Traffic control: p120-catenin acts as a gatekeeper to control the fate of classical cadherins in mammalian cells

Journal of Cell Biology

Volumn 163, Issue 3, 2003, Pages 437-440

  Peifer, Mark ^a   Yap, Alpha S ^b  

^a UNIVERSITY OF NORTH CAROLINA   (United States)

^b UNIVERSITY OF QUEENSLAND   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

CADHERIN; CATENIN; PROTEIN P120;

CELL ADHESION; CELL JUNCTION; CELL SURVIVAL; DIMERIZATION; MAMMAL CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; PROTEIN TARGETING; PROTEIN TRANSPORT; REVIEW; SIGNAL TRANSDUCTION;

ADHERENS JUNCTIONS; ANIMALS; CADHERINS; CELL ADHESION; CELL ADHESION MOLECULES; CELL MEMBRANE; HUMANS; MAMMALS; PHOSPHOPROTEINS; PROTEIN TRANSPORT; SIGNAL TRANSDUCTION;

CHEN; MAMMALIA; PYRONIA TITHONUS;

EID: 0242677758     PISSN: 00219525     EISSN: None     Source Type: Journal    
DOI: 10.1083/jcb.200310090     Document Type: Review

References (21)

1. Anastasiadis, P.Z., and P.B. Reynolds. 2000. The p120 catenin family: complex roles in adhesion, signaling and cancer. J. Cell Sci. 113:1319-1334.
2. Angst, B.D., C. Marcozzi, and A.I. Magee. 2001. The cadherin superfamily: diversity in form and function. J. Cell Sci. 114:629-641.
3. Chen, Y.-H., D.B. Stewart, and W.J. Nelson. 1999. Coupling assembly of the E-cadherin/β-catenin complex to efficient endoplasmic reticulum exit and basal-lateral membrane targeting of E-cadherin in polarized MDCK cells. Cell Biol. 144:687-699.
4. Chen, X., S.-I. Kojima, G.G. Borisy, and K.J. Green. 2003. p120 catenin associates with kinesin and facilitates the transport of cadherin-catenin complexes to intercellular junctions. J. Cell Biol. 163:547-557.
5. Davis, M.A., R.C. Ireton, and A.B. Reynolds. 2003. A core function for p120-catenin in cadherin turnover. J. Cell Biol. 163:525-534.
6. Fujita, Y., G. Krause, M. Scheffner, D. Zechner, H.E. Leddy, J. Behrens, T. Sommer, and W. Birchmeier. 2002. Hakai, a c-Cbl-like protein, ubiquitinates and induces endocytosis of the E-cadherin complex. Nat. Cell Biol. 4:222-231.
7. Goodwin, M., E.M. Kovacs, M.A. Thoreson, A.B. Reynolds, and A.S. Yap. 2003. Minimal mutation of the cytoplasmic tail inhibits the ability of E-cadherin to activate Rac but not phosphatidylinositol 3-kinase: direct evidence of a role for cadherin-activated Rac signaling in adhesion and contact formation. J. Biol. Chem. 278:20533-20539.
8. Ireton, R.C., M.A. Davis, J. van Hengel, D.J. Mariner, K. Barnes, M.A. Thoreson, P.Z. Anastasiadis, L. Matrisian, L.M. Bundy, L. Sealy, et al. 2002. A novel role for p120 catenin in E-cadherin function. J. Cell Biol. 159:465-476.
9. Le, T.L., A.S. Yap, and J.L. Stow. 1999. Recycling of E-cadherin: a potential mechanism for regulating cadherin dynamics. J. Cell Biol. 146:219-232.
10. Mary, S., S. Charrasse, M. Meriane, F. Comunale, P. Travo, A. Blangy, and C. Gauthier-Rouviere. 2002. Biogenesis of N-cadherin-dependent cell-cell contacts in living fibroblasts is a microtubule-dependent kinesin-driven mechanism. Mol. Biol. Cell. 13:285-301.
11. Miranda, K.C., T. Khromykh, P. Christy, T.L. Le, C.J. Gottardi, A.S. Yap, J.L. Stow, and R.D. Teasdale. 2001. A dileucine motif targets E-cadherin to the basolateral cell surface in Madin-Darby canine kidney and LLC-PK1 epithelial cells. J. Biol. Chem. 276:22565-22572.
12. Myster, S.H., R. Cavallo, C.T. Anderson, D.T. Fox, and M. Peifer. 2003. Drosophila p120catenin plays a supporting role in cell adhesion but is not an essential adherens junction component. J. Cell Biol. 160:433-449.
13. Ozawa, M., and R. Kemler. 1998. The membrane-proximal region of the E-cadherin cytoplasmic domain prevents dimerization and negatively regulates adhesion activity. J. Cell Biol. 142:1605-1613.
14. Pacquelet, A., L. Lin, and P. Rorth. 2003. Binding site for p120/delta-catenin is not required for Drosophila E-cadherin function in vivo. J. Cell Biol. 160:313-319.
15. Palacios, F., L. Price, J. Schweitzer, J.G. Collard, and C. D'Souza-Schorey. 2001. An essential role for ARF6-regulated membrane traffic in adherens junction turnover and epithelial cell migration. EMBO J. 20:4973-4986.
16. Paterson, A.D., R.G. Parton, C. Ferguson, J.L. Stow, and A.S. Yap. 2003. Characterization of E-cadherin endocytosis in isolated MCF-7 and chinese hamster ovary cells: the initial fate of unbound E-cadherin. J. Biol. Chem. 278:21050-21057.
17. Pettitt, J., E.A. Cox, I.D. Broadbent, A. Flett, and J. Hardin. 2003. The Caenorhabditis elegans p120 catenin homologue, JAC-1, modulates cadherin-catenin function during epidermal morphogenesis. J. Cell Biol. 162:15-22.
18. Shore, E.M., and W.J. Nelson. 1991. Biosynthesis of the cell adhesion molecule uvomorulin (E-cadherin) in Madin-Darby canine kidney epithelial cells. J. Biol. Chem. 266:19672-19680.
19. ctn from E-cadherin disrupts strong adhesion. J. Cell Biol. 148: 189-201.
20. Xiao, K., D.F. Allison, K.M. Buckley, M. Kottke, P.A. Vincent, V. Faundez, and A.P. Kowalczyk. 2003. Cellular levels of p120-catenin function as a set point for cadherin expression levels in microvascular endothelial cells. J. Cell Biol. 163:535-545.
21. Yap, A.S., C.M. Niessen, and B.M. Gumbiner. 1998. The juxtamembrane region of the cadherin cytoplasmic tail supports lateral clustering, adhesive strengthening, and interaction with p120ctn. J. Cell Biol. 141:779-789.