A yeast platform for high-level synthesis of tetrahydroisoquinoline alkaloids

Nature Communications

Volumn 11, Issue 1, 2020, Pages

  Pyne, Michael E ^a,b   Kevvai, Kaspar ^a,b   Grewal, Parbir S ^c   Narcross, Lauren ^a,b   Choi, Brian ^c   Bourgeois, Leanne ^a,b   Dueber, John E ^d,e   Martin, Vincent J J ^a,b  

^a Gina Cody School of Engineering and Computer Science   (Canada)

^b and Centre for Structural and Functional Genomics   (Canada)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d University of California at Berkeley   (United States)

^e LAWRENCE BERKELEY NATIONAL LABORATORY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3' HYDROXY N METHYLCOCOCLAURINE; ALDEHYDE DEHYDROGENASE; BENZYLISOQUINOLINE DERIVATIVE; COCLAURINE; CYTOCHROME P450 REDUCTASE; DOPAMINE; INDOLE 3 GLYCEROL PHOSPHATE SYNTHASE; N METHYLCOCOCLAURINE; NORCOCLAURINE; PREPHENATE DEHYDRATASE; PREPHENATE DEHYDROGENASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE DEHYDROGENASE; RETICULINE; SALSOLINOL; TETRAHYDROISOQUINOLINE DERIVATIVE; TYROSOL; UNCLASSIFIED DRUG; 1,2,3,4-TETRAHYDROISOQUINOLINE; ALKALOID; BIOLOGICAL PRODUCT; NARCOTIC ANALGESIC AGENT;

ALKALOID; AMINO ACID; CHEMICAL COMPOUND; YEAST;

ARTICLE; CHIRALITY; CONTROLLED STUDY; CRISPR-CAS9 SYSTEM; DNA INTEGRATION; DRUG MANUFACTURE; DRUG SYNTHESIS; ENZYME SPECIFICITY; FED BATCH CULTURE; FLUORESCENCE MICROSCOPY; GENE CASSETTE; GENE DELETION; GENE EXPRESSION; GENE OVEREXPRESSION; GROWTH CURVE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LIQUID CHROMATOGRAPHY-MASS SPECTROMETRY; METHYLATION; MICROTITER PLATE ASSAY; NONHUMAN; SACCHAROMYCES CEREVISIAE; TIME OF FLIGHT MASS SPECTROMETRY; ULTRAVIOLET SPECTROSCOPY; BIOSYNTHESIS; CHEMICAL MODEL; CHEMICAL STRUCTURE; CHEMISTRY; GENETIC ENGINEERING; GENETICS; METABOLISM;

ALKALOIDS; ANALGESICS, OPIOID; BENZYLISOQUINOLINES; BIOLOGICAL PRODUCTS; BIOSYNTHETIC PATHWAYS; GENETIC ENGINEERING; MODELS, CHEMICAL; MOLECULAR STRUCTURE; SACCHAROMYCES CEREVISIAE; TETRAHYDROISOQUINOLINES;

EID: 85087393023     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/s41467-020-17172-x     Document Type: Article

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