sheridan, M.R.5
Van Der Kogel, A.J.6
Harris, A.L.7
Stratford, I.J.8
-
56
-
-
0029888061
-
The role of the aryl hydrocarbon receptor nuclear translocator (ARNT) in hypoxic induction of gene expression
-
Wood S.M., Gleadle J.M., Pugh C.W., Hankinson O., Ratcliffe P.J. The role of the aryl hydrocarbon receptor nuclear translocator (ARNT) in hypoxic induction of gene expression. J Biol Chem. 271:1996;15117-15123
-
(1996)
J Biol Chem
, vol.271
, pp. 15117-15123
-
-
Wood, S.M.1
Gleadle, J.M.2
Pugh, C.W.3
Hankinson, O.4
Ratcliffe, P.J.5
-
57
-
-
0032478823
-
Selection and analysis of a mutant cell line defective in the hypoxia-inducible factor-1α-subunit (HIF-1α)
-
Wood S.M., Wiesener M.S., Yeates K.M., Okada N., Pugh C.W., Maxwell P.H., Ratcliffe P.J. Selection and analysis of a mutant cell line defective in the hypoxia-inducible factor-1α-subunit (HIF-1α). J Biol Chem. 273:1998;8360-8368
-
(1998)
J Biol Chem
, vol.273
, pp. 8360-8368
-
-
Wood, S.M.1
Wiesener, M.S.2
Yeates, K.M.3
Okada, N.4
Pugh, C.W.5
Maxwell, P.H.6
Ratcliffe, P.J.7
-
58
-
-
16744368637
-
United Kingdom Co-ordinating Committee on Cancer Research (UKCCCR) Guidelines for the Welfare of Animals in Experimental Neoplasia (Second Edition)
-
Workman P., Twentyman P., Balkwill F., Balmain A., Chaplin D., Double J., Embleton J., Newell D., Raymond R., Stables J., Stephens T., Wallace J. United Kingdom Co-ordinating Committee on Cancer Research (UKCCCR) Guidelines for the Welfare of Animals in Experimental Neoplasia (Second Edition). Br J Cancer. 77:1998;1-10
-
(1998)
Br J Cancer
, vol.77
, pp. 1-10
-
-
Workman, P.1
Twentyman, P.2
Balkwill, F.3
Balmain, A.4
Chaplin, D.5
Double, J.6
Embleton, J.7
Newell, D.8
Raymond, R.9
Stables, J.10
Stephens, T.11
Wallace, J.12
-
59
-
-
0037414180
-
YC-1: A potential anticancer drug targeting hypoxia-inducible factor 1
-
Yeo E.-.J., Chun Y.-.S., Cho Y.-.S., Kim J., Lee J.-.C., Kim M.-.S., Park J.-.W. YC-1. a potential anticancer drug targeting hypoxia-inducible factor 1 J Natl Cancer Inst. 95:2003;516-525
-
(2003)
J Natl Cancer Inst
, vol.95
, pp. 516-525
-
-
Yeo -., E.J.1
Chun -., Y.S.2
Cho -., Y.S.3
Kim, J.4
Lee -., J.C.5
Kim -., M.S.6
Park -., J.W.7
-
60
-
-
0010170555
-
Hypoxia induces DNA overreplication and enhances metastatic potential of murine tumor cells
-
Young S.D., Marshall R.S., Hill R.P. Hypoxia induces DNA overreplication and enhances metastatic potential of murine tumor cells. Proc Natl Acad Sci USA. 85:1988;9533-9537
-
(1988)
Proc Natl Acad Sci USA
, vol.85
, pp. 9533-9537
-
-
Young, S.D.1
Marshall, R.S.2
Hill, R.P.3
-
61
-
-
0033571682
-
Overexpression of hypoxia-inducible factor 1alpha in common human cancers and their metastases
-
Zhong H., De Marzo A.M., Laughner E., Lim M., Hilton D.A., Zagzag D., Buechler P., Isaacs W.B., Semenza G.L., Simons J.W. Overexpression of hypoxia-inducible factor 1alpha in common human cancers and their metastases. Cancer Res. 59:1999;5830-5835
-
(1999)
Cancer Res
, vol.59
, pp. 5830-5835
-
-
Zhong, H.1
De Marzo, A.M.2
Laughner, E.3
Lim, M.4
Hilton, D.A.5
Zagzag, D.6
Buechler, P.7
Isaacs, W.B.8
Semenza, G.L.9
Simons, J.W.10
-
62
-
-
0034050050
-
Loss of PTEN facilitates HIF-1-mediated gene expression
-
Zundel W., Schindler C., Haas-Kogan D., Koong A., Kaper F., Chen E., Gottschalk A.R., Ryan H.E., Johnson R.S., Jefferson A.B., Stokoe D., Giaccia A.J. Loss of PTEN facilitates HIF-1-mediated gene expression. Genes Dev. 15:2000;391-396
-
(2000)
Genes Dev
, vol.15
, pp. 391-396
-
-
Zundel, W.1
Schindler, C.2
Haas-Kogan, D.3
Koong, A.4
Kaper, F.5
Chen, E.6
Gottschalk, A.R.7
Ryan, H.E.8
Johnson, R.S.9
Jefferson, A.B.10
Stokoe, D.11
Giaccia, A.J.12
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