C1orf106 is a colitis risk gene that regulates stability of epithelial adherens junctions

Science

Volumn 359, Issue 6380, 2018, Pages 1161-1166

  Mohanan, Vishnu ^a,b   Nakata, Toru ^a,b   Desch, A Nicole ^a,b   Lévesque, Chloé ^c   Boroughs, Angela ^b   Guzman, Gaelen ^a   Cao, Zhifang ^b   Creasey, Elizabeth ^b   Yao, Junmei ^b   Boucher, Gabrielle ^c   Charron, Guy ^c   Bhan, Atul K ^b   Schenone, Monica ^a   Carr, Steven A ^a   Reinecker, Hans–Christian ^b   Daly, Mark J ^a,b   Rioux, John D ^c,d   Lassen, Kara G ^a,b   Xavier, Ramnik J ^a,b,e  

^a BROAD INSTITUTE OF MIT AND HARVARD   (United States)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

^c MONTREAL HEART INSTITUTE   (Canada)

^d UNIVERSITÉ DE MONTRÉAL   (Canada)

^e Massachusetts Institute of Technology Cambridge   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE DIPHOSPHATE RIBOSYLATION FACTOR 6; CYTOHESIN 1; ADENOSINE DIPHOSPHATE RIBOSYLATION FACTOR; ADP-RIBOSYLATION FACTOR 6; C1ORF109 PROTEIN, HUMAN; CYTOHESIN-1; GUANINE NUCLEOTIDE EXCHANGE FACTOR; PHOSPHOPROTEIN;

BIODEGRADATION; CELL; DISEASE; GENE; GENE EXPRESSION; PATHOGEN; PHENOTYPE; POLYMORPHISM; TURNOVER;

ADHERENS JUNCTION; ANIMAL TISSUE; ARTICLE; C1ORF106 GENE; CELL JUNCTION; COLITIS; CONTROLLED STUDY; ENZYME ACTIVATION; GENE; GENE FUNCTION; GENETIC POLYMORPHISM; INFLAMMATORY BOWEL DISEASE; INTESTINE EPITHELIUM; MOUSE; NONHUMAN; PERMEABILITY BARRIER; PRIORITY JOURNAL; PROTEIN FUNCTION; UBIQUITINATION; ANIMAL; CACO-2 CELL LINE; GENETICS; HEK293 CELL LINE; HUMAN; IMMUNOPRECIPITATION; INTESTINE MUCOSA; METABOLISM; MUTANT MOUSE STRAIN; PATHOLOGY; PROTEIN DEGRADATION; RISK;

MUS;

ADHERENS JUNCTIONS; ADP-RIBOSYLATION FACTORS; ANIMALS; CACO-2 CELLS; GUANINE NUCLEOTIDE EXCHANGE FACTORS; HEK293 CELLS; HUMANS; IMMUNOPRECIPITATION; INFLAMMATORY BOWEL DISEASES; INTESTINAL MUCOSA; MICE; MICE, MUTANT STRAINS; PHOSPHOPROTEINS; POLYMORPHISM, GENETIC; PROTEOLYSIS; RISK; UBIQUITINATION;

EID: 85041632732     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.aan0814     Document Type: Article

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