Desmosomes: Structure and function in normal and diseased epidermis

Journal of Dermatology

Volumn 28, Issue 6, 2001, Pages 291-298

  McMillan, J R ^a   Shimizu, H ^a  

^a HOKKAIDO UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Adherens junction; Cadherins; Desmosomal plaque; Intermediate filaments; Plakophilin 1

Indexed keywords

CADHERIN; CALCIUM CHANNEL; CALCIUM ION; DESMOCOLLIN; DESMOGLEIN; DESMOPLAKIN; PLAKOGLOBIN; PLAKOPHILIN 1; UNCLASSIFIED DRUG;

AUTOIMMUNE DISEASE; CELL ADHESION; DARIER DISEASE; DESMOSOME; EPIDERMIS; HAILEY HAILEY DISEASE; HAIR DISEASE; HUMAN; KERATOSIS PALMOPLANTARIS; NAIL DISEASE; NONHUMAN; PEMPHIGUS FOLIACEUS; PEMPHIGUS VULGARIS; REVIEW; SKIN DISEASE;

EID: 0034923678     PISSN: 03852407     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1346-8138.2001.tb00136.x     Document Type: Review

References (56)

1. Desmosomes and hemidesmosomes
2. Making a connection: Direct binding between keratin intermediate filaments and desmosomal proteins
3. Desmosomes and hemidesmosomes: Structure and function of molecular components
4. Desmosomes and cancer
5. Desmosomes: Intercellular adhesive junctions specialized for attachment of intermediate filaments
6. The desmosome-intermediate filament complex
7. Desmosomal proteins: New markers for identification and classification of tumours
8. Desmosomes and hemidesmosomes: Constitutive molecular components
9. Desmosomes and cytoskeletal architecture in epithelial differentiation: Cell type-specific plaque components and intermediate filament anchorage
10. Structure and interactions of desmosomal and other cadherins
11. Analysis of desmosomal cadherin-adhesive function and stoichiometry of desmosomal cadherin-plakoglobin complexes
12. Demonstration of desmosomal antigens by electron microscopy using cryofixed and cryosubstituted skin with silver-enhanced gold probe
13. Pemphigus vulgaris and pemphigus foliaceus sera show an inversely graded binding pattern to extracellular regions of desmosomes in different layers of human epidermis
14. Aspects of the structure and assembly of desmosomes
15. Cloning and sequence analysis of desmosomal glycoproteins 2 and 3 (desmocollins): Cadherin-like desmosomal adhesion molecules with heterogeneous cytoplasmic domains
16. Identification of desmoglein, a constitutive desmosomal glycoprotein, as a member of the cadherin family of cell adhesion molecules
17. Desmosomal cadherins: Another growing multigene family of adhesion molecules
18. Interaction of plakophilins with desmoplakin and intermediate filament proteins: An in vitro analysis
19. Identification of a basic protein of Mr 75000 as an accessory desmosomal plaque protein in stratified and complex epithelia
20. The function of plakophilin 1 in desmosome assembly and actin filament organisation
21. Interactions of the cytoplasmic domain of the desmosomal cadherin Dsg1 with plakoglobin
22. Identification of the plakoglobin-binding domain in desmoglein and its role in plaque assembly and intermediate filament anchorage
23. Plakoglobin domains that define its association with the desmosomal cadherins and the classical cadherins: Identification of unique and shared domains
24. Molecular organization of the desmoglein-plakoglobin complex
25. Defining the interactions between intermediate filaments and desmosomes
26. Coexpression of both types of desmosomal cadherin and plakoglobin confers strong intercellular adhesion
27. The distribution of the desmosomal protein, plakophilin 1, in human skin and skin tumors
28. Band 6 protein, a major constituent of desmosomes from stratified epithelia, is a novel member of the armadillo multigene family
29. Molecular map of the desmosomal plaque
30. Localization of major desmosomal components in human epidermis
31. Desmoplakins of epithelial and myocardial desmosomes are immunologically and biochemically related
32. Immunocytochemical identification of epithelium-derived human tumors with antibodies to desmosomal plaque proteins
33. Hereditary diseases of desmosomes
34. Mutations in the plakophilin 1 gene result in ectodermal dysplasia/skin fragility syndrome
35. Skin fragility and hypohidrotic ectodermal dysplasia resulting from ablation of plakophilin 1
36. Genomic amplification of the human plakophilin 1 gene and detection of a new mutation in ectodermal dysplasia/skin fragility syndrome
37. Haploinsufficiency of desmoplakin causes a striate subtype of palmoplantar keratoderma
38. Striate palmoplantar keratoderma resulting from desmoplakin haploinsufficiency
39. N-terminal deletion in a desmosomal cadherin causes the autosomal dominant skin disease striate palmoplantar keratoderma
40. Identification of a deletion in plakoglobin in arrhythmogenic right ventricular cardiomyopathy with palmoplantar keratoderma and woolly hair (Naxos disease)
41. Mutations in ATP2A2, encoding a Ca2+ pump, cause Darier disease
42. Mutations in ATP2C1, encoding a calcium pump, cause Hailey-Hailey disease
43. Hailey-Hailey disease is caused by mutations in ATP2C1 encoding a novel Ca(2+) pump
44. ATP2A2 mutations in Darier's disease and their relationship to neuropsychiatric phenotypes
45. The gene for Naegeli-Franceschetti-Jadassohn syndrome maps to 17 q21
46. Embryonic heart and skin defects in mice lacking plakoglobin
47. Targeted mutation of plakoglobin in mice reveals essential functions of desmosomes in the embryonic heart
48. Desmosomal localization of beta-catenin in the skin of plakoglobin null-mutant mice
49. Targeted disruption of the pemphigus vulgaris antigen (desmoglein 3) gene in mice causes loss of keratinocyte cell adhesion with a phenotype similar to pemphigus vulgaris
50. Autoantibodies against the amino-terminal cadherin-like binding domain of pemphigus vulgaris antigen are pathogenic
51. Antigen-specific immunoadsorption of pathogenic autoantibodies in pemphigus foliaceus
52. Targeted inactivation of plectin reveals essential function in maintaining the integrity of skin muscle and heart cytoarchitecture
53. The pathogenic effect of IgG4 autoantibodies in endemic pemphigus foliaceus (fogo selvagem)
54. Autoimmunity against desmosomal cadherins in pemphigus
55. The desmosome and hemidesmosome in cutaneous autoimmunity
56. Pemphigus. Loss of desmosomal cell-cell contact