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Volumn 31, Issue 11, 2020, Pages 818-834

Gut Microbial Metabolites of Aromatic Amino Acids as Signals in Host–Microbe Interplay

Author keywords

aromatic amino acids; host microbe interaction; microbial metabolism; signaling metabolites

Indexed keywords

AROMATIC AMINO ACID; BACTERIAL ENZYME;

EID: 85083007403     PISSN: 10432760     EISSN: 18793061     Source Type: Journal    
DOI: 10.1016/j.tem.2020.02.012     Document Type: Review
Times cited : (196)

References (89)
  • 1
    • 84861982483 scopus 로고    scopus 로고
    • Honor thy gut symbionts redux
    • Gordon, J.I., Honor thy gut symbionts redux. Science 336 (2012), 1251–1253.
    • (2012) Science , vol.336 , pp. 1251-1253
    • Gordon, J.I.1
  • 2
    • 84990234576 scopus 로고    scopus 로고
    • Signals from the gut microbiota to distant organs in physiology and disease
    • Schroeder, B., Backhed, F., Signals from the gut microbiota to distant organs in physiology and disease. Nat. Med. 22 (2016), 1079–1089.
    • (2016) Nat. Med. , vol.22 , pp. 1079-1089
    • Schroeder, B.1    Backhed, F.2
  • 3
    • 85044279631 scopus 로고    scopus 로고
    • Bile acid-microbiota crosstalk in gastrointestinal inflammation and carcinogenesis
    • Jia, W., et al. Bile acid-microbiota crosstalk in gastrointestinal inflammation and carcinogenesis. Nat. Rev. Gastroenterol. Hepatol. 15 (2018), 111–128.
    • (2018) Nat. Rev. Gastroenterol. Hepatol. , vol.15 , pp. 111-128
    • Jia, W.1
  • 4
    • 85061738433 scopus 로고    scopus 로고
    • Causal relationships among the gut microbiome, short-chain fatty acids and metabolic diseases
    • Sanna, S., et al. Causal relationships among the gut microbiome, short-chain fatty acids and metabolic diseases. Nat. Genet. 51 (2019), 600–605.
    • (2019) Nat. Genet. , vol.51 , pp. 600-605
    • Sanna, S.1
  • 5
    • 84861978076 scopus 로고    scopus 로고
    • Host-gut microbiota metabolic interactions
    • Nicholson, J.K., et al. Host-gut microbiota metabolic interactions. Science 336 (2012), 1262–1267.
    • (2012) Science , vol.336 , pp. 1262-1267
    • Nicholson, J.K.1
  • 6
    • 85026285162 scopus 로고    scopus 로고
    • Kynurenines: tryptophan's metabolites in exercise, inflammation, and mental health
    • Cervenka, I., et al. Kynurenines: tryptophan's metabolites in exercise, inflammation, and mental health. Science, 357, 2017, eaaf9794.
    • (2017) Science , vol.357
    • Cervenka, I.1
  • 7
    • 84975749522 scopus 로고    scopus 로고
    • Phenylketonuria pathophysiology: on the role of metabolic alterations
    • Schuck, P.F., et al. Phenylketonuria pathophysiology: on the role of metabolic alterations. Aging Dis. 6 (2015), 390–399.
    • (2015) Aging Dis. , vol.6 , pp. 390-399
    • Schuck, P.F.1
  • 8
    • 51249118269 scopus 로고    scopus 로고
    • Monoamine oxidase inactivation: from pathophysiology to therapeutics
    • Bortolato, M., et al. Monoamine oxidase inactivation: from pathophysiology to therapeutics. Adv. Drug Deliv. Rev. 60 (2008), 1527–1533.
    • (2008) Adv. Drug Deliv. Rev. , vol.60 , pp. 1527-1533
    • Bortolato, M.1
  • 9
    • 85036500288 scopus 로고    scopus 로고
    • A gut bacterial pathway metabolizes aromatic amino acids into nine circulating metabolites
    • Dodd, D., et al. A gut bacterial pathway metabolizes aromatic amino acids into nine circulating metabolites. Nature 551 (2017), 648–652.
    • (2017) Nature , vol.551 , pp. 648-652
    • Dodd, D.1
  • 10
    • 85050804703 scopus 로고    scopus 로고
    • Identification of phenol- and p-cresol-producing intestinal bacteria by using media supplemented with tyrosine and its metabolites
    • Saito, Y., et al. Identification of phenol- and p-cresol-producing intestinal bacteria by using media supplemented with tyrosine and its metabolites. FEMS Microbiol. Ecol., 94, 2018, fiy125.
    • (2018) FEMS Microbiol. Ecol. , vol.94
    • Saito, Y.1
  • 11
    • 20444437973 scopus 로고    scopus 로고
    • Biochemical characterization of a prokaryotic phenylalanine ammonia lyase
    • Xiang, L., Moore, B.S., Biochemical characterization of a prokaryotic phenylalanine ammonia lyase. J. Bacteriol. 187 (2005), 4286–4289.
    • (2005) J. Bacteriol. , vol.187 , pp. 4286-4289
    • Xiang, L.1    Moore, B.S.2
  • 12
    • 0000006456 scopus 로고
    • Metabolism of cinnamic acid and hydroxy-cinnamic acids by Lactobacillus pastorianus var. quinicus
    • Whiting, G.C., Carr, J.G., Metabolism of cinnamic acid and hydroxy-cinnamic acids by Lactobacillus pastorianus var. quinicus. Nature 184 (1959), 1427–1428.
    • (1959) Nature , vol.184 , pp. 1427-1428
    • Whiting, G.C.1    Carr, J.G.2
  • 13
    • 85047213592 scopus 로고    scopus 로고
    • Gut microbiota regulation of tryptophan metabolism in health and disease
    • Agus, A., et al. Gut microbiota regulation of tryptophan metabolism in health and disease. Cell Host Microbe 23 (2018), 716–724.
    • (2018) Cell Host Microbe , vol.23 , pp. 716-724
    • Agus, A.1
  • 14
    • 84960354427 scopus 로고    scopus 로고
    • Roles of indole as an interspecies and interkingdom signaling molecule
    • Lee, J.H., et al. Roles of indole as an interspecies and interkingdom signaling molecule. Trends Microbiol. 23 (2015), 707–718.
    • (2015) Trends Microbiol. , vol.23 , pp. 707-718
    • Lee, J.H.1
  • 15
    • 85072909752 scopus 로고    scopus 로고
    • Interplay between the human gut microbiome and host metabolism
    • Visconti, A., et al. Interplay between the human gut microbiome and host metabolism. Nat. Commun., 10, 2019, 4505.
    • (2019) Nat. Commun. , vol.10 , pp. 4505
    • Visconti, A.1
  • 16
    • 84908072394 scopus 로고    scopus 로고
    • Discovery and characterization of gut microbiota decarboxylases that can produce the neurotransmitter tryptamine
    • Williams, B.B., et al. Discovery and characterization of gut microbiota decarboxylases that can produce the neurotransmitter tryptamine. Cell Host Microbe 16 (2014), 495–503.
    • (2014) Cell Host Microbe , vol.16 , pp. 495-503
    • Williams, B.B.1
  • 17
    • 85051746264 scopus 로고    scopus 로고
    • Microbial tryptophan catabolites in health and disease
    • Roager, H.M., Licht, T.R., Microbial tryptophan catabolites in health and disease. Nat. Commun., 9, 2018, 3294.
    • (2018) Nat. Commun. , vol.9 , pp. 3294
    • Roager, H.M.1    Licht, T.R.2
  • 18
    • 85027063083 scopus 로고    scopus 로고
    • Lactobacillus reuteri induces gut intraepithelial CD4(+)CD8alphaalpha(+) T cells
    • Cervantes-Barragan, L., et al. Lactobacillus reuteri induces gut intraepithelial CD4(+)CD8alphaalpha(+) T cells. Science 357 (2017), 806–810.
    • (2017) Science , vol.357 , pp. 806-810
    • Cervantes-Barragan, L.1
  • 19
    • 85042195471 scopus 로고    scopus 로고
    • Lactobacillus accelerates ISCs regeneration to protect the integrity of intestinal mucosa through activation of STAT3 signaling pathway induced by LPLs secretion of IL-22
    • Hou, Q., et al. Lactobacillus accelerates ISCs regeneration to protect the integrity of intestinal mucosa through activation of STAT3 signaling pathway induced by LPLs secretion of IL-22. Cell Death Differ. 25 (2018), 1657–1670.
    • (2018) Cell Death Differ. , vol.25 , pp. 1657-1670
    • Hou, Q.1
  • 20
    • 84907597269 scopus 로고    scopus 로고
    • Symbiotic bacterial metabolites regulate gastrointestinal barrier function via the xenobiotic sensor PXR and Toll-like receptor 4
    • Venkatesh, M., et al. Symbiotic bacterial metabolites regulate gastrointestinal barrier function via the xenobiotic sensor PXR and Toll-like receptor 4. Immunity 41 (2014), 296–310.
    • (2014) Immunity , vol.41 , pp. 296-310
    • Venkatesh, M.1
  • 21
    • 85045053813 scopus 로고    scopus 로고
    • Microbiota-derived indole metabolites promote human and murine intestinal homeostasis through regulation of interleukin-10 receptor
    • Alexeev, E.E., et al. Microbiota-derived indole metabolites promote human and murine intestinal homeostasis through regulation of interleukin-10 receptor. Am. J. Pathol. 188 (2018), 1183–1194.
    • (2018) Am. J. Pathol. , vol.188 , pp. 1183-1194
    • Alexeev, E.E.1
  • 22
    • 84912137874 scopus 로고    scopus 로고
    • Bacterial metabolite indole modulates incretin secretion from intestinal enteroendocrine L cells
    • Chimerel, C., et al. Bacterial metabolite indole modulates incretin secretion from intestinal enteroendocrine L cells. Cell Rep. 9 (2014), 1202–1208.
    • (2014) Cell Rep. , vol.9 , pp. 1202-1208
    • Chimerel, C.1
  • 23
    • 85048206165 scopus 로고    scopus 로고
    • Gut microbiota-produced tryptamine activates an epithelial G-protein-coupled receptor to increase colonic secretion
    • Bhattarai, Y., et al. Gut microbiota-produced tryptamine activates an epithelial G-protein-coupled receptor to increase colonic secretion. Cell Host Microbe 23 (2018), 775–785.
    • (2018) Cell Host Microbe , vol.23 , pp. 775-785
    • Bhattarai, Y.1
  • 24
    • 85045954399 scopus 로고    scopus 로고
    • Gut microbiota-derived tryptophan metabolites modulate inflammatory response in hepatocytes and macrophages
    • Krishnan, S., et al. Gut microbiota-derived tryptophan metabolites modulate inflammatory response in hepatocytes and macrophages. Cell Rep. 23 (2018), 1099–1111.
    • (2018) Cell Rep. , vol.23 , pp. 1099-1111
    • Krishnan, S.1
  • 25
    • 85045252363 scopus 로고    scopus 로고
    • Indole, a signaling molecule produced by the gut microbiota, negatively impacts emotional behaviors in rats
    • Jaglin, M., et al. Indole, a signaling molecule produced by the gut microbiota, negatively impacts emotional behaviors in rats. Front. Neurosci., 12, 2018, 216.
    • (2018) Front. Neurosci. , vol.12 , pp. 216
    • Jaglin, M.1
  • 26
    • 85066828373 scopus 로고    scopus 로고
    • Metabolites of lactic acid bacteria present in fermented foods are highly potent agonists of human hydroxycarboxylic acid receptor 3
    • Peters, A., et al. Metabolites of lactic acid bacteria present in fermented foods are highly potent agonists of human hydroxycarboxylic acid receptor 3. PLoS Genet., 15, 2019, e1008145.
    • (2019) PLoS Genet. , vol.15
    • Peters, A.1
  • 27
    • 80052007530 scopus 로고    scopus 로고
    • Functional interaction between trace amine-associated receptor 1 and dopamine D2 receptor
    • Espinoza, S., et al. Functional interaction between trace amine-associated receptor 1 and dopamine D2 receptor. Mol. Pharmacol. 80 (2011), 416–425.
    • (2011) Mol. Pharmacol. , vol.80 , pp. 416-425
    • Espinoza, S.1
  • 28
    • 79551496011 scopus 로고    scopus 로고
    • Role of tyramine synthesis by food-borne Enterococcus durans in adaptation to the gastrointestinal tract environment
    • Fernandez de Palencia, P., et al. Role of tyramine synthesis by food-borne Enterococcus durans in adaptation to the gastrointestinal tract environment. Appl. Environ. Microbiol. 77 (2011), 699–702.
    • (2011) Appl. Environ. Microbiol. , vol.77 , pp. 699-702
    • Fernandez de Palencia, P.1
  • 29
    • 85049182757 scopus 로고    scopus 로고
    • Trace amines and their receptors
    • Gainetdinov, R.R., et al. Trace amines and their receptors. Pharmacol. Rev. 70 (2018), 549–620.
    • (2018) Pharmacol. Rev. , vol.70 , pp. 549-620
    • Gainetdinov, R.R.1
  • 30
    • 33845637306 scopus 로고    scopus 로고
    • Trace amine-associated receptors and their ligands
    • Zucchi, R., et al. Trace amine-associated receptors and their ligands. Br. J. Pharmacol. 149 (2006), 967–978.
    • (2006) Br. J. Pharmacol. , vol.149 , pp. 967-978
    • Zucchi, R.1
  • 31
    • 85028296036 scopus 로고    scopus 로고
    • Cross sectional evaluation of the gut–microbiome metabolome axis in an Italian cohort of IBD patients
    • Santoru, M.L., et al. Cross sectional evaluation of the gut–microbiome metabolome axis in an Italian cohort of IBD patients. Sci. Rep., 7, 2017, 9523.
    • (2017) Sci. Rep. , vol.7 , pp. 9523
    • Santoru, M.L.1
  • 32
    • 68149099597 scopus 로고    scopus 로고
    • Metabolomics reveals metabolic biomarkers of Crohn's disease
    • Jansson, J., et al. Metabolomics reveals metabolic biomarkers of Crohn's disease. PLoS ONE, 4, 2009, e6386.
    • (2009) PLoS ONE , vol.4
    • Jansson, J.1
  • 33
    • 84992648249 scopus 로고    scopus 로고
    • A disease-associated microbial and metabolomics state in relatives of pediatric inflammatory bowel disease patients
    • Jacobs, J.P., et al. A disease-associated microbial and metabolomics state in relatives of pediatric inflammatory bowel disease patients. Cell Mol. Gastroenterol. Hepatol. 2 (2016), 750–766.
    • (2016) Cell Mol. Gastroenterol. Hepatol. , vol.2 , pp. 750-766
    • Jacobs, J.P.1
  • 34
    • 85067007334 scopus 로고    scopus 로고
    • Metagenomic and metabolomic analyses reveal distinct stage-specific phenotypes of the gut microbiota in colorectal cancer
    • Yachida, S., et al. Metagenomic and metabolomic analyses reveal distinct stage-specific phenotypes of the gut microbiota in colorectal cancer. Nat. Med. 25 (2019), 968–976.
    • (2019) Nat. Med. , vol.25 , pp. 968-976
    • Yachida, S.1
  • 35
    • 85011629242 scopus 로고    scopus 로고
    • p-Cresyl sulfate
    • Gryp, T., et al. p-Cresyl sulfate. Toxins (Basel), 2017, 52–59.
    • (2017) Toxins (Basel) , pp. 52-59
    • Gryp, T.1
  • 36
    • 85055500170 scopus 로고    scopus 로고
    • Modelling the role of microbial p-cresol in colorectal genotoxicity
    • Al Hinai, E.A., et al. Modelling the role of microbial p-cresol in colorectal genotoxicity. Gut Microbes 10 (2018), 398–411.
    • (2018) Gut Microbes , vol.10 , pp. 398-411
    • Al Hinai, E.A.1
  • 37
    • 85035117631 scopus 로고    scopus 로고
    • Increased tryptophan metabolism is associated with activity of inflammatory bowel diseases
    • Nikolaus, S., et al. Increased tryptophan metabolism is associated with activity of inflammatory bowel diseases. Gastroenterology 153 (2017), 1504–1516.
    • (2017) Gastroenterology , vol.153 , pp. 1504-1516
    • Nikolaus, S.1
  • 38
    • 84966526506 scopus 로고    scopus 로고
    • CARD9 impacts colitis by altering gut microbiota metabolism of tryptophan into aryl hydrocarbon receptor ligands
    • Lamas, B., et al. CARD9 impacts colitis by altering gut microbiota metabolism of tryptophan into aryl hydrocarbon receptor ligands. Nat. Med. 22 (2016), 598–605.
    • (2016) Nat. Med. , vol.22 , pp. 598-605
    • Lamas, B.1
  • 39
    • 84882664672 scopus 로고    scopus 로고
    • Tryptophan catabolites from microbiota engage aryl hydrocarbon receptor and balance mucosal reactivity via interleukin-22
    • Zelante, T., et al. Tryptophan catabolites from microbiota engage aryl hydrocarbon receptor and balance mucosal reactivity via interleukin-22. Immunity 39 (2013), 372–385.
    • (2013) Immunity , vol.39 , pp. 372-385
    • Zelante, T.1
  • 40
    • 85009909922 scopus 로고    scopus 로고
    • Dietary tryptophan alleviates dextran sodium sulfate-induced colitis through aryl hydrocarbon receptor in mice
    • Islam, J., et al. Dietary tryptophan alleviates dextran sodium sulfate-induced colitis through aryl hydrocarbon receptor in mice. J. Nutr. Biochem. 42 (2017), 43–50.
    • (2017) J. Nutr. Biochem. , vol.42 , pp. 43-50
    • Islam, J.1
  • 41
    • 85021811792 scopus 로고    scopus 로고
    • Indoleacrylic acid produced by commensal Peptostreptococcus species suppresses inflammation
    • Wlodarska, M., et al. Indoleacrylic acid produced by commensal Peptostreptococcus species suppresses inflammation. Cell Host Microbe 22 (2017), 25–37.
    • (2017) Cell Host Microbe , vol.22 , pp. 25-37
    • Wlodarska, M.1
  • 42
    • 84954288595 scopus 로고    scopus 로고
    • The severity of nonalcoholic fatty liver disease is associated with gut dysbiosis and shift in the metabolic function of the gut microbiota
    • Boursier, J., et al. The severity of nonalcoholic fatty liver disease is associated with gut dysbiosis and shift in the metabolic function of the gut microbiota. Hepatology 63 (2016), 764–775.
    • (2016) Hepatology , vol.63 , pp. 764-775
    • Boursier, J.1
  • 43
    • 85056004239 scopus 로고    scopus 로고
    • Impaired aryl hydrocarbon receptor ligand production by the gut microbiota is a key factor in metabolic syndrome
    • Natividad, J.M., et al. Impaired aryl hydrocarbon receptor ligand production by the gut microbiota is a key factor in metabolic syndrome. Cell Metab. 28 (2018), 737–749.
    • (2018) Cell Metab. , vol.28 , pp. 737-749
    • Natividad, J.M.1
  • 44
    • 80052465307 scopus 로고    scopus 로고
    • UPLC-MS-based urine metabolomics reveals indole-3-lactic acid and phenyllactic acid as conserved biomarkers for alcohol-induced liver disease in the Ppara-null mouse model
    • Manna, S.K., et al. UPLC-MS-based urine metabolomics reveals indole-3-lactic acid and phenyllactic acid as conserved biomarkers for alcohol-induced liver disease in the Ppara-null mouse model. J. Proteome Res. 10 (2011), 4120–4133.
    • (2011) J. Proteome Res. , vol.10 , pp. 4120-4133
    • Manna, S.K.1
  • 45
    • 85033773204 scopus 로고    scopus 로고
    • Gut microbial dysbiosis is associated with altered hepatic functions and serum metabolites in chronic hepatitis B patients
    • Wang, J., et al. Gut microbial dysbiosis is associated with altered hepatic functions and serum metabolites in chronic hepatitis B patients. Front. Microbiol., 8, 2017, 2222.
    • (2017) Front. Microbiol. , vol.8 , pp. 2222
    • Wang, J.1
  • 46
    • 85048963660 scopus 로고    scopus 로고
    • Molecular phenomics and metagenomics of hepatic steatosis in non-diabetic obese women
    • Hoyles, L., et al. Molecular phenomics and metagenomics of hepatic steatosis in non-diabetic obese women. Nat. Med. 24 (2018), 1070–1080.
    • (2018) Nat. Med. , vol.24 , pp. 1070-1080
    • Hoyles, L.1
  • 47
    • 85046905840 scopus 로고    scopus 로고
    • The gut microbiota and the brain-gut-kidney axis in hypertension and chronic kidney disease
    • Yang, T., et al. The gut microbiota and the brain-gut-kidney axis in hypertension and chronic kidney disease. Nat. Rev. Nephrol. 14 (2018), 442–456.
    • (2018) Nat. Rev. Nephrol. , vol.14 , pp. 442-456
    • Yang, T.1
  • 48
    • 85006117379 scopus 로고    scopus 로고
    • Modulation of a circulating uremic solute via rational genetic manipulation of the gut microbiota
    • Devlin, A.S., et al. Modulation of a circulating uremic solute via rational genetic manipulation of the gut microbiota. Cell Host Microbe 20 (2016), 709–715.
    • (2016) Cell Host Microbe , vol.20 , pp. 709-715
    • Devlin, A.S.1
  • 49
    • 85068327761 scopus 로고    scopus 로고
    • Intestinal microbiome and fitness in kidney disease
    • Meijers, B., et al. Intestinal microbiome and fitness in kidney disease. Nat. Rev. Nephrol. 15 (2019), 531–545.
    • (2019) Nat. Rev. Nephrol. , vol.15 , pp. 531-545
    • Meijers, B.1
  • 50
    • 0043245105 scopus 로고    scopus 로고
    • Increased plasma phenylacetic acid in patients with end-stage renal failure inhibits iNOS expression
    • Jankowski, J., et al. Increased plasma phenylacetic acid in patients with end-stage renal failure inhibits iNOS expression. J. Clin. Investig. 112 (2003), 256–264.
    • (2003) J. Clin. Investig. , vol.112 , pp. 256-264
    • Jankowski, J.1
  • 51
    • 84954444245 scopus 로고    scopus 로고
    • The aryl hydrocarbon receptor is a critical regulator of tissue factor stability and an antithrombotic target in uremia
    • Shivanna, S., et al. The aryl hydrocarbon receptor is a critical regulator of tissue factor stability and an antithrombotic target in uremia. J. Am. Soc. Nephrol. 27 (2016), 189–201.
    • (2016) J. Am. Soc. Nephrol. , vol.27 , pp. 189-201
    • Shivanna, S.1
  • 52
    • 85041844679 scopus 로고    scopus 로고
    • Microbial modulation of cardiovascular disease
    • Brown, J.M., Hazen, S.L., Microbial modulation of cardiovascular disease. Nat. Rev. Microbiol. 16 (2018), 171–181.
    • (2018) Nat. Rev. Microbiol. , vol.16 , pp. 171-181
    • Brown, J.M.1    Hazen, S.L.2
  • 53
    • 85067314112 scopus 로고    scopus 로고
    • Serum metabolic signatures of coronary and carotid atherosclerosis and subsequent cardiovascular disease
    • Tzoulaki, I., et al. Serum metabolic signatures of coronary and carotid atherosclerosis and subsequent cardiovascular disease. Eur. Heart J. 40 (2019), 2883–2896.
    • (2019) Eur. Heart J. , vol.40 , pp. 2883-2896
    • Tzoulaki, I.1
  • 54
    • 85039038884 scopus 로고    scopus 로고
    • Plasma microbiome-modulated indole- and phenyl-derived metabolites associate with advanced atherosclerosis and postoperative outcomes
    • Cason, C.A., et al. Plasma microbiome-modulated indole- and phenyl-derived metabolites associate with advanced atherosclerosis and postoperative outcomes. J. Vasc. Surg. 68 (2018), 1552–1562.
    • (2018) J. Vasc. Surg. , vol.68 , pp. 1552-1562
    • Cason, C.A.1
  • 55
    • 84983638440 scopus 로고    scopus 로고
    • Intestinal microbial metabolites are linked to severity of myocardial infarction in rats
    • Lam, V., et al. Intestinal microbial metabolites are linked to severity of myocardial infarction in rats. PLoS ONE, 11, 2016, e0160840.
    • (2016) PLoS ONE , vol.11
    • Lam, V.1
  • 56
    • 85068174104 scopus 로고    scopus 로고
    • The gut microbiota regulates white adipose tissue inflammation and obesity via a family of microRNAs
    • Virtue, A.T., et al. The gut microbiota regulates white adipose tissue inflammation and obesity via a family of microRNAs. Sci. Transl. Med., 11, 2019, eaav1892.
    • (2019) Sci. Transl. Med. , vol.11
    • Virtue, A.T.1
  • 57
    • 85048952408 scopus 로고    scopus 로고
    • Genetic deficiency of indoleamine 2,3-dioxygenase promotes gut microbiota-mediated metabolic health
    • Laurans, L., et al. Genetic deficiency of indoleamine 2,3-dioxygenase promotes gut microbiota-mediated metabolic health. Nat. Med. 24 (2018), 1113–1120.
    • (2018) Nat. Med. , vol.24 , pp. 1113-1120
    • Laurans, L.1
  • 58
    • 85036551713 scopus 로고    scopus 로고
    • Salt-responsive gut commensal modulates TH17 axis and disease
    • Wilck, N., et al. Salt-responsive gut commensal modulates TH17 axis and disease. Nature 551 (2017), 585–589.
    • (2017) Nature , vol.551 , pp. 585-589
    • Wilck, N.1
  • 59
    • 0033618295 scopus 로고    scopus 로고
    • Potent neuroprotective properties against the Alzheimer b-amyloid by an endogenous melatonin-related indole structure, indole-3-propionic acid
    • Yau-Jan Chyan, B.P., et al. Potent neuroprotective properties against the Alzheimer b-amyloid by an endogenous melatonin-related indole structure, indole-3-propionic acid. J. Biol. Chem. 274 (1999), 21937–21942.
    • (1999) J. Biol. Chem. , vol.274 , pp. 21937-21942
    • Yau-Jan Chyan, B.P.1
  • 60
    • 85047764155 scopus 로고    scopus 로고
    • Microglial control of astrocytes in response to microbial metabolites
    • Rothhammer, V., et al. Microglial control of astrocytes in response to microbial metabolites. Nature 557 (2018), 724–728.
    • (2018) Nature , vol.557 , pp. 724-728
    • Rothhammer, V.1
  • 61
    • 84966658995 scopus 로고    scopus 로고
    • Type I interferons and microbial metabolites of tryptophan modulate astrocyte activity and central nervous system inflammation via the aryl hydrocarbon receptor
    • Rothhammer, V., et al. Type I interferons and microbial metabolites of tryptophan modulate astrocyte activity and central nervous system inflammation via the aryl hydrocarbon receptor. Nat. Med. 22 (2016), 586–597.
    • (2016) Nat. Med. , vol.22 , pp. 586-597
    • Rothhammer, V.1
  • 62
    • 85065520847 scopus 로고    scopus 로고
    • A forward chemical genetic screen reveals gut microbiota metabolites that modulate host physiology
    • Chen, H., et al. A forward chemical genetic screen reveals gut microbiota metabolites that modulate host physiology. Cell 177 (2019), 1217–1231.
    • (2019) Cell , vol.177 , pp. 1217-1231
    • Chen, H.1
  • 63
    • 0021675977 scopus 로고
    • Central tryptamine turnover in depression, schizophrenia, and anorexia: measurement of indoleacetic acid in cerebrospinal fluid
    • Anderson, G.M., et al. Central tryptamine turnover in depression, schizophrenia, and anorexia: measurement of indoleacetic acid in cerebrospinal fluid. Biol. Psychiatry 19 (1984), 1427–1435.
    • (1984) Biol. Psychiatry , vol.19 , pp. 1427-1435
    • Anderson, G.M.1
  • 64
    • 77956439232 scopus 로고    scopus 로고
    • Altered interactions of tryptophan metabolites in first-episode neuroleptic-naive patients with schizophrenia
    • Yao, J.K., et al. Altered interactions of tryptophan metabolites in first-episode neuroleptic-naive patients with schizophrenia. Mol. Psychiatry 15 (2010), 938–953.
    • (2010) Mol. Psychiatry , vol.15 , pp. 938-953
    • Yao, J.K.1
  • 65
    • 85026298013 scopus 로고    scopus 로고
    • Pharmacology of human trace amine-associated receptors: therapeutic opportunities and challenges
    • Berry, M.D., et al. Pharmacology of human trace amine-associated receptors: therapeutic opportunities and challenges. Pharmacol. Ther. 180 (2017), 161–180.
    • (2017) Pharmacol. Ther. , vol.180 , pp. 161-180
    • Berry, M.D.1
  • 66
    • 33748179785 scopus 로고    scopus 로고
    • A rapid functional assay for the human trace amine-associated receptor 1 based on the mobilization of internal calcium
    • Navarro, H.A., et al. A rapid functional assay for the human trace amine-associated receptor 1 based on the mobilization of internal calcium. J. Biomol. Screen. 11 (2006), 688–693.
    • (2006) J. Biomol. Screen. , vol.11 , pp. 688-693
    • Navarro, H.A.1
  • 67
    • 85062881986 scopus 로고    scopus 로고
    • Mining the microbiota for microbial and metabolite-based immunotherapies
    • Skelly, A.N., et al. Mining the microbiota for microbial and metabolite-based immunotherapies. Nat. Rev. Immunol. 19 (2019), 305–323.
    • (2019) Nat. Rev. Immunol. , vol.19 , pp. 305-323
    • Skelly, A.N.1
  • 68
    • 85029128985 scopus 로고    scopus 로고
    • Commensal bacteria make GPCR ligands that mimic human signalling molecules
    • Cohen, L.J., et al. Commensal bacteria make GPCR ligands that mimic human signalling molecules. Nature 549 (2017), 48–53.
    • (2017) Nature , vol.549 , pp. 48-53
    • Cohen, L.J.1
  • 69
    • 85019662341 scopus 로고    scopus 로고
    • The path towards microbiome-based metabolite treatment
    • Suez, J., Elinav, E., The path towards microbiome-based metabolite treatment. Nat. Microbiol., 2, 2017, 17075.
    • (2017) Nat. Microbiol. , vol.2 , pp. 17075
    • Suez, J.1    Elinav, E.2
  • 70
    • 85052313625 scopus 로고    scopus 로고
    • Development of a gut microbe-targeted nonlethal therapeutic to inhibit thrombosis potential
    • Roberts, A.B., et al. Development of a gut microbe-targeted nonlethal therapeutic to inhibit thrombosis potential. Nat. Med. 24 (2018), 1407–1417.
    • (2018) Nat. Med. , vol.24 , pp. 1407-1417
    • Roberts, A.B.1
  • 71
    • 85068876378 scopus 로고    scopus 로고
    • Precision medicine goes microscopic: engineering the microbiome to improve drug outcomes
    • Lam, K.N., et al. Precision medicine goes microscopic: engineering the microbiome to improve drug outcomes. Cell Host Microbe 26 (2019), 22–34.
    • (2019) Cell Host Microbe , vol.26 , pp. 22-34
    • Lam, K.N.1
  • 72
    • 85048148179 scopus 로고    scopus 로고
    • A microbial drugstore for motility
    • Cryan, J.F., et al. A microbial drugstore for motility. Cell Host Microbe 23 (2018), 691–692.
    • (2018) Cell Host Microbe , vol.23 , pp. 691-692
    • Cryan, J.F.1
  • 73
    • 85070285680 scopus 로고    scopus 로고
    • Mapping interactions of microbial metabolites with human G-protein-coupled receptors
    • Colosimo, D.A., et al. Mapping interactions of microbial metabolites with human G-protein-coupled receptors. Cell Host Microbe 26 (2019), 273–282.
    • (2019) Cell Host Microbe , vol.26 , pp. 273-282
    • Colosimo, D.A.1
  • 74
    • 84992363298 scopus 로고    scopus 로고
    • Stable engraftment of Bifidobacterium longum AH1206 in the human gut depends on individualized features of the resident microbiome
    • Maldonado-Gomez, M.X., et al. Stable engraftment of Bifidobacterium longum AH1206 in the human gut depends on individualized features of the resident microbiome. Cell Host Microbe 20 (2016), 515–526.
    • (2016) Cell Host Microbe , vol.20 , pp. 515-526
    • Maldonado-Gomez, M.X.1
  • 75
    • 85052953665 scopus 로고    scopus 로고
    • Regional variation limits applications of healthy gut microbiome reference ranges and disease models
    • He, Y., et al. Regional variation limits applications of healthy gut microbiome reference ranges and disease models. Nat. Med. 24 (2018), 1532–1535.
    • (2018) Nat. Med. , vol.24 , pp. 1532-1535
    • He, Y.1
  • 76
    • 85037376418 scopus 로고    scopus 로고
    • Practical considerations for large-scale gut microbiome studies
    • Vandeputte, D., et al. Practical considerations for large-scale gut microbiome studies. FEMS Microbiol. Rev. 41 (2017), S154–S167.
    • (2017) FEMS Microbiol. Rev. , vol.41 , pp. S154-S167
    • Vandeputte, D.1
  • 77
    • 66449093986 scopus 로고    scopus 로고
    • First evidence of a membrane-bound, tyramine and beta-phenylethylamine producing, tyrosine decarboxylase in Enterococcus faecalis: a two-dimensional electrophoresis proteomic study
    • Pessione, E., et al. First evidence of a membrane-bound, tyramine and beta-phenylethylamine producing, tyrosine decarboxylase in Enterococcus faecalis: a two-dimensional electrophoresis proteomic study. Proteomics 9 (2009), 2695–2710.
    • (2009) Proteomics , vol.9 , pp. 2695-2710
    • Pessione, E.1
  • 78
    • 85058406774 scopus 로고    scopus 로고
    • Indole-3-pyruvic acid, an aryl hydrocarbon receptor activator, suppresses experimental colitis in mice
    • Aoki, R., et al. Indole-3-pyruvic acid, an aryl hydrocarbon receptor activator, suppresses experimental colitis in mice. J. Immunol. 201 (2018), 3683–3693.
    • (2018) J. Immunol. , vol.201 , pp. 3683-3693
    • Aoki, R.1
  • 79
    • 84875055328 scopus 로고    scopus 로고
    • Major phenylpropanoid-derived metabolites in the human gut can arise from microbial fermentation of protein
    • Russell, W.R., et al. Major phenylpropanoid-derived metabolites in the human gut can arise from microbial fermentation of protein. Mol. Nutr. Food Res. 57 (2013), 523–535.
    • (2013) Mol. Nutr. Food Res. , vol.57 , pp. 523-535
    • Russell, W.R.1
  • 80
    • 0029847006 scopus 로고    scopus 로고
    • Enumeration of human colonic bacteria producing phenolic and indolic compounds: effects of pH, carbohydrate availability and retention time on dissimilatory aromatic amino acid metabolism
    • Smith, E.A., Macfarlane, G.T., Enumeration of human colonic bacteria producing phenolic and indolic compounds: effects of pH, carbohydrate availability and retention time on dissimilatory aromatic amino acid metabolism. J. Appl. Bacteriol. 81 (1996), 288–302.
    • (1996) J. Appl. Bacteriol. , vol.81 , pp. 288-302
    • Smith, E.A.1    Macfarlane, G.T.2
  • 81
    • 0017129337 scopus 로고
    • The end products of the metabolism of aromatic amino acids by Clostridia
    • Elsden, S.R., et al. The end products of the metabolism of aromatic amino acids by Clostridia. Arch. Microbiol. 107 (1976), 283–288.
    • (1976) Arch. Microbiol. , vol.107 , pp. 283-288
    • Elsden, S.R.1
  • 82
    • 85064339636 scopus 로고    scopus 로고
    • Improving 3-phenyllactic acid production of Lactobacillus plantarum AB-1 by enhancing its quorum-sensing capacity
    • Yang, X., et al. Improving 3-phenyllactic acid production of Lactobacillus plantarum AB-1 by enhancing its quorum-sensing capacity. J. Food Sci. Technol. 56 (2019), 2605–2610.
    • (2019) J. Food Sci. Technol. , vol.56 , pp. 2605-2610
    • Yang, X.1
  • 83
    • 0033938369 scopus 로고    scopus 로고
    • The involvement of coenzyme A esters in the dehydration of (R)-phenyllactate to (E)-cinnamate by Clostridium sporogenes
    • Dickert, S., et al. The involvement of coenzyme A esters in the dehydration of (R)-phenyllactate to (E)-cinnamate by Clostridium sporogenes. Eur. J. Biochem. 267 (2000), 3874–3884.
    • (2000) Eur. J. Biochem. , vol.267 , pp. 3874-3884
    • Dickert, S.1
  • 84
    • 79956079794 scopus 로고    scopus 로고
    • Cinnamic acid production using Streptomyces lividans expressing phenylalanine ammonia lyase
    • Noda, S., et al. Cinnamic acid production using Streptomyces lividans expressing phenylalanine ammonia lyase. J. Ind. Microbiol. Biotechnol. 38 (2011), 643–648.
    • (2011) J. Ind. Microbiol. Biotechnol. , vol.38 , pp. 643-648
    • Noda, S.1
  • 85
    • 85075368360 scopus 로고    scopus 로고
    • Indole-3-acetic acid in Burkholderia pyrrocinia JK-SH007: enzymatic identification of the indole-3-acetamide synthesis pathway
    • Liu, W.H., et al. Indole-3-acetic acid in Burkholderia pyrrocinia JK-SH007: enzymatic identification of the indole-3-acetamide synthesis pathway. Front. Microbiol., 10, 2019, 2559.
    • (2019) Front. Microbiol. , vol.10 , pp. 2559
    • Liu, W.H.1
  • 86
    • 0018699826 scopus 로고
    • Indole-3-lactic acid as a tryptophan metabolite produced by Bifidobacterium spp
    • Aragozzini, F., et al. Indole-3-lactic acid as a tryptophan metabolite produced by Bifidobacterium spp. Appl. Environ. Microbiol. 38 (1979), 544–546.
    • (1979) Appl. Environ. Microbiol. , vol.38 , pp. 544-546
    • Aragozzini, F.1
  • 87
    • 84890952604 scopus 로고    scopus 로고
    • Simultaneous involvement of a tungsten-containing aldehyde:ferredoxin oxidoreductase and a phenylacetaldehyde dehydrogenase in anaerobic phenylalanine metabolism
    • Debnar-Daumler, C., et al. Simultaneous involvement of a tungsten-containing aldehyde:ferredoxin oxidoreductase and a phenylacetaldehyde dehydrogenase in anaerobic phenylalanine metabolism. J. Bacteriol. 196 (2014), 483–492.
    • (2014) J. Bacteriol. , vol.196 , pp. 483-492
    • Debnar-Daumler, C.1
  • 88
    • 85045759885 scopus 로고    scopus 로고
    • A three-ring circus: metabolism of the three proteogenic aromatic amino acids and their role in the health of plants and animals
    • Parthasarathy, A., et al. A three-ring circus: metabolism of the three proteogenic aromatic amino acids and their role in the health of plants and animals. Front. Mol. Biosci., 5, 2018, 29.
    • (2018) Front. Mol. Biosci. , vol.5 , pp. 29
    • Parthasarathy, A.1
  • 89
    • 84870936271 scopus 로고    scopus 로고
    • Gut microbial activity, implications for health and disease: the potential role of metabolite analysis
    • Nyangale, E.P., et al. Gut microbial activity, implications for health and disease: the potential role of metabolite analysis. J. Proteome Res. 11 (2012), 5573–5585.
    • (2012) J. Proteome Res. , vol.11 , pp. 5573-5585
    • Nyangale, E.P.1


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