메뉴 건너뛰기




Volumn 13, Issue 3, 1997, Pages 311-317

Glycosylation of CHO-derived recombinant tPA produced under elevated pCO2

Author keywords

[No Author keywords available]

Indexed keywords

CARBON DIOXIDE; MANNOSE; MONOSACCHARIDE; N ACETYLNEURAMINIC ACID; N GLYCOLOYLNEURAMINIC ACID; N-GLYCOLYLNEURAMINIC ACID; NEURAMINIC ACID DERIVATIVE; RECOMBINANT PROTEIN; TISSUE PLASMINOGEN ACTIVATOR;

EID: 0031149388     PISSN: 87567938     EISSN: None     Source Type: Journal    
DOI: 10.1021/bp9700162     Document Type: Article
Times cited : (56)

References (40)
  • 2
    • 0029636676 scopus 로고
    • The effect of ammonia on the O-linked glycosylation of granulocyte colony-stimulating factor produced by Chinese hamster ovary cells
    • Anderson, D. C.; Goochee, C. F. The effect of ammonia on the O-linked glycosylation of granulocyte colony-stimulating factor produced by Chinese hamster ovary cells. Biotechnol. Bioeng. 1995, 47, 96-105.
    • (1995) Biotechnol. Bioeng. , vol.47 , pp. 96-105
    • Anderson, D.C.1    Goochee, C.F.2
  • 3
    • 0000375281 scopus 로고
    • Aeration of cell culture bioreactors
    • Rehm, H.-J., Reed, G., Puhler, A., Stadler, P. J. W., Stephanopoulos, G., Eds.; VCH Verlag: Weinheim, Germany
    • Aunins, J.; Henzler, H.-J. Aeration of cell culture bioreactors. In Biotechnology, Vol. 3, Bioprocessing (reaction and process engineering); Rehm, H.-J., Reed, G., Puhler, A., Stadler, P. J. W., Stephanopoulos, G., Eds.; VCH Verlag: Weinheim, Germany, 1993.
    • (1993) Biotechnology, Vol. 3, Bioprocessing (Reaction and Process Engineering) , vol.3
    • Aunins, J.1    Henzler, H.-J.2
  • 4
    • 0026055038 scopus 로고
    • Signal and propeptide processing of human tissue plasminogen activator: Activity of a pro-tPA derivative
    • Berg, D. T.; Grinnell, B. W. Signal and propeptide processing of human tissue plasminogen activator: activity of a pro-tPA derivative. Biochem. Biophys. Res. Commun. 1991, 179, 1289-1296.
    • (1991) Biochem. Biophys. Res. Commun. , vol.179 , pp. 1289-1296
    • Berg, D.T.1    Grinnell, B.W.2
  • 5
    • 0027470964 scopus 로고
    • In vivo clearance of tissue plasminogen activator: The complex role of sites of glycosylation and level of sialylation
    • Cole, E. S.; Nichols, E. H.; Poisson, L.; Harnois, M. L.; Livingston, D. J. In vivo clearance of tissue plasminogen activator: the complex role of sites of glycosylation and level of sialylation. Fibrinolysis 1993, 7, 15-22.
    • (1993) Fibrinolysis , vol.7 , pp. 15-22
    • Cole, E.S.1    Nichols, E.H.2    Poisson, L.3    Harnois, M.L.4    Livingston, D.J.5
  • 6
    • 0025316859 scopus 로고
    • Structural determinants of the noncatalytic chain of tissue-type plasminogen activator that modulate its association rate with plasminogen activator inhibitor-1
    • de Serrano, V. S.; Castellino, F. J. Structural determinants of the noncatalytic chain of tissue-type plasminogen activator that modulate its association rate with plasminogen activator inhibitor-1. J. Biol. Chem. 1990, 265, 10473-10478.
    • (1990) J. Biol. Chem. , vol.265 , pp. 10473-10478
    • De Serrano, V.S.1    Castellino, F.J.2
  • 7
    • 0000623424 scopus 로고
    • The oligosaccharides of glycoproteins: Factors affecting their synthesis and their influence on glycoprotein properties
    • Todd, P, Sikdar, S. K., Bier, M., Eds.; American Chemical Society: Washington, D.C.
    • Goochee, C. F.; Gramer, M. J.; Andersen, D. C.; Bahr, J. B.; Rasmussen, J. R. The oligosaccharides of glycoproteins: factors affecting their synthesis and their influence on glycoprotein properties. In Frontiers in bioprocessing II; 1st ed.; Todd, P, Sikdar, S. K., Bier, M., Eds.; American Chemical Society: Washington, D.C., 1992; pp 199-240.
    • (1992) Frontiers in Bioprocessing II; 1st Ed. , pp. 199-240
    • Goochee, C.F.1    Gramer, M.J.2    Andersen, D.C.3    Bahr, J.B.4    Rasmussen, J.R.5
  • 8
    • 0027628305 scopus 로고
    • Glycosidase activities in Chinese hamster ovary cell lysate and cell culture supernatant
    • Gramer, M. J.; Goochee, C. F. Glycosidase activities in Chinese hamster ovary cell lysate and cell culture supernatant. Biotechnol. Prog. 1993, 9, 366-373.
    • (1993) Biotechnol. Prog. , vol.9 , pp. 366-373
    • Gramer, M.J.1    Goochee, C.F.2
  • 10
    • 0343268209 scopus 로고    scopus 로고
    • 2 levels on CHO cell based perfusion reactor performance
    • San Diego, CA, Jan. 28-Feb. 2
    • 2 levels on CHO cell based perfusion reactor performance. Presented at the Cell Culture Engineering V Meeting, San Diego, CA, Jan. 28-Feb. 2, 1996.
    • (1996) Cell Culture Engineering V Meeting
    • Gray, D.R.1    Chen, S.2
  • 11
    • 0027692930 scopus 로고
    • Identification of carbohydrate structures in glycoprotein peptide maps by the use of LC/MS with selected ion extraction with special reference to tissue plasminogen activator and a glycosylation variant produced by site directed mutagenesis
    • Guzzetta, A. W.; Basa, L. J.; Hancock, W. S.; Keyt, B. A.; Bennett, W. F. Identification of carbohydrate structures in glycoprotein peptide maps by the use of LC/MS with selected ion extraction with special reference to tissue plasminogen activator and a glycosylation variant produced by site directed mutagenesis. Anal. Chem. 1993, 65, 2953-2962.
    • (1993) Anal. Chem. , vol.65 , pp. 2953-2962
    • Guzzetta, A.W.1    Basa, L.J.2    Hancock, W.S.3    Keyt, B.A.4    Bennett, W.F.5
  • 12
    • 0023877998 scopus 로고
    • Monosaccharide analysis of glycoconjugates by anion exchange chromatography with pulsed amperometric detection
    • Hardy, M. R.; Townsend, R. R.; Lee, Y. C. Monosaccharide analysis of glycoconjugates by anion exchange chromatography with pulsed amperometric detection. Anal. Biochem. 1988, 170, 54-62.
    • (1988) Anal. Biochem. , vol.170 , pp. 54-62
    • Hardy, M.R.1    Townsend, R.R.2    Lee, Y.C.3
  • 13
    • 0025872471 scopus 로고
    • Tissue plasminogen activator has an O-linked fucose attached to threonine-61 in the epidermal growth factor domain
    • Harris, R. J.; Leonard, C. K.; Guzzetta, A. W.; Spellman, M. W. Tissue plasminogen activator has an O-linked fucose attached to threonine-61 in the epidermal growth factor domain. Biochemistry 1991, 30, 2311-2314.
    • (1991) Biochemistry , vol.30 , pp. 2311-2314
    • Harris, R.J.1    Leonard, C.K.2    Guzzetta, A.W.3    Spellman, M.W.4
  • 14
    • 0021225302 scopus 로고
    • Purification of human tissue type plasminogen activator
    • Heussen, C.; Joubert, F.; Dowdle, E. Purification of human tissue type plasminogen activator. J. Biol. Chem. 1984, 259, 11635-11638.
    • (1984) J. Biol. Chem. , vol.259 , pp. 11635-11638
    • Heussen, C.1    Joubert, F.2    Dowdle, E.3
  • 15
    • 0021967069 scopus 로고
    • Characterization of N-glycolylneuraminic acid-containing gangliosides as tumor-associated Hanganutziu-Deicher antigen in human colon cancer
    • Higashi, H.; Hirbayashi, Y.; Fukui, Y.; Naiki, M.; Matsumoto, M.; Ueda, S.; Kato, S. Characterization of N-glycolylneuraminic acid-containing gangliosides as tumor-associated Hanganutziu-Deicher antigen in human colon cancer. Cancer Res. 1985, 45, 3796-3802.
    • (1985) Cancer Res. , vol.45 , pp. 3796-3802
    • Higashi, H.1    Hirbayashi, Y.2    Fukui, Y.3    Naiki, M.4    Matsumoto, M.5    Ueda, S.6    Kato, S.7
  • 16
    • 0025184040 scopus 로고
    • Sialylated carbohydrate chains of recombinant human glycoproteins expressed in Chinese hamster ovary cells contain traces of N-glycolylneuraminic acid
    • Hokke, C. H.; Bergwerff, A. A.; Van Dedem, G. W. K.; Van Oostrum, J.; Vliegenthart, J. F. G. Sialylated carbohydrate chains of recombinant human glycoproteins expressed in Chinese hamster ovary cells contain traces of N-glycolylneuraminic acid. FEBS Lett. 1990, 275, 9-14.
    • (1990) FEBS Lett. , vol.275 , pp. 9-14
    • Hokke, C.H.1    Bergwerff, A.A.2    Van Dedem, G.W.K.3    Van Oostrum, J.4    Vliegenthart, J.F.G.5
  • 18
    • 0028224656 scopus 로고
    • Glycosylation of recombinant proteins: Problems and prospects
    • Jenkins, N.; Curling, E. M. A. Glycosylation of recombinant proteins: problems and prospects. Enzyme Microb. Technol. 1994, 16, 354-364.
    • (1994) Enzyme Microb. Technol. , vol.16 , pp. 354-364
    • Jenkins, N.1    Curling, E.M.A.2
  • 19
    • 0342833370 scopus 로고    scopus 로고
    • Ph.D. Thesis, Northwestern University, Evanston, IL, June
    • Kimura, R. Ph.D. Thesis, Northwestern University, Evanston, IL, June 1996.
    • (1996)
    • Kimura, R.1
  • 20
    • 0030571206 scopus 로고    scopus 로고
    • 2 and/or osmolality on the growth and recombinant tPA production of CHO cells
    • 2 and/or osmolality on the growth and recombinant tPA production of CHO cells. Biotechnol. Bioeng. 1996, 52, 152-160.
    • (1996) Biotechnol. Bioeng. , vol.52 , pp. 152-160
    • Kimura, R.1    Miller, W.M.2
  • 21
    • 0023871704 scopus 로고
    • Regulation of cell pH by ambient bicarbonate, carbon dioxide tension, and pH in the rabbit proximal convoluted tubule
    • Krapf, R.; Berry, C. A.; Alpern, R. J.; Rector, F. C., Jr. Regulation of cell pH by ambient bicarbonate, carbon dioxide tension, and pH in the rabbit proximal convoluted tubule. J. Clin. Invest. 1988, 81, 381-389.
    • (1988) J. Clin. Invest. , vol.81 , pp. 381-389
    • Krapf, R.1    Berry, C.A.2    Alpern, R.J.3    Rector F.C., Jr.4
  • 22
    • 0014949207 scopus 로고
    • Cleavage of structural proteins during the assembly of the head of bacteriophage T4
    • Laemmli, U. K. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 1970, 227, 680-685.
    • (1970) Nature , vol.227 , pp. 680-685
    • Laemmli, U.K.1
  • 23
    • 0027626501 scopus 로고
    • Production of tPA in recombinant CHO cells under oxygen-limited conditions
    • Lin, A. A.; Kimura, R.; Miller, W. M. Production of tPA in recombinant CHO cells under oxygen-limited conditions. Biotechnol. Bioeng. 1993, 42, 339-350.
    • (1993) Biotechnol. Bioeng. , vol.42 , pp. 339-350
    • Lin, A.A.1    Kimura, R.2    Miller, W.M.3
  • 24
    • 0026713528 scopus 로고
    • Deamidation: A source of microheterogeneity in pharmaceutical proteins
    • Liu, D. T.-Y. Deamidation: a source of microheterogeneity in pharmaceutical proteins. Trends Biotechnol. 1992, 10, 364-369.
    • (1992) Trends Biotechnol. , vol.10 , pp. 364-369
    • Liu, D.T.-Y.1
  • 25
    • 0024286746 scopus 로고
    • Regulation of intracellular pH in eukaryotic cells
    • Madshus, I. H. Regulation of intracellular pH in eukaryotic cells. Biochem. J. 1988, 250, 1-8.
    • (1988) Biochem. J. , vol.250 , pp. 1-8
    • Madshus, I.H.1
  • 27
    • 0028798520 scopus 로고
    • Immunogenicity of N-glycolylneuraminic acid-containing carbohydrate chains of recombinant human erythropoietin expressed in Chinese hamster ovary cells
    • Noguchi, A.; Mukuria, C. J.; Suzuki, E.; Naiki, M. Immunogenicity of N-glycolylneuraminic acid-containing carbohydrate chains of recombinant human erythropoietin expressed in Chinese hamster ovary cells. J. Biochem. 1995, 117, 59-62.
    • (1995) J. Biochem. , vol.117 , pp. 59-62
    • Noguchi, A.1    Mukuria, C.J.2    Suzuki, E.3    Naiki, M.4
  • 29
    • 0023824137 scopus 로고
    • The biosynthesis of N-glycolylneuraminic acid occurs by hydroxylation of the CMP-glycoside of N-acetylneuraminic acid
    • Shaw, L.; Schauer, R. The biosynthesis of N-glycolylneuraminic acid occurs by hydroxylation of the CMP-glycoside of N-acetylneuraminic acid. Biol. Chem. Hoppe-Seyler 1988, 369, 477-486.
    • (1988) Biol. Chem. Hoppe-Seyler , vol.369 , pp. 477-486
    • Shaw, L.1    Schauer, R.2
  • 30
    • 0024424145 scopus 로고
    • Detection of CMP-N-acetylneuraminic acid hydroxylase activity in fractionated mouse liver
    • Shaw, L.; Schauer, R. Detection of CMP-N-acetylneuraminic acid hydroxylase activity in fractionated mouse liver. Biochem. J. 1989, 263, 355-363.
    • (1989) Biochem. J. , vol.263 , pp. 355-363
    • Shaw, L.1    Schauer, R.2
  • 31
    • 0024286486 scopus 로고
    • Binding properties of a mannose-specific lectin from the snowdrop (Galanthus nivalis) bulb
    • Shibuya, N.; Goldstein, I. J.; Van Damme, E. J. M.; Peumans, W. J. Binding properties of a mannose-specific lectin from the snowdrop (Galanthus nivalis) bulb. J. Biol. Chem. 1988, 263, 728-734.
    • (1988) J. Biol. Chem. , vol.263 , pp. 728-734
    • Shibuya, N.1    Goldstein, I.J.2    Van Damme, E.J.M.3    Peumans, W.J.4
  • 32
    • 0021916466 scopus 로고
    • Regulation of intracellular pH in human neutrophils
    • Simchowitz, L.; Roos, A. Regulation of intracellular pH in human neutrophils. J. Gen. Physiol. 1985, 85, 443-470.
    • (1985) J. Gen. Physiol. , vol.85 , pp. 443-470
    • Simchowitz, L.1    Roos, A.2
  • 35
    • 0022530474 scopus 로고
    • Chloroquine and ammonium chloride prevent terminal glycosylation of immunoglobulins in plasma cells without affecting secretion
    • Thorens, B.; Vassalli, P. Chloroquine and ammonium chloride prevent terminal glycosylation of immunoglobulins in plasma cells without affecting secretion. Nature 1986, 321, 618-620.
    • (1986) Nature , vol.321 , pp. 618-620
    • Thorens, B.1    Vassalli, P.2
  • 36
    • 0001127374 scopus 로고
    • Isolation of Chinese hamster ovary cell mutants deficient in dihydrofolate reductase activity
    • Urlaub, G.; Chasin, L. A. Isolation of Chinese hamster ovary cell mutants deficient in dihydrofolate reductase activity. Proc. Natl. Acad. Sci. U.S.A. 1980, 77, 4216-4220.
    • (1980) Proc. Natl. Acad. Sci. U.S.A. , vol.77 , pp. 4216-4220
    • Urlaub, G.1    Chasin, L.A.2
  • 38
    • 0027456341 scopus 로고
    • Monosaccharide and oligosaccharide analysis of proteins transferred to polyvinylidene fluoride membranes after sodium dodecyl sulfate-polyacrylamide gel electrophoresis
    • Weitzhandler, M.; Kadlecek, D.; Avdalovic, N.; Forte, J. G.; Chow, D.; Townsend, R. R. Monosaccharide and oligosaccharide analysis of proteins transferred to polyvinylidene fluoride membranes after sodium dodecyl sulfate-polyacrylamide gel electrophoresis. J. Biol. Chem. 1993, 268, 5121-5130.
    • (1993) J. Biol. Chem. , vol.268 , pp. 5121-5130
    • Weitzhandler, M.1    Kadlecek, D.2    Avdalovic, N.3    Forte, J.G.4    Chow, D.5    Townsend, R.R.6
  • 39
    • 0024467392 scopus 로고
    • Effects of N-glycosylation on in vitro activity of Bowes melanoma and human colon fibroblast derived tissue plasminogen activator
    • Wittwer, A. J.; Howard, S. C.; Carr, L. S.; Harakas, N. K.; Feder, J.; Parekh, R. B.; Rudd, P. M.; Dwek, R. A.; Rademacher, T. W. Effects of N-glycosylation on in vitro activity of Bowes melanoma and human colon fibroblast derived tissue plasminogen activator. Biochemistry 1989, 28, 7662-7669.
    • (1989) Biochemistry , vol.28 , pp. 7662-7669
    • Wittwer, A.J.1    Howard, S.C.2    Carr, L.S.3    Harakas, N.K.4    Feder, J.5    Parekh, R.B.6    Rudd, P.M.7    Dwek, R.A.8    Rademacher, T.W.9
  • 40
    • 0002593444 scopus 로고
    • The structure of sialic acids and their quantitation
    • Gottschalk, A., Ed.; Elsevier Publishing Co.: New York
    • Yuppy, H.; Gottschalk, A. The structure of sialic acids and their quantitation. In Glycoproteins, their composition, structure and function; Gottschalk, A., Ed.; Elsevier Publishing Co.: New York, 1972; pp 403-449.
    • (1972) Glycoproteins, Their Composition, Structure and Function , pp. 403-449
    • Yuppy, H.1    Gottschalk, A.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.