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Volumn 18, Issue 7, 1999, Pages 1738-1747

A new crystal structure, Ca2+ dependence and mutational analysis reveal molecular details of E-cadherin homoassociation

Author keywords

Cell adhesion; E cadherin; Electron microscopy; Mechanism; X ray crystallography

Indexed keywords

CALCIUM ION; MATRIX PROTEIN; OLIGOMER; UVOMORULIN;

EID: 0033119626     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/18.7.1738     Document Type: Article
Times cited : (348)

References (46)
  • 1
    • 0030000980 scopus 로고    scopus 로고
    • Cadherin-catenin complex: Protein interactions and their implications for cadherin function
    • Aberle, H., Schwartz, H. and Kemler, R. (1996) Cadherin-catenin complex: protein interactions and their implications for cadherin function. J. Cell. Biochem., 61, 514-523.
    • (1996) J. Cell. Biochem. , vol.61 , pp. 514-523
    • Aberle, H.1    Schwartz, H.2    Kemler, R.3
  • 3
    • 0025238409 scopus 로고
    • Identification of a cadherin cell adhesion recognition sequence
    • Blaschuk, O.W., Sullivan, R., David, S. and Pouliot, Y. (1990) Identification of a cadherin cell adhesion recognition sequence. Dev. Biol., 139, 227-229.
    • (1990) Dev. Biol. , vol.139 , pp. 227-229
    • Blaschuk, O.W.1    Sullivan, R.2    David, S.3    Pouliot, Y.4
  • 4
    • 0028820577 scopus 로고
    • Calcium ions as extracellular messengers
    • Brown, E.M., Vassilev, P.M. and Hebert, S.C. (1995) Calcium ions as extracellular messengers. Cell, 83, 679-682.
    • (1995) Cell , vol.83 , pp. 679-682
    • Brown, E.M.1    Vassilev, P.M.2    Hebert, S.C.3
  • 6
    • 0025727179 scopus 로고
    • Differentiation and survival of rat olfactory epithelial neurons in dissociated cell culture
    • Chuah, M.I., David, S. and Blaschuk, O. (1991) Differentiation and survival of rat olfactory epithelial neurons in dissociated cell culture. Brain Res. Dev. Brain Res., 60, 123-132.
    • (1991) Brain Res. Dev. Brain Res. , vol.60 , pp. 123-132
    • Chuah, M.I.1    David, S.2    Blaschuk, O.3
  • 7
    • 0028103275 scopus 로고
    • The CCP4 suite: Programs for protein crystallography
    • Collaborative Computational Project No. 4 (1994) The CCP4 suite: programs for protein crystallography. Acta Crystallogr., D50, 760-763.
    • (1994) Acta Crystallogr. , vol.D50 , pp. 760-763
  • 8
    • 0026033488 scopus 로고
    • Neurite outgrowth in response to transfected N-CAM and N-cadherin reveals fundamental differences in neuronal responsiveness to CAMs
    • Doherty, P., Rowett, L.H., Moore, S.E., Mann, D.A. and Walsh, F.S. (1991) Neurite outgrowth in response to transfected N-CAM and N-cadherin reveals fundamental differences in neuronal responsiveness to CAMs. Neuron, 6, 247-258.
    • (1991) Neuron , vol.6 , pp. 247-258
    • Doherty, P.1    Rowett, L.H.2    Moore, S.E.3    Mann, D.A.4    Walsh, F.S.5
  • 9
    • 0028213804 scopus 로고
    • The thrombospondin-like chains of cartilage oligomeric matrix protein are assembled by a five-stranded α-helical bundle between residues 20 and 83
    • Efimov, V.P., Lustig, A. and Engel, J. (1994) The thrombospondin-like chains of cartilage oligomeric matrix protein are assembled by a five-stranded α-helical bundle between residues 20 and 83. FEBS Lett., 341, 54-58.
    • (1994) FEBS Lett. , vol.341 , pp. 54-58
    • Efimov, V.P.1    Lustig, A.2    Engel, J.3
  • 10
    • 0028936928 scopus 로고
    • Electron microscopy of extracellular matrix components
    • Engel, J. (1994) Electron microscopy of extracellular matrix components. Methods Enzymol., 245, 469-488.
    • (1994) Methods Enzymol. , vol.245 , pp. 469-488
    • Engel, J.1
  • 11
    • 79952608525 scopus 로고
    • Accurate bond and angle parameters for X-ray protein structure refinement
    • Engh, R.A. and Huber, R. (1991) Accurate bond and angle parameters for X-ray protein structure refinement. Acta Crystallog. sect. A, 47, 392-400.
    • (1991) Acta Crystallog. Sect. A , vol.47 , pp. 392-400
    • Engh, R.A.1    Huber, R.2
  • 12
    • 0027609916 scopus 로고
    • SETOR: Harvard-lighted three dimensional solid model representation of macromolecules
    • Evans, S.V. (1993) SETOR: Harvard-lighted three dimensional solid model representation of macromolecules. J. Mol. Graph., 11, 134-142.
    • (1993) J. Mol. Graph. , vol.11 , pp. 134-142
    • Evans, S.V.1
  • 13
    • 0025325983 scopus 로고
    • The megaprimer method of site directed mutagenesis
    • Gobinda, S. and Sommer, S.S. (1990) The megaprimer method of site directed mutagenesis. BioTechniques, 8, 404-407.
    • (1990) BioTechniques , vol.8 , pp. 404-407
    • Gobinda, S.1    Sommer, S.S.2
  • 14
    • 0030056968 scopus 로고    scopus 로고
    • Cell adhesion: The molecular basis of tissue architecture and morphogenesis
    • Gumbiner, B.M. (1996) Cell adhesion: the molecular basis of tissue architecture and morphogenesis. Cell, 84, 345-357.
    • (1996) Cell , vol.84 , pp. 345-357
    • Gumbiner, B.M.1
  • 15
    • 0003124714 scopus 로고
    • Site directed mutagenesis and gene splicing by overlap extension
    • Ho, S. (1990) Site directed mutagenesis and gene splicing by overlap extension. DNA Protein Eng., 2, 50-55.
    • (1990) DNA Protein Eng. , vol.2 , pp. 50-55
    • Ho, S.1
  • 16
    • 0019771667 scopus 로고
    • Cell-cell interactions in early embryogenesis: A molecular approach to the role of calcium
    • Hyafil, F., Babinet, C. and Jacob, F. (1981) Cell-cell interactions in early embryogenesis: a molecular approach to the role of calcium. Cell, 26, 447-454.
    • (1981) Cell , vol.26 , pp. 447-454
    • Hyafil, F.1    Babinet, C.2    Jacob, F.3
  • 17
    • 0020997912 scopus 로고
    • Dictionary of secondary structures: Pattern recognition of hydrogen-bonded and geometrical features
    • Kabsch, W. and Sander, C. (1983) Dictionary of secondary structures: pattern recognition of hydrogen-bonded and geometrical features. Biopolymers, 22, 2577-2637.
    • (1983) Biopolymers , vol.22 , pp. 2577-2637
    • Kabsch, W.1    Sander, C.2
  • 18
    • 0024745305 scopus 로고
    • 2+-dependent cell adhesion molecule
    • 2+-dependent cell adhesion molecule. BioEssays, 11, 88-91.
    • (1989) BioEssays , vol.11 , pp. 88-91
    • Kemler, R.1    Ozawa, M.2
  • 19
    • 0030842356 scopus 로고    scopus 로고
    • Calcium binding and homoassociation of E-cadherin domains
    • Koch, A.W., Pokutta, S., Lustig, A. and Engel, J. (1997) Calcium binding and homoassociation of E-cadherin domains. Biochemistry, 36, 7697-7705.
    • (1997) Biochemistry , vol.36 , pp. 7697-7705
    • Koch, A.W.1    Pokutta, S.2    Lustig, A.3    Engel, J.4
  • 21
    • 0029911261 scopus 로고    scopus 로고
    • The crystal structure of a five-stranded coiled coil in COMP: A prototype ion channel?
    • Malashkevich, V.N., Kammerer, R.A., Efimov, V.P., Schulthess, T. and Engel, J. (1996) The crystal structure of a five-stranded coiled coil in COMP: a prototype ion channel? Science, 274, 761-765.
    • (1996) Science , vol.274 , pp. 761-765
    • Malashkevich, V.N.1    Kammerer, R.A.2    Efimov, V.P.3    Schulthess, T.4    Engel, J.5
  • 23
    • 0029045234 scopus 로고
    • The role of cadherin in the generation of multinucleated osteoclasts from mononuclear precursors in murine marrow
    • Mbalaviele, G., Chen, H., Boyce, B.F., Mundy, G.R. and Yoneda, T. (1995) The role of cadherin in the generation of multinucleated osteoclasts from mononuclear precursors in murine marrow. J. Clin. Invest., 95, 2757-2765.
    • (1995) J. Clin. Invest. , vol.95 , pp. 2757-2765
    • Mbalaviele, G.1    Chen, H.2    Boyce, B.F.3    Mundy, G.R.4    Yoneda, T.5
  • 24
    • 0027398589 scopus 로고
    • Spatial and temporal dissection of immediate and early events following cadherin-mediated epithelial cell adhesion
    • McNeill, H., Ryan,T.A., Smith, S.J. and Nelson, W.J. (1993) Spatial and temporal dissection of immediate and early events following cadherin-mediated epithelial cell adhesion. J. Cell Biol., 120, 1217-1226.
    • (1993) J. Cell Biol. , vol.120 , pp. 1217-1226
    • McNeill, H.1    Smith, S.J.2    Nelson, W.J.3
  • 25
    • 0027103923 scopus 로고
    • N-cadherin and N-CAM in myoblast fusion: Compared localisation and effect of blockade by peptides and antibodies
    • Mege, R.M., Goudou, D., Diaz, C., Nicolet, M., Garcia, L., Geraud, G. and Rieger, F. (1992) N-cadherin and N-CAM in myoblast fusion: compared localisation and effect of blockade by peptides and antibodies. J. Cell Sci., 103, 897-906.
    • (1992) J. Cell Sci. , vol.103 , pp. 897-906
    • Mege, R.M.1    Goudou, D.2    Diaz, C.3    Nicolet, M.4    Garcia, L.5    Geraud, G.6    Rieger, F.7
  • 26
    • 0029980542 scopus 로고    scopus 로고
    • Structural basis of calcium-induced E-cadherin rigidification and dimerization
    • Nagar, B., Overduin, M., Ikura, M. and Rini, J.M. (1996) Structural basis of calcium-induced E-cadherin rigidification and dimerization. Nature, 380, 360-354.
    • (1996) Nature , vol.380 , pp. 360-1354
    • Nagar, B.1    Overduin, M.2    Ikura, M.3    Rini, J.M.4
  • 27
    • 84920325457 scopus 로고
    • AMORE: An automated procedure for molecular replacement
    • Navaza, J. (1994) AMORE: an automated procedure for molecular replacement. Acta Crystallogr., A50, 157-163.
    • (1994) Acta Crystallogr. , vol.A50 , pp. 157-163
    • Navaza, J.1
  • 28
    • 0031801571 scopus 로고    scopus 로고
    • Contributions of extracellular and intracellular domains of full length and chimeric cadherin molecules to junction assembly in epithelial cells
    • Norvell, S. and Green, K. (1998) Contributions of extracellular and intracellular domains of full length and chimeric cadherin molecules to junction assembly in epithelial cells. J. Cell Sci., 111, 1305-1318.
    • (1998) J. Cell Sci. , vol.111 , pp. 1305-1318
    • Norvell, S.1    Green, K.2
  • 29
    • 0025239290 scopus 로고
    • Localization of specificity determining sites in cadherin cell adhesion molecules
    • Nose, A., Tsuji, K. and Takeichi, M. (1990) Localization of specificity determining sites in cadherin cell adhesion molecules. Cell, 61, 147-155.
    • (1990) Cell , vol.61 , pp. 147-155
    • Nose, A.1    Tsuji, K.2    Takeichi, M.3
  • 30
    • 0028956981 scopus 로고
    • Solution structure of the epithelial cadherin domain responsible for selective cell adhesion
    • Overduin, M., Harvey, T.S., Bagby, S., Tong, K.I., Yau, P., Takeichi, M. and Ikura, M. (1995) Solution structure of the epithelial cadherin domain responsible for selective cell adhesion. Science, 267, 386-389.
    • (1995) Science , vol.267 , pp. 386-389
    • Overduin, M.1    Harvey, T.S.2    Bagby, S.3    Tong, K.I.4    Yau, P.5    Takeichi, M.6    Ikura, M.7
  • 31
    • 0025064957 scopus 로고
    • Correct proteolytic cleavage is required for the cell adhesive function of uvomorulin
    • Ozawa, M. and Kemler, R. (1990) Correct proteolytic cleavage is required for the cell adhesive function of uvomorulin. J. Cell Biol., 111, 1645-1650.
    • (1990) J. Cell Biol. , vol.111 , pp. 1645-1650
    • Ozawa, M.1    Kemler, R.2
  • 32
    • 0025612251 scopus 로고
    • 2+ binding site of uvomorulin abolishes the adhesive function
    • 2+ binding site of uvomorulin abolishes the adhesive function. Cell 63, 1033-1038.
    • (1990) Cell , vol.63 , pp. 1033-1038
    • Ozawa, M.1    Engel, J.2    Kemler, R.3
  • 34
    • 0028093281 scopus 로고
    • Conformational changes of the recombinant extracellular domain of E-cadherin upon calcium binding
    • Pokutta, S., Herrenknecht, K., Kemler, R. and Engel, J. (1994) Conformational changes of the recombinant extracellular domain of E-cadherin upon calcium binding. Eur. J. Biochem., 223, 1019-1026.
    • (1994) Eur. J. Biochem. , vol.223 , pp. 1019-1026
    • Pokutta, S.1    Herrenknecht, K.2    Kemler, R.3    Engel, J.4
  • 35
    • 0028040474 scopus 로고
    • Cadherins and catenins: Interactions and functions in embryonic development
    • Ranscht, B. (1994) Cadherins and catenins: interactions and functions in embryonic development. Curr. Opin. Cell Biol., 6, 740-746.
    • (1994) Curr. Opin. Cell Biol. , vol.6 , pp. 740-746
    • Ranscht, B.1
  • 36
    • 0028986780 scopus 로고
    • Structural basis of cell-cell adhesion by cadherins
    • Shapiro, L. et al. (1995) Structural basis of cell-cell adhesion by cadherins. Nature, 374, 327-337.
    • (1995) Nature , vol.374 , pp. 327-337
    • Shapiro, L.1
  • 37
    • 0344545617 scopus 로고    scopus 로고
    • Dimeric E-cadherin functions as a fundamental unit at the cell-cell adhesive interface
    • in press
    • Takeda, H., Nagafuchi, A., Shimoyama, Y. and Hirohashi, S. (1999) Dimeric E-cadherin functions as a fundamental unit at the cell-cell adhesive interface. Nature Struct. Biol., in press.
    • (1999) Nature Struct. Biol.
    • Takeda, H.1    Nagafuchi, A.2    Shimoyama, Y.3    Hirohashi, S.4
  • 38
    • 0025325167 scopus 로고
    • Cadherins: A molecular family important in selective cell-cell adhesion
    • Takeichi, M. (1990) Cadherins: a molecular family important in selective cell-cell adhesion. Annu. Rev. Biochem., 59, 237-252.
    • (1990) Annu. Rev. Biochem. , vol.59 , pp. 237-252
    • Takeichi, M.1
  • 39
    • 0025894092 scopus 로고
    • Cadherin cell adhesion receptors as a morphogenetic regulator
    • Takeichi, M. (1991) Cadherin cell adhesion receptors as a morphogenetic regulator. Science, 251, 1451-1455.
    • (1991) Science , vol.251 , pp. 1451-1455
    • Takeichi, M.1
  • 40
    • 0032102397 scopus 로고    scopus 로고
    • Structure-function analysis of cell adhesion by neural (N-) cadherin
    • Tamura, K., Shan, W.-S., Hendrickson, W.A., Colman, D.R. and Shapiro, L. (1998) Structure-function analysis of cell adhesion by neural (N-) cadherin. Neuron, 20, 1153-1163.
    • (1998) Neuron , vol.20 , pp. 1153-1163
    • Tamura, K.1    Shan, W.-S.2    Hendrickson, W.A.3    Colman, D.R.4    Shapiro, L.5
  • 41
    • 0032103412 scopus 로고    scopus 로고
    • A role for the cadherin family of cell adhesion molecules in hippocampal long-term potentiation
    • Tang, L., Hung, C.P. and Schuman, E.M. (1998) A role for the cadherin family of cell adhesion molecules in hippocampal long-term potentiation. Neuron, 20, 1165-1175.
    • (1998) Neuron , vol.20 , pp. 1165-1175
    • Tang, L.1    Hung, C.P.2    Schuman, E.M.3
  • 42
    • 0029939591 scopus 로고    scopus 로고
    • Homophilic adhesion of E-cadherin occurs by a co-operative two-step interaction of N-terminal domains
    • Tomschy, A., Fauser, C., Landwehr, R. and Engel, J. (1996) Homophilic adhesion of E-cadherin occurs by a co-operative two-step interaction of N-terminal domains. EMBO J., 15, 3507-3514.
    • (1996) EMBO J. , vol.15 , pp. 3507-3514
    • Tomschy, A.1    Fauser, C.2    Landwehr, R.3    Engel, J.4
  • 44
    • 0028921280 scopus 로고
    • E-cadherin: A distant member of the immunoglobulin superfamily
    • Wagner, G. (1995) E-cadherin: a distant member of the immunoglobulin superfamily. Science, 267, 342.
    • (1995) Science , vol.267 , pp. 342
    • Wagner, G.1
  • 45
    • 0031149109 scopus 로고    scopus 로고
    • Lateral clustering of the adhesive ectodomain: A fundamental determinant of cadherin function
    • Yap, A.S., Brieher, W.M., Pruschy, M. and Gumbiner, B.M. (1997) Lateral clustering of the adhesive ectodomain: a fundamental determinant of cadherin function. Curr. Biol., 7, 308-315.
    • (1997) Curr. Biol. , vol.7 , pp. 308-315
    • Yap, A.S.1    Brieher, W.M.2    Pruschy, M.3    Gumbiner, B.M.4
  • 46
    • 0032482201 scopus 로고    scopus 로고
    • The juxtamembrane region of the cadherin cytoplasmic tail supports lateral clustering, adhesive strengthening and interaction with p120 (ctn)
    • Yap, A.S., Niessen, C.M. and Gumbiner, B.M. (1998) The juxtamembrane region of the cadherin cytoplasmic tail supports lateral clustering, adhesive strengthening and interaction with p120 (ctn). J. Cell Biol., 141, 779-789.
    • (1998) J. Cell Biol. , vol.141 , pp. 779-789
    • Yap, A.S.1    Niessen, C.M.2    Gumbiner, B.M.3


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