Modulation of JNK and p38 stress activated protein kinases in isolated islets of Langerhans: Insulin as an autocrine survival signal

Annals of Surgery

Volumn 233, Issue 1, 2001, Pages 124-133

  Paraskevas, Steven ^a   Aikin, Reid ^a   Maysinger, Dusica ^a   Lakey, Jonathan R T ^b   Cavanagh, Thomas J ^c   Agapitos, Despina ^a   Wang, Rennian ^a   Rosenberg, Lawrence ^a  

^a MONTREAL GENERAL HOSPITAL   (Canada)

^b UNIVERSITY OF ALBERTA   (Canada)

^c Roche Molecular Biochemicals   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; DNA FRAGMENT; INSULIN; INTERLEUKIN 1BETA; PROTEIN INHIBITOR; STRESS ACTIVATED PROTEIN KINASE; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL SURVIVAL; CONTROLLED STUDY; DOG; DOSE RESPONSE; ENZYME ACTIVITY; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOBLOTTING; NONHUMAN; PANCREAS ISLET; PHOSPHORYLATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ADULT; ANALYSIS OF VARIANCE; ANIMALS; APOPTOSIS; BLOTTING, WESTERN; CADAVER; CARRIER PROTEINS; DOGS; ENZYME INHIBITORS; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMANS; IMIDAZOLES; IMMUNOHISTOCHEMISTRY; IN SITU NICK-END LABELING; INSULIN; INTERLEUKIN-1; ISLETS OF LANGERHANS; MALE; MIDDLE AGED; MITOGEN-ACTIVATED PROTEIN KINASES; NERVE TISSUE PROTEINS; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0035164537     PISSN: 00034932     EISSN: None     Source Type: Journal    
DOI: 10.1097/00000658-200101000-00018     Document Type: Article

References (56)

1. Clinical islet transplantation: Are we there yet?
2. Natural history of intrahepatic canine islet cell autografts
3. A selective decrease in beta cell mass of human islets transplanted into diabetic nude mice
4. Early changes in syngeneic islet grafts: Effect of recipient's metabolic control on graft outcome
5. Vulnerability of islets in the post-transplant period dynamic changes in structure and function
6. Apoptosis occurs in freshly isolated human islets under standard culture conditions
7. Beneficial influence of glycemic control upon the growth and function of transplanted islets
8. Sounding the alarm: Protein kinase cascades activated by stress and inflammation
9. Characterization of the mitogen-activated protein kinase kinase 4 (MKK4)/c-Jun NH2-terminal kinase 1 and MKK3/p38 pathways regulated by MEK kinases 2 and 3. MEK kinase 3 activates MKK3 but does not cause activation of p38 kinase in vivo
10. Selective interaction of JNK protein kinase isoforms with transcription factors
11. Protein kinase C and protein kinase A inhibit calcium-dependent but not stress-dependent c-Jun N-terminal kinase activation in rat liver epithelial cells
12. Reconstitution of novel signalling cascades responding to cellular stresses
13. Anti-apoptotic versus pro-apoptotic signal transduction: Checkpoints and stop signs along the road to death
14. The stress-activated protein kinase subfamily of c-Jun kinases
15. A MAP kinase targeted by endotoxin and hyperosmolarity in mammalian cells
16. JNK1: A protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain
17. Pro-inflammatory cytokines and environmental stress cause p38 mitogen-activated protein kinase activation by dual phosphorylation on tyrosine and threonine
18. Reactive oxygen species mediate cytokine activation of c-Jun NH2-terminal kinases
19. Protein kinase cascades activated by stress and inflammatory cytokines
20. Activation of c-Jun N-terminal kinase in bacterial lipopolysaccharide-stimulated macrophages
21. The role of c-Jun N-terminal kinase (JNK) in apoptosis induced by ultraviolet C and gamma radiation. Duration of JNK activation may determine cell death and proliferation
22. Apoptosis induced by withdrawal of trophic factors is mediated by p38 mitogen-activated protein kinase
23. Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis
24. Inhibition of p38 mitogen-activated protein kinase by insulin in cultured fetal neurons
25. Evidence for the presence of insulin receptors in rat islets of Langerhans
26. Quantitative electron microscopic autoradiography of insulin, glucagon and somatostatin binding sites on islets
27. Glucose-induced insulin receptor tyrosine phosphorylation in insulin-secreting beta cells
28. Expression of insulin receptor mRNA and insulin receptor subsrate 1 in pancreatic islet beta-cells
29. A protein kinase involved in the regulation of inflammatory cytokine biosynthesis
30. SB203580 is a specific inhibitor of a MAP kinase homologue which is stimulated by cellular stresses and interleukin-1
31. A highly specific inhibitor of human p38 MAP kinase binds in the ATP pocket
32. Pyridinyl imidazole inhibitors of p38 mitogen-activated protein kinase bind in the ATP site
33. Inhibitors of p38 mitogen-activated protein kinase promote neuronal survival in vitro
34. Automated method for isolation of human pancreatic islets
35. Islet purification
36. Evaluation of a purified enzyme blend for the recovery and function of canine pancreatic islets
37. ATF-2 contains a phosphorylation-dependent transcriptional activation domain
38. Fluorometric quantification of DNA in cells and tissue
39. Activation and expression of ERK, JNK, and p38 MAP-kinases in isolated islets of Langerhans: Implications for cultured islet survival
40. Feedback inhibition of insulin on insulin secretion in isolated pancreatic islets
41. Evidence for a feedback inhibition of insulin on insulin secretion in the isolated, perfused canine pancreas
42. Feedback inhibition of insulin secretion by insulin: Relation to the hyperinsulinemia of obesity
43. Modulation of insulin secretion by insulin and glucose in type II diabetes mellitus
44. Insulin suppresses its own secretion in vivo
45. Glucose- and insulin-induced phosphorylation of the insulin receptor and its primary substrates IRS-1 and IRS-2 in rat pancreatic islets
46. Insulin receptor signaling in the beta-cell influences insulin gene expression and insulin content: Evidence for autocrine beta-cell regulation
47. Exocytosis of insulin promotes insulin gene transcription via the insulin receptor/PI-3 kinase/p70 s6 kinase and CaM kinase pathways
48. The p38/reactivating kinase mitogen-activated protein kinase cascade mediates the activation of the transcription factor insulin upstream factor 1 and insulin gene transcription by high glucose in pancreatic beta-cells
49. Glucose stimulates translocation of the homeodomain transcription factor PDX1 from the cytoplasm to the nucleus in pancreatic beta-cells
50. Mechanisms and genes of cellular suicide
51. Regulation of neuronal survival by the serine-threonine protein kinase Akt
52. Interleukin-1 beta-induced ceramide and diacylglycerol generation may lead to activation of the c-Jun NH2-terminal kinase and the transcription factor ATF2 in the insulin-producing cell line R1Nm5F
53. Independent regulation of JNK/p38 mitogen-activated protein kinases by metabolic oxidative stress in the liver
54. Characterization of integrin expression in islets isolated from hamster, canine, porcine and human pancreas
55. Anoikis, extracellular matrix, and apoptosis factors in isolated cell transplantation
56. Structural and functional changes resulting from islet isolation lead to islet cell death