Metformin restores insulin secretion altered by chronic exposure to free fatty acids or high glucose: A direct metformin effect on pancreatic β-cells

Diabetes

Volumn 49, Issue 5, 2000, Pages 735-740

  Patanè, Giovanni ^a   Piro, Salvatore ^a   Rabuazzo, Agata Maria ^a   Anello, Marcello ^a   Vigneri, Riccardo ^a   Purrello, Francesco ^a,b  

^a UNIVERSITY OF CATANIA   (Italy)

^b GARIBALDI HOSPITAL   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

FATTY ACID; GLUCOSE; INSULIN; METFORMIN;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; GLUCOSE UTILIZATION; INSULIN RELEASE; LIPID OXIDATION; MALE; NONHUMAN; PANCREAS ISLET BETA CELL; PANCREAS ISLET CELL FUNCTION; PRIORITY JOURNAL; RAT;

EID: 0034072962     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diabetes.49.5.735     Document Type: Article

References (40)

1. Bailey CJ, Path MCR, Turner RC: Metformin. N Engl J Med 334:574-579, 1996
2. Stumvoll M, Nurjhan N, Perriello G, Dailey G, Gerich JE: Metabolic effects of metformin in non-insulin-dependent diabetes mellitus. N Engl J Med 333:550-554, 1995
3. Jackson RA, Hawa MI, Jaspan JB, Sim BM, Disilvio L, Featherbe D, Kurtz AB: Mechanism of metformin action in non-insulin-dependent diabetes. Diabetes 36:632-640, 1987
4. DeFronzo RA, Barzilai N, Simonson DC: Mechanism of metformin action in obese and lean non-insulin-dependent diabetic subjecls. J Clin Endocrinol Metab 73:1294-1301, 1991
5. Reaven GM, Johnston P, Hollenbeck CB, Skowronski R, Zhang JC, Goldfine ID, Chen YD: Combined metformin-sulfonylurea treatment of patients with noninsulin-dependent diabetes in fair to poor glycemic control. J Clin Endocrinol Metab 74:1020-1026, 1992
6. Boyd K, Rogers C, Boreham C, Andrews WJ, Hadden DR: Insulin, glibenclamide or metformin treatment for non insulin dependent diabetes: heterogeneous responses of standard measures of insulin action and insulin secretion before and after differing hypoglycaemic therapy. Diabetes Res 19:69-76, 1992
7. Rossetti L, DeFronzo RA, Gherzi R, Stein P, Andraghetti C, Falzetti C, Shulmann GI, Klein-Robbenhaar E, Cordera R: Effect of metformin treatment on insulin action in diabetic rat: in vivo and in vitro correlations. Metabolism 39:425-435, 1990
8. Galuska D, Nolte LA, Zierath JR, Walberg-Henriksson H: Effect of metformin on insulin-stimulated glucose transport in isolated skeletal muscle obtained from patients with NIDDM. Diabetologia 37:826-832, 1994
9. Muntoni S: Inhibition of fatty acid oxidation by biguanides: implication for metabolic physiopathology. Adv Lipid Res 12:311-377, 1974
10. Perriello G, Misericordia P, Volpi E, Santucci A, Santucci C, Ferrannini E, Ventura MN, Santeusanio F, Brunetti P, Bolli GB: Evidence for suppression of lipid oxidation and hepatic glucose production. Diabetes 43:920-928, 1994
11. Grodsky GM, Bolaffi JL: Desensitization of the insulin-secreting beta cell. J Cell Biochem 48:3-11, 1992
12. Leahy JL, Cooper HE, Deal DA, Weir GC: Chronic hyperglycemia is associated with impaired glucose influence on insulin secretion. J Clin Invest 77:908-915, 1986
13. Hoenig M, MacGregor LC, Matschinsky FM: In vitro exhaustion of pancreatic β-cells. Am J Physiol 250:E502-E511, 1986
14. Purrello F, Vetri M, Gatta C, Gullo D, Vigneri R: Effects of high glucose on insulin secretion by isolated rat islets and purified β-cells and possible role of glycosylation. Diabetes 38:1417-1422, 1989
15. Bjorklund A, Yaney G, McGarry JD, Weir G: Fatty acids and beta-cell function. Diabetologia 40 (Suppl 3):B21-B26, 1997
16. Prentki M, Vischer S, Glennon MC, Regazzi R, Deeney JT, Corkey BE: Malonyl-CoA and long chain acyl-Coa esters as metabolic coupling factors in nutrient-induced insulin secretion. J Biol Chem 267:5802-5810, 1992
17. Paolisso G, Gambardella A, Amato L, Tortoriello R, D'Amore A, Varricchio M, D'Onofrio F: Opposite effects of short- and long-term fatty acids infusion on insulin secretion in healthy subjects. Diabetologia 38:1295-1299, 1995
18. Sako Y, Grill VE: A 48-hour lipid infusion in the rat time-dependently inhibits glucose-induced insulin secretion and β cell oxidation through a process likely coupled to fatty acid oxidation. Endocrinology 127:1580-1589, 1990
19. Hosokawa H, Corkey BE, Leahy JL: Beta-cells hypersensitivity to glucose following 24-h exposure of rat islets to fatty acids. Diabetologia 40:392-397, 1997
20. Elks MN: Chronic perifusion of rat islets with palmitate suppresses glucose-stimulated insulin release. Endocrinology 133:208-214, 1993
21. McGarry JD, Dobbins RL: as, lipotoxicity and insulin secretion. Diabetologia 42:128-138, 1999
22. Randle PJ, Garland PB, Hales CN, Newsholm EA: The glucose fatty acids cycle, ils role in insulin sensitivity and the metabolic disturbances in diabetes mellitus. Lancet i:785-789, 1963
23. Zhou YP, Grill V: Long-term exposure of rat pancreatic islets to fatty acids inhibits glucose-induced insulin secretion and biosynthesis through glucose fatty acid cycle. J Clin Invest 93:870-876, 1994
24. Anello M, Rabuazzo AM, Degano C, Caltabiano V, Patané G, Vigneri R, Purrello F: Fast reversibility of glucose-induced desensitization in rat pancreatic islets: evidence for an involvement of ionic fluxes. Diabetes 45:502-506, 1996
25. Lee Y, Hiroshi H, Makoto O, Johnson JH, McGarry JD, Unger RH: β-Cell lipotoxicity in the pathogenesis of non-insulin-dependent diabetes mellitus of obese rats: impairment in adipocyte-β-cell relationship. Proc Natl Acad Sci U S A 91:10878-10882, 1994
26. Purrello F, Buscema N, Rabuazzo AM, Caltabiano V, Forte F, Vinci C, Vetri M, Vigneri R: Glucose modulates glucose transporter affinity, glucokinase activity and secretory response in rat pancreatic β-cells. Diabetes 42:199-205, 1993
27. Rabuazzo AM, Buscema M, Caltabiano V, Anello M, Patané G, Vigneri R, Purello F: Interleukin-1β inhibition of insulin release in rat pancreatic islet: possible involvement of G-proteins in the signal transduction pathway. Diabetologia 38:779-784, 1995
28. Chen S, Ogawa A, Makoto O, Unger RH, Foster DW, McGarry JD: More direct evidence for a malonyl-CoA-carnitine palmitoyltransferase I interaction as a key event in pancreatic β-cell signaling. Diabetes 43:878-883, 1994
29. Shimabukuro M, Koyama K, Chen G. Wang MY, Lee Y, Newgard CB, Unger RH: Direct antidiabetic effects of leptin through triglyceride depletion of tissue. Proc Natl Acad Sci U S A 94:4637-4641, 1997
30. Lupi R, Del Guerra S, Tellini C, Giannarelli R, Coppelli A, Lorenzetti M, Carmellini M, Mosca F, Navalesi R, Marchetti P: The biguanide compound metformin prevents desensitization of human pancreatic islets induced by high glucose. Eur J Pharmacol 8:205-209, 1999
31. Randle PJ, Kerbey AL, Espinal J: Mechanism decreasing glucose oxidation in diabetes and starvation: role of lipid fuels hormones. Diabetes Metab Rev 4:623-638, 1988
32. Zhou YP, Berggren PO, Grill VE: A fatty acid-induced decrease in pyruvate dehydrogenase activity is an important determinant of β-cell dysfunction in the obese diabetic db/db mouse. Diabetes 45:580-586, 1996
33. Zhou YP, Grill VE: Palmitate-induced β-cell insensitivity to glucose is coupled to decreased pyruvate dehydrogenase activity and enhanced kinase activity in rat pancreatic islets. Diabetes 44:394-399, 1995
34. Liu YQ, Tornheim K, Leahy JL: Shared biochemical properties of glucotoxicity and lipotoxicity in islets decrease citrate synthase activity and increase phosphofructokinase activity. Diabetes 47:1889-1893, 1998
35. Portha B, Giroix MH, Serradas P, Morin L, Saulnier C, Bailbe D: Glucose refractoriness of pancreatic beta cells in rat models of non-insulin dependent diabetes. Diabetes Metab 20:108-115, 1994
36. Unger RH: Lipotoxicity in the pathogenesis of obesity-dependent NIDDM: genetic and clinical implications. Diabetes, 44:863-870, 1995
37. Hirose H, Lee YH, Lindsey RI, Yoshitaka N, Johnson JH, Unger RH: Defective fatty acid-mediated β-cell compensation in Zucker diabetic fatty rats: pathogenic implications for obesity-dependent diabetes. J Biol Chem 271:5633-5637, 1996
38. Koyama K, Shimabukuro M, Chen G, Wang MY, Lee Y, Kalra PS, Dube MG, Kalra SP, Newgard CB, Unger RH: Resistance to adenovirally induced hyperleptinemia in rats: comparison of ventromedial hypothalamic lesions and mutated leptin receptors. J Clin Invest 102:728-733, 1998
39. Koyama K, Chen G, Wang MY Lee Y. Shimabukuro M, Newgard CB, Unger RH: β-Cell function in normal rats made chronically hyperleptinemic by adenovirus-leptin gene therapy. Diabetes 46:1276-1280, 1997
40. Sreenan S, Sturis J, Pugh W, Burant CF, Polonsky KS: Prevention of hyperglycemia in the Zucker diabetic fatty rat by treatment with metformin or troglitazone. Am J Physiol 271:E742-E747, 1996