Analysis of the signaling activities of localization mutants of β- catenin during axis specification in Xenopus

Journal of Cell Biology

Volumn 139, Issue 1, 1997, Pages 229-243

  Miller, Jeffrey R ^a   Moon, Randall T ^a,b  

^a UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF WASHINGTON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA CATENIN; CADHERIN;

ARTICLE; AXIS; CELL DIFFERENTIATION; CELLULAR DISTRIBUTION; EMBRYO; EMBRYO DEVELOPMENT; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; XENOPUS;

ADENOMATOUS POLYPOSIS COLI PROTEIN; ANIMALS; BETA CATENIN; BINDING, COMPETITIVE; CADHERINS; CELL NUCLEUS; CYTOPLASM; CYTOSKELETAL PROTEINS; DESMOPLAKINS; DESMOSOMES; DOWN-REGULATION; EMBRYO, NONMAMMALIAN; GAMMA CATENIN; GENE EXPRESSION REGULATION; GENES, APC; GREEN FLUORESCENT PROTEINS; HUMANS; INTRACELLULAR FLUID; LUMINESCENT PROTEINS; MEMBRANE PROTEINS; MUTAGENESIS; PHOSPHORYLATION; SIGNAL TRANSDUCTION; TRANS-ACTIVATORS; XENOPUS; XENOPUS PROTEINS;

EID: 0030861128     PISSN: 00219525     EISSN: None     Source Type: Journal    
DOI: 10.1083/jcb.139.1.229     Document Type: Article

References (50)

1. Behrens, J., J.P. von Kries, M. Kuhl, L. Bruhn, D. Wedlich, R. Grosschedl, and W. Birchmeier. 1996. Functional interaction of β-catenin with the transcription factor LEF-1. Nature (Lond.). 382:638-642.
2. Brannon, M., and D. Kimelman. 1996. Activation of Siamois by the Wnt pathway. Dev. Biol. 180:344-347.
3. Brannon, M., M. Gomperts, L. Sumoy, R.T. Moon, and D. Kimelman. 1997. A β-catenin/XTcF-3 complex binds to the siamois promoter to regulate dorsal axis specification in Xenopus. Genes Dev. 11:2359-2370.
4. Brunner, E., O. Peter, L. Schweizer, and K. Basler. 1997. pangolin encodes a Lef-1 homologue that acts downstream of Armadillo to transduce the Wingless signal in Drosophila. Nature (Lond.). 385:829-833.
5. Carnac, G., L. Kodjabachian, J.B. Gurdon, and P. Lemaire. 1996. The bomeobox gene Siamois is a target of the Wnt dorsalisation pathway and triggers organiser activity in the absence of mesoderm. Development (Camb.). 122:3055-3065.
6. Cox, R.T., C. Kirkpatrick, and M. Peifer. 1996. Armadillo is required for adherens junction assembly, cell polarity, and morphogenesis during Drosophila embryogenesis. J. Cell Biol. 134:133-148.
7. Detrick, R.J., D. Dickey, and C.R. Kintner. 1990. The effects of N-cadherin misexpression on morphogenesis in Xenopus embryos. Neuron. 4:493-506.
8. Evan, G.I., G.K. Lewis, G. Ransay, and J.M. Bishop. 1985. Isolation of monoclonal antibodies specific for human c-myc protooncogene product. Mol. Cell Biol. 5:3610-3616.
9. Fagotto, F., N. Funayama, U. Gluck, and B.M. Gumbiner. 1996. Binding to cadherins antagonizes the signaling activity of β-catenin during axis formation in Xenopus. J. Cell Biol. 132:1105-1114.
10. Fagotto, F., K. Guger, and B.M. Gumbiner. 1997. Induction of the primary dorsalizing center in Xenopus by the Wnt/GSK/β-catenin signaling pathway, but not by Vg1, Activin or Noggin. Development (Camb.). 124:453-460.
11. Funayama, N., F. Fagotto, P. McCrea, and B.M. Gumbiner. 1995. Embryonic axis induction by the armadillo repeat domain of β-catenin: evidence for intracellular signaling. J. Cell Biol. 128:959-968.
12. Giebelhaus, D.H., B.D. Zelus, S.K. Henchman, and R.T. Moon. 1987. Changes in expression of α-fodrin during embryonic development of Xenopus laevis. J. Cell Biol. 105:843-853.
13. Guger, K.A., and B.M. Gumbiner. 1995. β-Catenin has Wnt-like activity and mimics the Nieuwkoop signaling center in Xenopus dorsal-ventral patterning. Dev. Biol. 172:115-125.
14. Hayashi, S., B. Rubinfeld, B. Souza, P. Polakis, E. Wieschaus, and A.J. Levine. 1997. A Drosophila homolog of the tumor suppressor gene adenomatous polyposis coli down-regulates β-catenin but its zygotic expression is not essential for the regulation of Armadillo. Proc. Natl. Acad. Sci. USA. 94:242-247.
15. Heim, R., A.B. Cubitt, and R.Y. Tsien. 1995. Improved green fluorescence. Nature (Lond.). 373:663-664.
16. Huber, O., R. Korn, J. McLaughlin, M. Ohsugi, B.G. Herrmann, and R. Kemler. 1996. Nuclear localization of β-catenin by interaction with transcription factor LEF-1. Mech. Dev. 59:3-10.
17. Kalderon, D., B.L. Roberts, W.D. Richardson, and A.E. Smith. 1984. A short amino acid sequence able to specify nuclear location. Cell. 39:499-509.
18. Karnovsky, A., and M. W. Klymkowsky. 1995. Anterior axis duplication in Xenopus induced by the overexpression of the cadherin-binding protein plakoglobin. Proc. Natl. Acad. Sci. USA. 92:4522-4526.
19. Kemler, R. 1993. From cadherins to catenins: cytoplasmic protein interactions and regulation of cell adhesion. Trends Genet. 9:317-321.
20. Kimelman, D., J.L. Christian, and R.T. Moon. 1992. Synergistic principles of development: overlapping patterning systems in Xenopus mesoderm induction. Development (Camb.). 116:1-9.
21. Kofron, M., A. Spagnuolo, M. Klymkowsky, C. Wylie, and J. Heasman. 1997. The roles of maternal α-catenin and plakoglobin in the early Xenopus embryo. Development (Camb.). 124:1553-1560.
22. Korinek, V., N. Barker, P.J. Morin, D. van Wichen, R. de Weger, K.W. Kinzler, B. Vogelstein, and H. Clevers. 1997. Constitutive transcriptional activation by a β-catenin-Tcf complex in APC-/-colon carcinoma. Science (Wash. DC). 275:1784-1787.
23. Kozak, M. 1984. Compilation and analysis of sequences upstream from translational start site in eukaryotic mRNAs. Nucleic Acids Res. 12:857-872.
24. Lanford, R.E., and J.S. Butel. 1984. Constructions and characterization of an SV40 mutant defective in nuclear transport of T antigen. Cell. 39:801-813.
25. Larabell, C.A., M. Torres, B.A. Rowning, C. Yost, J.R. Miller, M. Wu, D. Kimelman, and R.T. Moon. 1997. Establishment of the dorso-ventral axis in Xenopus embryos is presaged by early asymmetries in β-catenin that are modulated by the Wnt signaling pathway. J. Cell Biol. 136:1123-1136.
26. Merriam, J.M., A.B. Rubenstein, and M.W. Klymkowsky. 1997. Cytoplasmically-anchored plakoglobin induces a WNT-like phenotype in Xenopus. Dev. Biol. 185:67-81.
27. Miller, J.R., and R.T. Moon. 1996. Signal transduction through β-catenin and specification of cell fate during embryogenesis. Genes Dev. 10:2527-2539.
28. Molenaar, M., M. van de Wetering, M. Oosterwegel, J. Peterson Maduro, S. Godsave, V. Korinek, J. Roose, O. Destree, and H. Clevers. 1996. XTcf-3 transcription factor mediates β-catenin-induced axis formation in Xenopus embryos. Cell. 86:391-399.
29. Moon, R.T., J.D. Brown, and M. Torres. 1997. Wnts modulate cell fate and behavior during vertebrate development. Trends Genet. 13:157-162.
30. Morin, P.J., A.B. Sparks, V. Korinek, N. Barker, H. Clevers, B. Vogelstein, and K.W. Kinzler. 1997. Activation of β-catenin-Tcf signaling in colon cancer by mutations in β-catenin or APC. Science (Wash. DC). 275:1787-1790.
31. Munemitsu, S., I. Albert, B. Souza, B. Rubinfeld, and P. Polakis. 1995. Regulation of intracellular β-catenin levels by the adenomatous polyposis coli (APC) tumor-suppressor protein. Proc. Natl. Acad. Sci. USA. 92:3046-3050.
32. Näthke, I.S., C.L. Adams, P. Polakis, J.H. Sellin, and W.J. Nelson. 1996. The adenomatous polyposis coli tumor suppressor protein localizes to plasma membrane sites involved in active cell migration. J. Cell Biol. 134:165-179.
33. Orsulic, S., and M. Peifer. 1996. An in vivo structure-function study of Armadillo, the β-catenin homologue, reveals both separate and overlapping regions of the protein required for cell adhesion and for Wingless signaling. J. Cell Biol. 134:1283-1300.
34. Papkoff, J., B. Rubinfeld, B. Schryver, and P. Polakis. 1996. Wnt-1 regulates free pools of catenins and stabilizes APC-catenin complexes. Mol. Cell Biol. 16:2128-2134.
35. Peifer, M. 1995. Cell adhesion and signal transduction: the Armadillo connection. Trends Cell Biol. 5:224-229.
36. Peifer, M., and E. Wieschaus. 1990. The segment polarity gene armadillo encodes a functionally modular protein that is the Drosophila homolog of human plakoglobin. Cell. 63:1167-1176.
37. Peifer, M., L.-M. Pai, and M. Casey. 1994. Phosphorylation of the Drosophila adherens junction protein Armadillo: roles for Wingless signal and Zeste-white 3 kinase. Dev. Biol. 166:543-556.
38. Peifer, M., D. Sweeton, M. Casey, and E. Wieschaus. 1994. Wingless signal and Zeste-white 3 kinase trigger opposing changes in the intracellular distribution of Armadillo. Development (Camb.). 120:369-380.
39. Riese, J., X. Yu. A. Munnerlyn, S. Eresh, S.-C. Hsu, R. Grosschedl, and M. Bienz. 1997. LEF-1, a nuclear factor coordinating signaling inputs from wingless and decapentopalegic. Cell. 88:777-787.
40. Rubinfeld, B., B. Souza, I. Albert, O. Muller, S.H. Chamberlain, F.R. Masiarz, S. Munemitsu, and P. Polakis. 1993. Association of the APC gene product with β-catenin. Science (Wash. DC). 262:1731-1734.
41. Rubinfeld, B., P. Robbins, M. EI-Gamil, I. Albert, E. Porfiri, and P. Polakis. 1997. Stabilization of β-catenin by genetic defects in melanoma cell lines. Science (Wash. DC). 275:1790-1792.
42. Sanson, B., P. White, and J.P. Vincent. 1996. Uncoupling cadherin-based adhesion from wingless signaling in Drosophila. Nature (Lond.). 383:627-630.
43. Schneider, S., H. Steinbeisser, R.M. Warga, and P. Hausen. 1996. β-Catenin translocation into nuclei demarcates the dorsalizing centers of frog and fish embryos. Mech. Dev. 57:191-198.
44. Su, L.K., B. Vogelstein, and K.W. Kinzler. 1993. Association of the APC tumor suppressor protein with catenins. Science (Wash. DC). 262:1734-1737.
45. Torres, M.A., J.A. Yang Snyder, S.M. Purcell, A.A. DeMarais, L.L. McGrew, and R.T. Moon. 1996. Activities of the Wnt-1 class of secreted signaling factors are antagonized by the Wnt-5A class and by a dominant negative cadherin in early Xenopus development. J. Cell Biol. 133:1123-1137.
46. van de Wetering, M., R. Cavallo, D. Dooijes, M. van Beest, J. van Es, J. Loureiro, A. Ypma, D. Hursh, T. Jones, A. Bejsovec, et al. 1997. Armadillo coactivates transcription driven by the product of the Drosophila segment polarity gene dTCF. Cell. 88:789-799.
47. Wen, W., A.T. Harootunian, S.R. Adams, J. Feramisco, R. Tsien, J.L. Meinkoth, and S.S. Taylor. 1994. Heat-stable inhibitors of cAMP-dependent protein kinase carry a nuclear export signal. J. Biol. Chem. 269:32214-32220.
48. Wen, W., J.L. Meinkoth, R.Y. Tsien, and S.S. Taylor. 1995. Identification of a signal for rapid export of proteins from the nucleus. Cell. 82:463-473.
49. Yang-Snyder, J., J.R. Miller, J.D. Brown, C.-J. Lai, and R.T. Moon. 1996. A frizzled homolog functions in a vertebrate Wnt signaling pathway. Curr. Biol. 6:1302-1306.
50. Yost, C., M. Torres, J.R. Miller, E. Huang, D. Kimelman, and R.T. Moon. 1996. The axis-inducing activity, stability, and subcellular distribution of β-catenin is regulated in Xenopus embryos by glycogen synthase kinase 3. Genes Dev. 10:1443-1454.