Coupled Single-Cell CRISPR Screening and Epigenomic Profiling Reveals Causal Gene Regulatory Networks

Cell

Volumn 176, Issue 1-2, 2019, Pages 361-376.e17

  Rubin, Adam J ^a   Parker, Kevin R ^a   Satpathy, Ansuman T ^a   Qi, Yanyan ^a   Wu, Beijing ^a   Ong, Alvin J ^a   Mumbach, Maxwell R ^a   Ji, Andrew L ^a   Kim, Daniel S ^a   Cho, Seung Woo ^a   Zarnegar, Brian J ^a   Greenleaf, William J ^a,b,c   Chang, Howard Y ^a   Khavari, Paul A ^a,d  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b STANFORD UNIVERSITY   (United States)

^c CHAN ZUCKERBERG BIOHUB   (United States)

^d VA PALO ALTO HEALTH CARE SYSTEM   (United States)

Author keywords

ATAC seq; chromatin accessibility; CRISPR; epigenomics; pooled screens; single cell genomics

Indexed keywords

TRANSCRIPTION FACTOR; UNTRANSLATED RNA;

ARTICLE; B LYMPHOCYTE; CELL DIFFERENTIATION; CELL FATE; CHROMATIN; CLUSTERED REGULARLY INTERSPACED SHORT PALINDROMIC REPEAT; CONTROLLED STUDY; EPIDERMIS CELL; EPIGENETICS; EPISTASIS; GENE REGULATORY NETWORK; GENOTYPE PHENOTYPE CORRELATION; HUMAN; HUMAN CELL; KERATINOCYTE; NUCLEOSOME; PRIORITY JOURNAL; SINGLE CELL ANALYSIS; CHROMATIN ASSEMBLY AND DISASSEMBLY; DNA SEQUENCE; GENETICS; HIGH THROUGHPUT SEQUENCING; METABOLISM; PHYSIOLOGY; PROCEDURES;

CHROMATIN; CHROMATIN ASSEMBLY AND DISASSEMBLY; CLUSTERED REGULARLY INTERSPACED SHORT PALINDROMIC REPEATS; EPIGENOMICS; GENE REGULATORY NETWORKS; HIGH-THROUGHPUT NUCLEOTIDE SEQUENCING; HUMANS; SEQUENCE ANALYSIS, DNA; SINGLE-CELL ANALYSIS; TRANSCRIPTION FACTORS;

EID: 85059878068     PISSN: 00928674     EISSN: 10974172     Source Type: Journal    
DOI: 10.1016/j.cell.2018.11.022     Document Type: Article

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