Paclitaxel induces primary and postmitotic G1 arrest in human arterial smooth muscle cells

Cell Cycle

Volumn 3, Issue 8, 2004, Pages 1048-1054

  Blagosklonny, Mikhail V ^a   Darzynkiewicz, Zbigniew ^a   Halicka, H Dorota ^a   Pozarowski, Piotr ^a   Demidenko, Zoya N ^a   Barry, James J ^b   Kamath, Kalpana R ^b   Herrmann, Robert A ^b  

^a NEW YORK MEDICAL COLLEGE   (United States)

^b BOSTON SCIENTIFIC CORPORATION   (United States)

Author keywords

Apoptosis; Cell cycle; Human coronary artery smooth muscle cells; Paclitaxel; Restenosis

Indexed keywords

CASPASE; PACLITAXEL; PROTEIN P21;

APOPTOSIS; ARTERY MUSCLE; ARTICLE; CELL CYCLE G1 PHASE; CELL DEATH; CELL PROLIFERATION; CELL STRUCTURE; CELL VIABILITY; CONTROLLED STUDY; CORONARY ARTERY; CYTOKINESIS; DIPLOIDY; DNA CONTENT; DRUG EFFECT; HUMAN; HUMAN CELL; MITOSIS; MITOSIS INHIBITION; MULTINUCLEAR CELL; PROTEIN EXPRESSION; SMOOTH MUSCLE FIBER; TETRAPLOIDY;

EID: 9644258011     PISSN: 15384101     EISSN: 15514005     Source Type: Journal    
DOI: 10.4161/cc.3.8.986     Document Type: Article

References (55)

1. Kuntz RE, Baim DS. Prevention of coronary restenosis. The evolving evidence base for radiation therapy. Circulation 2000; 101:2130-3.
2. Sousa JE, Costa MA, Sousa AG, Abizaid AC, Seixas AC, Abizaid AS, Feres F, Mattos LA, Falotico R, Jaeger J, Popma JJ, Serruys PW. Two-year angiographic and intravascular ultrasound follow-up after implantation of sirolimus-eluting stents in human coronary arteries. Circulation 2003; 107:381-3.
3. Axel DI, Kunert W, Goggelmann C, Oberhoff M, Herdeg C, Kuttner A, Wild DH, Brehm BR, Riessen R, Koveker G, Karsch KR. Paclitaxel inhibits arterial smooth muscle cell proliferation and migration in vitro and in vivo using local drug delivery. Circulation 1997; 96:636-45.
4. Garza L, Aude YW, Saucedo JF. Can we prevent in-stent restenosis? Curr Opin Cardiol 2002; 17:518-25.
5. Grube E, Silber S, Hauptmann KE, Mueller R, Buellesfeld L, Gerckens U, Russell ME. TAXUS I: Six- and twelve-month results from a randomized, double-blind trial on a slow-release PTX-eluting stent for de novo coronary lesions. Circulation 2003; 107:38-42.
6. Ferguson JE, Patterson C. Break the cycle: The role of cell-cycle modulation in the prevention of vasculoproliferative diseases. Cell Cycle 2003; 2:211-9.
7. Park SJ, Shim WH, Ho DS, Raizner AE, Park SW, Hong MK, Lee CW, Choi D, Jang Y, Lam R, Weissman NJ, Mintz GS. A paclitaxel-eluting stent for the prevention of coronary restenosis. N Engl J Med 2003; 348:1537-45.
8. Rowinsky EK, Donehower RC. Paclitaxel (Taxol). N Engl J Med 1995; 332:1004-14.
9. Rowinsky EK. Update on the antitumor activity of PTX in clinical trials. Ann Pharmacother 1994; 28:S18-22.
10. Abal M, Andreu JM, Barasoain I. Taxanes: Microtubule and centrosome targets, and cell cycle dependent mechanisms of action. Curr Cancer Drug Targets 2003; 3:193-203.
11. Jordan MA, Toso RJ, Thrower D, Wilson L. Mechanism of mitotic block and inhibition of cell proliferation by taxol at low concentrations. Proc Natl Acad Sci USA 1993; 90:9552-6.
12. Jordan MA, Wilson L. Microtubules and actin filaments: Dynamic targets for cancer chemotherapy. Curr Opin Cell Biol 1998; 10:123-30.
13. Schiff PB, Horwitz SB. Taxol stabilizes microtubules in mouse fibroblast cells. Proc Natl Acad Sci USA 1980; 77:1561-5.
14. 1 phase by interference with spindle formation without affecting other microtubule functions during anaphase and telephase. Cancer Res 1994; 54:4355-61.
15. Goncalves A, Braguer D, Carles G, Andre N, Prevot C, Briand C. Caspase-8 activation independent of CD95/CD95-L interaction during paclitaxel-induced apoptosis in human colon cancer cells (HT29-D4). Biochem Pharmacol 2000; 60:1579-84.
16. Donaldson KL, Goolsby G, Kiener PA, Wahl AF. Activation of p34cdc coincident with taxol-induced apoptosis. Cell Growth Diff 1994; 5:1041-50.
17. Kung AL, Sherwood SW, Schimke RT. Cell line-specific differences in control of cell cycle progression in the absence of mitosis. Proc Natl Acad Sci USA 1990; 87:9553-7.
18. Woods CM, Zhu J, McQueney PA, Bollag D, Lazarides E. Taxol-induced mitotic block triggers rapid onset of a p53-independent apoptotic pathway. Mol Medicine 1995; 1:506-26.
19. Ling Y-H, YY, Tornos C, Singh B, Perez-Soler R. Paclitaxel-induced apoptosis is associated with expression and activation of c-Mos gene product in human ovarian carcinoma SKOV3 cells. Cancer Res 1998; 58:3633-40.
20. Bhalla KN. Microtubule-targeted anticancer agents and apoptosis. Oncogene 2003; 22:9075-86.
21. Li X, Gong J, Feldman E, Seiter K, Traganos F, Darzynkiewicz Z. Apoptotic cell death during treatment of leukemias. Leuk Lymphoma 1994; 13:65-70.
22. Perkins CL, Fang G, Kim CN, Bhalla KN. The role of Apaf-1, caspase-9, and bid proteins in etoposide- or paclitaxel-induced mitochondrial events during apoptosis. Cancer Res 2000; 60:1645-53.
23. Blagosklonny MV, Chuman Y, Bergan RC, Fojo T. Mitogen activated protein kinase pathway is dispensible for microtubule-active drug-induced Raf-1/Bcl-2 phosphorylation and apoptosis in leukemia cells. Leukemia 1999; 13:1028-36.
24. 2 cell cycle arrest instead of mitotic arrest: Molecular determinants of PTX-induced cytoroxicity. Oncogene 2001; 20:3806-13.
25. Torres K, Horwitz SB. Mechanisms of Taxol-induced cell death are concentration dependent. Cancer Res 1998; 58:3620-6.
26. Blagosklonny MV, Schulte TW, Nguyen P, Mimnaugh EG, Trepel J, Neckers L. Taxol induction of p21waf1 and p53 requires c-raf-1. Cancer Res 1995; 55:4623-6.
27. Tishler RB, Lamppu DM, Park S, Price BD. Microtubule-accive drugs, Taxol, vinblastine and nocodazole increase the levels of transcriptionally active p53. Cancer Res 1995; 55:6021-5.
28. Casenghi M, Mangiacasale R, Tuynder M, Caillet-Fauquet P, Elhajouji A, Lavia P, Mousset S, Kirsch-Volders M, Cundaci E. p53-independent apoptosis and p53-dependent block of DNA rereplication following mitotic spindle inhibition in human cells. Exp Cell Res 1999; 250:339-50.
29. 2/M arrest and apoptosis. Nat Med 1996; 2:724-5.
30. Kasai T, Iwanaga Y, Iha H, Jeang KT. Prevalent loss of mitotic spindle checkpoint in adult T-cell leukemia confers resistance to microtubule inhibitors. J Biol Chem 2002; 277:5187-93.
31. Anand S, Penrhyn-Lowe S, Venkitaraman AR. AURORA-A amplification overrides the mitotic spindle assembly checkpoint, inducing resistance to Taxol. Cancer Cell 2003; 3:51-62.
32. Giannakakou P, Nakano M, Nicolaou KC, O'Brate A, Yu J, Blagosklonny MV, Greber UF, Fojo T. Enhanced micro tubule-dependent trafficking and p53 nuclear accumulation by suppression of microtubule dynamics. Proc Nail Acad Sci USA 2002; 99:10855-60.
33. WAF1/CIP1, and induction of apoptosis are independent markers of proteosome inhibition. Leukemia 2000; 14:1276-83.
34. Panvichian R, Orth K, Day ML, Day KC, Pilat MJ, Pienta KJ. Paclitaxel-associated multimininucleation is permitted by the inhibition of caspase activation: A potential early step in drug resistance. Cancer Res 1998; 58:4667-72.
35. Merlin JL, Bour-Dill C, Marchal S, Bastien L, Gramain MP. Resistance to paclitaxel induces time-delayed multinucleation and DNA fragmentation into large fragments in MCF-7 human breast adenocarcinoma cells. Anti-Cancer Drugs 2000; 11:295-302.
36. Broker LE, Huisman C, Ferreira CG, Rodriguez JA, Kruyt FAE, Giaccone G. Late activation of apoptotic pathways plays a negligible role in mediating the cytotoxic effects of discodermolide and epothilone B in nonsmall cell lung cancer cells. Cancer Res 2002; 62:4031-3.
37. Blagosklonny MV, Robey R, Sheikh MS, Fojo T. Paclitaxel-induced FasL-independent apoptosis and slow (nonapoptotic) cell death. Cancer Biol Ther 2002; 1:113-7.
38. Roberts JR, Allison DC, Donehower RC, Rowinsky EK. Development of polyploidization in taxol resistant human leukemia cells in vitro. Cancer Res 1990; 50:710-6.
39. Weitzel DH, Vandre DD. Differential spindle assembly checkpoint response in human lung adenocarcinoma cells. Cell Tissue Res 2000; 300:57-65.
40. Lanzi C, Cassinelli G, Cuccuru G, Supino R, Zuco V, Ferlini C, Scambia G, Zunino F. Cell cycle checkpoint efficiency and cellular response to paclitaxel in prostate cancer cells. Prostate 2001; 48:254-64.
41. Cross SM, Sanchez CA, Morgan CA, Schimke MK, Ramel S, Idzerda RL, Raskind WH, Reid BJ. A p53-dependent mouse spindle checkpoint. Science 1995; 267:1353-6.
42. Lanni JS, Jacks T. Characterization of the p53-dependent postmitotic checkpoint following spindle disruption. Mol Cell Biol 1998; 18:1055-1064.
43. 1 phase microtubule integrity and is crucial for restriction point transition. Cell Cycle 2002; 1:327-36.
44. Sablina AA, Ilyinskaya GV, Rubtsova SN, Agapova LS, Chumakov PM, Kopnin BP. Activation of p53-mediated cell cycle checkpoint in response to micronuclei formation. J Cell Sci 1998; 111:977-84.
45. 1. Mol Biol Cell 2001; 12:1315-28.
46. 2-M arrest and apoptosis induced by PTX in human sarcoma cells lacking both p53 and functional Rb protein. Mol Pharmacol 1999; 55:1088-93.
47. Heliez C, Baricault L, Barboule N, Valette A. Paclitaxel increases p21 synthesis and accumulation of its AKT-phosphorylated form in the cytoplasm of cancer cells. Oncogene 2003;22:3260-8.
48. Cip1, which inhibits p34Cdc2 kinase. Mol Cell 1998; 2:581-91.
49. Hixon ML, Gualberto A. Vascular smooth muscle polyploidization: From mitotic checkpoints to hypertension. Cell Cycle 2003; 2:105-10.
50. Devlin AM, Gordon JF, Davidson AO, Clark JS, Hamilton CA, Morton JJ, Campbell AM, Reid JL, Dominiczak AF. The effect of perindopril on vascular smooth muscle polyploidy in stroke-ptone spontaneously hypertensive rats. J Hypertens 1995; 13:211-8.
51. Engelmann G, Vitullo J, Gerrity R. Age-related changes in ploidy levels and biochemical parameters in cardiac myocvtes isolated from spontaneously hypertensive rats. Circ Res 1986; 58:137-47.
52. Brodsky W, Uryvaeva IV. Cell polyploidy. Its relation to tissue growth and function. Int Rev Cytol 1977; 50:275-332.
53. Owens GK. Control of hypertrophic versus hyperplastic growth of vascular smooth muscle cells. Am J Physiol 1989; 257:H1755-H65.
54. Barrett TB, Sampson P, Owens GK, Schwartz SM, Benditt EP. Polyploid nuclei in human artery wall smooth muscle cells. Proc Natl Acad Sci USA 1983; 80:882-5.
55. Galitski T, Saldanha AJ, Styles CA, Lander ES, Fink GR. Ploidy regulation of gene expression. Science 1999; 285:251-4.