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Volumn , Issue , 2005, Pages 299-348

Cell Culture Kinetics and Modeling

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EID: 85134939545     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1201/9780849351068-12     Document Type: Chapter
Times cited : (9)

References (202)
  • 1
    • 0023061766 scopus 로고
    • Effect of glucose on the cultivation of mammalian cells
    • Hu W-S, Dodge TC, Frame KK, Himes VB. Effect of glucose on the cultivation of mammalian cells. Dev Biol Stand 1987; 66:279-290.
    • (1987) Dev Biol Stand , vol.66 , pp. 279-290
    • Hu, W.-S.1    Dodge, T.C.2    Frame, K.K.3    Himes, V.B.4
  • 2
    • 0024278869 scopus 로고
    • Mathematical description of hybridoma culture kinetics. I. Initial metabolic rates
    • Glacken MW, Adema E, Sinskey AJ. Mathematical description of hybridoma culture kinetics. I. Initial metabolic rates. Biotechnol Bioeng 1988; 32:491-506.
    • (1988) Biotechnol Bioeng , vol.32 , pp. 491-506
    • Glacken, M.W.1    Adema, E.2    Sinskey, A.J.3
  • 3
    • 0024645305 scopus 로고
    • Mathematical description of hybridoma culture kinetics. III. Simulation of fed-batch bioreactors
    • Glacken MW, Huang C, Sinskey AJ. Mathematical description of hybridoma culture kinetics. III. Simulation of fed-batch bioreactors. J Biotechnol 1989; 10:39-66.
    • (1989) J Biotechnol , vol.10 , pp. 39-66
    • Glacken, M.W.1    Huang, C.2    Sinskey, A.J.3
  • 4
    • 84988106827 scopus 로고
    • A kinetic analysis of hybridoma growth and metabolism in batch and continuous suspension culture: Effect of nutrient concentration, dilution rate, and pH
    • Miller WM, Blanch HW, Wilke CR. A kinetic analysis of hybridoma growth and metabolism in batch and continuous suspension culture: effect of nutrient concentration, dilution rate, and pH. Biotechnol Bioeng 1988; 32:947-965.
    • (1988) Biotechnol Bioeng , vol.32 , pp. 947-965
    • Miller, W.M.1    Blanch, H.W.2    Wilke, C.R.3
  • 5
    • 84996113208 scopus 로고
    • Transient responses of hybridoma cells to nutrient additions in continuous culture: I. Glucose pulse and step changes
    • Miller WM, Wilke CR, Blanch HW. Transient responses of hybridoma cells to nutrient additions in continuous culture: I. Glucose pulse and step changes. Biotechnol Bioeng 1989; 33:477-486.
    • (1989) Biotechnol Bioeng , vol.33 , pp. 477-486
    • Miller, W.M.1    Wilke, C.R.2    Blanch, H.W.3
  • 6
    • 84996094699 scopus 로고
    • Transient responses of hybridoma cells to nutrient additions in continuous culture: II. Glutamine pulse and step changes
    • Miller WM, Wilke CR, Blanch HW. Transient responses of hybridoma cells to nutrient additions in continuous culture: II. Glutamine pulse and step changes. Biotechnol Bioeng 1989; 33:487-499.
    • (1989) Biotechnol Bioeng , vol.33 , pp. 487-499
    • Miller, W.M.1    Wilke, C.R.2    Blanch, H.W.3
  • 7
    • 0024593319 scopus 로고
    • Cultivation of hybridoma cells in continuous cultures: Kinetics of growth and product formation
    • Ray NG, Karkare SB, Runstadler PW. Cultivation of hybridoma cells in continuous cultures: kinetics of growth and product formation. Biotechnol Bioeng 1989; 33:724-730.
    • (1989) Biotechnol Bioeng , vol.33 , pp. 724-730
    • Ray, N.G.1    Karkare, S.B.2    Runstadler, P.W.3
  • 8
    • 0026416428 scopus 로고
    • Kinetic study of hybridoma cell growth in continuous culture. I. A model for non-producing cells
    • Frame KK, Hu WS. Kinetic study of hybridoma cell growth in continuous culture. I. A model for non-producing cells. Biotechnol Bioeng 1991; 37:55-64.
    • (1991) Biotechnol Bioeng , vol.37 , pp. 55-64
    • Frame, K.K.1    Hu, W.S.2
  • 9
    • 0026261759 scopus 로고
    • Kinetic study of hybridoma cell growth in continuous culture. II. Behavior of producers and comparison to non-producers
    • Frame KK, Hu WS. Kinetic study of hybridoma cell growth in continuous culture. II. Behavior of producers and comparison to non-producers. Biotechnol Bioeng 1991; 38:1020-1028.
    • (1991) Biotechnol Bioeng , vol.38 , pp. 1020-1028
    • Frame, K.K.1    Hu, W.S.2
  • 10
    • 0026136107 scopus 로고
    • The effect of specific growth rate and death rate on monoclonal antibody production in hybridoma chemostat cultures
    • Linardos TI, Kalogerakis N, Behie LA. The effect of specific growth rate and death rate on monoclonal antibody production in hybridoma chemostat cultures. Can J Chem Eng 1991; 69:429-438.
    • (1991) Can J Chem Eng , vol.69 , pp. 429-438
    • Linardos, T.I.1    Kalogerakis, N.2    Behie, L.A.3
  • 11
    • 0026262162 scopus 로고
    • Kinetics of recombinant immunoglobulin production by mammalian cells in continuous culture
    • Robinson DK, Memmert K. Kinetics of recombinant immunoglobulin production by mammalian cells in continuous culture. Biotechnol Bioeng 1991; 38:972-976.
    • (1991) Biotechnol Bioeng , vol.38 , pp. 972-976
    • Robinson, D.K.1    Memmert, K.2
  • 12
    • 0026417325 scopus 로고
    • A kinetic analysis of hybridoma growth and metabolism in continuous suspension culture on serum-free medium
    • Hiller GW, Aeschlimann AD, Clark DS, Blanch HW. A kinetic analysis of hybridoma growth and metabolism in continuous suspension culture on serum-free medium. Biotechnol Bioeng 1991; 38:733-741.
    • (1991) Biotechnol Bioeng , vol.38 , pp. 733-741
    • Hiller, G.W.1    Aeschlimann, A.D.2    Clark, D.S.3    Blanch, H.W.4
  • 13
    • 0027609692 scopus 로고
    • Cell retention-chemostat studies of hybridoma cells-analysis of hybridoma growth and metabolism in continuous suspension culture on serum-free medium
    • Hiller GW, Clark DS, Blanch HW. Cell retention-chemostat studies of hybridoma cells-analysis of hybridoma growth and metabolism in continuous suspension culture on serum-free medium. Biotechnol Bioeng 1993; 42:185-195.
    • (1993) Biotechnol Bioeng , vol.42 , pp. 185-195
    • Hiller, G.W.1    Clark, D.S.2    Blanch, H.W.3
  • 14
    • 0028474159 scopus 로고
    • Transient responses of hybridoma cells in continuous culture to step changes in amino acid and vitamin concentrations
    • Hiller GW, Clark DS, Blanch HW. Transient responses of hybridoma cells in continuous culture to step changes in amino acid and vitamin concentrations. Biotechnol Bioeng 1994; 44:303-321.
    • (1994) Biotechnol Bioeng , vol.44 , pp. 303-321
    • Hiller, G.W.1    Clark, D.S.2    Blanch, H.W.3
  • 15
    • 0026816686 scopus 로고
    • Effects of ammonia and lactate on hybridoma growth, metabolism, and antibody production
    • Ozturk SS, Riley MR, Palsson BO. Effects of ammonia and lactate on hybridoma growth, metabolism, and antibody production. Biotechnol Bioeng 1992; 39:418-431.
    • (1992) Biotechnol Bioeng , vol.39 , pp. 418-431
    • Ozturk, S.S.1    Riley, M.R.2    Palsson, B.O.3
  • 16
    • 0026560544 scopus 로고
    • Growth kinetics of hybridoma cells in high cell density culture
    • Shirai Y, Hashimoto K, Yamaji H, Kawahara H. Growth kinetics of hybridoma cells in high cell density culture. J Ferment Bioeng 1992; 73:159-165.
    • (1992) J Ferment Bioeng , vol.73 , pp. 159-165
    • Shirai, Y.1    Hashimoto, K.2    Yamaji, H.3    Kawahara, H.4
  • 17
    • 0026512475 scopus 로고
    • Continuous hybridoma suspension cultures with and without cell retention: Kinetics of growth metabolism and product formation
    • Schmid G, Wilke CR, Blanch HW. Continuous hybridoma suspension cultures with and without cell retention: kinetics of growth metabolism and product formation. J Biotechnol 1992; 22:31-40.
    • (1992) J Biotechnol , vol.22 , pp. 31-40
    • Schmid, G.1    Wilke, C.R.2    Blanch, H.W.3
  • 18
    • 0027596213 scopus 로고
    • Fractional factorial study of hybridoma behavior. 1. Kinetics of growth and antibody production
    • Gaertner JG, Dhurjati P. Fractional factorial study of hybridoma behavior. 1. Kinetics of growth and antibody production. Biotechnol Prog 1993; 9:298-308.
    • (1993) Biotechnol Prog , vol.9 , pp. 298-308
    • Gaertner, J.G.1    Dhurjati, P.2
  • 19
    • 0027596218 scopus 로고
    • Fractional factorial study of hybridoma behavior. 2. Kinetics of nutrient uptake and waste production
    • Gaertner JG, Dhurjati P. Fractional factorial study of hybridoma behavior. 2. Kinetics of nutrient uptake and waste production. Biotechnol Prog 1993; 9:309-316.
    • (1993) Biotechnol Prog , vol.9 , pp. 309-316
    • Gaertner, J.G.1    Dhurjati, P.2
  • 20
    • 0027295683 scopus 로고
    • Kinetic study of hybridoma metabolism and antibody production in continuous culture using serum-free medium
    • Kurokawa H, Ogawa T, Kamihira M, Park YS, Iijima S, Kobayashi T. Kinetic study of hybridoma metabolism and antibody production in continuous culture using serum-free medium. J Ferment Bioeng 1993; 76:128-133.
    • (1993) J Ferment Bioeng , vol.76 , pp. 128-133
    • Kurokawa, H.1    Ogawa, T.2    Kamihira, M.3    Park, Y.S.4    Iijima, S.5    Kobayashi, T.6
  • 21
    • 0028339634 scopus 로고
    • Kinetic study on HBs-MAb production in continuous cultivation
    • Harigae M, Matsmura M, Kataoka H. Kinetic study on HBs-MAb production in continuous cultivation. J Biotechnol 1994; 34:227-235.
    • (1994) J Biotechnol , vol.34 , pp. 227-235
    • Harigae, M.1    Matsmura, M.2    Kataoka, H.3
  • 22
    • 0031194880 scopus 로고    scopus 로고
    • Stoichiometry, kinetics, and regulation of glucose and amino acid metabolism of a recombinant BHK cell line in batch and continuous cultures
    • Linz M, Zeng A-P, Wagner R, Deckwer W.-D. Stoichiometry, kinetics, and regulation of glucose and amino acid metabolism of a recombinant BHK cell line in batch and continuous cultures. Biotechnol Prog 1997; 13:453-463.
    • (1997) Biotechnol Prog , vol.13 , pp. 453-463
    • Linz, M.1    Zeng, A.-P.2    Wagner, R.3    Deckwer, W.-D.4
  • 23
    • 0029636793 scopus 로고
    • Mathematical modeling and analysis of glucose and glutamine utilization and regulation in cultures of continuous mammalian cells
    • Zeng A-P, Deckwer W.-D. Mathematical modeling and analysis of glucose and glutamine utilization and regulation in cultures of continuous mammalian cells. Biotechnol Bioeng 1995; 47:334-346.
    • (1995) Biotechnol Bioeng , vol.47 , pp. 334-346
    • Zeng, A.-P.1    Deckwer, W.-D.2
  • 24
    • 0030570126 scopus 로고    scopus 로고
    • Analysis and mathematical modeling of monoclonal antibody production by hybridoma cells
    • Zeng A.-P. Analysis and mathematical modeling of monoclonal antibody production by hybridoma cells. Biotechnol Bioeng 1996; 50:238-247.
    • (1996) Biotechnol Bioeng , vol.50 , pp. 238-247
    • Zeng, A.-P.1
  • 25
    • 0030574824 scopus 로고    scopus 로고
    • Quantitative assessment of effect of cell density on metabolism and monoclonal antibody production of hybridoma cells
    • Zeng A.-P. Quantitative assessment of effect of cell density on metabolism and monoclonal antibody production of hybridoma cells. J Biotechnol 1996; 45:243-251.
    • (1996) J Biotechnol , vol.45 , pp. 243-251
    • Zeng, A.-P.1
  • 26
    • 0032549607 scopus 로고    scopus 로고
    • Determinants and rate laws of growth and death of animal cells in continuous cultures
    • Zeng A-P, Deckwer W-D, Hu W.-S. Determinants and rate laws of growth and death of animal cells in continuous cultures. Biotechnol Bioeng 1998; 57:642-654.
    • (1998) Biotechnol Bioeng , vol.57 , pp. 642-654
    • Zeng, A.-P.1    Deckwer, W.-D.2    Hu, W.-S.3
  • 27
    • 0024962243 scopus 로고
    • A structured kinetic modeling framework for the dynamics of hybridoma growth and monoclonal antibody production in continuous suspension cultures
    • Batt BC, Kompala DS. A structured kinetic modeling framework for the dynamics of hybridoma growth and monoclonal antibody production in continuous suspension cultures. Biotechnol Bioeng 1989; 34:515-531.
    • (1989) Biotechnol Bioeng , vol.34 , pp. 515-531
    • Batt, B.C.1    Kompala, D.S.2
  • 28
    • 0024791973 scopus 로고
    • Cell cycle model for antibody production kinetics
    • Suzuki E, Ollis DF. Cell cycle model for antibody production kinetics. Biotechnol Bioeng 1989; 34:1398-1402.
    • (1989) Biotechnol Bioeng , vol.34 , pp. 1398-1402
    • Suzuki, E.1    Ollis, D.F.2
  • 29
    • 0026416511 scopus 로고
    • A structured model for monoclonal antibody synthesis in exponentially growing and stationary phase hybridoma cells
    • Bibila TA, Flickinger MC. A structured model for monoclonal antibody synthesis in exponentially growing and stationary phase hybridoma cells. Biotechnol Bioeng 1991; 37:210-226.
    • (1991) Biotechnol Bioeng , vol.37 , pp. 210-226
    • Bibila, T.A.1    Flickinger, M.C.2
  • 30
    • 0026417324 scopus 로고
    • A model of interorganelle monoclonal antibody transport and secretion in mouse hybridoma cells
    • Bibila TA, Flickinger MC. A model of interorganelle monoclonal antibody transport and secretion in mouse hybridoma cells. Biotechnol Bioeng 1991; 38:767-780.
    • (1991) Biotechnol Bioeng , vol.38 , pp. 767-780
    • Bibila, T.A.1    Flickinger, M.C.2
  • 31
    • 0026898329 scopus 로고
    • Cell cycle model for growth rate and death rate in continuous suspension hybridoma cultures
    • Linardos TI, Kalogerakis N, Behie LA. Cell cycle model for growth rate and death rate in continuous suspension hybridoma cultures. Biotechnol Bioeng 1992; 40:359-368.
    • (1992) Biotechnol Bioeng , vol.40 , pp. 359-368
    • Linardos, T.I.1    Kalogerakis, N.2    Behie, L.A.3
  • 32
    • 0026722196 scopus 로고
    • A single-cell model for CHO cells
    • Wu P, Ray NG, Shuler ML. A single-cell model for CHO cells. Ann NY Acad Sci 1992; 665:152-186.
    • (1992) Ann NY Acad Sci , vol.665 , pp. 152-186
    • Wu, P.1    Ray, N.G.2    Shuler, M.L.3
  • 33
    • 85134934674 scopus 로고
    • A systematic approach for modeling animal cell cultures: Methodology and experimental results
    • Chotteau V, Bastin G. A systematic approach for modeling animal cell cultures: methodology and experimental results. Cytotechnology 1994; 16:196-196.
    • (1994) Cytotechnology , vol.16 , pp. 196
    • Chotteau, V.1    Bastin, G.2
  • 34
    • 0029294162 scopus 로고
    • A kinetic model for product formation of microbial and mammalian cells
    • Zeng A.-P. A kinetic model for product formation of microbial and mammalian cells. Biotechnol Bioeng 1995; 46:314-324.
    • (1995) Biotechnol Bioeng , vol.46 , pp. 314-324
    • Zeng, A.-P.1
  • 36
    • 0030475292 scopus 로고    scopus 로고
    • Hybridomas in a bioreactor cascade: Modeling and determination of growth and death kinetics
    • Bakker WAM, Schaefer T, Beeftink HH, Tramper J, De-Gooijer CF. Hybridomas in a bioreactor cascade: modeling and determination of growth and death kinetics. Cytotechnology 1996; 21:263-277.
    • (1996) Cytotechnology , vol.21 , pp. 263-277
    • Bakker, W.A.M.1    Schaefer, T.2    Beeftink, H.H.3    Tramper, J.4    De-Gooijer, C.F.5
  • 37
    • 0033735745 scopus 로고    scopus 로고
    • Structured modeling of recombinant protein production in batch and fed-batch culture of baculovirus-infected insect cells
    • Jang JD, Sanderson CS, Chan LCL, Barford JP, Reid S. Structured modeling of recombinant protein production in batch and fed-batch culture of baculovirus-infected insect cells. Cytotechnology 2000; 34:71-82.
    • (2000) Cytotechnology , vol.34 , pp. 71-82
    • Jang, J.D.1    Sanderson, C.S.2    Chan, L.C.L.3    Barford, J.P.4    Reid, S.5
  • 38
    • 0034281581 scopus 로고    scopus 로고
    • Cybernetic modeling and regulation of metabolic pathways in multiple steady states of hybridoma cells
    • Guardia MJ, Gambhir A, Europa AF, Ramkrishna D, Hu W.-S. Cybernetic modeling and regulation of metabolic pathways in multiple steady states of hybridoma cells. Biotechnol Prog 2000; 16:847-853.
    • (2000) Biotechnol Prog , vol.16 , pp. 847-853
    • Guardia, M.J.1    Gambhir, A.2    Europa, A.F.3    Ramkrishna, D.4    Hu, W.-S.5
  • 39
    • 0027953249 scopus 로고
    • Modelling of cell culture processes
    • Tziampazis E, Sambanis A. Modelling of cell culture processes. Cytotechnology 1994; 14:191-204.
    • (1994) Cytotechnology , vol.14 , pp. 191-204
    • Tziampazis, E.1    Sambanis, A.2
  • 40
    • 0030595039 scopus 로고    scopus 로고
    • Modeling of hybridoma cell growth and metabolism-a comparison of selected models and data
    • Pörtner R, Schafer T. Modeling of hybridoma cell growth and metabolism-a comparison of selected models and data. J Biotechnol 1996; 49:119-135.
    • (1996) J Biotechnol , vol.49 , pp. 119-135
    • Pörtner, R.1    Schafer, T.2
  • 42
    • 0026112527 scopus 로고
    • Influence of inoculum age on hybridoma culture kinetics
    • Martial A, Marc A, Engasser JM. Influence of inoculum age on hybridoma culture kinetics. Cytotechnology 1991; 5:165-171.
    • (1991) Cytotechnology , vol.5 , pp. 165-171
    • Martial, A.1    Marc, A.2    Engasser, J.M.3
  • 43
    • 0017686335 scopus 로고
    • Metabolic crowding effect in suspension of cultured lymphcytes
    • Sand T, Condi R, Rosenberg A. Metabolic crowding effect in suspension of cultured lymphcytes. Blood 1977; 50:337-386.
    • (1977) Blood , vol.50 , pp. 337-386
    • Sand, T.1    Condi, R.2    Rosenberg, A.3
  • 44
    • 0022059389 scopus 로고
    • Amechanistic analysis of the inoculum requirement for the cultivation of mammalian cells on microcarriers
    • Hu W-S, Meier J, Wang DIC.Amechanistic analysis of the inoculum requirement for the cultivation of mammalian cells on microcarriers. Biotechnol Bioeng 1985; 27:585-595.
    • (1985) Biotechnol Bioeng , vol.27 , pp. 585-595
    • Hu, W.-S.1    Meier, J.2    Wang, D.I.C.3
  • 45
    • 0025514374 scopus 로고
    • Effect of initial cell density on hybridoma growth, metabolism, and monoclonal antibody production
    • Ozturk SS, Palsson BO. Effect of initial cell density on hybridoma growth, metabolism, and monoclonal antibody production. J Biotechnol 1990; 16:259-278.
    • (1990) J Biotechnol , vol.16 , pp. 259-278
    • Ozturk, S.S.1    Palsson, B.O.2
  • 46
    • 0026737392 scopus 로고
    • Intracellular ribonucleotide pools as a tool for monitoring the physiological state of in vitro cultivated mammalian cells during production processes
    • Ryll T, Wagner R. Intracellular ribonucleotide pools as a tool for monitoring the physiological state of in vitro cultivated mammalian cells during production processes. Biotechnol Bioeng 1992; 40:934-946.
    • (1992) Biotechnol Bioeng , vol.40 , pp. 934-946
    • Ryll, T.1    Wagner, R.2
  • 47
    • 0033751654 scopus 로고    scopus 로고
    • The effect of glucose and glutamine on the intracellular nucleotide pool and oxygen uptake rate of a murine hybridoma
    • Barnabé N, Butler M. The effect of glucose and glutamine on the intracellular nucleotide pool and oxygen uptake rate of a murine hybridoma. Cytotechnology 2000; 34:47-57.
    • (2000) Cytotechnology , vol.34 , pp. 47-57
    • Barnabé, N.1    Butler, M.2
  • 48
    • 0034281483 scopus 로고    scopus 로고
    • A comparison of different methods to determine the end of exponential growth in CHO cell cultures for optimization of scale-up
    • Schoenherr I, Stapp T, Ryll T. A comparison of different methods to determine the end of exponential growth in CHO cell cultures for optimization of scale-up. Biotechnol Prog 2000; 16:815-821.
    • (2000) Biotechnol Prog , vol.16 , pp. 815-821
    • Schoenherr, I.1    Stapp, T.2    Ryll, T.3
  • 49
    • 0029097924 scopus 로고
    • Characterization of changes in the glycosylation pattern of recombinant proteins from BHK21 cells due to different culture conditions
    • Gawlitzek M, Valley U, Nimtz M, Wagner R, Conradt HS. Characterization of changes in the glycosylation pattern of recombinant proteins from BHK21 cells due to different culture conditions. J Biotechnology 1995; 42:117-131.
    • (1995) J Biotechnology , vol.42 , pp. 117-131
    • Gawlitzek, M.1    Valley, U.2    Nimtz, M.3    Wagner, R.4    Conradt, H.S.5
  • 50
    • 0034691229 scopus 로고    scopus 로고
    • Ammonium alters N-glycan structures of recombinant TNFR-IgG: Degradative versus biosynthetic mechanisms
    • Gawlitzek M, Ryll T, Lofgren J, Sliwkowski MB. Ammonium alters N-glycan structures of recombinant TNFR-IgG: degradative versus biosynthetic mechanisms. Biotechnol Bioeng 2000; 68:637-646.
    • (2000) Biotechnol Bioeng , vol.68 , pp. 637-646
    • Gawlitzek, M.1    Ryll, T.2    Lofgren, J.3    Sliwkowski, M.B.4
  • 51
    • 0032485239 scopus 로고    scopus 로고
    • Ammonium ion and glucosamine dependent increases of oligosaccharide complexity in recombinant glycoproteins secreted from cultivated BHK21 cells
    • Gawlitzek M, Valley U, Wagner R. Ammonium ion and glucosamine dependent increases of oligosaccharide complexity in recombinant glycoproteins secreted from cultivated BHK21 cells. Biotechnol Bioeng 1998; 57:518-528.
    • (1998) Biotechnol Bioeng , vol.57 , pp. 518-528
    • Gawlitzek, M.1    Valley, U.2    Wagner, R.3
  • 52
    • 0025649375 scopus 로고
    • Recombinant human interferon-g: Differences in glycosylation and proteolytic processing lead to heterogeneity in batch culture
    • Curling EMA, Hayter PM, Baines AJ, Bull AT, Gull K, Strange PG, Jenkins N. Recombinant human interferon-g: differences in glycosylation and proteolytic processing lead to heterogeneity in batch culture. Biochem J 1990; 272:333-337.
    • (1990) Biochem J , vol.272 , pp. 333-337
    • Curling, E.M.A.1    Hayter, P.M.2    Baines, A.J.3    Bull, A.T.4    Gull, K.5    Strange, P.G.6    Jenkins, N.7
  • 53
    • 0025499794 scopus 로고
    • Cell cycle- and growth phase-dependent variations in size distribution, antibody productivity, and oxygen demand in hybridoma cultures
    • Ramirez OT, Mutharasan R. Cell cycle- and growth phase-dependent variations in size distribution, antibody productivity, and oxygen demand in hybridoma cultures. Biotechnol Bioeng 1990; 36:839-843.
    • (1990) Biotechnol Bioeng , vol.36 , pp. 839-843
    • Ramirez, O.T.1    Mutharasan, R.2
  • 54
    • 0031615181 scopus 로고    scopus 로고
    • Apoptosis and cell culture technology
    • Al-Rubeai M. Apoptosis and cell culture technology. Adv Biochem Biotechnol 1997; 59:225-249.
    • (1997) Adv Biochem Biotechnol , vol.59 , pp. 225-249
    • Al-Rubeai, M.1
  • 55
    • 0033735339 scopus 로고    scopus 로고
    • Relationship between cell size, cell cycle and specific recombinant protein productivity
    • Lloyd DR, Holmes P, Jackson LP, Emery AN, Al-Rubeai M. Relationship between cell size, cell cycle and specific recombinant protein productivity. Cytotechnology 2000; 34:59-70.
    • (2000) Cytotechnology , vol.34 , pp. 59-70
    • Lloyd, D.R.1    Holmes, P.2    Jackson, L.P.3    Emery, A.N.4    Al-Rubeai, M.5
  • 56
    • 0025730563 scopus 로고
    • Flow cytometric study of cultured mammalian cells
    • Al-Rubeai M, Emery AN, Chalder S. Flow cytometric study of cultured mammalian cells. J Biotechnol 1991; 19:67-81.
    • (1991) J Biotechnol , vol.19 , pp. 67-81
    • Al-Rubeai, M.1    Emery, A.N.2    Chalder, S.3
  • 58
    • 0027031095 scopus 로고
    • Fragmented DNA and apoptotic bodies document the programmed way of cell death in hybridoma cultures
    • Franek F, Vomastek T, Dolnikova J. Fragmented DNA and apoptotic bodies document the programmed way of cell death in hybridoma cultures. Cytotechnology 1992; 9:117-123.
    • (1992) Cytotechnology , vol.9 , pp. 117-123
    • Franek, F.1    Vomastek, T.2    Dolnikova, J.3
  • 59
    • 0027398235 scopus 로고
    • Kinetics of development of spontaneous apoptosis in B cell hybridoma cultures
    • Vomastek T, Franek F. Kinetics of development of spontaneous apoptosis in B cell hybridoma cultures. Immunol Lett 1993; 35:19-24.
    • (1993) Immunol Lett , vol.35 , pp. 19-24
    • Vomastek, T.1    Franek, F.2
  • 61
    • 0028765762 scopus 로고
    • Induction of apoptosis in nutrient-deprived cultures of hybridoma and myeloma cells
    • Mercille S, Massie B. Induction of apoptosis in nutrient-deprived cultures of hybridoma and myeloma cells. Biotechnol Bioeng 1994; 44:1140-1154.
    • (1994) Biotechnol Bioeng , vol.44 , pp. 1140-1154
    • Mercille, S.1    Massie, B.2
  • 62
    • 0028718665 scopus 로고
    • Induction of apoptosis in oxygen-deprived cultures of hybridoma cells
    • Mercille S, Massie B. Induction of apoptosis in oxygen-deprived cultures of hybridoma cells. Cytotechnology 1994; 15:117-128.
    • (1994) Cytotechnology , vol.15 , pp. 117-128
    • Mercille, S.1    Massie, B.2
  • 63
    • 0029256479 scopus 로고
    • Death mechanisms of animal cells in conditions of intensive agitation
    • Al-Rubeai M, Singh RP, Goldman MH, Emery AN. Death mechanisms of animal cells in conditions of intensive agitation. Biotechnol Bioeng 1995; 45:463-472.
    • (1995) Biotechnol Bioeng , vol.45 , pp. 463-472
    • Al-Rubeai, M.1    Singh, R.P.2    Goldman, M.H.3    Emery, A.N.4
  • 64
    • 0029043888 scopus 로고
    • A novel assay for apoptosis:Flow cytometric detection of phosphatidylserine expression on early apoptotic cells using fluorescein labeled annexin V
    • Vermes I, Haanen C, Steffens-Nakken H, Reutelingsperger C. A novel assay for apoptosis:flow cytometric detection of phosphatidylserine expression on early apoptotic cells using fluorescein labeled annexin V. J Immunol Meth 1995; 184:39-51.
    • (1995) J Immunol Meth , vol.184 , pp. 39-51
    • Vermes, I.1    Haanen, C.2    Steffens-Nakken, H.3    Reutelingsperger, C.4
  • 65
    • 0032017978 scopus 로고    scopus 로고
    • Critical aspects in the analysis of apoptosis and necrosis
    • Darzynkiewicz Z, Bedner E, Traganos F. Critical aspects in the analysis of apoptosis and necrosis. Human Cell 1998; 11:3-12.
    • (1998) Human Cell , vol.11 , pp. 3-12
    • Darzynkiewicz, Z.1    Bedner, E.2    Traganos, F.3
  • 67
    • 0025397850 scopus 로고
    • Chemical decomposition of glutamine in cell culture media:Effect of media type, pH, and serum concentration
    • Ozturk SS, Palsson BO. Chemical decomposition of glutamine in cell culture media:effect of media type, pH, and serum concentration. Biotechnol Prog 1990; 6:121-128.
    • (1990) Biotechnol Prog , vol.6 , pp. 121-128
    • Ozturk, S.S.1    Palsson, B.O.2
  • 68
    • 0000409606 scopus 로고
    • Spontaneous decomposition of glutamine in cell culture media
    • Tritsch GL, Moore GE. Spontaneous decomposition of glutamine in cell culture media. Exp Cell Res 1962; 28:360-364.
    • (1962) Exp Cell Res , vol.28 , pp. 360-364
    • Tritsch, G.L.1    Moore, G.E.2
  • 69
    • 0032077416 scopus 로고    scopus 로고
    • Variation of stoichiometric ratios and their correlation for monitoring and control of animal cell cultures
    • Zeng A-P, Hu W-S, Deckwer W.-D. Variation of stoichiometric ratios and their correlation for monitoring and control of animal cell cultures. Biotechnol Prog 1998; 14:434-441.
    • (1998) Biotechnol Prog , vol.14 , pp. 434-441
    • Zeng, A.-P.1    Hu, W.-S.2    Deckwer, W.-D.3
  • 70
    • 0006863623 scopus 로고    scopus 로고
    • Demain AL, Solomon NAManual of Industrial Microbiology and Biotechnology. 2nd ed. Washington, DC: American Society for Microbiology
    • Zeng A.-P. Continuous culture. Demain AL, Solomon NAManual of Industrial Microbiology and Biotechnology. 2nd ed. Washington, DC: American Society for Microbiology, 1999:151-164.
    • (1999) Continuous culture , pp. 151-164
    • Zeng, A.-P.1
  • 71
    • 0026593024 scopus 로고
    • Safety and economic aspects of continuous mammalian cell culture
    • Werner RG, Walz F, Noé W, Konrad A. Safety and economic aspects of continuous mammalian cell culture. J Biotechnol 1992; 22:51-68.
    • (1992) J Biotechnol , vol.22 , pp. 51-68
    • Werner, R.G.1    Walz, F.2    Noé, W.3    Konrad, A.4
  • 72
    • 0028170886 scopus 로고
    • An investigation of cell density effects on hybridoma metabolism in a homogeneous perfusion reactor
    • Banik GG, Heath CA. An investigation of cell density effects on hybridoma metabolism in a homogeneous perfusion reactor. Bioprocess Eng 1994; 11:229-237.
    • (1994) Bioprocess Eng , vol.11 , pp. 229-237
    • Banik, G.G.1    Heath, C.A.2
  • 73
    • 0028865073 scopus 로고
    • Hybridoma growth and antibody production as a function of cell density and specific growth rate in perfusion culture
    • Banik GG, Heath CA. Hybridoma growth and antibody production as a function of cell density and specific growth rate in perfusion culture. Biotechnol Bioeng 1995; 48:289-300.
    • (1995) Biotechnol Bioeng , vol.48 , pp. 289-300
    • Banik, G.G.1    Heath, C.A.2
  • 74
    • 0027112095 scopus 로고
    • The use of lactate dehydrogenase release kinetics for the evaluation of death and growth of mammalian cells in perfusion reactor
    • Wagner A, Marc A, Engasser JM, Einsele A. The use of lactate dehydrogenase release kinetics for the evaluation of death and growth of mammalian cells in perfusion reactor. Biotechnol Bioeng 1992; 39:320-326.
    • (1992) Biotechnol Bioeng , vol.39 , pp. 320-326
    • Wagner, A.1    Marc, A.2    Engasser, J.M.3    Einsele, A.4
  • 75
    • 0029138762 scopus 로고
    • A kinetic model for substrate and energy consumption of microbial growth under substrate-sufficient conditions
    • Zeng A-P, Deckwer W.-D. A kinetic model for substrate and energy consumption of microbial growth under substrate-sufficient conditions. Biotechnol Prog 1995; 11:71-79.
    • (1995) Biotechnol Prog , vol.11 , pp. 71-79
    • Zeng, A.-P.1    Deckwer, W.-D.2
  • 76
    • 0030049769 scopus 로고    scopus 로고
    • Comparative analysis of glucose and glutamine metabolism in transformed mammalian cell lines, insect and primary liver cells
    • Neermann J, Wagner R. Comparative analysis of glucose and glutamine metabolism in transformed mammalian cell lines, insect and primary liver cells. J Cell Physiol 1996; 166:152-169.
    • (1996) J Cell Physiol , vol.166 , pp. 152-169
    • Neermann, J.1    Wagner, R.2
  • 77
    • 0026560877 scopus 로고
    • Characterization of glutamine metabolism in two related murine hybridomas
    • Jenkins HA, Bulter M, Dickson AJ. Characterization of glutamine metabolism in two related murine hybridomas. J Biotechnol 1992; 23:167-182.
    • (1992) J Biotechnol , vol.23 , pp. 167-182
    • Jenkins, H.A.1    Bulter, M.2    Dickson, A.J.3
  • 78
    • 0026484670 scopus 로고
    • Glutamine limited fed-batch culture reduce the overflow metabolism of amino acids in myloma cells
    • Ljunggren J, Häggström L. Glutamine limited fed-batch culture reduce the overflow metabolism of amino acids in myloma cells. Cytotechnology 1992; 8:45-56.
    • (1992) Cytotechnology , vol.8 , pp. 45-56
    • Ljunggren, J.1    Häggström, L.2
  • 80
    • 0029937194 scopus 로고    scopus 로고
    • The importance of ammonia in mammalian cell culture
    • Schneider M, Marison IW, von Stockar U. The importance of ammonia in mammalian cell culture. J Biotechnol 1996; 46:161-185.
    • (1996) J Biotechnol , vol.46 , pp. 161-185
    • Schneider, M.1    Marison, I.W.2    von Stockar, U.3
  • 81
    • 0029636676 scopus 로고
    • The effect of ammonia on the O-linked glycosylation of granulocyte colony-stimulating factor produced by Chinese hamster ovary cells
    • Andersen DC, Goochee CF. The effect of ammonia on the O-linked glycosylation of granulocyte colony-stimulating factor produced by Chinese hamster ovary cells. Biotechnol Bioeng 1995; 47:96-105.
    • (1995) Biotechnol Bioeng , vol.47 , pp. 96-105
    • Andersen, D.C.1    Goochee, C.F.2
  • 82
    • 29244437367 scopus 로고
    • Biochemistry of growth inhibition by ammonia ions in mammalian cells
    • Ryll T, Valley U, Wagner R. Biochemistry of growth inhibition by ammonia ions in mammalian cells. Biotechnol Bioeng 1994; 40:934-946.
    • (1994) Biotechnol Bioeng , vol.40 , pp. 934-946
    • Ryll, T.1    Valley, U.2    Wagner, R.3
  • 83
    • 0028888674 scopus 로고
    • In situ removal of ammonia and lactate through electrical means for hybridoma cells
    • Chang YHD, Grodzinsky AJ, Wang DIC. In situ removal of ammonia and lactate through electrical means for hybridoma cells. Biotechnol Bioeng 1995; 47:308-318.
    • (1995) Biotechnol Bioeng , vol.47 , pp. 308-318
    • Chang, Y.H.D.1    Grodzinsky, A.J.2    Wang, D.I.C.3
  • 84
    • 0028436953 scopus 로고
    • Stoichiometric analysis of animal cell growth and its application in medium design
    • Xie L, Wang DIC. Stoichiometric analysis of animal cell growth and its application in medium design. Biotechnol Bioeng 1994; 43:1164-1174.
    • (1994) Biotechnol Bioeng , vol.43 , pp. 1164-1174
    • Xie, L.1    Wang, D.I.C.2
  • 85
    • 0028708951 scopus 로고
    • Low temperature cultivation-a step towards process optimization
    • Weidemann R, Ludwig A, Kretzmer G. Low temperature cultivation-a step towards process optimization. Cytotechnology 1994; 15:111-116.
    • (1994) Cytotechnology , vol.15 , pp. 111-116
    • Weidemann, R.1    Ludwig, A.2    Kretzmer, G.3
  • 88
    • 0033527082 scopus 로고    scopus 로고
    • Effects of cell density and temperature on oxygen consumption rates for different mammalian cell lines
    • Jorjani P, Ozturk S.-S. Effects of cell density and temperature on oxygen consumption rates for different mammalian cell lines. Biotechnol Bioeng 1999; 64:349-356.
    • (1999) Biotechnol Bioeng , vol.64 , pp. 349-356
    • Jorjani, P.1    Ozturk, S.-S.2
  • 89
    • 0033526546 scopus 로고    scopus 로고
    • Influence if low temperature on productivity, proteome and protein phosphorylation of CHO cells
    • Kaufmann H, Mazur X, Fussenegger M, Bailey JE. Influence if low temperature on productivity, proteome and protein phosphorylation of CHO cells. Biotechnol Bioeng 1999; 63:573-582.
    • (1999) Biotechnol Bioeng , vol.63 , pp. 573-582
    • Kaufmann, H.1    Mazur, X.2    Fussenegger, M.3    Bailey, J.E.4
  • 90
    • 0030889612 scopus 로고    scopus 로고
    • Molecular chaperones and the heat shock response at Cold Spring Harbor
    • Hightower LE, Hendershot LM. Molecular chaperones and the heat shock response at Cold Spring Harbor. Cell Stress Chaperones 1997; 2:1-11.
    • (1997) Cell Stress Chaperones , vol.2 , pp. 1-11
    • Hightower, L.E.1    Hendershot, L.M.2
  • 91
    • 0036096124 scopus 로고    scopus 로고
    • Effects of heat and cold stress on mammalian gene expression (invited review)
    • Sonna LA, Fujita J, Gaffin SL, Lilly CM. Effects of heat and cold stress on mammalian gene expression (invited review). J Appl Physiol 2002; 92:1725-1742.
    • (2002) J Appl Physiol , vol.92 , pp. 1725-1742
    • Sonna, L.A.1    Fujita, J.2    Gaffin, S.L.3    Lilly, C.M.4
  • 94
    • 0020459984 scopus 로고
    • Effect of temperature on the production of human fibroblast interferon
    • Giard DJ, Fleischaker RJ, Fabrikant M. Effect of temperature on the production of human fibroblast interferon. Proc Soc Exp Biol Med 1982; 170:155-159.
    • (1982) Proc Soc Exp Biol Med , vol.170 , pp. 155-159
    • Giard, D.J.1    Fleischaker, R.J.2    Fabrikant, M.3
  • 95
    • 0027525814 scopus 로고
    • Effect of temperature and oxygen on cell growth and recombinant protein production in insect cell cultures
    • Reuveny S, Kim YP, Kemp CW, Shiloach J. Effect of temperature and oxygen on cell growth and recombinant protein production in insect cell cultures. Appl Microbiol Biotechnol 1993; 38:619-623.
    • (1993) Appl Microbiol Biotechnol , vol.38 , pp. 619-623
    • Reuveny, S.1    Kim, Y.P.2    Kemp, C.W.3    Shiloach, J.4
  • 96
    • 0026416508 scopus 로고
    • The influence of temperature on a mouse-mouse hybridoma growth and monoclonal antibody production
    • Sureshkumar GK, Mutharasan R. The influence of temperature on a mouse-mouse hybridoma growth and monoclonal antibody production. Biotechnol Bioeng 1991; 37:292-295.
    • (1991) Biotechnol Bioeng , vol.37 , pp. 292-295
    • Sureshkumar, G.K.1    Mutharasan, R.2
  • 97
    • 0035916852 scopus 로고    scopus 로고
    • Comparative analysis of two controlled proliferation strategies regarding product quality, influence on tetracycline- regulated gene expression, and productivity
    • Kaufmann H, Mazur X, Marone R, Bailey JE, Fussenegger M. Comparative analysis of two controlled proliferation strategies regarding product quality, influence on tetracycline- regulated gene expression, and productivity. Biotechnol Bioeng 2001; 72:592-602.
    • (2001) Biotechnol Bioeng , vol.72 , pp. 592-602
    • Kaufmann, H.1    Mazur, X.2    Marone, R.3    Bailey, J.E.4    Fussenegger, M.5
  • 98
    • 0031933027 scopus 로고    scopus 로고
    • Mathematical modeling and analysis in biochemical engineering: Past accomplishments and future opportunities
    • Bailey JE. Mathematical modeling and analysis in biochemical engineering: past accomplishments and future opportunities. Biotechnol Prog 1998; 14:8-20.
    • (1998) Biotechnol Prog , vol.14 , pp. 8-20
    • Bailey, J.E.1
  • 99
    • 0031056790 scopus 로고    scopus 로고
    • Quality control of glycosyl phosphatidylinositol anchor attachment in mammalian cells: A biochemical study
    • Wainwright LJ, Field MC. Quality control of glycosyl phosphatidylinositol anchor attachment in mammalian cells: a biochemical study. Biochem J 1997; 321:655-664.
    • (1997) Biochem J , vol.321 , pp. 655-664
    • Wainwright, L.J.1    Field, M.C.2
  • 101
    • 0026482585 scopus 로고
    • Influence of the temperature on the shear stress sensitivity of adherent BHK21 cells
    • Ludwig A, Tomeczkowski J, Kretzmer G. Influence of the temperature on the shear stress sensitivity of adherent BHK21 cells. Appl Microbiol Biotechnol 1992; 38:323-327.
    • (1992) Appl Microbiol Biotechnol , vol.38 , pp. 323-327
    • Ludwig, A.1    Tomeczkowski, J.2    Kretzmer, G.3
  • 102
    • 0015086239 scopus 로고
    • Effect of pH on the growth cycle of HeLa cells in batch suspension culture without oxygen control
    • Barton ME. Effect of pH on the growth cycle of HeLa cells in batch suspension culture without oxygen control. Biotechnol Bioeng 1971; 13:471-492.
    • (1971) Biotechnol Bioeng , vol.13 , pp. 471-492
    • Barton, M.E.1
  • 103
    • 0018816178 scopus 로고
    • The effect of pH on the growth and carbohydrate metabolism of a lymphoblastoid cell line
    • Birch JR, Edwards DJ. The effect of pH on the growth and carbohydrate metabolism of a lymphoblastoid cell line. Dev Biol Stand 1980; 46:59-63.
    • (1980) Dev Biol Stand , vol.46 , pp. 59-63
    • Birch, J.R.1    Edwards, D.J.2
  • 104
    • 0028385741 scopus 로고
    • Effects of abrupt and gradual osmotic stress on antibody production and content in hybridoma cells that differ in production kinetics
    • Reddy S, Miller WM. Effects of abrupt and gradual osmotic stress on antibody production and content in hybridoma cells that differ in production kinetics. Biotechnol Prog 1994; 10:165-173.
    • (1994) Biotechnol Prog , vol.10 , pp. 165-173
    • Reddy, S.1    Miller, W.M.2
  • 105
    • 0032552821 scopus 로고    scopus 로고
    • Serum increases the CD 13 receptor expression, reduces the transduction of fluid-mechanical forces, and alters the metabolism of HL60 cells cultured in agitated bioreactors
    • McDowell CL, Papoutsakis ET. Serum increases the CD 13 receptor expression, reduces the transduction of fluid-mechanical forces, and alters the metabolism of HL60 cells cultured in agitated bioreactors. Biotechnol Bioeng 1998; 60:259-268.
    • (1998) Biotechnol Bioeng , vol.60 , pp. 259-268
    • McDowell, C.L.1    Papoutsakis, E.T.2
  • 106
    • 0025001352 scopus 로고
    • Hybridoma growth, metabolism and product formulation in HEPES-buffered medium: II. Effect of pH
    • Schmid G, Blanch HW, Wilke CR. Hybridoma growth, metabolism and product formulation in HEPES-buffered medium: II. Effect of pH. Biotechnol Lett 1990; 12:633-638.
    • (1990) Biotechnol Lett , vol.12 , pp. 633-638
    • Schmid, G.1    Blanch, H.W.2    Wilke, C.R.3
  • 107
    • 0002032474 scopus 로고    scopus 로고
    • pH: Effects on growth productivity of cell lines producing monoclonal antibodies: Control in large scale fermenters
    • Wayte J, Boraston R, Bland H, Varley J, Brown M. pH: effects on growth productivity of cell lines producing monoclonal antibodies: control in large scale fermenters. Cytotechnology 1997; 22:87-94.
    • (1997) Cytotechnology , vol.22 , pp. 87-94
    • Wayte, J.1    Boraston, R.2    Bland, H.3    Varley, J.4    Brown, M.5
  • 108
    • 0022235521 scopus 로고
    • Low pH value of pericellular medium as a factor limiting cell proliferation in dense cultures
    • Akatov VS, Lezhnev EI, Vexler AM, Kublik LN. Low pH value of pericellular medium as a factor limiting cell proliferation in dense cultures. Exp Cell Res 1985; 160:421-428.
    • (1985) Exp Cell Res , vol.160 , pp. 421-428
    • Akatov, V.S.1    Lezhnev, E.I.2    Vexler, A.M.3    Kublik, L.N.4
  • 109
    • 0035812878 scopus 로고    scopus 로고
    • The response of GS-NSO myeloma cells to pH shifts and pH perturbations
    • Osman JJ, Birch J, Varley J. The response of GS-NSO myeloma cells to pH shifts and pH perturbations. Biotechnol Bioeng 2001; 75:63-73.
    • (2001) Biotechnol Bioeng , vol.75 , pp. 63-73
    • Osman, J.J.1    Birch, J.2    Varley, J.3
  • 110
    • 0037143810 scopus 로고    scopus 로고
    • The response of GS-NSO myeloma cells to single and multiple pH perturbations
    • Osman JJ, Birch J, Varley J. The response of GS-NSO myeloma cells to single and multiple pH perturbations. Biotechnol Bioeng 2002; 79:398-407.
    • (2002) Biotechnol Bioeng , vol.79 , pp. 398-407
    • Osman, J.J.1    Birch, J.2    Varley, J.3
  • 111
    • 0024508462 scopus 로고
    • Clonal analysis of the glycosylation of immunoglobulin G secreted by murine hybridomas
    • Rothman RJ, Warren L, Vliegenthart JF, Hard KJ. Clonal analysis of the glycosylation of immunoglobulin G secreted by murine hybridomas. Biochemistry 1989; 28:1377-1384.
    • (1989) Biochemistry , vol.28 , pp. 1377-1384
    • Rothman, R.J.1    Warren, L.2    Vliegenthart, J.F.3    Hard, K.J.4
  • 112
    • 14744285958 scopus 로고
    • Culture pH affects expression rates and glycosylation of recombinant mouse placental lactogen proteins by Chinese hamster ovary (CHO) cells
    • Borys MC, Linzer DIH, Papoutsakis M. Culture pH affects expression rates and glycosylation of recombinant mouse placental lactogen proteins by Chinese hamster ovary (CHO) cells. BioTechnology 1993; 11:720-724.
    • (1993) BioTechnology , vol.11 , pp. 720-724
    • Borys, M.C.1    Linzer, D.I.H.2    Papoutsakis, M.3
  • 113
    • 0032432557 scopus 로고    scopus 로고
    • Use of intracellular pH and annexin-V flow cytometric assays to monitor apoptosis and its suppression by bcl-2 over-expression in hybridoma cell culture
    • Ishaque A, Al-Rubeai M. Use of intracellular pH and annexin-V flow cytometric assays to monitor apoptosis and its suppression by bcl-2 over-expression in hybridoma cell culture. J Immunol Methods 1998; 221:43-57.
    • (1998) J Immunol Methods , vol.221 , pp. 43-57
    • Ishaque, A.1    Al-Rubeai, M.2
  • 114
    • 0030053817 scopus 로고    scopus 로고
    • Intracellular pH governs the subcellular distribution of hexokinase in a glioma cell line
    • Miccoli L, Oudard S, Sureau F, Poirson B, Dutrillaux B, Poupon M. Intracellular pH governs the subcellular distribution of hexokinase in a glioma cell line. Biochem J 1996; 313:957-962.
    • (1996) Biochem J , vol.313 , pp. 957-962
    • Miccoli, L.1    Oudard, S.2    Sureau, F.3    Poirson, B.4    Dutrillaux, B.5    Poupon, M.6
  • 115
    • 0037137888 scopus 로고    scopus 로고
    • Optimization of L-phenylalanine production of Corynebacterium glutamicum under product feedback inhibition by elevated oxygen transfer rate
    • Shu CH, Liao CC. Optimization of L-phenylalanine production of Corynebacterium glutamicum under product feedback inhibition by elevated oxygen transfer rate. Biotechnol Bioeng 2002; 77:131-141.
    • (2002) Biotechnol Bioeng , vol.77 , pp. 131-141
    • Shu, C.H.1    Liao, C.C.2
  • 116
    • 0344690099 scopus 로고    scopus 로고
    • Experimental and theoretical considerations on oxygen supply for animal cell growth in fixed-bed reactors
    • Fassnacht D, Portner R. Experimental and theoretical considerations on oxygen supply for animal cell growth in fixed-bed reactors. J Biotechnol 1999; 72:169-184.
    • (1999) J Biotechnol , vol.72 , pp. 169-184
    • Fassnacht, D.1    Portner, R.2
  • 117
    • 0034688445 scopus 로고    scopus 로고
    • Understanding factors that limit the productivity of suspension-based perfusion cultures operated at high medium renewal rates
    • Mercille S, Johnson M, Lanthier S, Kamen AA, Massie B. Understanding factors that limit the productivity of suspension-based perfusion cultures operated at high medium renewal rates. Biotechnol Bioeng 2000; 67:435-450.
    • (2000) Biotechnol Bioeng , vol.67 , pp. 435-450
    • Mercille, S.1    Johnson, M.2    Lanthier, S.3    Kamen, A.A.4    Massie, B.5
  • 118
    • 0021017121 scopus 로고
    • Effect of oxygen tension on chromosomal aberrations in Fanconi anaemia
    • Joenje H, Oostra AB. Effect of oxygen tension on chromosomal aberrations in Fanconi anaemia. Hum Genet 1983; 65:99-101.
    • (1983) Hum Genet , vol.65 , pp. 99-101
    • Joenje, H.1    Oostra, A.B.2
  • 120
    • 0034816897 scopus 로고    scopus 로고
    • Free radicals, exercise, apoptosis, and heat shock proteins
    • Fehrenbach E, Northoff H. Free radicals, exercise, apoptosis, and heat shock proteins. Exerc, Immunol Rev 2001; 7:66-89.
    • (2001) Exerc, Immunol Rev , vol.7 , pp. 66-89
    • Fehrenbach, E.1    Northoff, H.2
  • 121
  • 122
    • 0027949202 scopus 로고
    • Oxidative damage and mitochondrial decay in aging
    • Shigenaga MK, Hagen TM, Ames BN. Oxidative damage and mitochondrial decay in aging. Proc Acad Sci 1994; 91:10771-10778.
    • (1994) Proc Acad Sci , vol.91 , pp. 10771-10778
    • Shigenaga, M.K.1    Hagen, T.M.2    Ames, B.N.3
  • 123
    • 0032839261 scopus 로고    scopus 로고
    • Elevation of apoptotic potential by anoxia hyperoxia shift in NIH3T3 cells
    • Chen YC, Tsai SH, Lin-Shiau SY, Lin JK. Elevation of apoptotic potential by anoxia hyperoxia shift in NIH3T3 cells. Mol Cell Biochem 1999; 197:147-159.
    • (1999) Mol Cell Biochem , vol.197 , pp. 147-159
    • Chen, Y.C.1    Tsai, S.H.2    Lin-Shiau, S.Y.3    Lin, J.K.4
  • 125
    • 0023483203 scopus 로고
    • Effect of dissolved oxygen concentration on hybridoma growth and metabolism in continuous culture
    • Miller WM, Wilke CR, Blanch HW. Effect of dissolved oxygen concentration on hybridoma growth and metabolism in continuous culture. J Cell Physiol 1987; 132:524-530.
    • (1987) J Cell Physiol , vol.132 , pp. 524-530
    • Miller, W.M.1    Wilke, C.R.2    Blanch, H.W.3
  • 126
    • 0025514467 scopus 로고
    • Effects of dissolved oxygen on hybridoma cell growth, metabolism, and antibody production kinetics in continuous culture
    • Ozturk SS, Palsson BO. Effects of dissolved oxygen on hybridoma cell growth, metabolism, and antibody production kinetics in continuous culture. Biotechnol Prog 1990; 6:437-446.
    • (1990) Biotechnol Prog , vol.6 , pp. 437-446
    • Ozturk, S.S.1    Palsson, B.O.2
  • 127
    • 0034162844 scopus 로고    scopus 로고
    • Continuous exposure to high concentrations of nitric oxide leads to persistent inhibition of oxygen consumption by J774 cells as well as extraction of oxygen by the extracellular medium
    • Orsi A, Beltran B, Clementi E, Hallen K, Feelisch M, Moncada S. Continuous exposure to high concentrations of nitric oxide leads to persistent inhibition of oxygen consumption by J774 cells as well as extraction of oxygen by the extracellular medium. Biochem J 2000; 346(Pt 2):407-412.
    • (2000) Biochem J , vol.346 , pp. 407-412
    • Orsi, A.1    Beltran, B.2    Clementi, E.3    Hallen, K.4    Feelisch, M.5    Moncada, S.6
  • 128
    • 0026656831 scopus 로고
    • Modulation of glutathione level in CHO cells. Effects of oxygen concentration and prior exposure to hypoxia
    • Lin AA, Miller WM. Modulation of glutathione level in CHO cells. Effects of oxygen concentration and prior exposure to hypoxia. Ann NY Acad Sci 1992; 665:117-126.
    • (1992) Ann NY Acad Sci , vol.665 , pp. 117-126
    • Lin, A.A.1    Miller, W.M.2
  • 129
    • 0017405185 scopus 로고
    • Low oxygen concentration extends the lifespan of cultured human diploid cells
    • Packer L, Fuehr K. Low oxygen concentration extends the lifespan of cultured human diploid cells. Nature 1977; 267:423-425.
    • (1977) Nature , vol.267 , pp. 423-425
    • Packer, L.1    Fuehr, K.2
  • 131
    • 0020987672 scopus 로고
    • Growth and oxygen requirement of antibody-producing mouse hybridoma cells in suspension culture
    • Boraston R, Thompson PW, Garland S, Birch JR. Growth and oxygen requirement of antibody-producing mouse hybridoma cells in suspension culture. Dev Biol Stand 1983; 55:103-111.
    • (1983) Dev Biol Stand , vol.55 , pp. 103-111
    • Boraston, R.1    Thompson, P.W.2    Garland, S.3    Birch, J.R.4
  • 132
    • 0027957574 scopus 로고
    • A method for simultaneous determination of solubility and transfer coefficient of oxygen in aqueous media using off-gas mass spectrometry
    • Dorresteijn RC, Degooijer CD, Tramper J, Beuvery EC. A method for simultaneous determination of solubility and transfer coefficient of oxygen in aqueous media using off-gas mass spectrometry. Biotechnol Bioeng 1994; 43:149-154.
    • (1994) Biotechnol Bioeng , vol.43 , pp. 149-154
    • Dorresteijn, R.C.1    Degooijer, C.D.2    Tramper, J.3    Beuvery, E.C.4
  • 133
    • 34250093455 scopus 로고
    • Transient responses of hybridoma metabolism to changes in the oxygen supply rate in continuous culture
    • Miller WM, Wilke CR, Blanch HW. Transient responses of hybridoma metabolism to changes in the oxygen supply rate in continuous culture. Bioprocess Eng 1988; 3:103-113.
    • (1988) Bioprocess Eng , vol.3 , pp. 103-113
    • Miller, W.M.1    Wilke, C.R.2    Blanch, H.W.3
  • 134
    • 0029635979 scopus 로고
    • On-line gas analysis in animal cell cultivation: II. Methods for oxygen uptake rate estimation and its application to controlled feeding of glutamine
    • Eyer K, Oeggerli A, Heinzle E. On-line gas analysis in animal cell cultivation: II. Methods for oxygen uptake rate estimation and its application to controlled feeding of glutamine. Biotechnol Bioeng 1995; 45:54-62.
    • (1995) Biotechnol Bioeng , vol.45 , pp. 54-62
    • Eyer, K.1    Oeggerli, A.2    Heinzle, E.3
  • 135
    • 0028454939 scopus 로고
    • On-line characterization of a hybridoma cell culture process
    • Zhou W, Hu W.-S. On-line characterization of a hybridoma cell culture process. Biotechnol Bioeng 1994; 44:170-177.
    • (1994) Biotechnol Bioeng , vol.44 , pp. 170-177
    • Zhou, W.1    Hu, W.-S.2
  • 136
    • 0028483537 scopus 로고
    • Continuous, real-time monitoring of the oxygen-uptake rate (OUR) in animal-cell bioreactors
    • Yoon S, Konstantinov KB. Continuous, real-time monitoring of the oxygen-uptake rate (OUR) in animal-cell bioreactors. Biotechnol Bioeng 1994; 44:983-990.
    • (1994) Biotechnol Bioeng , vol.44 , pp. 983-990
    • Yoon, S.1    Konstantinov, K.B.2
  • 138
    • 0028066753 scopus 로고
    • Use of on-line gas analysis to monitor recombinant mammalian cell cultures
    • Lovrecz G, Gray P. Use of on-line gas analysis to monitor recombinant mammalian cell cultures. Cytotechnology 1994; 14:167-175.
    • (1994) Cytotechnology , vol.14 , pp. 167-175
    • Lovrecz, G.1    Gray, P.2
  • 140
    • 84984086633 scopus 로고
    • The cultivation of animal cells at controlled oxygen dissolved oxygen partial pressure
    • Kilburn DG, Webb FC. The cultivation of animal cells at controlled oxygen dissolved oxygen partial pressure. Biotechnol Bioeng 1968; 10:801-814.
    • (1968) Biotechnol Bioeng , vol.10 , pp. 801-814
    • Kilburn, D.G.1    Webb, F.C.2
  • 141
    • 0033585825 scopus 로고    scopus 로고
    • Cell death from bursting bubbles: Role of cell attachment to rising bubbles in sparged reactors
    • Meier SJ, Hatton TA, Wang DIC. Cell death from bursting bubbles: role of cell attachment to rising bubbles in sparged reactors. Biotechnol Bioeng 1999; 62:468-478.
    • (1999) Biotechnol Bioeng , vol.62 , pp. 468-478
    • Meier, S.J.1    Hatton, T.A.2    Wang, D.I.C.3
  • 142
    • 0000375281 scopus 로고
    • Stephanopoulos G, Rehm HJ, Reed G, Puhler A, Stadler PJW, eds. Biotechnology: A Multi-Volume Comprehensive Treatise. Bioprocessing. Vol. 3. Weinheim, Germany: VCH Verlag
    • Aunins J, Henzler HJ. Aeration in cell culture bioreactors. Stephanopoulos G, Rehm HJ, Reed G, Puhler A, Stadler PJW, eds. Biotechnology: A Multi-Volume Comprehensive Treatise. Bioprocessing. Vol. 3. Weinheim, Germany: VCH Verlag, 1993:223-281.
    • (1993) Aeration in cell culture bioreactors , pp. 223-281
    • Aunins, J.1    Henzler, H.J.2
  • 144
    • 0344507414 scopus 로고    scopus 로고
    • Measurement of volumetric (OUR) and determination of specific (qO2) oxygen uptake rates in animal cell cultures
    • Ruffieux PA, von Stockar U, Marison IW. Measurement of volumetric (OUR) and determination of specific (qO2) oxygen uptake rates in animal cell cultures. J Biotechnol 1998; 63:85-95.
    • (1998) J Biotechnol , vol.63 , pp. 85-95
    • Ruffieux, P.A.1    von Stockar, U.2    Marison, I.W.3
  • 145
    • 0032891763 scopus 로고    scopus 로고
    • Estimation of rate of oxygen uptake and carbon dioxide evolution of animal cell culture using material and energy balances
    • Xiu Z-L, Deckwer W-D, Zeng A.-P. Estimation of rate of oxygen uptake and carbon dioxide evolution of animal cell culture using material and energy balances. Cytotechnology 1999; 29:159-166.
    • (1999) Cytotechnology , vol.29 , pp. 159-166
    • Xiu, Z.-L.1    Deckwer, W.-D.2    Zeng, A.-P.3
  • 146
    • 0025514522 scopus 로고
    • Gas-liquid mass transfer in stirred tanks
    • Arrua LA, McCoy BJ, Smith JM. Gas-liquid mass transfer in stirred tanks. AIChE J 1990; 36:1768-1772.
    • (1990) AIChE J , vol.36 , pp. 1768-1772
    • Arrua, L.A.1    McCoy, B.J.2    Smith, J.M.3
  • 147
    • 0343488535 scopus 로고    scopus 로고
    • Determination of carbon dioxide evolution rate using on-line gas analysis during dynamic degradation experiments
    • Spérandio M, Paul E. Determination of carbon dioxide evolution rate using on-line gas analysis during dynamic degradation experiments. Biotechnol Bioeng 1997; 53:243-252.
    • (1997) Biotechnol Bioeng , vol.53 , pp. 243-252
    • Spérandio, M.1    Paul, E.2
  • 148
    • 0028984114 scopus 로고
    • Effect of CO2 absorption on the measurement of CO2 evolution rate in aerobic and anaerobic continuous cultures
    • Zeng A.-P. Effect of CO2 absorption on the measurement of CO2 evolution rate in aerobic and anaerobic continuous cultures. Appl Microbiol Biotechnol 1995; 42:688-691.
    • (1995) Appl Microbiol Biotechnol , vol.42 , pp. 688-691
    • Zeng, A.-P.1
  • 149
    • 0037083193 scopus 로고    scopus 로고
    • Characterization of hybridoma cell responses to elevated pCO2 and osmolality: Intracellular pH, cell size, apoptosis, and metabolism
    • deZengotita VM, Schmelzer AE, Miller WM. Characterization of hybridoma cell responses to elevated pCO2 and osmolality: intracellular pH, cell size, apoptosis, and metabolism. Biotechnol Bioeng 2002; 77:369-380.
    • (2002) Biotechnol Bioeng , vol.77 , pp. 369-380
    • deZengotita, V.M.1    Schmelzer, A.E.2    Miller, W.M.3
  • 150
    • 0031149388 scopus 로고    scopus 로고
    • Glycosylation of CHO-derived recombinant tPA produced under elevated pCO2
    • Kimura R, Miller WM. Glycosylation of CHO-derived recombinant tPA produced under elevated pCO2. Biotechnol Prog 1997; 73:311-317.
    • (1997) Biotechnol Prog , vol.73 , pp. 311-317
    • Kimura, R.1    Miller, W.M.2
  • 154
    • 0037083051 scopus 로고    scopus 로고
    • Effects of osmoprotectant compounds on NCAM polysialylation under hyperosmotic stress and elevated pCO2
    • Schmelzer AE, Miller WM. Effects of osmoprotectant compounds on NCAM polysialylation under hyperosmotic stress and elevated pCO2. Biotechnol Bioeng 2002; 77:359-368.
    • (2002) Biotechnol Bioeng , vol.77 , pp. 359-368
    • Schmelzer, A.E.1    Miller, W.M.2
  • 156
    • 0030431007 scopus 로고    scopus 로고
    • Dissolved carbon dioxide accumulation in a large scale and high density production of TGFb receptor with baculovirus infected Sf-9 cells
    • Garnier A, Voyer R, Tom R, Perret S, Jardin B, Kamen A. Dissolved carbon dioxide accumulation in a large scale and high density production of TGFb receptor with baculovirus infected Sf-9 cells. Cytotechnology 1996; 22:53-63.
    • (1996) Cytotechnology , vol.22 , pp. 53-63
    • Garnier, A.1    Voyer, R.2    Tom, R.3    Perret, S.4    Jardin, B.5    Kamen, A.6
  • 157
    • 0032442233 scopus 로고    scopus 로고
    • Effects of CO2 and osmolality on hybridoma cells: Growth, metabolism and monoclonal antibody production
    • deZengotita VM, Kimura R, Miller WM. Effects of CO2 and osmolality on hybridoma cells: growth, metabolism and monoclonal antibody production. Cytotechnology 1998; 28:213-227.
    • (1998) Cytotechnology , vol.28 , pp. 213-227
    • deZengotita, V.M.1    Kimura, R.2    Miller, W.M.3
  • 158
    • 85134973203 scopus 로고
    • Culture of Animal Cells. 2nd ed. New York: Liss
    • Freshney RI. In: Alan R, e. Culture of Animal Cells. 2nd ed. New York: Liss, 1987.
    • (1987) In: Alan R, e
    • Freshney, R.I.1
  • 159
    • 0025465336 scopus 로고
    • Growth behavior of Chinese hamster ovary cells in a compact loop bioreactor: 1. Effects of physical and chemical environments
    • Kurano N, Leist C, Messi F, Kurano S, Fiechter A. Growth behavior of Chinese hamster ovary cells in a compact loop bioreactor: 1. Effects of physical and chemical environments. J Biotechnol 1990; 15:101-111.
    • (1990) J Biotechnol , vol.15 , pp. 101-111
    • Kurano, N.1    Leist, C.2    Messi, F.3    Kurano, S.4    Fiechter, A.5
  • 160
    • 0026147822 scopus 로고
    • Effect of medium osmolality on hybridoma growth, metabolism, and antibody production
    • Ozturk SS, Palsson BO. Effect of medium osmolality on hybridoma growth, metabolism, and antibody production. Biotechnol Bioeng 1991; 37:989-993.
    • (1991) Biotechnol Bioeng , vol.37 , pp. 989-993
    • Ozturk, S.S.1    Palsson, B.O.2
  • 161
    • 0033589369 scopus 로고    scopus 로고
    • Bicarbonate concentration and osmolality are key determinants in the inhibition of CHO cell polysialylation under elevated pCO2 or pH
    • Zanghi JA, Schmelzer AE, Mendoza TP, Knop RH, Miller WM. Bicarbonate concentration and osmolality are key determinants in the inhibition of CHO cell polysialylation under elevated pCO2 or pH. Biotechnol Bioeng 1999; 65:182-191.
    • (1999) Biotechnol Bioeng , vol.65 , pp. 182-191
    • Zanghi, J.A.1    Schmelzer, A.E.2    Mendoza, T.P.3    Knop, R.H.4    Miller, W.M.5
  • 162
    • 0033524372 scopus 로고    scopus 로고
    • Application of hypoosmolar medium to fed-batch culture of hybridoma cells for improvement of culture longevity
    • Ryu JS, Lee G. Application of hypoosmolar medium to fed-batch culture of hybridoma cells for improvement of culture longevity. Biotechnol Bioeng 1999; 62:120-123.
    • (1999) Biotechnol Bioeng , vol.62 , pp. 120-123
    • Ryu, J.S.1    Lee, G.2
  • 163
    • 0026592689 scopus 로고
    • Evidence for posttranscriptional stimulation of monoclonal antibody secretion by l-glutamine during slow hybridoma growth
    • Flickinger MC, Goebel NK, Bibila T, Boyce-Jacino S. Evidence for posttranscriptional stimulation of monoclonal antibody secretion by l-glutamine during slow hybridoma growth. J Biotechnol 1992; 22:201-226.
    • (1992) J Biotechnol , vol.22 , pp. 201-226
    • Flickinger, M.C.1    Goebel, N.K.2    Bibila, T.3    Boyce-Jacino, S.4
  • 164
    • 0022631608 scopus 로고
    • Factors affecting cell growth and monoclonal antibody production in stirred reactors
    • Reuveny S, Velez D, Macmillan JD, Miller L. Factors affecting cell growth and monoclonal antibody production in stirred reactors. J Immunol Methods 1986; 86:53-59.
    • (1986) J Immunol Methods , vol.86 , pp. 53-59
    • Reuveny, S.1    Velez, D.2    Macmillan, J.D.3    Miller, L.4
  • 165
    • 0025428793 scopus 로고
    • Enhanced antibody production at slowed growth rates: Experimental demonstration and a simple structured model
    • Suzuki E, Ollis DF. Enhanced antibody production at slowed growth rates: experimental demonstration and a simple structured model. Biotechnol Prog 1990; 6:231-236.
    • (1990) Biotechnol Prog , vol.6 , pp. 231-236
    • Suzuki, E.1    Ollis, D.F.2
  • 166
    • 0025500378 scopus 로고
    • Mechanisms and kinetics of monoclonal antibody synthesis and secretion in synchronous and asynchronous hybridoma cell cultures
    • Al-Rubeai M, Emery AN. Mechanisms and kinetics of monoclonal antibody synthesis and secretion in synchronous and asynchronous hybridoma cell cultures. J Biotechnol 1990; 16:67-76.
    • (1990) J Biotechnol , vol.16 , pp. 67-76
    • Al-Rubeai, M.1    Emery, A.N.2
  • 167
    • 0026219281 scopus 로고
    • Factors controlling cell proliferation and antibody production in mouse hybridoma cells: I. Influence of the amino acid supply
    • Duval D, Demangel C, Munier-Jolain K, Miossec S, Geahel I. Factors controlling cell proliferation and antibody production in mouse hybridoma cells: I. Influence of the amino acid supply. Biotechnol Bioeng 1991; 38:561-570.
    • (1991) Biotechnol Bioeng , vol.38 , pp. 561-570
    • Duval, D.1    Demangel, C.2    Munier-Jolain, K.3    Miossec, S.4    Geahel, I.5
  • 168
    • 0027314871 scopus 로고
    • Influence of ammonium ion and glucose on mAb production in suspension and fixed bed hybridoma cultures
    • Racher AJ, Looby D, Griffiths JB. Influence of ammonium ion and glucose on mAb production in suspension and fixed bed hybridoma cultures. J Biotechnol 1993; 29:145-156.
    • (1993) J Biotechnol , vol.29 , pp. 145-156
    • Racher, A.J.1    Looby, D.2    Griffiths, J.B.3
  • 169
    • 0028028140 scopus 로고
    • Hyper-stimulation of monoclonal antibody production by high osmolarity stress in eRDF medium
    • Chua FK, Yap MGS, Oh SKW. Hyper-stimulation of monoclonal antibody production by high osmolarity stress in eRDF medium. J Biotechnol 1994; 37:265-275.
    • (1994) J Biotechnol , vol.37 , pp. 265-275
    • Chua, F.K.1    Yap, M.G.S.2    Oh, S.K.W.3
  • 170
    • 0028029024 scopus 로고
    • Cell cycle kinetics of accumulation of heavy and light chain immunoglobulin proteins in a mouse hybridoma cell line
    • Kromenaker SJ, Srienc F. Cell cycle kinetics of accumulation of heavy and light chain immunoglobulin proteins in a mouse hybridoma cell line. Cytotechnology 1994; 14:205-218.
    • (1994) Cytotechnology , vol.14 , pp. 205-218
    • Kromenaker, S.J.1    Srienc, F.2
  • 171
    • 0023839257 scopus 로고
    • Evidence that monoclonal antibody production kinetics is related to the integral of the viable cells curve in batch systems
    • Renard JM, Spagnoli R, Mazier C, Salles MF, Mandine E. Evidence that monoclonal antibody production kinetics is related to the integral of the viable cells curve in batch systems. Biotechnol Lett 1988; 10:91-96.
    • (1988) Biotechnol Lett , vol.10 , pp. 91-96
    • Renard, J.M.1    Spagnoli, R.2    Mazier, C.3    Salles, M.F.4    Mandine, E.5
  • 172
    • 0027024341 scopus 로고
    • Specific monoclonal antibody productivity and the cell cycle-comparisons of batch, continuous and perfusion cultures
    • Al-Rubeai M, Emery AN, Chalder S, Jan DC. Specific monoclonal antibody productivity and the cell cycle-comparisons of batch, continuous and perfusion cultures. Cytotechnology 1992; 9:85-97.
    • (1992) Cytotechnology , vol.9 , pp. 85-97
    • Al-Rubeai, M.1    Emery, A.N.2    Chalder, S.3    Jan, D.C.4
  • 173
    • 0000163903 scopus 로고
    • Determination of specific monoclonal antibody secretion rate during very slow hybridoma growth
    • Flickinger MC, Goebel NK, Bohn MA. Determination of specific monoclonal antibody secretion rate during very slow hybridoma growth. Bioprocess Eng 1990; 5:155-164.
    • (1990) Bioprocess Eng , vol.5 , pp. 155-164
    • Flickinger, M.C.1    Goebel, N.K.2    Bohn, M.A.3
  • 174
    • 0026878379 scopus 로고
    • Relationship between hybridoma growth and monoclonal antibody production
    • Hayter PM, Kirkby NF, Spier RE. Relationship between hybridoma growth and monoclonal antibody production. Enzyme Microb Technol 1992; 14:454-461.
    • (1992) Enzyme Microb Technol , vol.14 , pp. 454-461
    • Hayter, P.M.1    Kirkby, N.F.2    Spier, R.E.3
  • 175
    • 0032438796 scopus 로고    scopus 로고
    • Apoptosis-resistant NS=0-E1B-19K myeloma cells exhibit increased viability and chB43 monoclonal antibody productivity using cell cycle modulators
    • Mercille S, Massie B. Apoptosis-resistant NS=0-E1B-19K myeloma cells exhibit increased viability and chB43 monoclonal antibody productivity using cell cycle modulators. Cytotechnology 1998; 28:189-203.
    • (1998) Cytotechnology , vol.28 , pp. 189-203
    • Mercille, S.1    Massie, B.2
  • 176
    • 0037279450 scopus 로고    scopus 로고
    • Improved fermentation processes for NS0 cell lines expressing human antibodies and glutamine synthetase
    • Dempsey J, Ruddock S, Osborne M, Ridley A, Sturt S, Field R. Improved fermentation processes for NS0 cell lines expressing human antibodies and glutamine synthetase. Biotechnol Prog 2003; 19:175-178.
    • (2003) Biotechnol Prog , vol.19 , pp. 175-178
    • Dempsey, J.1    Ruddock, S.2    Osborne, M.3    Ridley, A.4    Sturt, S.5    Field, R.6
  • 177
    • 0031945008 scopus 로고    scopus 로고
    • Controlled proliferation by multigene metabolic engineering enhances the productivity of Chinese hamster ovary cells
    • Fussenegger M, Schlatter S, Datwyler D, Mazur X, Bailey JE. Controlled proliferation by multigene metabolic engineering enhances the productivity of Chinese hamster ovary cells. Nat Biotechnol 1998; 16:468-472.
    • (1998) Nat Biotechnol , vol.16 , pp. 468-472
    • Fussenegger, M.1    Schlatter, S.2    Datwyler, D.3    Mazur, X.4    Bailey, J.E.5
  • 178
    • 0037021802 scopus 로고    scopus 로고
    • Regulation of cell cycle and productivity in NSO cells by the over-expression of p21CIPl
    • Watanabe S, Shuttleworth J, Al-Rubeai M. Regulation of cell cycle and productivity in NSO cells by the over-expression of p21CIPl. Biotechnol Bioeng 2002; 77:1-7.
    • (2002) Biotechnol Bioeng , vol.77 , pp. 1-7
    • Watanabe, S.1    Shuttleworth, J.2    Al-Rubeai, M.3
  • 179
    • 0037274318 scopus 로고    scopus 로고
    • Modulation of cell cycle for enhancement of antibody productivity in perfusion culture of NSO cells
    • Ibarra N, Watanabe B, Bi JX, Shuttleworth J, Al-Rubeai M. Modulation of cell cycle for enhancement of antibody productivity in perfusion culture of NSO cells. Biotechnol Prog 2003; 19:224-228.
    • (2003) Biotechnol Prog , vol.19 , pp. 224-228
    • Ibarra, N.1    Watanabe, B.2    Bi, J.X.3    Shuttleworth, J.4    Al-Rubeai, M.5
  • 180
    • 1542410260 scopus 로고    scopus 로고
    • Uncoupling of cell growth and proliferation results in enhancement of productivity in p21CIP1-arrested CHO cells
    • Bi JX, Shuttleworth J, Al-Rubeai M. Uncoupling of cell growth and proliferation results in enhancement of productivity in p21CIP1-arrested CHO cells. Biotechnol Bioeng 2004; 85:721-749.
    • (2004) Biotechnol Bioeng , vol.85 , pp. 721-749
    • Bi, J.X.1    Shuttleworth, J.2    Al-Rubeai, M.3
  • 181
    • 0026706471 scopus 로고
    • Growth and production kinetics of human X mouse and mouse hybridoma cells at reduced temperature and serum content
    • Borth N, Heider R, Assadian A, Katinger H. Growth and production kinetics of human X mouse and mouse hybridoma cells at reduced temperature and serum content. J Biotechnol 1992; 25:319-331.
    • (1992) J Biotechnol , vol.25 , pp. 319-331
    • Borth, N.1    Heider, R.2    Assadian, A.3    Katinger, H.4
  • 182
    • 0025700669 scopus 로고
    • Glutamine-limited batch hybridoma growth and antibody production: Experiment and model
    • Dalili M, Sayles GD, Ollis D. Glutamine-limited batch hybridoma growth and antibody production: experiment and model. Biotechnol Bioeng 1990; 36:74-82.
    • (1990) Biotechnol Bioeng , vol.36 , pp. 74-82
    • Dalili, M.1    Sayles, G.D.2    Ollis, D.3
  • 183
    • 0025484537 scopus 로고
    • Growth and product inhibition kinetics of T-cell hybridomas producing lymphokines in batch and continuous culture
    • Shaughnessy TS, Kargi F. Growth and product inhibition kinetics of T-cell hybridomas producing lymphokines in batch and continuous culture. Enzyme Microb Technol 1990; 12:669-684.
    • (1990) Enzyme Microb Technol , vol.12 , pp. 669-684
    • Shaughnessy, T.S.1    Kargi, F.2
  • 184
    • 0022536233 scopus 로고
    • Posttranslational association of immunoglobulin heavy chain binding protein with nascent heavy chains in nonsecreting and secreting hybridomas
    • Bole DG, Hendershot LM, Kearney JF. Posttranslational association of immunoglobulin heavy chain binding protein with nascent heavy chains in nonsecreting and secreting hybridomas. J Cell Biol 1986; 102:1558-1566.
    • (1986) J Cell Biol , vol.102 , pp. 1558-1566
    • Bole, D.G.1    Hendershot, L.M.2    Kearney, J.F.3
  • 185
    • 0026456864 scopus 로고
    • The enhancement of specific antibody production rate in glucose- and glutamine-controlled fed-batch culture
    • Omasa T, Ishimoto M, Higashiyama K-L, Shioya S, Suga KI. The enhancement of specific antibody production rate in glucose- and glutamine-controlled fed-batch culture. Cytotechnology 1992; 8:75-84.
    • (1992) Cytotechnology , vol.8 , pp. 75-84
    • Omasa, T.1    Ishimoto, M.2    Higashiyama, K.-L.3    Shioya, S.4    Suga, K.I.5
  • 186
    • 0026190789 scopus 로고
    • A model of secretory protein trafficking in recombinant AtT-20 cells
    • Sambanis A, Lodish HF, Stephanopoulos G. A model of secretory protein trafficking in recombinant AtT-20 cells. Biotechnol Bioeng 1991; 38:280-295.
    • (1991) Biotechnol Bioeng , vol.38 , pp. 280-295
    • Sambanis, A.1    Lodish, H.F.2    Stephanopoulos, G.3
  • 187
    • 0027295683 scopus 로고
    • Kinetic study of hybridoma metabolism and antibody production in continuous culture using serum-free medium
    • Kurokawa H, Ogawa T, Kamihira M, Park YS, Iijima S, Kobayashi T. Kinetic study of hybridoma metabolism and antibody production in continuous culture using serum-free medium. J Ferment Bioeng 1993; 76:128-133.
    • (1993) J Ferment Bioeng , vol.76 , pp. 128-133
    • Kurokawa, H.1    Ogawa, T.2    Kamihira, M.3    Park, Y.S.4    Iijima, S.5    Kobayashi, T.6
  • 188
    • 0024674868 scopus 로고
    • Growth and metabolism of hybridomas immobilized in packed beds: Comparison with static and suspension cultures
    • Murdin AD, Thorpe JS, Groves DJ, Spier RE. Growth and metabolism of hybridomas immobilized in packed beds: comparison with static and suspension cultures. Enzyme Microb Technol 1989; 11:341-346.
    • (1989) Enzyme Microb Technol , vol.11 , pp. 341-346
    • Murdin, A.D.1    Thorpe, J.S.2    Groves, D.J.3    Spier, R.E.4
  • 190
    • 0025008342 scopus 로고
    • Kinetics of growth and antibody production by a hybridoma cell line in a perfusion culture
    • Seamans TC, Hu W.-H. Kinetics of growth and antibody production by a hybridoma cell line in a perfusion culture. J Ferment Bioeng 1990; 70:241-245.
    • (1990) J Ferment Bioeng , vol.70 , pp. 241-245
    • Seamans, T.C.1    Hu, W.-H.2
  • 191
    • 0027998559 scopus 로고
    • Autocrine signals enable chondrocytes to survive in culture
    • Ishizaki Y, Burne J, Raff MC. Autocrine signals enable chondrocytes to survive in culture. J Cell Biol 1994; 126:1069-1077.
    • (1994) J Cell Biol , vol.126 , pp. 1069-1077
    • Ishizaki, Y.1    Burne, J.2    Raff, M.C.3
  • 192
    • 0028954484 scopus 로고
    • Density-dependent induction of apoptosis by transforming growth factor beta-1 in a human ovarian carcinoma cell line
    • Mathieu C, Jozan S, Mazars P, Come MG, Moisand A, Valette A. Density-dependent induction of apoptosis by transforming growth factor beta-1 in a human ovarian carcinoma cell line. Exp Cell Res 1995; 216:13-20.
    • (1995) Exp Cell Res , vol.216 , pp. 13-20
    • Mathieu, C.1    Jozan, S.2    Mazars, P.3    Come, M.G.4    Moisand, A.5    Valette, A.6
  • 193
    • 0030877457 scopus 로고    scopus 로고
    • Cell density dependent apoptosis in HL-60 cells, which is mediated by an unknown soluble factor, is inhibited by transforming growth factor bl and overexpression of bcl-2
    • Saeki K, Yuo A, Kato M, Miyazona K, Yazaki Y, Takaku F. Cell density dependent apoptosis in HL-60 cells, which is mediated by an unknown soluble factor, is inhibited by transforming growth factor bl and overexpression of bcl-2. J Biol Chem 1997; 272:20003-20010.
    • (1997) J Biol Chem , vol.272 , pp. 20003-20010
    • Saeki, K.1    Yuo, A.2    Kato, M.3    Miyazona, K.4    Yazaki, Y.5    Takaku, F.6
  • 194
    • 0024657262 scopus 로고
    • Regulation of mammalian cell growth by autocrine growth factors: Analysis of consequences for inoculum cell density effects
    • Lauffenburger D, Cozens C. Regulation of mammalian cell growth by autocrine growth factors: Analysis of consequences for inoculum cell density effects. Biotechnol Bioeng 1989; 33:1365-1378.
    • (1989) Biotechnol Bioeng , vol.33 , pp. 1365-1378
    • Lauffenburger, D.1    Cozens, C.2
  • 195
    • 0025486621 scopus 로고
    • Effects of cell density and glucose and glutamine levels on the respiration rates of hybridoma cells
    • Wohlpart D, Kirwan D, Gainer J. Effects of cell density and glucose and glutamine levels on the respiration rates of hybridoma cells. Biotechnol Bioeng 1990; 36:630-635.
    • (1990) Biotechnol Bioeng , vol.36 , pp. 630-635
    • Wohlpart, D.1    Kirwan, D.2    Gainer, J.3
  • 196
    • 0017011515 scopus 로고
    • Formulation of structured growth models
    • Fredrickson AG. Formulation of structured growth models. Biotechnol Bioeng 1976; 18:1481-1486.
    • (1976) Biotechnol Bioeng , vol.18 , pp. 1481-1486
    • Fredrickson, A.G.1
  • 197
    • 0033136118 scopus 로고    scopus 로고
    • Model simulation and analysis of perfusion cultures of animal cells at high cell density
    • Zeng A-P, Deckwer W.-D. Model simulation and analysis of perfusion cultures of animal cells at high cell density. Biotechnol Prog 1999; 15:373-382.
    • (1999) Biotechnol Prog , vol.15 , pp. 373-382
    • Zeng, A.-P.1    Deckwer, W.-D.2
  • 198
    • 0027628304 scopus 로고
    • A computer model for intracellular pH regulation in Chinese hamster ovary cells
    • Wu P, Ray NG, Shuler ML. A computer model for intracellular pH regulation in Chinese hamster ovary cells. Biotechnol Prog 1993; 9:374-384.
    • (1993) Biotechnol Prog , vol.9 , pp. 374-384
    • Wu, P.1    Ray, N.G.2    Shuler, M.L.3
  • 199
    • 0021403731 scopus 로고
    • Computer model for glucose- limited growth of a single cell of Escherichia coli B=rA
    • Domach MM, Leung SK, Cahn RE, Cocks GG, Shuler ML. Computer model for glucose- limited growth of a single cell of Escherichia coli B=rA. Biotechnol Bioeng 1984; 26:203-216.
    • (1984) Biotechnol Bioeng , vol.26 , pp. 203-216
    • Domach, M.M.1    Leung, S.K.2    Cahn, R.E.3    Cocks, G.G.4    Shuler, M.L.5
  • 200
    • 0021473901 scopus 로고
    • A finite model for an asynchronous culture of E. coli
    • Domach MM, Shuler ML. A finite model for an asynchronous culture of E. coli. Biotechnol Bioeng 1984; 26:877-884.
    • (1984) Biotechnol Bioeng , vol.26 , pp. 877-884
    • Domach, M.M.1    Shuler, M.L.2
  • 201
    • 0028472596 scopus 로고
    • Cell cycle kinetics and monoclonal antibody productivity of hybridoma cells during perfusion culture
    • Park SH, Ryu DDY. Cell cycle kinetics and monoclonal antibody productivity of hybridoma cells during perfusion culture. Biotechnol Bioeng 1994; 44:361-367.
    • (1994) Biotechnol Bioeng , vol.44 , pp. 361-367
    • Park, S.H.1    Ryu, D.D.Y.2
  • 202
    • 0030440688 scopus 로고    scopus 로고
    • Engineering challenges in high density cell culture system
    • Ozturk SS. Engineering challenges in high density cell culture system. Cytotechnology 1996; 22:3-16
    • (1996) Cytotechnology , vol.22 , pp. 3-16
    • Ozturk, S.S.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.