Metabolic engineering of a tyrosine-overproducing yeast platform using targeted metabolomics

Microbial Cell Factories

Volumn 14, Issue 1, 2015, Pages

  Gold, Nicholas D ^a   Gowen, Christopher M ^b   Lussier, Francois Xavier ^a   Cautha, Sarat C ^b   Mahadevan, Radhakrishnan ^b,c   Martin, Vincent J J ^a  

^a Dept of Electrical and Computer Engineering   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c UNIVERSITY OF TORONTO   (Canada)

Author keywords

Aromatic amino acids; Cyclohexadienyl dehydrogenase; Glucose 6 phosphate dehydrogenase; L tyrosine; Metabolic engineering; Phenylpyruvate decarboxylase; Prephenate dehydrogenase; Pyruvate kinase; Saccharomyces cerevisiae; Targeted metabolomics

Indexed keywords

3 DEOXY 7 PHOSPHOHEPTULONATE SYNTHASE; BACTERIAL PROTEIN; CHORISMATE MUTASE; FUNGAL PROTEIN; METHIONINE; MINICHROMOSOME MAINTENANCE PROTEIN 2; PHOSPHOENOLPYRUVATE; PREPHENATE DEHYDROGENASE; PROTEIN ARO1; PROTEIN ARO10; PROTEIN ARO4; PROTEIN ARO7; PROTEIN TYR1; PROTEIN TYRC; PYRUVATE DECARBOXYLASE; PYRUVIC ACID; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; TYROSINE; UNCLASSIFIED DRUG; GLUCOSE 6 PHOSPHATE DEHYDROGENASE;

ARTICLE; BACTERIAL GENE; CELLULAR PARAMETERS; CONTROLLED STUDY; CYTOSOL; DEGRADATION KINETICS; DRY CELL WEIGHT; FUNGAL GENE; FUNGAL GENOME; FUNGAL STRAIN; GENE DELETION; GENETIC CODE; GENOME ANALYSIS; INHIBITION KINETICS; METABOLIC ENGINEERING; METABOLOMICS; NONHUMAN; PROTEIN EXPRESSION; RHODOBACTER SPHAEROIDES; SACCHAROMYCES CEREVISIAE; STEADY STATE; TAL GENE; ZWF1 GENE; ZYMOMONAS MOBILIS; METABOLISM; PROCEDURES;

GLUCOSEPHOSPHATE DEHYDROGENASE; METABOLIC ENGINEERING; METABOLIC NETWORKS AND PATHWAYS; METABOLOMICS; SACCHAROMYCES CEREVISIAE; TYROSINE;

EID: 84931041879     PISSN: None     EISSN: 14752859     Source Type: Journal    
DOI: 10.1186/s12934-015-0252-2     Document Type: Article

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