Six- and twelve-month results from a randomized, double-blind trial on a slow-release paclitaxel-eluting stent for de novo coronary lesions

Circulation

Volumn 107, Issue 1, 2003, Pages 38-42

  Grube, Eberhard ^a   Silber, Sigmund ^b   Hauptmann, Karl Eugen ^c   Mueller, Ralf ^a   Buellesfeld, Lutz ^a   Gerckens, Ulrich ^a   Russell, Mary E ^d  

^a Heart Center Siegburg   (Germany)

^b Klinik Dr Mueller   (Germany)

^c KRANKENHAUS DER BARMHERZIGEN BRÜDER   (Germany)

^d Heart Center Siegburg ^*

Author keywords

Coronary disease; Drugs; Restenosis; Revascularization; Stents

Indexed keywords

PACLITAXEL;

ADULT; AGED; ANGIOGRAPHY; ARTERY INTIMA PROLIFERATION; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CORONARY ARTERY DISEASE; DOUBLE BLIND PROCEDURE; DRUG SAFETY; DRUG TOLERANCE; FEASIBILITY STUDY; HUMAN; INTRAVASCULAR ULTRASOUND; MAJOR CLINICAL STUDY; MATERIAL COATING; PRIORITY JOURNAL; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL; RESTENOSIS; SLOW RELEASE FORMULATION; ANGIOCARDIOGRAPHY; COMPARATIVE STUDY; CORONARY ARTERY ATHEROSCLEROSIS; CORONARY ARTERY THROMBOSIS; CORONARY BLOOD VESSEL; DEMOGRAPHY; DRUG IMPLANT; ECHOGRAPHY; FEMALE; FOLLOW UP; MALE; MIDDLE AGED; MULTICENTER STUDY; STENT;

AGED; CORONARY ANGIOGRAPHY; CORONARY ARTERIOSCLEROSIS; CORONARY RESTENOSIS; CORONARY THROMBOSIS; CORONARY VESSELS; DEMOGRAPHY; DOUBLE-BLIND METHOD; DRUG IMPLANTS; FEASIBILITY STUDIES; FEMALE; FOLLOW-UP STUDIES; HUMANS; MALE; MIDDLE AGED; PACLITAXEL; STENTS;

EID: 0037422604     PISSN: 00097322     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.CIR.0000047700.58683.A1     Document Type: Article

References (12)

1. Drachman DE, Edelman ER, Seifert P, et al. Neointimal thickening after stent delivery of paclitaxel: change in composition and arrest of growth over six months. J Am Coll Cardiol. 2000;36:2325-2332.
2. Herdeg C, Oberhoff M, Baumbach A, et al. Local paclitaxel delivery for the prevention of restenosis: biological effects and efficacy in vivo. J Am Coll Cardiol. 2000;35:1969-1976.
3. Axel DI, Kunert W, Goggelmann C, et al. Paclitaxel inhibits arterial smooth muscle cell proliferation and migration in vitro and in vivo using local drug delivery. Circulation. 1997;96:636-645.
4. Giannakakou P, Robey R, Fojo T, et al. Low concentrations of paclitaxel induce cell type-dependent p53, p21 and G1/G2 arrest instead of mitotic arrest: molecular determinants of paclitaxel-induced cytotoxicity. Oncogene. 2001;20:3806-3813.
5. Hui A, Min WX, Tang J, et al. Inhibition of activator protein 1 activity by paclitaxel suppresses interleukin-1-induced collagenase and stromelysin expression by bovine chondrocytes. Arthritis Rheum. 1998;41:869-876.
6. Jackson JK, Tudan C, Sahl B, et al. Calcium pyrophosphate dihydrate crystals activate MAP kinase in human neutrophils: inhibition of MAP kinase, oxidase activation and degranulation responses of neutrophils by taxol. Immunology. 1997;90:502-510.
7. Belotti D, Vergani V, Drudis T, et al. The microtubule-affecting drug paclitaxel has antiangiogenic activity. Clin Cancer Res. 1996;2:1843-1849.
8. Hiatt B, Ikeno F, Yeung A, et al. Drug-eluting stents for the prevention of restenosis: in quest for the Holy Grail. Catheter Cardiovasc Interv. 2002;55:409-417.
9. Sousa JE, Costa MA, Abizaid A, et al. Lack of neointimal proliferation after implantation of sirolimus-coated stents in human coronary arteries: a quantitative coronary angiography and three-dimensional intravascular ultrasound study. Circulation. 2001;103:192-195.
10. Morice MC, Serruys PW, Sousa JE, et al, for the RAVEL Study Group. A randomized comparison of a sirolimus-eluting stent with a standard stent for coronary revascularization. N Engl J Med. 2002;346:1773-1780.
11. Liistro F, Colombo A. Late acute thrombosis after paclitaxel eluting stent implantation. Heart. 2001;86:262-264.
12. Liistro F, Stankovic G, Di Mario C, et al. First clinical experience with a paclitaxel derivate-eluting polymer stent system implantation for in-stent restenosis: immediate and long-term clinical and angiographic outcome. Circulation. 2002;105:1883-1886.