Regulation of desmosome assembly and adhesion

Seminars in Cell and Developmental Biology

Volumn 15, Issue 6 SPEC. ISS., 2004, Pages 665-677

  Yin, Taofei ^a   Green, Kathleen J ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

Author keywords

Armadillo protein; Cadherin; Junction

Indexed keywords

CALCIUM;

BINDING SITE; CALCIUM CELL LEVEL; CELL ACTIVITY; CELL ADHESION; CELL COMPOSITION; CELL DIFFERENTIATION; CELL FUNCTION; CELL JUNCTION; CELL MATURATION; CELL STRUCTURE; CELL TYPE; CYTOLOGY; DESMOSOME; DIMERIZATION; EMBRYO DEVELOPMENT; HUMAN; MOLECULAR DYNAMICS; MORPHOGENESIS; NONHUMAN; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; REGULATORY MECHANISM; REVIEW; SIGNAL TRANSDUCTION;

ARMADILLO;

EID: 9244238200     PISSN: 10849521     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.semcdb.2004.09.005     Document Type: Article

References (145)

1. O. Huber Structure and function of desmosomal proteins and their role in development and disease Cell Mol Life Sci 60 9 2003 1872 1890
2. S. Getsios, A.C. Huen, and K.J. Green Working out the strength and flexibility of desmosomes Nat Rev Mol Cell Biol 5 2004 271 281
3. D.R. Garrod, A.J. Merritt, and Z. Nie Desmosomal cadherins Curr Opin Cell Biol 14 5 2002 537 545
4. A. Kljuic, H. Bazzi, J.P. Sundberg, A. Martinez-Mir, R. O'Shaughnessy, and M.G. Mahoney Desmoglein 4 in hair follicle differentiation and epidermal adhesion: evidence from inherited hypotrichosis and acquired pemphigus vulgaris Cell 113 2 2003 249 260
5. N.V. Whittock, and C. Bower Genetic evidence for a novel human desmosomal cadherin, desmoglein 4 J Invest Dermatol 120 4 2003 523 530
6. S. Bonne, B. Gilbert, M. Hatzfeld, X. Chen, K.J. Green, and F. van Roy Defining desmosomal plakophilin-3 interactions J Cell Biol 161 2 2003 403 416
7. M. Hatzfeld The armadillo family of structural proteins Int Rev Cytol 186 1999 179 224
8. C.C. Calkins, B.L. Hoepner, C.M. Law, M.R. Novak, S.V. Setzer, and M. Hatzfeld The Armadillo family protein p0071 is a VE-cadherin- and desmoplakin-binding protein J Biol Chem 278 3 2003 1774 1783
9. X. Chen, S. Bonne, M. Hatzfeld, F. van Roy, and K.J. Green Protein binding and functional characterization of plakophilin 2. Evidence for its diverse roles in desmosomes and beta-catenin signaling J Biol Chem 277 12 2002 10512 10522
10. C.L. Leung, K.J. Green, and R.K. Liem Plakins: a family of versatile cytolinker proteins Trends Cell Biol 12 1 2002 37 45
11. A.J. North, W.G. Bardsley, J. Hyam, E.A. Bornslaeger, H.C. Cordingley, and B. Trinnaman Molecular map of the desmosomal plaque J Cell Sci 112 Pt 23 1999 4325 4336
12. E.A. Smith, and E. Fuchs Defining the interactions between intermediate filaments and desmosomes J Cell Biol 141 5 1998 1229 1241
13. E.A. Bornslaeger, L.M. Godsel, C.M. Corcoran, J.K. Park, M. Hatzfeld, and A.P. Kowalczyk Plakophilin 1 interferes with plakoglobin binding to desmoplakin, yet together with plakoglobin promotes clustering of desmosomal plaque complexes at cell-cell borders J Cell Sci 114 Pt 4 2001 727 738
14. S.M. Troyanovsky, R.B. Troyanovsky, L.G. Eshkind, R.E. Leube, and W.W. Franke Identification of amino acid sequence motifs in desmocollin, a desmosomal glycoprotein, that are required for plakoglobin binding and plaque formation Proc Natl Acad Sci USA 91 1994 10790 10794
15. C. Marcozzi, I.D. Burdett, R.S. Buxton, and A.I. Magee Coexpression of both types of desmosomal cadherin and plakoglobin confers strong intercellular adhesion J Cell Sci 111 Pt 4 1998 495 509
16. P. Ruiz, V. Brinkmann, B. Ledermann, M. Behrend, C. Grund, and C. Thalhammer Targeted mutation of plakoglobin in mice reveals essential functions of desmosomes in the embryonic heart J Cell Biol 135 1 1996 215 225
17. H.L. Palka, and K.J. Green Roles of plakoglobin end domains in desmosome assembly J Cell Sci 110 Pt 19 1997 2359 2371
18. A.P. Kowalczyk, E.A. Bornslaeger, J.E. Borgwardt, H.L. Palka, A.S. Dhaliwal, and C.M. Corcoran The amino-terminal domain of desmoplakin binds to plakoglobin and clusters desmosomal cadherin-plakoglobin complexes J Cell Biol 139 1997 773 784
19. J. Koeser, S.M. Troyanovsky, C. Grund, and W.W. Franke De novo formation of desmosomes in cultured cells upon transfection of genes encoding specific desmosomal components Exp Cell Res 285 1 2003 114 130
20. A.C. Huen, J.K. Park, L.M. Godsel, X. Chen, L.J. Bannon, and E.V. Amargo Intermediate filament-membrane attachments function synergistically with actin-dependent contacts to regulate intercellular adhesive strength J Cell Biol 159 6 2002 1005 1017
21. T.S. Stappenbeck, and K.J. Green The desmoplakin carboxyl terminus coaligns with and specifically disrupts intermediate filament networks when expressed in cultured cells J Cell Biol 116 5 1992 1197 1209
22. T.S. Stappenbeck, J.A. Lamb, C.M. Corcoran, and K.J. Green Phosphorylation of the desmoplakin COOH terminus negatively regulates its interaction with keratin intermediate filament networks J Biol Chem 269 47 1994 29351 29354
23. P.D. Kouklis, E. Hutton, and E. Fuchs Making a connection: direct binding between keratin intermediate filaments and desmosomal proteins J Cell Biol 127 1994 1049 1060
24. J.-J. Meng, E.A. Bornslaeger, K.J. Green, P.M. Steinert, and W. Ip Two hybrid analysis reveals fundamental differences in direct interactions between desmoplakin and cell type specific intermediate filaments J Biol Chem 272 1997 21495 21503
25. L. Fontao, B. Favre, S. Riou, D. Geerts, F. Jaunin, and J.H. Saurat Interaction of the bullous pemphigoid antigen 1 (BP230) and desmoplakin with intermediate filaments is mediated by distinct sequences within their COOH terminus Mol Biol Cell 14 5 2003 1978 1992
26. H.J. Choi, S. Park-Snyder, L.T. Pascoe, K.J. Green, and W.I. Weis Structures of two intermediate filament-binding fragments of desmoplakin reveal a unique repeat motif structure Nat Struct Biol 9 8 2002 612 620
27. G.I. Gallicano, P. Kouklis, C. Bauer, M. Yin, V. Vasioukhin, and L. Degenstein Desmoplakin is required early in development for assembly of desmosomes and cytoskeletal linkage J Cell Biol 143 1998 2009 2022
28. A. Maatta, T. DiColandrea, K. Groot, and F.M. Watt Gene targeting of envoplakin, a cytoskeletal linker protein and precursor of the epidermal cornified envelope Mol Cell Biol 21 20 2001 7047 7053
29. G. Wiche Role of plectin in cytoskeleton organization and dynamics J Cell Sci 111 1998 2477 2486
30. 2+ dependence and mutational analysis reveal molecular details of E-cadherin homoassociation EMBO J 18 7 1999 1738 1747
31. 2+-dependent heterophilic interaction between desmosomal cadherins, desmoglein and desmocollin, contributes to cell-cell adhesion J Cell Biol 138 1 1997 193 201
32. S.E. Syed, B. Trinnaman, S. Martin, S. Major, J. Hutchinson, and A.I. Magee Molecular interactions between desmosomal cadherins Biochem J 362 Pt 2 2002 317 327
33. M. Amagai, S. Karpati, V. Klaus-Kovtun, M.C. Udey, and J.R. Stanley The extracellular domain of pemphigus vulgaris antigen (desmoglein 3) mediates weak homophilic adhesion J Invest Dermatol 102 1994 402 408
34. A.P. Kowalczyk, J.E. Borgwardt, and K.J. Green Analysis of desmosomal cadherin-adhesive function and stoichiometry of desmosomal cadherin-plakoglobin complexes J Invest Dermatol 107 1996 293 300
35. C. Tselepis, M. Chidgey, A. North, and D. Garrod Desmosomal adhesion inhibits invasive behavior Proc Natl Acad Sci USA 95 14 1998 8064 8069
36. S.K. Runswick, M.J. O'Hare, L. Jones, C.H. Streuli, and D.R. Garrod Desmosomal adhesion regulates epithelial morphogenesis and cell positioning Nat Cell Biol 3 9 2001 823 830
37. W. He, P. Cowin, and D.L. Stokes Untangling desmosomal knots with electron tomography Science 302 5642 2003 109 113
38. P.J. Koch, M.G. Mahoney, H. Ishikawa, L. Pulkkinen, J. Uitto, and L. Shultz Targeted disruption of the pemphigus vulgaris antigen (desmoglein 3) gene in mice causes loss of keratinocyte cell adhesion with a phenotype similar to pemphigus vulgaris J Cell Biol 137 1997 1091 1102
39. M. Amagai Autoimmunity against desmosomal cadherins in pemphigus J Dermatol Sci 20 2 1999 92 102
40. J.R. Stanley, T. Nishikawa, L.A. Diaz, and M. Amagai Pemphigus: is there another half of the story? J Invest Dermatol 116 4 2001 489 490
41. M. Amagai, N. Matsuyoshi, Z.H. Wang, C. Andl, and J.R. Stanley Toxin in bullous impetigo and staphylococcal scalded-skin syndrome targets desmoglein 1 Nat Med 6 11 2000 1275 1277
42. M. Amagai, T. Yamaguchi, Y. Hanakawa, K. Nishifuji, M. Sugai, and J.R. Stanley Staphylococcal exfoliative toxin B specifically cleaves desmoglein 1 J Invest Dermatol 118 5 2002 845 850
43. Y. Hanakawa, T. Selwood, D. Woo, C. Lin, N.M. Schechter, and J.R. Stanley Calcium-dependent conformation of desmoglein 1 is required for its cleavage by exfoliative toxin J Invest Dermatol 121 2 2003 383 389
44. J.A. McGrath Hereditary diseases of desmosomes J Dermatol Sci 20 1999 85 91
45. J.R. McMillan, and H. Shimizu Desmosomes: structure and function in normal and diseased epidermis J Dermatol 28 6 2001 291 298
46. G. McKoy, N. Protonotarios, A. Crosby, A. Tsatsopoulou, A. Anastasakis, and A. Coonar Identification of a deletion in plakoglobin in arrhythmogenic right ventricular cardiomyopathy with palmoplantar keratoderma and woolly hair (Naxos disease) [In Process Citation] Lancet 355 9221 2000 2119 2124
47. E.E. Norgett, S.J. Hatsell, L. Carvajal-Huerta, J.C. Cabezas, J. Common, and P.E. Purkis Recessive mutation in desmoplakin disrupts desmoplakin- intermediate filament interactions and causes dilated cardiomyopathy, woolly hair and keratoderma Hum Mol Genet 9 18 2000 2761 2766
48. A. Rampazzo, A. Nava, S. Malacrida, G. Beffagna, B. Bauce, and V. Rossi Mutation in human desmoplakin domain binding to plakoglobin causes a dominant form of arrhythmogenic right ventricular cardiomyopathy Am J Hum Genet 71 5 2002 1200 1206
49. R. Alcalai, S. Metzger, S. Rosenheck, V. Meiner, and T. Chajek-Shaul A recessive mutation in desmoplakin causes arrhythmogenic right ventricular dysplasia, skin disorder, and woolly hair J Am Coll Cardiol 42 2 2003 319 327
50. L. Eshkind, Q. Tian, A. Schmidt, W.W. Franke, R. Windoffer, and R.E. Leube Loss of desmoglein 2 suggests essential functions for early embryonic development and proliferation of embryonal stem cells Eur J Cell Biol 81 11 2002 592 598
51. T.P. Fleming, D.R. Garrod, and A.J. Elsmore Desmosome biogenesis in the mouse preimplantation embryo Development 112 1991 527 539
52. U.A. Nuber, S. Schafer, A. Schmidt, P.J. Koch, and W.W. Franke The widespread human desmocollin Dsc2 and tissue-specific patterns of synthesis of various desmocollin subtypes Eur J Cell Biol 66 1 1995 69 74
53. K. Akat, H.D. Mennel, P. Kremer, N. Gassler, C.K. Bleck, and J. Kartenbeck Molecular characterization of desmosomes in meningiomas and arachnoidal tissue Acta Neuropathol (Berl) 106 4 2003 337 347
54. N.V. Whittock Genomic sequence analysis of the mouse desmoglein cluster reveals evidence for six distinct genes: characterization of mouse DSG4, DSG5, and DSG6 J Invest Dermatol 120 6 2003 970 980
55. L. Pulkkinen, Y.W. Choi, A. Kljuic, J. Uitto, and M.G. Mahoney Novel member of the mouse desmoglein gene family: Dsg1-beta Exp Dermatol 12 1 2003 11 19
56. M.A. Chidgey, K.K. Yue, S. Gould, C. Byrne, and D.R. Garrod Changing pattern of desmocollin 3 expression accompanies epidermal organisation during skin development Dev Dyn 210 3 1997 315 327
57. P.M. Elias, N. Matsuyoshi, H. Wu, C. Lin, Z.H. Wang, and B.E. Brown Desmoglein isoform distribution affects stratum corneum structure and function J Cell Biol 153 2 2001 243 249
58. A.J. Merritt, M.Y. Berika, W. Zhai, S.E. Kirk, B. Ji, and M.J. Hardman Suprabasal desmoglein 3 expression in the epidermis of transgenic mice results in hyperproliferation and abnormal differentiation Mol Cell Biol 22 16 2002 5846 5858
59. D.M. Hunt, V.K. Sahota, K. Taylor, D. Simrak, N. Hornigold, and J. Arnemann Clustered cadherin genes: a sequence-ready contig for the desmosomal cadherin locus on human chromosome 18 Genomics 62 3 1999 445 455
60. Smith C, Zhu K, Merritt A, Picton R, Youngs D, Garrod D, et al. Regulation of desmocollin gene expression in epidermis: CCAAT/enhancer binding proteins modulate early and late events in keratinocyte differentiation. Biochem J 2004.
61. M.F. Denning, S.G. Guy, S.M. Ellerbroek, S.M. Norvell, A.P. Kowalczyk, and K.J. Green The expression of desmoglein isoforms in cultured human keratinocytes is regulated by calcium, serum, and protein kinase C Exp Cell Res 239 1998 50 59
62. I. Moll, H. Kurzen, L. Langbein, and W.W. Franke The distribution of the desmosomal protein, plakophilin 1, in human skin and skin tumors J Invest Dermatol 108 2 1997 139 146
63. A.J. North, M.A. Chidgey, J.P. Clarke, W.G. Bardsley, and D.R. Garrod Distinct desmocollin isoforms occur in the same desmosomes and show reciprocally graded distributions in bovine nasal epidermis Proc Natl Acad Sci USA 93 15 1996 7701 7705
64. K. Ishii, S.M. Norvell, L.J. Bannon, E.V. Amargo, L.T. Pascoe, and K.J. Green Assembly of desmosomal cadherins into desmosomes is isoform dependent J Invest Dermatol 117 1 2001 26 35
65. R. Windoffer, M. Borchert-Stuhltrager, and R.E. Leube Desmosomes: interconnected calcium-dependent structures of remarkable stability with significant integral membrane protein turnover J Cell Sci 115 Pt 8 2002 1717 1732
66. P.M. Steinert, and L.N. Marekov Initiation of assembly of the cell envelope barrier structure of stratified squamous epithelia Mol Biol Cell 10 12 1999 4247 4261
67. G. Serre, V. Mils, M. Haftek, C. Vincent, F. Croute, and A. Reano Identification of late differentiation antigens of human cornified epithelia, expressed in re-organized desmosomes and bound to cross-linked envelope J Invest Dermatol 97 6 1991 1061 1072
68. M. Simon, N. Jonca, M. Guerrin, M. Haftek, D. Bernard, and C. Caubet Refined characterization of corneodesmosin proteolysis during terminal differentiation of human epidermis and its relationship to desquamation J Biol Chem 276 23 2001 20292 20299
69. L. Eckhart, W. Declercq, J. Ban, M. Rendl, B. Lengauer, and C. Mayer Terminal differentiation of human keratinocytes and stratum corneum formation is associated with caspase-14 activation J Invest Dermatol 115 6 2000 1148 1151
70. M. Weil, M.C. Raff, and V.M. Braga Caspase activation in the terminal differentiation of human epidermal keratinocytes Curr Biol 9 7 1999 361 364
71. M. Pasdar, and W.J. Nelson Regulation of desmosome assembly in epithelial cells: kinetics of synthesis, transport, and stabilization of desmoglein I, a major protein of the membrane core domain J Cell Biol 109 1 1989 163 177
72. M. Pasdar, and W.J. Nelson Kinetics of desmosome assembly in Madin-Darby canine kidney epithelial cells: temporal and spatial regulation of desmoplakin organization and stabilization upon cell-cell contact. I. Biochemical analysis J Cell Biol 106 3 1988 677 685
73. M. Pasdar, and W.J. Nelson Kinetics of desmosome assembly in Madin-Darby canine kidney epithelial cells: temporal and spatial regulation of desmoplakin organization and stabilization upon cell-cell contact. II. Morphological analysis J Cell Biol 106 3 1988 687 695
74. M. Pasdar, Z. Li, and V. Chlumecky Plakoglobin: kinetics of synthesis, phosphorylation, stability, and interactions with desmoglein and E-cadherin Cell Motil Cytoskelet 32 4 1995 258 272
75. 2+ pump, cause Darier disease [see comments] Nat Genet 21 3 1999 271 277
76. R. Sudbrak, J. Brown, C. Dobson-Stone, S. Carter, J. Ramser, and J. White Hailey-Hailey disease is caused by mutations in ATP2C1 encoding a novel Ca(2+) pump Hum Mol Genet 9 7 2000 1131 1140
77. A.P. Kowalczyk, H.L. Palka, H.H. Luu, L.A. Nilles, J.E. Anderson, and M.J. Wheelock Posttranslational regulation of plakoglobin expression. Influence of the desmosomal cadherins on plakoglobin metabolic stability J Biol Chem 269 49 1994 31214 31223
78. C.D. Andl, and J.R. Stanley Central role of the plakoglobin-binding domain for desmoglein 3 incorporation into desmosomes J Invest Dermatol 117 5 2001 1068 1074
79. I.D. Burdett, and K.H. Sullivan Desmosome assembly in MDCK cells: transport of precursors to the cell surface occurs by two phases of vesicular traffic and involves major changes in centrosome and Golgi location during a Ca(2+) shift Exp Cell Res 276 2 2002 296 309
80. Y. Hanakawa, M. Amagai, Y. Shirakata, K. Sayama, and K. Hashimoto Different effects of dominant negative mutants of desmocollin and desmoglein on the cell-cell adhesion of keratinocytes J Cell Sci 113 Pt 10 2000 1803 1811
81. M. Pasdar, K.A. Krzeminski, and W.J. Nelson Regulation of desmosome assembly in MDCK epithelial cells: coordination of membrane core and cytoplasmic plaque domain assembly at the plasma membrane J Cell Biol 113 1991 645 655
82. Jones JCR, and R.D. Goldman Intermediate filaments and the initiation of desmosome assembly J Cell Biol 101 1985 506 517
83. R. Duden, and W.W. Franke Organization of desmosomal plaque proteins in cells growing at low calcium concentrations J Cell Biol 107 3 1988 1049 1063
84. D.L. Mattey, and D.R. Garrod Calcium-induced desmosome formation in cultured kidney epithelial cells J Cell Sci 85 1986 95 111
85. N.A. Gloushankova, T. Wakatsuki, R.B. Troyanovsky, E. Elson, and S.M. Troyanovsky Continual assembly of desmosomes within stable intercellular contacts of epithelial A-431 cells Cell Tissue Res 314 3 2003 399 410
86. D.L. Mattey, and D.R. Garrod Splitting and internalization of the desmosomes of cultured kidney epithelial cells by reduction in calcium concentration J Cell Sci 85 1986 113 124
87. S. Wallis, S. Lloyd, I. Wise, G. Ireland, T.P. Fleming, and D. Garrod The alpha isoform of protein kinase C is involved in signaling the response of desmosomes to wounding in cultured epithelial cells Mol Biol Cell 11 3 2000 1077 1092
88. G.K. Menon, S. Grayson, and P.M. Elias Ionic calcium reservoirs in mammalian epidermis: ultrastructural localization by ion-capture cytochemistry J Invest Dermatol 84 6 1985 508 512
89. J.E. Lewis, J.K. Wahl III, K.M. Sass, P.J. Jensen, K.R. Johnson, and M.J. Wheelock Cross-talk between adherens junctions and desmosomes depends on plakoglobin J Cell Biol 136 4 1997 919 934
90. C. Bierkamp, K.J. McLaughlin, H. Schwarz, O. Huber, and R. Kemler Embryonic heart and skin defects in mice lacking plakoglobin Dev Biol 180 2 1996 780 785
91. M. Hatzfeld, K.J. Green, and H. Sauter Targeting of p0071 to desmosomes and adherens junctions is mediated by different protein domains J Cell Sci 116 Pt 7 2003 1219 1233
92. J.V. Hengel, L. Gohon, E. Bruyneel, S. Vermeulen, M. Cornelissen, and M. Mareel Protein kinase C activation upregulates intercellular adhesion of a-catenin-negative human colon cancer cell variants via induction of desmosomes J Cell Biol 137 1997 1103 1116
93. V. Vasioukhin, C. Bauer, M. Yin, and E. Fuchs Directed actin polymerization is the driving force for epithelial cell-cell adhesion Cell 100 2 2000 209 219
94. M.P. Demlehner, S. Schafer, C. Grund, and W.W. Franke Continual assembly of half-desmosomal structures in the absence of cell contacts and their frustrated endocytosis: a coordinated Sisyphus cycle J Cell Biol 131 3 1995 745 760
95. V. Vasioukhin, E. Bowers, C. Bauer, L. Degenstein, and E. Fuchs Desmoplakin is essential in epidermal sheet formation Nat Cell Biol 3 12 2001 1076 1085
96. C. Brancolini, A. Sgorbissa, and C. Schneider Proteolytic processing of the adherens junctions components beta-catenin and gamma-catenin/plakoglobin during apoptosis Cell Death Differ 5 12 1998 1042 1050
97. J. Weiske, T. Schoneberg, W. Schroder, M. Hatzfeld, R. Tauber, and O. Huber The fate of desmosomal proteins in apoptotic cells J Biol Chem 276 44 2001 41175 41181
98. L.S. Amar, A.H. Shabana, M. Oboeuf, N. Martin, and N. Forest Involvement of desmoplakin phosphorylation in the regulation of desmosomes by protein kinase C, in HeLa cells Cell Adhes Commun 7 2 1999 125 138
99. J. van Hengel, L. Gohon, E. Bruyneel, S. Vermeulen, M. Cornelissen, and M. Mareel Protein kinase C activation upregulates intercellular adhesion of alpha-catenin-negative human colon cancer cell variants via induction of desmosomes J Cell Biol 137 5 1997 1103 1116
100. M. Pasdar, Z. Li, and H. Chan Desmosome assembly and disassembly are regulated by reversible protein phosphorylation in cultured epithelial cells Cell Motil Cytoskelet 30 2 1995 108 121
101. C.A. Gaudry, H.L. Palka, R.L. Dusek, A.C. Huen, M.J. Khandekar, and L.G. Hudson Tyrosine-phosphorylated plakoglobin is associated with desmogleins but not desmoplakin after epidermal growth factor receptor activation J Biol Chem 276 27 2001 24871 24880
102. S. Miravet, J. Piedra, J. Castano, I. Raurell, C. Franci, and M. Dunach Tyrosine phosphorylation of plakoglobin causes contrary effects on its association with desmosomes and adherens junction components and modulates beta-catenin-mediated transcription Mol Cell Biol 23 20 2003 7391 7402
103. E. Calautti, S. Cabodi, P.L. Stein, M. Hatzfeld, N. Kedersha, and G. Paolo Dotto Tyrosine phosphorylation and src family kinases control keratinocyte cell-cell adhesion J Cell Biol 141 6 1998 1449 1465
104. E. Calautti, M. Grossi, C. Mammucari, Y. Aoyama, M. Pirro, and Y. Ono Fyn tyrosine kinase is a downstream mediator of Rho/PRK2 function in keratinocyte cell-cell adhesion J Cell Biol 156 1 2002 137 148
105. S. Kodama, S. Ikeda, T. Asahara, M. Kishida, and A. Kikuchi Axin directly interacts with plakoglobin and regulates its stability J Biol Chem 274 39 1999 27682 27688
106. S. Hatsell, L. Medina, J. Merola, R. Haltiwanger, and P. Cowin Plakoglobin is O-glycosylated close to the N-terminal destruction box J Biol Chem 278 39 2003 37745 37752
107. E. Sadot, I. Simcha, K. Iwai, A. Ciechanover, B. Geiger, and A. Ben-Ze'ev Differential interaction of plakoglobin and beta-catenin with the ubiquitin-proteasome system Oncogene 19 16 2000 1992 2001
108. Y. Aoyama, M.K. Owada, and Y. Kitajima A pathogenic autoantibody, pemphigus vulgaris-IgG, induces phosphorylation of desmoglein 3, and its dissociation from plakoglobin in cultured keratinocytes Eur J Immunol 29 7 1999 2233 2240
109. Y. Aoyama, and Y. Kitajima Pemphigus vulgaris-IgG causes a rapid depletion of desmoglein 3 (Dsg3) from the Triton X-100 soluble pools, leading to the formation of Dsg3-depleted desmosomes in a human squamous carcinoma cell line, DJM-1 cells J Invest Dermatol 112 1 1999 67 71
110. K. Osada, M. Seishima, Y. Kitajima, and Pemphigus IgG activates and translocates protein kinase C from the cytosol to the particulate/cytoskeleton fractions in human keratinocytes J Invest Dermatol 108 4 1997 482 487
111. C. Esaki, M. Seishima, T. Yamada, K. Osada, and Y. Kitajima Pharmacologic evidence for involvement of phospholipase C in pemphigus IgG-induced inositol 1,4,5-trisphosphate generation, intracellular calcium increase, and plasminogen activator secretion in DJM-1 cells, a squamous cell carcinoma line J Invest Dermatol 105 3 1995 329 333
112. R. Caldelari, A. de Bruin, D. Baumann, M.M. Suter, C. Bierkamp, and V. Balmer A central role for the armadillo protein plakoglobin in the autoimmune disease pemphigus vulgaris J Cell Biol 153 4 2001 823 834
113. J. Zhurinsky, M. Shtutman, and A. Ben-Ze'ev Plakoglobin and beta-catenin: protein interactions, regulation and biological roles J Cell Sci 113 Pt 18 2000 3127 3139
114. A. Karnovsky, and M.W. Klymkowsky Anterior axis duplication in Xenopus induced by the over-expression of the cadherin-binding protein plakoglobin Proc Natl Acad Sci USA 92 10 1995 4522 4526
115. I. Simcha, M. Shtutman, D. Salomon, J. Zhurinsky, E. Sadot, and B. Geiger Differential nuclear translocation and transactivation potential of beta-catenin and plakoglobin J Cell Biol 141 6 1998 1433 1448
116. J. Zhurinsky, M. Shtutman, and A. Ben-Ze'ev Differential mechanisms of LEF/TCF family-dependent transcriptional activation by beta-catenin and plakoglobin Mol Cell Biol 20 12 2000 4238 4252
117. J. Behrens, J.P. von Kries, M. Kuhl, L. Bruhn, D. Wedlich, and R. Grosschedl Functional interaction of beta-catenin with the transcription factor LEF-1 Nature 382 6592 1996 638 642
118. O. Huber, R. Korn, J. McLaughlin, M. Ohsugi, B.G. Herrmann, and R. Kemler Nuclear localization of beta-catenin by interaction with transcription factor LEF-1 Mech Dev 59 1 1996 3 10
119. M. Kofron, A. Spagnuolo, M. Klymkowsky, C. Wylie, and J. Heasman The roles of maternal alpha-catenin and plakoglobin in the early Xenopus embryo Development 124 8 1997 1553 1560
120. P. White, H. Aberle, and J.P. Vincent Signaling and adhesion activities of mammalian beta-catenin and plakoglobin in Drosophila J Cell Biol 140 1 1998 183 195
121. J. Huelsken, R. Vogel, V. Brinkmann, B. Erdmann, C. Birchmeier, and W. Birchmeier Requirement for beta-catenin in anterior-posterior axis formation in mice J Cell Biol 148 3 2000 567 578
122. J.M. Merriam, A.B. Rubenstein, and M.W. Klymkowsky Cytoplasmically anchored plakoglobin induces a WNT-like phenotype in Xenopus Dev Biol 185 1 1997 67 81
123. M.W. Klymkowsky, B.O. Williams, G.D. Barish, H.E. Varmus, and Y.E. Vourgourakis Membrane-anchored plakoglobins have multiple mechanisms of action in Wnt signaling Mol Biol Cell 10 10 1999 3151 3169
124. J.R. Miller, and R.T. Moon Analysis of the signaling activities of localization mutants of beta-catenin during axis specification in Xenopus J Cell Biol 139 1 1997 229 243
125. B.O. Williams, G.D. Barish, M.W. Klymkowsky, and H.E. Varmus A comparative evaluation of beta-catenin and plakoglobin signaling activity Oncogene 19 50 2000 5720 5728
126. E. Charpentier, R.M. Lavker, E. Acquista, and P. Cowin Plakoglobin suppresses epithelial proliferation and hair growth in vivo J Cell Biol 149 2 2000 503 520
127. U. Gat, R. DasGupta, L. Degenstein, and E. Fuchs De novo hair follicle morphogenesis and hair tumors in mice expressing a truncated beta-catenin in skin Cell 95 5 1998 605 614
128. S.E. Millar, K. Willert, P.C. Salinas, H. Roelink, R. Nusse, and D.J. Sussman WNT signaling in the control of hair growth and structure Dev Biol 207 1 1999 133 149
129. J.S. Lee, A. Ishimoto, and S. Yanagawa Characterization of mouse dishevelled (Dvl) proteins in Wnt/Wingless signaling pathway J Biol Chem 274 30 1999 21464 21470
130. O. Maeda, N. Usami, M. Kondo, M. Takahashi, H. Goto, and K. Shimokata Plakoglobin (gamma-catenin) has TCF/LEF family-dependent transcriptional activity in beta-catenin-deficient cell line Oncogene 23 4 2004 964 972
131. F.T. Kolligs, B. Kolligs, K.M. Hajra, G. Hu, M. Tani, and K.R. Cho Gamma-catenin is regulated by the APC tumor suppressor and its oncogenic activity is distinct from that of beta-catenin Genes Dev 14 11 2000 1319 1331
132. H. Aberle, C. Bierkamp, D. Torchard, O. Serova, T. Wagner, and E. Natt The human plakoglobin gene localizes on chromosome 17q21 and is subjected to loss of heterozygosity in breast and ovarian cancers Proc Natl Acad Sci USA 92 14 1995 6384 6388
133. R. Amitay, D. Nass, D. Meitar, I. Goldberg, B. Davidson, and L. Trakhtenbrot Reduced expression of plakoglobin correlates with adverse outcome in patients with neuroblastoma Am J Pathol 159 1 2001 43 49
134. P. Hu, P. Berkowitz, E.J. O'Keefe, and D.S. Rubenstein Keratinocyte adherens junctions initiate nuclear signaling by translocation of plakoglobin from the membrane to the nucleus J Invest Dermatol 121 2 2003 242 251
135. A. Schmidt, L. Langbein, M. Rode, S. Pratzel, R. Zimbelmann, and W.W. Franke Plakophilins 1a and 1b: widespread nuclear proteins recruited in specific epithelial cells as desmosomal plaque components Cell Tissue Res 290 3 1997 481 499
136. M.W. Klymkowsky Plakophilin, armadillo repeats, and nuclear localization Microsc Res Tech 45 1 1999 43 54
137. S. Bonne, J. van Hengel, F. Nollet, P. Kools, and F. van Roy Plakophilin-3, a novel armadillo-like protein present in nuclei and desmosomes of epithelial cells J Cell Sci 112 Pt 14 1999 2265 2276
138. C. Mertens, C. Kuhn, and W.W. Franke Plakophilins 2a and 2b: constitutive proteins of dual location in the karyoplasm and the desmosomal plaque J Cell Biol 135 4 1996 1009 1025
139. J. Muller, D.A. Ritt, T.D. Copeland, and D.K. Morrison Functional analysis of C-TAK1 substrate binding and identification of PKP2 as a new C-TAK1 substrate EMBO J 22 17 2003 4431 4442
140. P. Savagner, K.M. Yamada, and J.P. Thiery The zinc-finger protein slug causes desmosome dissociation, an initial and necessary step for growth factor-induced epithelial-mesenchymal transition J Cell Biol 137 1997 1403 1419
141. W.J. Nelson, and R. Nusse Convergence of Wnt, beta-catenin, and cadherin pathways Science 303 5663 2004 1483 1487
142. M. Peifer, and A.S. Yap Traffic control: p120-catenin acts as a gatekeeper to control the fate of classical cadherins in mammalian cells J Cell Biol 163 3 2003 437 440
143. M.J. Wheelock, and K.R. Johnson Cadherins as modulators of cellular phenotype Annu Rev Cell Dev Biol 19 2003 207 235
144. E. Dejana Endothelial cell-cell junctions: happy together Nat Rev Mol Cell Biol 5 2004 261 270
145. J.H. Lorch, J. Klessner, J.K. Park, S. Getsios, Y.L. Wu, M.S. Stack, and K.J. Green Epidermal growth factor receptor inhibition promotes desmosome assembly and strengthens intracellular adhesion in squamous cell carcinoma cells J. Biol. Chem. 279 2004 37191 37200