Mechanism for phosphorylation-induced activation of the phagocyte NADPH oxidase protein p47(phox). Triple replacement of serines 303, 304, and 328 with aspartates disrupts the SH3 domain-mediated intramolecular interaction in p47(phox), thereby activating the oxidase

Journal of Biological Chemistry

Volumn 274, Issue 47, 1999, Pages 33644-33653

  Ago, Tetsuro ^a   Nunoi, Hiroyuki ^b   Ito, Takashi ^c   Sumimoto, Hideki ^a  

^a KYUSHU UNIVERSITY   (Japan)

^b KUMAMOTO UNIV SCHOOL OF MEDICINE   (Japan)

^c UNIVERSITY OF TOKYO   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE;

AMINO ACID SUBSTITUTION; ARTICLE; BINDING SITE; CARBOXY TERMINAL SEQUENCE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME MECHANISM; GENE DISRUPTION; HUMAN; HUMAN CELL; MOLECULAR INTERACTION; PHAGOCYTE; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION;

AMINO ACID SUBSTITUTION; ENZYME ACTIVATION; HUMANS; K562 CELLS; MUTAGENESIS, SITE-DIRECTED; NADPH OXIDASE; PHAGOCYTES; PHOSPHOPROTEINS; PHOSPHORYLATION; PROTEIN BINDING; PROTEIN CONFORMATION; SRC HOMOLOGY DOMAINS;

EID: 0033585122     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.274.47.33644     Document Type: Article

References (51)

1. Pawson, T. (1995) Nature 373, 573-580
2. Cohen, G. B., Ren, R., and Baltimore, D. (1995) Cell 80, 237-248
3. Birge, R. B., and Hanafusa, H. (1993) Science 262, 1522-1524
4. Feng, S., Kasahara, C., Rickles, R. J., and Schreiber, S. L. (1995) Proc. Natl. Acad. Sci. U. S. A. 92, 12408-12415
5. Sumimoto, H., Kage, Y., Nunoi, H., Sasaki, H., Nose, T., Fukumaki, Y., Ohno, M., Minakami, S., and Takeshige, K. (1994) Proc. Natl. Acad. Sci. U. S. A. 91, 5345-5349
6. Leto, T. L., Adams, A. G., and de Mendez, I. (1994) Proc. Natl. Acad. Sci. U. S. A. 91, 10650-10654
7. Alexandropoulos, K., and Baltimore, D. (1996) Genes Dev. 10, 1341-1355
8. Park, H., Wahl, M. I., Afar, D. E. H., Turck, C. W., Rawlings, D. J., Tam, C., Scharenberg, A. M., Kinet, J.-P., and Witte, O. N. (1996) Immunity 4, 515-525
9. Andreotti, A. H., Bunnell, S. C., Feng, G., Berg, L. J., and Schreiber, S. L. (1997) Nature 375, 93-97
10. Hu, K.-Q., and Settleman, J. (1997) EMBO J. 16, 473-483
11. Moarefi, I., LaFevre-Bernt, M., Sicheri, F., Huse, M., Lee, C.-H., Kuriyan, J., and Miller, W. T. (1997) Nature 385, 650-653
12. Briggs, S. D., Sharkey, M., Stevenson, M., and Smithgall, T. E. (1997) J. Biol. Chem. 272, 17899-17902
13. Nguyen, J. T., and Lim, W. A. (1997) Nat. Struct. Biol. 4, 256-260
14. Wu, Y., Spencer, S. D., and Lasky, L. A. (1998) J. Biol. Chem. 273, 5766-5770
15. Lin, H., Hutchcroft, J. E., Andoniou, C. E., Kamoun, M., Band, H., and Bierer, B. E. (1998) J. Biol. Chem. 273, 19914-19921
16. Okkenhaug, K., and Rottapel, R. (1998) J. Biol. Chem. 273, 21194-21202
17. Smith, R. M., and Curnutte, J. T. (1991) Blood 77, 673-686
18. Chanock, S. J., el Benna, J., Smith, R. M., and Babior, B. M. (1994) J. Biol. Chem. 269, 24519-24522
19. Jones, O. T. G. (1994) BioEssays 16, 919-923
20. Roos, D., de Boer, M., Kuribayashi, F., Meischl, C., Weening, R. S., Segal, A. W., Åhlin, A., Nemet, K., Hossle, J. P., Bernatowska-Matuszkiewicz, E., and Middleton-Price, H. (1996) Blood 87, 1663-1681
21. DeLeo, F. R., and Quinn, M. T. (1996) J. Leukocyte Biol. 60, 677-691
22. Sumimoto, H., Ito, T., Hata, K., Mizuki, K., Nakamura, R., Kage, Y., Sakaki, Y., Nakamura, M., and Takeshige, K. (1997) in Membrane Proteins: Structure, Function, and Expression Control (Hamasaki, N., and Mihara, K., eds) pp. 235-245, Kyushu University Press, Fukuoka/S Karger AG, Basel
23. Leusen, J. H. W., Bolscher, B. G. J. M., Hilarius, P. M., Weening, R. S., Kaulfersch, W., Segar, R. A., Roos, D., and Verhoeven, A. J. (1994) J. Exp. Med. 180, 2329-2334
24. Sumimoto, H., Hata, K., Mizuki, K., Ito, T., Kage, Y., Sakaki, Y., Fukumaki, Y., Nakamura, M., and Takeshige, K. (1996) J. Biol. Chem. 271, 22152-22158
25. de Mendez, I., Homayounpour, N., and Leto, T. L. (1997) Mol. Cell. Biol. 17, 2177-2185
26. Hata, K., Ito, T., Takeshige, K., and Sumimoto, H. (1998) J. Biol. Chem. 273, 4232-4236
27. Bromberg, Y., and Pick, E. (1985) J. Biol. Chem. 260, 13539-13545
28. Swain, S. D., Helgerson, S. L., Davis, A. R., Nelson, L. K., and Quinn, M. T. (1997) J. Biol. Chem. 272, 29502-29510
29. Segal, A. W. P., Heyworth, S., Cockcroft, S., and Barrowman, M. M. (1985) Nature 316, 547-549
30. Okamura, N., Curnutte, J. T., Roberts, R. L., and Babior, B. M. (1988) J. Biol. Chem. 263, 6777-6782
31. Rotrosen, D., and Leto, T. L. (1990) J. Biol. Chem. 265, 19910-19915
32. el Benna, J., Faust, L. P., and Babior, B. M. (1994) J. Biol. Chem. 269, 23431-23436
33. Inanami, O., Johnson, J. L., McAdara, J. K., el Benna, J., Faust, L. P., Newburrger, P. E., and Babior, B. M. (1998) J. Biol. Chem. 273, 9539-9543
34. Cowley, S., Paterson, H., Kemp, P., and Marshall, C. J. (1994) Cell 77, 841-852
35. Diaz, B., Barnard, D., Filson, A., MacDonald, S., King, A., and Marshall, M. (1997) Mol. Cell. Biol. 17, 4509-4516
36. Huang, L., Wong, T. Y. W., Lin, R. C. C., and Furthmayr, H. (1999) J. Biol. Chem. 274, 12803-12810
37. Ito, T., Nakamura, R., Sumimoto, H., Takeshige, K., and Sakaki, Y. (1996) FEBS Lett. 385, 229-232
38. Sugimoto, Y., Aksentijevich, I., Gottesman, M. M., and Pastan, I. (1994) Bio/Technology 12, 694-698
39. de Mendez, I., Adams, A. G., Sokolic, R. A., Malech, H. L., and Leto, T. L. (1996) EMBO J. 15, 1211-1220
40. Nakamura, M., Murakami, M., Koga, T., Tanaka, Y., and Minakami, S. (1987) Blood 69, 1404-1408
41. Iwata, M., Nunoi, H., Matsuda, I., Kanegasaki, S., Tsuruo, T., and Sugimoto, Y. (1998) Hum. Genet. 103, 419-423
42. Mizuki, K., Kadomatsu, K., Hata, K., Ito, T., Fan, Q.-W., Kage, Y., Fukumaki, Y., Sakaki, Y., Takeshige, K., and Sumimoto, H. (1998) Eur. J. Biochem. 251, 573-582
43. Feng, S., Chen, J. K., Yu, H., Simon, J. A., and Schreiber, S. L. (1994) Science 266, 1241-1247
44. Lim, W. A., Richards, F. M., and Fox, R. O. (1994) Nature 372, 375-379
45. Terasawa, H., Kohda, D., Hatanaka, H., Tsuchiya, S., Ogura, K., Nagata, K., Ishii, S., Mandiyan, V., Ullrich, A., Schlessinger, J., and Inagaki, F. (1994) Nat. Struct. Biol. 1, 891-897
46. Wittekind, M., Mapelli, C., Farmer, B. T., II, Suen, K.-L., Goldfarb, V., Tsao, J., Lavoie, T., Barbacid, M., Meyers, C. A., and Mueller, L. (1994) Biochemistry 33, 13531-13539
47. el Benna, J., Faust, L. P., Johnson, J. L., and Babior, B. M. (1996) J. Biol. Chem. 271, 6374-6378
48. el Benna, J., Han, J., Park, J.-W., Schmid, E., Ulevitch, R. J., and Babior, B. M. (1996) Arch. Biochem. Biophys. 334, 395-400
49. Xu, W., Harrison, S. C., and Eck, M. J. (1997) Nature 385, 595-602
50. Sicheri, F., Moarefi, I., and Kuriyan, J. (1997) Nature 385, 602-609
51. Johnson, J. L., Park, J.-W., el Benna, J., Faust, L. P., Inanami, O., and Babior, B. M. (1998) J. Biol. Chem. 273, 35147-35152