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Volumn 7, Issue 1, 2017, Pages

Fructooligosaccharide (FOS) and Galactooligosaccharide (GOS) Increase Bifidobacterium but Reduce Butyrate Producing Bacteria with Adverse Glycemic Metabolism in healthy young population

Author keywords

[No Author keywords available]

Indexed keywords

BUTYRIC ACID DERIVATIVE; FRUCTOSE OLIGOSACCHARIDE; OLIGOSACCHARIDE; PREBIOTIC AGENT;

EID: 85029647310     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/s41598-017-10722-2     Document Type: Article
Times cited : (207)

References (53)
  • 1
    • 84866168894 scopus 로고    scopus 로고
    • Functional interactions between the gut microbiota and host metabolism
    • Tremaroli, V. & Backhed, F. Functional interactions between the gut microbiota and host metabolism. Nature. 489, 242-249, doi:10. 1038/nature11552 (2012).
    • (2012) Nature. , vol.489 , pp. 242-249
    • Tremaroli, V.1    Backhed, F.2
  • 2
    • 84883057637 scopus 로고    scopus 로고
    • Dietary intervention impact on gut microbial gene richness
    • Cotillard, A. et al. Dietary intervention impact on gut microbial gene richness. Nature. 500, 585-588, doi:10. 1038/nature12480 (2013).
    • (2013) Nature. , vol.500 , pp. 585-588
    • Cotillard, A.1
  • 3
    • 84883110880 scopus 로고    scopus 로고
    • Richness of human gut microbiome correlates with metabolic markers
    • Le Chatelier, E. et al. Richness of human gut microbiome correlates with metabolic markers. Nature. 500, 541-546, doi:10. 1038/ nature12506 (2013).
    • (2013) Nature. , vol.500 , pp. 541-546
    • Le Chatelier, E.1
  • 4
    • 34347399563 scopus 로고    scopus 로고
    • Metabolic endotoxemia initiates obesity and insulin resistance
    • Cani, P. D. et al. Metabolic endotoxemia initiates obesity and insulin resistance. Diabetes. 56, 1761-1772, doi:10. 2337/db06-1491 (2007).
    • (2007) Diabetes. , vol.56 , pp. 1761-1772
    • Cani, P.D.1
  • 5
    • 84878709716 scopus 로고    scopus 로고
    • Gut metagenome in European women with normal, impaired and diabetic glucose control
    • Karlsson, F. H. et al. Gut metagenome in European women with normal, impaired and diabetic glucose control. Nature. 498, 99-103, doi:10. 1038/nature12198 (2013).
    • (2013) Nature. , vol.498 , pp. 99-103
    • Karlsson, F.H.1
  • 6
    • 84867074831 scopus 로고    scopus 로고
    • A metagenome-wide association study of gut microbiota in type 2 diabetes
    • Qin, J. et al. A metagenome-wide association study of gut microbiota in type 2 diabetes. Nature. 490, 55-60, doi:10. 1038/ nature11450 (2012).
    • (2012) Nature , vol.490 , pp. 55-60
    • Qin, J.1
  • 7
    • 84883181684 scopus 로고    scopus 로고
    • Human gut microbiota changes reveal the progression of glucose intolerance
    • Zhang, X. et al. Human gut microbiota changes reveal the progression of glucose intolerance. PLoS One. 8, e71108, doi:10. 1371/ journal. pone. 0071108 (2013).
    • (2013) PLoS One. , vol.8 , pp. e71108
    • Zhang, X.1
  • 8
    • 84963843085 scopus 로고    scopus 로고
    • Prediabetes diagnosis and treatment: A review
    • Bansal, N. Prediabetes diagnosis and treatment: A review. World J Diabetes. 6, 296-303, doi:10. 4239/wjd. v6. i2. 296 (2015).
    • (2015) World J Diabetes. , vol.6 , pp. 296-303
    • Bansal, N.1
  • 9
    • 33847645068 scopus 로고    scopus 로고
    • Impaired fasting glucose and impaired glucose tolerance
    • Nathan, D. M. et al. Impaired Fasting Glucose and Impaired Glucose Tolerance. Diabetes Care. 30, 753-759, doi:10. 2337/dc07-9920 (2007).
    • (2007) Diabetes Care. , vol.30 , pp. 753-759
    • Nathan, D.M.1
  • 10
    • 0034128013 scopus 로고    scopus 로고
    • Dietary treatment of the metabolic syndrome-the optimal diet
    • Riccardi, G. & Rivellese, A. A. Dietary treatment of the metabolic syndrome-the optimal diet. Br J Nutr. 83(Suppl 1), S143-148 (2000).
    • (2000) Br J Nutr. , vol.83 , pp. S143-148
    • Riccardi, G.1    Rivellese, A.A.2
  • 11
    • 78149272756 scopus 로고    scopus 로고
    • Prebiotic effects: Metabolic and health benefits
    • Roberfroid, M. et al. Prebiotic effects: metabolic and health benefits. Br J Nutr. 104(Suppl 2), S1-63, doi:10. 1017/S0007114510003363 (2010).
    • (2010) Br J Nutr. , vol.104 , pp. S1-63
    • Roberfroid, M.1
  • 12
    • 0029013322 scopus 로고
    • Dietary modulation of the human colonic microbiota: Introducing the concept of prebiotics
    • Gibson, G. R. & Roberfroid, M. B. Dietary modulation of the human colonic microbiota: introducing the concept of prebiotics. J Nutr. 125, 1401-1412 (1995).
    • (1995) J Nutr. , vol.125 , pp. 1401-1412
    • Gibson, G.R.1    Roberfroid, M.B.2
  • 13
    • 84880270337 scopus 로고    scopus 로고
    • Insight into the prebiotic concept: Lessons from an exploratory, double blind intervention study with inulin-type fructans in obese women
    • Dewulf, E. M. et al. Insight into the prebiotic concept: lessons from an exploratory, double blind intervention study with inulin-type fructans in obese women. Gut. 62, 1112-1121, doi:10. 1136/gutjnl-2012-303304 (2013).
    • (2013) Gut. , vol.62 , pp. 1112-1121
    • Dewulf, E.M.1
  • 14
    • 84987623393 scopus 로고    scopus 로고
    • Effect of inulin-type fructans on blood lipid profile and glucose level: A systematic review and meta-analysis of randomized controlled trials
    • Liu, F., Prabhakar, M., Ju, J., Long, H. & Zhou, H. W. Effect of inulin-type fructans on blood lipid profile and glucose level: A systematic review and meta-analysis of randomized controlled trials. Eur J Clin Nutr. 71, 9-20, doi:10. 1038/ejcn. 2016. 156 (2017).
    • (2017) Eur J Clin Nutr. , vol.71 , pp. 9-20
    • Liu, F.1    Prabhakar, M.2    Ju, J.3    Long, H.4    Zhou, H.W.5
  • 15
    • 80755152887 scopus 로고    scopus 로고
    • Responses of gut microbiota and glucose and lipid metabolism to prebiotics in genetic obese and diet-induced leptin-resistant mice
    • Everard, A. et al. Responses of gut microbiota and glucose and lipid metabolism to prebiotics in genetic obese and diet-induced leptin-resistant mice. Diabetes. 60, 2775-2786, doi:10. 2337/db11-0227 (2011).
    • (2011) Diabetes. , vol.60 , pp. 2775-2786
    • Everard, A.1
  • 16
    • 84996483432 scopus 로고    scopus 로고
    • Variable responses of human microbiomes to dietary supplementation with resistant starch
    • Venkataraman, A. et al. Variable responses of human microbiomes to dietary supplementation with resistant starch. Microbiome. 4, 33-42, doi:10. 1186/s40168-016-0178-x (2016).
    • (2016) Microbiome. , vol.4 , pp. 33-42
    • Venkataraman, A.1
  • 17
    • 84897144707 scopus 로고    scopus 로고
    • Gut microbiota signatures predict host and microbiota responses to dietary interventions in obese individuals
    • Korpela, K. et al. Gut microbiota signatures predict host and microbiota responses to dietary interventions in obese individuals. PLoS One. 9, e90702, doi:10. 1371/journal. pone. 0090702 (2014).
    • (2014) PLoS One. , vol.9 , pp. e90702
    • Korpela, K.1
  • 18
    • 84947812071 scopus 로고    scopus 로고
    • Personalized nutrition by prediction of glycemic responses
    • Zeevi, D. et al. Personalized Nutrition by Prediction of Glycemic Responses. Cell. 163, 1079-1094, doi:10. 1016/j. cell. 2015. 11. 001 (2015).
    • (2015) Cell. , vol.163 , pp. 1079-1094
    • Zeevi, D.1
  • 19
    • 15744387573 scopus 로고    scopus 로고
    • Comparison of abdominal adiposity and overall obesity in predicting risk of type 2 diabetes among men
    • Wang, Y., Rimm, E. B., Stampfer, M. J., Willett, W. C. & Hu, F. B. Comparison of abdominal adiposity and overall obesity in predicting risk of type 2 diabetes among men. Am J Clin Nutr. 81, 555-563 (2005).
    • (2005) Am J Clin Nutr. , vol.81 , pp. 555-563
    • Wang, Y.1    Rimm, E.B.2    Stampfer, M.J.3    Willett, W.C.4    Hu, F.B.5
  • 20
    • 79960501919 scopus 로고    scopus 로고
    • Interaction between obesity and the gut microbiota: Relevance in nutrition
    • Delzenne, N. M. & Cani, P. D. Interaction between obesity and the gut microbiota: relevance in nutrition. Annu Rev Nutr. 31, 15-31, doi:10. 1146/annurev-nutr-072610-145146 (2011).
    • (2011) Annu Rev Nutr. , vol.31 , pp. 15-31
    • Delzenne, N.M.1    Cani, P.D.2
  • 21
    • 80052225187 scopus 로고    scopus 로고
    • Modulation of the gut microbiota by nutrients with prebiotic properties: Consequences for host health in the context of obesity and metabolic syndrome
    • Delzenne, N. M., Neyrinck, A. M. & Cani, P. D. Modulation of the gut microbiota by nutrients with prebiotic properties: consequences for host health in the context of obesity and metabolic syndrome. Microb Cell Fact. 10(Suppl 1), S10, doi:10. 1186/1475-2859-10-S1-S10 (2011).
    • (2011) Microb Cell Fact. , vol.10 , pp. S10
    • Delzenne, N.M.1    Neyrinck, A.M.2    Cani, P.D.3
  • 22
    • 84926359874 scopus 로고    scopus 로고
    • Effects of high performance inulin supplementation on glycemic status and lipid profile in women with type 2 diabetes: A randomized, placebo-controlled clinical trial
    • Dehghan, P., Pourghassem, G. B. & Asgharijafarabadi, M. Effects of high performance inulin supplementation on glycemic status and lipid profile in women with type 2 diabetes: A randomized, placebo-controlled clinical trial. Health Promot Perspect. 3, 55-63, doi:10. 5681/hpp. 2013. 007 (2013).
    • (2013) Health Promot Perspect. , vol.3 , pp. 55-63
    • Dehghan, P.1    Pourghassem, G.B.2    Asgharijafarabadi, M.3
  • 23
    • 0343183296 scopus 로고    scopus 로고
    • Chronic consumption of short-chain fructooligosaccharides does not affect basal hepatic glucose production or insulin resistance in type 2 diabetics
    • Luo, J. et al. Chronic consumption of short-chain fructooligosaccharides does not affect basal hepatic glucose production or insulin resistance in type 2 diabetics. J Nutr. 130, 1572-1577 (2000).
    • (2000) J Nutr. , vol.130 , pp. 1572-1577
    • Luo, J.1
  • 24
    • 0034128013 scopus 로고    scopus 로고
    • Dietary treatment of the metabolic syndrome-the optimal diet
    • Riccardi, G. & Rivellese, A. A. Dietary treatment of the metabolic syndrome-the optimal diet. Br. J. Nutr. 83(Suppl 1), S143-148 (2000).
    • (2000) Br. J. Nutr. , vol.83 , pp. S143-148
    • Riccardi, G.1    Rivellese, A.A.2
  • 25
    • 84907228623 scopus 로고    scopus 로고
    • Evidence for the gut microbiota short-chain fatty acids as key pathophysiological molecules improving diabetes
    • Alessandra, P., Roberta, S., Fabrizio, M. & Giorgio, L. V. Evidence for the Gut Microbiota Short-Chain Fatty Acids as Key Pathophysiological Molecules Improving Diabetes. Mediators Inflamm. 2014, 162021, doi:10. 1155/2014/162021 (2014).
    • (2014) Mediators Inflamm. , vol.2014 , pp. 162021
    • Alessandra, P.1    Roberta, S.2    Fabrizio, M.3    Giorgio, L.V.4
  • 26
    • 35748957503 scopus 로고    scopus 로고
    • The physiology of glucagon-like peptide 1
    • Holst, J. J. The physiology of glucagon-like peptide 1. Physiological Reviews 87, 1409-1439, doi:10. 1152/physrev. 00034. 2006 (2007).
    • (2007) Physiological Reviews , vol.87 , pp. 1409-1439
    • Holst, J.J.1
  • 27
    • 34347392490 scopus 로고    scopus 로고
    • Long-term administration of inulin-type fructans has no significant lipid-lowering effect in normolipidemic humans
    • Forcheron, F. & Beylot, M. Long-term administration of inulin-type fructans has no significant lipid-lowering effect in normolipidemic humans. Metabolism. 56, 1093-1098 (2007).
    • (2007) Metabolism. , vol.56 , pp. 1093-1098
    • Forcheron, F.1    Beylot, M.2
  • 28
    • 84901605077 scopus 로고    scopus 로고
    • The impact of oligofructose on stimulation of gut hormones, appetite regulation and adiposity
    • Daud, N. M. et al. The impact of oligofructose on stimulation of gut hormones, appetite regulation and adiposity. Obesity (Silver Spring). 22, 1430-1438, doi:10. 1002/oby. 20754 (2014).
    • (2014) Obesity (Silver Spring). , vol.22 , pp. 1430-1438
    • Daud, N.M.1
  • 29
    • 84872810220 scopus 로고    scopus 로고
    • Double blind randomized clinical trial controlled by placebo with a FOS enriched cookie on satiety and cardiovascular risk factors in obese patients
    • de Luis, D. A. et al. Double blind randomized clinical trial controlled by placebo with a FOS enriched cookie on satiety and cardiovascular risk factors in obese patients. Nutr Hosp. 28, 78-85, doi:10. 3305/nh. 2013. 28. 1. 6255 (2013).
    • (2013) Nutr Hosp. , vol.28 , pp. 78-85
    • De Luis, D.A.1
  • 30
    • 66849129539 scopus 로고    scopus 로고
    • Weight loss during oligofructose supplementation is associated with decreased ghrelin and increased peptide YY in overweight and obese adults
    • Parnell, J. A. & Reimer, R. A. Weight loss during oligofructose supplementation is associated with decreased ghrelin and increased peptide YY in overweight and obese adults. Am J Clin Nutr. 89, 1751-1759, doi:10. 3945/ajcn. 2009. 27465 (2009).
    • (2009) Am J Clin Nutr. , vol.89 , pp. 1751-1759
    • Parnell, J.A.1    Reimer, R.A.2
  • 31
    • 63549115890 scopus 로고    scopus 로고
    • Yacon syrup: Beneficial effects on obesity and insulin resistance in humans
    • Genta, S. et al. Yacon syrup: beneficial effects on obesity and insulin resistance in humans. Clin Nutr. 28, 182-187, doi:10. 1016/j. clnu. 2009. 01. 013 (2009).
    • (2009) Clin Nutr. , vol.28 , pp. 182-187
    • Genta, S.1
  • 32
    • 0032940447 scopus 로고    scopus 로고
    • Effect of nondigestible oligosaccharides on large-bowel functions, blood lipid concentrations and glucose absorption in young healthy male subjects
    • van Dokkum, W., Wezendonk, B., Srikumar, T. S. & van den Heuvel, E. G. Effect of nondigestible oligosaccharides on large-bowel functions, blood lipid concentrations and glucose absorption in young healthy male subjects. Eur J Clin Nutr. 53, 1-7 (1999).
    • (1999) Eur J Clin Nutr. , vol.53 , pp. 1-7
    • Van Dokkum, W.1    Wezendonk, B.2    Srikumar, T.S.3    Van Den Heuvel, E.G.4
  • 33
    • 33845901507 scopus 로고    scopus 로고
    • Microbial ecology: Human gut microbes associated with obesity
    • Ley, R. E., Turnbaugh, P. J., Klein, S. & Gordon, J. I. Microbial ecology: human gut microbes associated with obesity. Nature. 444, 1022-1023, doi:10. 1038/4441022a (2006).
    • (2006) Nature. , vol.444 , pp. 1022-1023
    • Ley, R.E.1    Turnbaugh, P.J.2    Klein, S.3    Gordon, J.I.4
  • 34
    • 77949393654 scopus 로고    scopus 로고
    • Gut microbiota in human adults with type 2 diabetes differs from non-diabetic adults
    • Larsen, N. et al. Gut microbiota in human adults with type 2 diabetes differs from non-diabetic adults. PLoS One. 5, e9085, doi:10. 1371/journal. pone. 0009085 (2010).
    • (2010) PLoS One. , vol.5 , pp. e9085
    • Larsen, N.1
  • 35
    • 85006192445 scopus 로고    scopus 로고
    • Dysbiosis of gut microbiota with reduced trimethylamine-n-oxide level in patients with large-artery atherosclerotic stroke or transient ischemic attack
    • Yin, J. et al. Dysbiosis of Gut Microbiota With Reduced Trimethylamine-N-Oxide Level in Patients With Large-Artery Atherosclerotic Stroke or Transient Ischemic Attack. J Am Heart Assoc. 4, e002699, doi:10. 1161/JAHA. 115. 002699 (2015).
    • (2015) J Am Heart Assoc. , vol.4 , pp. e002699
    • Yin, J.1
  • 36
    • 70449536475 scopus 로고    scopus 로고
    • The bifidogenic effect of inulin and oligofructose and its consequences for gut health
    • Meyer, D. & Stasse-Wolthuis, M. The bifidogenic effect of inulin and oligofructose and its consequences for gut health. Eur J Clin Nutr. 63, 1277-1289, doi:10. 1038/ejcn. 2009. 64 (2009).
    • (2009) Eur J Clin Nutr. , vol.63 , pp. 1277-1289
    • Meyer, D.1    Stasse-Wolthuis, M.2
  • 37
    • 56349145249 scopus 로고    scopus 로고
    • Gum Arabic establishes prebiotic functionality in healthy human volunteers in a dose-dependent manner
    • Calame, W., Weseler, A. R., Viebke, C., Flynn, C. & Siemensma, A. D. Gum arabic establishes prebiotic functionality in healthy human volunteers in a dose-dependent manner. Br J Nutr. 100, 1269-1275, doi:10. 1017/S0007114508981447 (2008).
    • (2008) Br J Nutr. , vol.100 , pp. 1269-1275
    • Calame, W.1    Weseler, A.R.2    Viebke, C.3    Flynn, C.4    Siemensma, A.D.5
  • 38
    • 34948828520 scopus 로고    scopus 로고
    • A double-blind placebo-controlled study to establish the bifidogenic dose of inulin in healthy humans
    • Kolida, S., Meyer, D. & Gibson, G. R. A double-blind placebo-controlled study to establish the bifidogenic dose of inulin in healthy humans. Eur J Clin Nutr. 61, 1189-1195, doi:10. 1038/sj. ejcn. 1602636 (2007).
    • (2007) Eur J Clin Nutr , vol.61 , pp. 1189-1195
    • Kolida, S.1    Meyer, D.2    Gibson, G.R.3
  • 39
    • 77649119543 scopus 로고    scopus 로고
    • Diversity of human colonic butyrate-producing bacteria revealed by analysis of the butyryl-CoA:acetate CoA-transferase gene
    • Louis, P., Young, P., Holtrop, G. & Flint, H. J. Diversity of human colonic butyrate-producing bacteria revealed by analysis of the butyryl-CoA:acetate CoA-transferase gene. Environ Microbiol. 12, 304-314, doi:10. 1111/j. 1462-2920. 2009. 02066. x (2010).
    • (2010) Environ Microbiol. , vol.12 , pp. 304-314
    • Louis, P.1    Young, P.2    Holtrop, G.3    Flint, H.J.4
  • 40
    • 63849241608 scopus 로고    scopus 로고
    • Diversity, metabolism and microbial ecology of butyrate-producing bacteria from the human large intestine
    • Louis, P. & Flint, H. J. Diversity, metabolism and microbial ecology of butyrate-producing bacteria from the human large intestine. Fems Microbiol Lett. 294, 1-8, doi:10. 1111/j. 1574-6968. 2009. 01514. x (2009).
    • (2009) Fems Microbiol Lett. , vol.294 , pp. 1-8
    • Louis, P.1    Flint, H.J.2
  • 42
    • 84866738529 scopus 로고    scopus 로고
    • Transfer of intestinal microbiota from lean donors increases insulin sensitivity in individuals with metabolic syndrome
    • Vrieze, A. et al. Transfer of intestinal microbiota from lean donors increases insulin sensitivity in individuals with metabolic syndrome. Gastroenterology. 143, 913-916, doi:10. 1053/j. gastro. 2012. 06. 031 (2012).
    • (2012) Gastroenterology. , vol.143 , pp. 913-916
    • Vrieze, A.1
  • 43
    • 78650037263 scopus 로고    scopus 로고
    • Differential adaptation of human gut microbiota to bariatric surgery-induced weight loss: Links with metabolic and low-grade inflammation markers
    • Furet, J. P. et al. Differential adaptation of human gut microbiota to bariatric surgery-induced weight loss: links with metabolic and low-grade inflammation markers. Diabetes. 59, 3049-3057, doi:10. 2337/db10-0253 (2010).
    • (2010) Diabetes. , vol.59 , pp. 3049-3057
    • Furet, J.P.1
  • 44
    • 84889102325 scopus 로고    scopus 로고
    • Comparison of direct boiling method with commercial kits for extracting fecal microbiome DNA by Illumina sequencing of 16S rRNA tags
    • Peng, X. et al. Comparison of direct boiling method with commercial kits for extracting fecal microbiome DNA by Illumina sequencing of 16S rRNA tags. J Microbiol Methods. 95, 455-462, doi:10. 1016/j. mimet. 2013. 07. 015 (2013).
    • (2013) J Microbiol Methods. , vol.95 , pp. 455-462
    • Peng, X.1
  • 45
    • 79953026036 scopus 로고    scopus 로고
    • BIPES, a cost-effective high-throughput method for assessing microbial diversity
    • Zhou, H. W. et al. BIPES, a cost-effective high-throughput method for assessing microbial diversity. ISME J. 5, 741-749, doi:10. 1038/ ismej. 2010. 160 (2011).
    • (2011) ISME J. , vol.5 , pp. 741-749
    • Zhou, H.W.1
  • 46
    • 77952243141 scopus 로고    scopus 로고
    • QIIME allows analysis of high-throughput community sequencing data
    • Caporaso, J. G. et al. QIIME allows analysis of high-throughput community sequencing data. Nat Methods. 7, 335-336, doi:10. 1038/ nmeth. f. 303 (2010).
    • (2010) Nat Methods. , vol.7 , pp. 335-336
    • Caporaso, J.G.1
  • 47
    • 77957244650 scopus 로고    scopus 로고
    • Search and clustering orders of magnitude faster than BLAST
    • Edgar, R. C. Search and clustering orders of magnitude faster than BLAST. Bioinformatics. 26, 2460-2461, doi:10. 1093/ bioinformatics/btq461 (2010).
    • (2010) Bioinformatics. , vol.26 , pp. 2460-2461
    • Edgar, R.C.1
  • 48
    • 75249107844 scopus 로고    scopus 로고
    • PyNAST: A flexible tool for aligning sequences to a template alignment
    • Caporaso, J. G. et al. PyNAST: A flexible tool for aligning sequences to a template alignment. Bioinformatics. 26, 266-267, doi:10. 1093/bioinformatics/btp636 (2010).
    • (2010) Bioinformatics. , vol.26 , pp. 266-267
    • Caporaso, J.G.1
  • 49
    • 67649327176 scopus 로고    scopus 로고
    • FastTree: Computing large minimum evolution trees with profiles instead of a distance matrix
    • Price, M. N., Dehal, P. S. & Arkin, A. P. FastTree: computing large minimum evolution trees with profiles instead of a distance matrix. Mol Biol Evol 26, 1641-1650, doi:10. 1093/molbev/msp077 (2009).
    • (2009) Mol Biol Evol , vol.26 , pp. 1641-1650
    • Price, M.N.1    Dehal, P.S.2    Arkin, A.P.3
  • 50
    • 84868270724 scopus 로고    scopus 로고
    • The Biological Observation Matrix (BIOM) format or: How i learned to stop worrying and love the ome-ome
    • McDonald, D. et al. The Biological Observation Matrix (BIOM) format or: how I learned to stop worrying and love the ome-ome. Gigascience. 1, 7, doi:10. 1186/2047-217X-1-7 (2012).
    • (2012) Gigascience. , vol.1 , pp. 7
    • McDonald, D.1
  • 51
    • 79959383523 scopus 로고    scopus 로고
    • Metagenomic biomarker discovery and explanation
    • Segata, N. et al. Metagenomic biomarker discovery and explanation. Genome Biol. 12, R60, doi:10. 1186/gb-2011-12-6-r60 (2011).
    • (2011) Genome Biol. , vol.12 , pp. R60
    • Segata, N.1
  • 52
    • 84874826205 scopus 로고    scopus 로고
    • The use of the R language for medicinal chemistry applications
    • Mente, S. & Kuhn, M. The use of the R language for medicinal chemistry applications. Curr Top Med Chem. 12, 1957-1964, doi:10. 2174/1568026611212180003 (2012).
    • (2012) Curr Top Med Chem. , vol.12 , pp. 1957-1964
    • Mente, S.1    Kuhn, M.2
  • 53
    • 0345548657 scopus 로고    scopus 로고
    • Random forest: A classification and regression tool for compound classification and QSAR modeling
    • Svetnik, V. et al. Random forest: A classification and regression tool for compound classification and QSAR modeling. J Chem Inf Comput Sci. 43, 1947-1958, doi:10. 1021/ci034160g (2003).
    • (2003) J Chem Inf Comput Sci. , vol.43 , pp. 1947-1958
    • Svetnik, V.1


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