Refined sgRNA efficacy prediction improves largeand small-scale CRISPR-Cas9 applications

Nucleic Acids Research

Volumn 46, Issue 3, 2018, Pages 1375-1385

  Labuhn, Maurice ^a   Adams, Felix F ^a   Ng, Michelle ^a   Knoess, Sabine ^a   Schambach, Axel ^a   Charpentier, Emmanuelle M ^b,c   Schwarzer, Adrian ^a   Mateo, Juan L ^d,e   Klusmann, Jan Henning ^a,f   Heckl, Dirk ^a  

^a HANNOVER MEDICAL SCHOOL   (Germany)

^b MAX PLANCK INSTITUTE FOR INFECTION BIOLOGY   (Germany)

^c UMEÅ UNIVERSITY   (Sweden)

^d UNIVERSITY OF HEIDELBERG   (Germany)

^e UNIVERSITY OF OVIEDO   (Spain)

^f MARTIN LUTHER UNIVERSITY HALLE WITTENBERG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOSINE; GUANINE; RNA; SGRNA; UNCLASSIFIED DRUG; CAS9 ENDONUCLEASE STREPTOCOCCUS PYOGENES; GUIDE RNA;

ALGORITHM; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; CRISPR-CAS9 SYSTEM; FLUORESCENCE ANALYSIS; GENE LOCUS; HUMAN; HUMAN CELL; LENTIVIRUS; NONHUMAN; PREDICTION; PREDICTIVE VALUE; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RNA ANALYSIS; CHEMISTRY; CLUSTERED REGULARLY INTERSPACED SHORT PALINDROMIC REPEAT; CONFORMATION; CRISPR CAS SYSTEM; CYTOLOGY; DNA BASE COMPOSITION; GENE EDITING; GENE TARGETING; GENETICS; HEK293 CELL LINE; LEUKOCYTE; METABOLISM; NUCLEOTIDE SEQUENCE; PROCEDURES; TUMOR CELL LINE;

ALGORITHMS; BASE COMPOSITION; BASE SEQUENCE; CELL LINE, TUMOR; CLUSTERED REGULARLY INTERSPACED SHORT PALINDROMIC REPEATS; CRISPR-ASSOCIATED PROTEIN 9; CRISPR-CAS SYSTEMS; GENE EDITING; GENE TARGETING; HEK293 CELLS; HUMANS; LEUKOCYTES; NUCLEIC ACID CONFORMATION; RNA, GUIDE;

EID: 85044625711     PISSN: 03051048     EISSN: 13624962     Source Type: Journal    
DOI: 10.1093/nar/gkx1268     Document Type: Article

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