Accumulation of β-amyloid fibrils in pancreas of transgenic mice

Neurobiology of Aging

Volumn 17, Issue 2, 1996, Pages 215-222

  Kawarabayashi, Takeshi ^a   Shoji, Mikio ^a   Sato, Masahiro ^b   Sasaki, Atsushi ^a   Ho, Libin ^c   Eckman, Christopher B ^c   Prada, Christian Mihail ^c   Younkin, Steven G ^c   Kobayashi, Takashi ^b   Tada, Norihiro ^b   Matsubara, Etsuro ^a   Iizuka, Tomomichi ^a   Harigaya, Yasuo ^a   Kasai, Kazuhiro ^b   Hirai, Shunsaku ^a  

^a GUNMA UNIVERSITY   (Japan)

^b SANOFI   (France)

^c CASE WESTERN RESERVE UNIVERSITY   (United States)

Author keywords

Alzheimer's disease; Amyloid fibrils; Amyloid protein; Amyloid protein precursor; Carboxyl terminal fragment; Pancreas; Transgenic mouse; actin promoter

Indexed keywords

AMYLOID PRECURSOR PROTEIN;

ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ELECTRON MICROSCOPY; MOUSE; NONHUMAN; PANCREAS; PRIORITY JOURNAL; PROMOTER REGION; TRANSGENIC MOUSE;

EID: 0029995485     PISSN: 01974580     EISSN: None     Source Type: Journal    
DOI: 10.1016/0197-4580(95)02061-6     Document Type: Article

References (30)

1. Buxbaum, J. D.; Christensen, J. L.; Ruefli, A. A.; Greengard, P.; Loring, J. F. Expression of APP in brains of transgenic mice containing the entire human APP gene. Biochem. Biophys. Res. Commun. 197:639-645; 1993.
2. Cai, X.-D.; Golde, T. E.; Younkin, S. G. Release of excess amyloid β protein from a mutant amyloid β protein precursor. Science 259:514-516; 1993.
3. Chirgwin, J. M.; Przybyla, A. E.; MacDonald, R. J.; Rutter, W. J. Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease. Biochemistry 18:5294-5299; 1979.
4. Citron, M.; Oltersdorf, T.; Haass, C.; McConlogue, L.; Hung, A. Y.; Seubert, P.; Vigo-Pelfrey, C.; Lieberburg, I.; Selkoe, D. J. Mutation of the β-amyloid precursor protein in familial Alzheimer's disease increases β-protem production. Nature 360:672-674; 1992.
5. Estus, S.; Golde, T. E.; Kunishita, T.; Blades, D.; Lowery, D.; Eisen, M.; Usiak, M.; Qu, X.; Tabira, T.; Greenberg, B. D.; Younkin, S. G. Potentially amyloidogenic, carboxyl-terminal derivatives of the amyloid protein precursor. Science 255:726-728; 1992.
6. Games, D.; Adams, D.; Alessandnni, R; Barbour, R.; Berthelette, P.; Blackwell, C.; Carr, T.; Clemens, J.; Donaldson, T.; Gillespie, F.; Guido, T.; Hagopian, S.; Johnson-Wood, K.; Khan, K.; Lee, M.; Leibowitz, P.; Lieberburg, I.; Little, S.; Masliah, E.; McConlogue, L.; Montoya-Zavala, M.; Mucke, L.; Paganini, L.; Penniman, E.; Power, M.; Schenk, D.; Seubert, P.; Snyder, B.; Soriano, F.; Tan, H.; Vitale, J.; Wadsworth, S.; Wolozin, B.; Zhao, J. Alzheimer-type neuropathology in transgenic mice overexpressing V717F β-amyloid precursor protein. Nature 373:523-527; 1995.
7. Glenner, G. G.; Wong, C. W. Alzheimer's disease: initial report of the purification and characterization of a novel cerebrovascular amyloid protein. Biochem. Biophys. Res. Commun. 120:885-890; 1984.
8. Gravina, S. A.; Ho, L.; Eckman, C. B.; Long, K. E.; Otvos, L., Jr.; Younkin, L. H.; Suzuki, N.; Younkin, S. G. Amyloid β protein (Aβ) in Alzheimer's disease brain: biochemical and immunocytochemical analysis with antibodies specific for forms ending at Aβ40 or Aβ42(43). J. Biol. Chem. 270:7013-7016; 1995.
9. Haass, C.; Koo, E. H.; Mellon, A.; Hung, A. Y.; Selkoe, D. J. Targeting of cell-surface β-amyloid precursor protein to lysosomes: alternative processing into amyloid-bearing fragments. Nature 357:500-503; 1992.
10. Harigaya, Y.; Shoji, M.; Kawarabayashi, T.; Kanai, M.; Nakamura, T.; Iizuka, T.; Igeta, Y.; Saido, T. C.; Sahara, N.; Mon, H.; Hirai, S. Modified amyloid β protein ending at 42 or 40 with different solubility accumulates in the brain of Alzheimer's disease. Biochem. Biophys. Res. Commun. 211:1015-1022; 1995.
11. Hogan, B.; Costantini F.; Lacy, E. Manipulating the mouse embryo: A laboratory manual. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory; 1986.
12. Iwatsubo, T.; Odaka, A.; Suzuki, N.; Mizusawa, H.; Nukina, N.; Ihara, Y. Visualization of Aβ42(43) and Aβ40 in senile plaques with end-specific Aβ monoclonals: evidence that an initially deposited species is Aβ42(43). Neuron 13:45-53; 1994.
13. Jarrett, J. T.; Berger, E. P.; Lansbury, P. T., Jr. The carboxy terminus of the β amyloid protein is critical for the seeding of amyloid formation: implications for the pathogenesis of Alzheimer's disease. Biochemistry 32:4693-4697; 1993.
14. Kammesheidt, A.; Boyce, F. M.; Spanoyannis, A. F.; Cummings, B. J.; Ortegón, M.: Cotman, C.; Vaught, J. L.; Neve, R. L. Deposition of β/A4 immunoreactivity and neuronal pathology in transgenic mice expressing the carboxyl-terminal fragment of the Alzheimer amyloid precursor in the brain. Proc. Natl. Acad. Sci. USA 89:10857-10861; 1992.
15. Kang, J.; Lemaire, H.-G.; Unterbeck, A.; Salbaum, J. M.; Masters, C. L.; Grzeschik, K.-H.; Multhaup, G.; Beyreuther, K.; Müller-Hill, B. The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor. Nature 325:733-736; 1987.
16. Kanno, H.; Nose, M.; Itoh, J.; Taniguchi, Y.; Kyogoku, M. Spontaneous development of pancreatitis in the MRL/Mp strain of mice in autoimmune mechanism. Clin. Exp. Immunol. 89:68-73; 1992.
17. Lamb, B. T.; Sisodia, S. S.; Lawler, A. M.; Slunt, H. H.; Kitt, C. A.; Kearns, W. G.; Pearson, P. L.; Price, D. L.; Gearhart, J. D. Introduction and expression of the 400 kilobase amyloid precursor protein gene in transgenic mice. Nature Genet. 5:22-30; 1993.
18. Masters, C. L.; Simms, G.; Weinman, N. A.; Multhaup, G.; McDonald, B. L.; Beyreuther, K. Amyloid plaque core protein in Alzheimer's disease and Down syndrome. Proc. Natl. Acad. Sci. USA 82:4245-4249; 1985.
19. Miyazaki, J.; Takaki, S.; Araki, K.; Tashiro, F.; Tominaga, A.; Takatsu, K.; Yamamura, K. Expression vector system based on the chicken β-actin promoter directs efficient production of interleukin-5. Gene 79:269-277; 1989.
20. Pearson, B. E.; Choi, T. K. Expression of the human β-amyloid precursor protein gene from a yeast artificial chromosome in transgenic mice. Proc. Natl. Acad. Sci. USA 90:10578-10582; 1993.
21. Quon, D.; Wang, Y.; Catalano, R.; Marian Scardina, J.; Murakami, K.; Cordell, B. Formation of β-amyloid protein deposits in brains of transgenic mice. Nature 352:239-241; 1991.
22. Roher, A. E.; Lowenson, J. D.; Clarke, S.; Wolkow, C.; Wang, R.; Cotter, R. J.; Reardon, I. M.; Zürcher-Neely, H. A.; Heinrikson, R. L.; Ball, M. J.; Greenberg, B. D. Structural alterations in the peptide backbone of β-amyloid core protein may account for its deposition and stability in Alzheimer's disease. J. Biol. Chem. 268:3072-3083; 1993.
23. Saido, T. C.; Yokota, M.; Maruyama, K.; Yamao-Harigaya, W.; Tani, E.; Ihara, Y.; Kawashima, S. Spatial resolution of the primary β-amyloidogenic process induced in postischemic hippocampus. J. Biol. Chem. 269:15253-15257; 1994.
24. Sandhu, F. A.; Salim, M.; Zain, S. B. Expression of the human β-amyloid protein of Alzheimer's disease specifically in the brains of transgenic mice. J. Biol. Chem. 266:21331-21334; 1991.
25. Shaffer, L. M.; Dority, M. D.; Younkin, S. G.; Brunden, K. R. Removal of liquid-phase and substrate-bound amyloid β peptide (Aβ) by microglia and other CNS cell types. Neurobiol. Aging 15 Suppl. 1:S152; 1994.
26. Shoji, M.; Golde, T. E.; Ghiso, J.; Cheung, T. T.; Estus, S.; Shaffer, L. M.; Cai, X.-D.; McKay, D. M.; Tintner, R.; Frangione, B.; Younkin, S. G. Production of the Alzheimer amyloid β protein by normal proteolytic processing. Science 258:126-129; 1992.
27. 717) mutants. Science 264:1336-1340: 1994.
28. 1-40 is linked to cerebral amyloid angiopathy. Am. J. Pathol. 145:452-460; 1994.
29. van Ooyen, A.; van den Berg, J.; Mantei, N.; Weissmann, C. Comparison of total sequence of a cloned rabbit β-globin gene and its flanking regions with a homologous mouse sequence. Science 206: 337-344; 1979.
30. Yamaguchi, H.; Hirai, S.; Morimatsu, M.; Shoji, M.; Ihara, Y. A variety of cerebral amyloid deposits in the brains of the Alzheimer-type dementia demonstrated by β protein immunostaining. Acta Neuropathol. 76:541-549; 1988.