Cybernetic modeling and regulation of metabolic pathways in multiple steady states of hybridoma cells

Biotechnology Progress

Volumn 16, Issue 5, 2000, Pages 847-853

  Guardia, M J ^a   Gambhir, A ^b   Europa, A F ^b   Ramkrishna, D ^c   Hu, W S ^b  

^a UNIVERSITY OF ALCALÁ   (Spain)

^b University of Minnesota   (United States)

^c PURDUE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYBERNETIC MODELING; GLUTAMINE; HYBRIDOMA CELLS; METABOLIC PATHWAYS;

BIOCHEMICAL PATHWAY; CELL CULTURE MONITORING; CELL GROWTH; CELL METABOLISM; COMPUTER MODEL; GLUCOSE; GLUTAMINE; HYBRIDOMA; STEADY STATE;

AMINES; BIOTECHNOLOGY; COMPUTER SIMULATION; GLUCOSE; GROWTH KINETICS; MATHEMATICAL MODELS; METABOLISM; NUMERICAL METHODS;

ANIMAL CELL CULTURE;

CELL CULTURE TECHNIQUES; CYBERNETICS; HYBRIDOMAS; KINETICS; MODELS, BIOLOGICAL;

ANIMALIA;

EID: 0034281581     PISSN: 87567938     EISSN: None     Source Type: Journal    
DOI: 10.1021/bp000069a     Document Type: Article

References (19)

1. Interactive dual control of glucose and glutamine feeding in hybridoma cultivation
2. Evidence that glutamine, not sugar, is the major energy source for cultured HeLa cells
3. Reduction of waste product excretion via nutrient control: Possible strategies for maximizing product and cell yields on serum in cultures of mammalian cells
4. Growth of human diploid fibroblasts in the absence of glucose utilization
5. Glutamine: A major energy source for cultured mammalian cells
6. Limitation of growth rate by two complementary nutrients: Some elementary but neglected considerations
7. An experimental study in the use of instrumentation to analyze metabolism and product formation in cell culture
8. Effect of glucose on the cultivation of mammalian cells
9. Monitoring and control of animal cell bioreactors: Biochemical engineering considerations
10. Reciprocal regulation of glucose and glutamine utilization by cultured human diploid fibroblasts
11. Alteration of cellular metabolism by consecutive fed-batch cultures of mammalian cells
12. Alteration of mammalian cell metabolism by dynamic nutrient feeding
13. Effect of insulin on a serum-free hybridoma culture
14. Growth characteristics in fed-batch culture of hybridoma cells with control of glucose and glutamine concentrations
15. Multiple steady states with distinct cellular metabolism in continuous culture of mammalian cells
16. Investigation of bacterial growth on mixed substrates experimental evaluation of cybernetic models
17. Cybernetic modeling of growth in mixed, substitutable substrate environments: Preferential and simultaneous utilization
18. Cybernetic modeling and regulation of metabolic pathways. Growth on complementary nutrients
19. Modeling of Bacterial growth under multiply limiting conditions. Experiments under carbon-or/and nitrogen-limiting conditions