Cutting Edge: Extracellular Signal-Regulated Kinases 1/2 Function as Integrators of TCR Signal Strength

Journal of Immunology

Volumn 172, Issue 10, 2004, Pages 5828-5832

  Schade, Andrew E ^a   Levine, Alan D ^a  

^a CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD14 ANTIGEN; CD16 ANTIGEN; CD19 ANTIGEN; CD36 ANTIGEN; CD56 ANTIGEN; CYTOKINE; GLYCOPHORIN A; GROWTH FACTOR; MITOGEN ACTIVATED PROTEIN KINASE 1; PHOSPHATIDYLINOSITOL 3 KINASE; T LYMPHOCYTE RECEPTOR;

ARTICLE; CELL FUNCTION; CONTROLLED STUDY; DRUG TARGETING; ENZYME ACTIVATION; ENZYME KINETICS; ENZYME REGULATION; HUMAN; HUMAN CELL; IMMUNE RESPONSE; IMMUNOTHERAPY; PRIORITY JOURNAL; PROTEIN CROSS LINKING; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; T LYMPHOCYTE ACTIVATION;

EID: 2442542309     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.172.10.5828     Document Type: Article

References (20)

1. Cosimi, A. B. 1987. Clinical development of Orthoclone OKT3. Transplant. Proc. 19:7.
2. Goldstein, G. 1987. Overview of the development of Orthoclone OKT3: monoclonal antibody for therapeutic use in transplantation. Transplant. Proc. 19:1.
3. Smith, J. A., J. Y. Tso, M. R. Clark, M. S. Cole, and J. A. Bluestone. 1997. Nonmitogenic anti-CD3 monoclonal antibodies deliver a partial T cell receptor signal and induce clonal anergy. J. Exp. Med. 185:1413.
4. Herold, K. C., J. B. Burton, F. Francois, E. Poumian-Ruiz, M. Glandt, and J. A. Bluestone. 2003. Activation of human T cells by FcR nonbinding anti-CD3 mAb, hOKT3γ1(Ala-Ala). J. Clin. Invest. 111:409.
5. Herold, K. C., W. Hagopian, J. A. Auger, E. Poumian-Ruiz, L. Taylor, D. Donaldson, S. E. Gitelman, D. M. Harlan, D. Xu, R. A. Zivin, and J. A. Bluestone. 2002. Anti-CD3 monoclonal antibody in new-onset type 1 diabetes mellitus. N. Engl. J. Med. 346:1692.
6. Schade, A. E., and A. D. Levine. 2002. Lipid raft heterogeneity in human peripheral blood T lymphoblasts: a mechanism for regulating the initiation of TCR signal transduction. J. Immunol. 168:2233.
7. Ina, K., J. Itoh, K. Fukushima, K. Kusugami, T. Yamaguchi, K. Kyokane, A. Imada, D. G. Binion, A. Musso, G. A. West, et al. 1999. Resistance of Crohn's disease T cells to multiple apoptotic signals is associated with a Bcl-2/Bax mucosal imbalance. J. Immunol. 163:1081.
8. Sturm, A., J. Itoh, J. W. Jacobberger, and C. Fiocchi. 2002. p53 negatively regulates intestinal immunity by delaying mucosal T cell. J. Clin. Invest. 109:1481.
9. Wong, V. L., and A. D. Levine. 1999. Regulation of intestinal immune tolerance and protection is mediated by signaling through the CD2 receptor on lamina propria T Cells. Surg. Forum L:54.
10. Hussain, S. F., C. F. Anderson, and D. L. Farber. 2002. Differential SLP-76 expression and TCR-mediated signaling in effector and memory CD4 T cells. J. Immunol. 168:1557.
11. Krishnan, S., V. G. Warke, M. P. Nambiar, G. C. Tsokos, and D. L. Farber. 2003. The FcRγ subunit and Syk kinase replace the CD3 ζ-chain and ZAP-70 kinase in the TCR signaling complex of human effector CD4 T cells. J. Immunol. 170:4189.
12. Gronda, M., S. Arab, B. Iafrate, H. Suzuki, and B. W. Zanke. 2001. Hematopoietic protein tyrosine phosphatase suppresses extracellular stimulus-regulated kinase activation. Mol. Cell. Biol. 21:6851.
13. Eder, A. M., L. Dominguez, T. F. Franke, and J. D. Ashwell. 1998. Phosphoinositide 3-kinase regulation of T cell receptor-mediated interleukin-2 gene expression in normal T cells. J. Biol. Chem. 273:28025.
14. Duckworth, B. C., and L. C. Candey. 1997. Conditional inhibition of the mitogen-activated protein kinase cascade by wortmannin: dependence on signal strength. J. Biol. Chem. 272:27665.
15. Brennan, P., J. W. Babbage, B. M. Burgering, B. Groner, K. Reif, and D. A. Cantrell. 1997. Phosphatidylinositol 3-kinase couples the interleukin-2 receptor to the cell cycle regulator E2F. Immunity 7:679.
16. Moon, J. J., and B. H. Nelson. 2001. Phosphatidylinositol 3-kinase potentiates, but does not trigger, T cell proliferation mediated by the IL-2 receptor. J. Immunol. 167:2714.
17. Marshall, C. J. 1995. Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation. Cell 80:179.
18. Murphy, L. O., S. Smith, R. H. Chen, D. C. Fingar, and J. Blenis. 2002. Molecular interpretation of ERK signal duration by immediate early gene products. Nat. Cell Biol. 4:556.
19. Bhalla, U. S., P. T. Ram, and R. Iyengar. 2002. MAP kinase phosphatase as a locus of flexibility in a mitogen-activated protein kinase signaling network. Science 297:1018.
20. Sloan-Lancaster, J., and P. M. Allen. 1995. Signalling events in the anergy induction of T helper 1 cells. Ciba Found. Symp. 195:189.