Paclitaxel inhibits arterial smooth muscle cell proliferation and migration in vitro and in vivo using local drug delivery

Circulation

Volumn 96, Issue 2, 1997, Pages 636-645

  Axel, Dorothea I ^a   Kunert, Wolfgang ^b   Göggelmann, Christoph ^b   Oberhoff, Martin ^b   Herdeg, Christian ^b   Küttner, Axel ^b   Wild, Doris H ^b   Brehm, Bernhard R ^b   Riessen, Reimer ^b   Köveker, Gerhard ^b   Karsch, Karl R ^b  

^a UNIVERSITY OF TÜBINGEN   (Germany)

^b NONE

Author keywords

Endothelium; Muscle, smooth; Paclitaxel; Pharmacology; Restenosis

Indexed keywords

BASIC FIBROBLAST GROWTH FACTOR; PACLITAXEL; PLATELET DERIVED GROWTH FACTOR; THROMBIN;

ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ATHEROSCLEROTIC PLAQUE; CELL MIGRATION; CELL PROLIFERATION; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; DRUG MECHANISM; GROWTH INHIBITION; IMMUNOHISTOCHEMISTRY; MALE; NONHUMAN; PRIORITY JOURNAL; RABBIT; SMOOTH MUSCLE FIBER;

EID: 0030840892     PISSN: 00097322     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.CIR.96.2.636     Document Type: Article

References (60)

1. Rowinsky EK, Donehower RC. Paclitaxel (Taxol). N Engl J Med. 1995;332:1004-1014.
2. Manthey CL, Qureshi N, Stütz PL, Vogel SN. Lipopolysaccharide antagonists block Taxol induced signaling in murine macrophages. J Exp Med. 1993;178:695-702.
3. Gelmon K. The taxoids: paclitaxel and docetaxel. Lancet. 1994;344: 1267-1272.
4. Schiff PB, Fant J, Horwitz SB. Promotion of microtubule assembly in vitro by Taxol. Nature. 1979;277:665-667.
5. cdc2 coincident with Taxol-induced apoptosis. Cell Growth Differ. 1994;5:1041-1050.
6. Pletjushkina OJ, Ivanova OJ, Kaverina IN, Vasiliev JM. Taxol-treated fibroblasts acquire an epithelioid shape and a circular pattern of actin bundles. Exp Cell Res. 1994;212:201-208.
7. Matsuoka H, Furusawa M, Tomoda H, Seo Y. Difference in cytotoxicity of paclitaxel against neoplastic and normal cells. Anticancer Res. 1994;14:163-168.
8. Gloushankova NA, Lyubimova AV, Tint IS, Feder HH, Vasiliev JM, Gelfand IM. Role of the microtubular system in morphological organization of normal and oncogene-transfected epithelial cells. Proc Natl Acad Sci U S A. 1994;91:8597-8601.
9. Schiff PB, Horwitz SB. Taxol stabilizes microtubules in mouse fibroblast cells. Proc Natl Acad Sci U S A. 1980;77:1561-1565.
10. Hämmerle H, Betz E, Herr D. Human endothelial cells are stimulated and vascular smooth muscle cells are inhibited in their proliferation and migration by heparins. Vasa. 1991;20:207-215.
11. Hanke H, Oberhoff M, Hanke S, Hassenstein S, Kamenz J, Schmid KM, Betz E, Karsch KR. Inhibition of cellular proliferation after experimental balloon angioplasty by low-molecular-weight heparin. Circulation. 1992;85:1548-1556.
12. Schwartz RS, Holmes DR, Topol EJ. The restenosis paradigm revisited: an alternative proposal for cellular mechanisms. J Am Coll Cardiol. 1992;20:1284-1293.
13. Straubinger RM, Sharma A, Murray M, Mayhew E. Novel Taxol formulations: Taxol-containing liposomes. Monogr Natl Cancer Inst. 1993;15:69-78.
14. Jordan MA, Toso RJ, Thrower D, Wilson L. Mechanism of mitotic block and inhibition of cell proliferation by Taxol at low concentrations. Proc Natl Acad Sci U S A. 1993;90:9552-9556.
15. Sollott SJ, Cheng L, Pauly RR, Jenkins GM, Monticone RE, Kuzuya M, Froehlich JP, Crow MT, Lakatta EG, Rowinsky EK, Kinsella JL. Taxol inhibits neointimal smooth muscle cell accumulation after angioplasty in the rat. J Clin Invest. 1995;95:1869-1876.
16. Roth DR, Axel DI, Betz EL. In vitro model of the inner parts of a vessel wall with cultured human vascular cells. Coron Artery Dis. 1993;4:283-291.
17. Axel DI, Brehm BR, Wolburg-Buchholz K, Betz EL, Köveker G, Karsch KR. Induction of cell-rich and lipid-rich plaques in a transfilter coculture system with human vascular cells. J Vasc Res. 1996; 33:327-339.
18. Jeppesen C, Nielsen PE. Photofootprinting of drug-binding sites on DNA using diazo- and azido-9-aminoacridine derivates. Eur J Biochem. 1989;182:437-444.
19. Gratzner HG. Monoclonal antibody to 5-bromo- and 5-iodode-oxyuridine: a new reagent for detection of DNA replication. Science. 1982;218:474-475.
20. Denizot F, Lang R. Rapid colorimetric assay for cell growth and survival. J Immunol Methods. 1986;89:271-277.
21. Gorczyca W, Gong J, Darzynkiewicz Z. Detection of DNA strand breaks in individual apoptotic cells by the in situ terminal deoxy-nucleotidyl transferase and nick translation assays. Cancer Res. 1993;53:1945-1951.
22. Hanke H, Strohschneider T, Oberhoff M, Betz E, Karsch KR. Time course of smooth muscle cell proliferation in the intima and media of arteries following experimental angioplasty. Circ Res. 1990;67: 651-659.
23. Lambert CR, Leone JE, Rowland SM. Local drug delivery catheters: functional comparison of porous and microporous designs. Coron Artery Dis. 1993;4:469-475.
24. Weidlinger FF, McLenachan JM, Cybulsky MI, Gordon JB, Rennke HG, Hollenberg NK, Fallon JT, Ganz P, Cooke JP. Persistent dysfunction of regenerated endothelium after balloon angioplasty of rabbit iliac artery. Circulation. 1990;81:1667-1679.
25. Hassenstein S, Hanke H, Kamenz J, Oberhoff M, Hanke S, Riessen R, Haase KK, Betz E, Karsch KR. Vascular injury and time course of smooth muscle cell proliferation after experimental holmium laser angioplasty. Circulation. 1992;86:1575-1583.
26. Wallenstein S, Zucker CL, Fleiss JL. Some statistical methods useful in circulation research. Circ Res. 1980;47:1-9.
27. Majno G, Joris I. Apoptosis, oncosis and necrosis: an overview of cell death. Am J Pathol. 1995;146:3-15.
28. Gotlieb AI, McBurnie-May L, Subrahmanyan L, Kalnins VI. Distribution of microtubule organizing centers in migrating sheets of endothelial cells. J Cell Biol. 1981;91:589-594.
29. Danowski B. Fibroblast contractility and actin organization are stimulated by microtubule inhibitors. J Cell Sci. 1989;93:255-266.
30. Herman B, Langevin MA, Albertini DF. The effects of Taxol on the organization of the cytoskeleton in cultured ovarian granulosa cells. Eur J Cell Biol. 1983;31:34-45.
31. Bartoli MH, Boitard M, Fessi H, Beriel H, Devissaguet JP, Picot F, Puisieux F. In vitro and in vivo antitumoral activity of free and encapsulated Taxol. J Microencapsul. 1990;7:191-197.
32. Crossin KL, Carney DH. Evidence that microtubule depolymerization early in the cell cycle is sufficient to initiate DNA synthesis. Cell. 1981;23:61-71.
33. 2/M arrest and apoptosis. Nat Med. 1996;2:72-79.
34. Donaldson KL, Goolsby GL, Wahl AF. Cytotoxicity of the anti-cancer agents cisplatin and Taxol during cell proliferation and the cell cycle. Int J Cancer. 1994;57:847-855.
35. Coomber BL, Gotlieb AI. In vitro endothelial wound repair: interaction of cell migration and proliferation. Arteriosclerosis. 1990;10: 215-222.
36. Donehower RC, Rowinsky EK. An overview of experience with Taxol (paclitaxel) in the USA. Cancer Treat Rev. 1993;19:63-78.
37. McClain DA, Edelman GM. Density-dependent stimulation and inhibition of cell growth by agents that disrupt microtubules. Proc Natl Acad Sci U S A. 1980;77:2748-2752.
38. De Brabander M, Geuens G, Nuydens R, Willebrords R, Aerts F, De Mey J. Microtubule dynamics during the cell cycle: the effect of Taxol and nocodazole on the microtubule system of Pt K2 cells at different stages of the mitotic cycle. Int Rev Cytol. 1986;101:215-274.
39. Edelman G. Surface modulation in cell recognition and cell growth. Science. 1976;192:218-226.
40. Manthey CL, Brandes ME, Perera PY, Vogel SN. Taxol increases steady-state levels of lipopolysaccharide-inducible genes and protein-tyrosine phosphorylation in murine macrophages. J Immunol. 1992;149:2459-2465.
41. Otto AM, Ulrich MO, Zumbe A, Jimenez de Asua L. Microtubule-disrupting agents affect two different events regulating the initiation of DNA synthesis in Swiss 3T3 cells. Proc Natl Acad Sci U S A. 1981;78:3063-3067.
42. Ding AH, Sanchez E, Nathan CF. Taxol shares the ability of bacterial lipopolysaccharide to induce tyrosine phosphorylation of microtubule-associated protein kinase. J Immunol. 1993;151: 5596-5602.
43. Nishio K, Arioka H, Ishida T, Fukumoto H, Kurokawa H, Sata M, Ohata M, Saijo N. Enhanced interactions between tubulin and microtubule-associated protein 2 via inhibition of MAP kinase and CDC2 kinase by paclitaxel. Int J Cancer. 1995;63:688-693.
44. Rosette C, Karin M. Cytoskeletal control of gene expression: depolymerization of microtubules activates NF-kB. J Cell Biol. 1995; 128:1111-1119.
45. Bhalla K, Ibrado AM, Torkina E, Tang C, Mahoney ME, Huang Y. Taxol induces internucleosomal DNA fragmentation associated with programmed cell death in human myeloid leukemia cells. Leukemia. 1993;7:563-568.
46. Friedkin M, Legg A, Rozengurt E. Enhancement of DNA synthesis by colchicine in 3T3 mouse fibroblasts stimulated with growth factors. Exp Cell Res. 1980;129:23-30.
47. Gradus-Pizlo I, Wilensky RL, March KL, Fineberg N, Michaels M, Sandusky GE, Hathaway DR. Local delivery of biodegradable microparticles containing colchicine or a colchicine analogue: effects on restenosis and implications for catheter-based drug delivery. J Am Coll Cardiol. 1995;26:1549-1557.
48. March KL, Mohanraj S, Ho PPK, Wilensky RL, Hathaway DR. Biodegradable microspheres containing a colchicine analogue inhibit DNA synthesis in vascular smooth muscle cells. Circulation. 1994;89:1929-1933.
49. Weiss RH, Maduri M. The mitogenic effect of thrombin in vascular smooth muscle cells is largely due to basic fibroblast growth factor. J Biol Chem. 1993;268:5724-5727.
50. Stouffer GA, Owens GK. TGF-β promotes proliferation of cultured SMC via both PDGF-AA-dependent and PDGF-AA-independent mechanisms. J Clin Invest. 1994;93:2048-2055.
51. Crossin KL, Carney DH. Microtubule stabilization by Taxol inhibits initiation of DNA synthesis by thrombin and by epidermal growth factor. Cell. 1981;27:341-350.
52. Axel DI, Brehm BR, Wild DH, Köveker G, Karsch KR. Determination of platelet-derived growth factor in conditioned media of monocultures and cocultures of human vascular cells in a transfilter culture system. Eur Heart J. 1995;16(suppl):28. Abstract.
53. Axel DI, Brehm BR, Betz EL, Karsch KR. Formation of an in vitro atheroma using LDL and monocytes in a transfilter coculture system with human vascular cells. Circulation. 1993;88(suppl):I-323. Abstract.
54. Weber E, Hämmerle H, Vatti R, Berti G, Betz E. Co-cultivation of endothelial and smooth muscle cells on opposite sides of a porous membrane. Appl Pathol. 1986;4:246-252.
55. 1 phase by interference with spindle formation without affecting other microtubule functions during anaphase and telophase. Cancer Res. 1994;54:4355-4361.
56. Derry B, Wilson L, Jordan MA. Substoichiometric binding of Taxol suppresses microtubule dynamics. Biochemistry. 1995;34:2203-2211.
57. Molè-Bajer J, Bajer AS. Action of Taxol on mitosis: modification of microtubule arrangements and function of the mitotic spindle in Haemanthus endosperm. J Cell Biol. 1983;96:527-540.
58. Kumar CC, Kim JH, Bushel P, Armstrong L, Catino JJ. Activation of smooth muscle α-actin promotor in ras-transformed cells by treatments with antimitotic agents: correlation with stimulation of SRF:SRE mediated gene transcription. J Biochem. 1995;118: 1285-1292.
59. Riessen R, Isner J. Prospects for site-specific delivery of pharmacologic and molecular therapies. J Am Coll Cardiol. 1994;23: 1234-1244.
60. Kunert W, Küttner A, Herdeg C, Horch B, Göggelmann C, Axel DI, Oberhoff M, Karsch KR. Paclitaxel inhibits development of restenosis following experimental balloon angioplasty in the rabbit carotid artery. Eur Heart J. 1996;17(suppl):386. Abstract.