Promoter of lncRNA Gene PVT1 Is a Tumor-Suppressor DNA Boundary Element

Cell

Volumn 173, Issue 6, 2018, Pages 1398-1412.e22

  Cho, Seung Woo ^a   Xu, Jin ^a   Sun, Ruping ^b,c   Mumbach, Maxwell R ^a   Carter, Ava C ^a   Chen, Y Grace ^a   Yost, Kathryn E ^a   Kim, Jeewon ^c   He, Jing ^a   Nevins, Stephanie A ^a   Chin, Suet Feung ^d   Caldas, Carlos ^d,e   Liu, S John ^f,g   Horlbeck, Max A ^f,g,h   Lim, Daniel A ^f,g,i   Weissman, Jonathan S ^f,g,h   Curtis, Christina ^b,c   Chang, Howard Y ^a  

^a STANFORD UNIVERSITY   (United States)

^b STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c STANFORD CANCER INSTITUTE   (United States)

^d UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^e CAMBRIDGE UNIVERSITY HOSPITALS NHS FOUNDATION TRUST   (United Kingdom)

^f UNIVERSITY OF CALIFORNIA   (United States)

^g UNIVERSITY OF CALIFORNIA   (United States)

^h UNIVERSITY OF CALIFORNIA   (United States)

ⁱ SAN FRANCISCO VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

CRISPRi; enhancer; lncRNA; MYC; promoter; PVT1; topological domains; transcriptional regulation; tumor suppressor

Indexed keywords

LONG UNTRANSLATED RNA; DNA; PVT1 LONG-NON-CODING RNA, HUMAN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER GROWTH; CANCER INHIBITION; CHROMOSOME; CLUSTERED REGULARLY INTERSPACED SHORT PALINDROMIC REPEAT; CONTROLLED STUDY; DNA BOUNDARY ELEMENT; DNA STRUCTURE; EMBRYO; ENHANCER REGION; FEMALE; GENE EDITING; GENE EXPRESSION; GENE FREQUENCY; GENE FUNCTION; GENE INSERTION; GENE INTERACTION; GENE LOCUS; GENETIC TRANSCRIPTION; HCT 116 CELL LINE; HEK293 CELL LINE; HELA CELL LINE; HUMAN; HUMAN CELL; IN VIVO STUDY; MCF-7 CELL LINE; MCF10CA1A CELL LINE; MDA-MB-231 CELL LINE; MOUSE; MOUSE EMBRYONIC STEM CELL; NEURAL STEM CELL; NOD SCID MOUSE; NONHUMAN; ONCOGENE MYC; PRIORITY JOURNAL; PROMOTER REGION; PVT1 GENE; RNA GENE; SK-BR-3 CELL LINE; TRANSCRIPTION REGULATION; TUMOR PROMOTION; TUMOR SUPPRESSOR GENE; WHOLE GENOME SEQUENCING; ANIMAL; BREAST TUMOR; CANCER TRANSPLANTATION; CARCINOGENESIS; CELL PROLIFERATION; CELL TRANSFORMATION; CHROMATIN; CRISPR CAS SYSTEM; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; MUTATION; NONOBESE DIABETIC MOUSE; TUMOR CELL LINE;

ANIMALS; BREAST NEOPLASMS; CARCINOGENESIS; CELL LINE, TUMOR; CELL PROLIFERATION; CELL TRANSFORMATION, NEOPLASTIC; CHROMATIN; CRISPR-CAS SYSTEMS; DNA, NEOPLASM; ENHANCER ELEMENTS, GENETIC; FEMALE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, NEOPLASTIC; GENES, MYC; HUMANS; MICE; MICE, INBRED NOD; MUTATION; NEOPLASM TRANSPLANTATION; PROMOTER REGIONS, GENETIC; RNA, LONG NONCODING; TRANSCRIPTION, GENETIC;

EID: 85046132762     PISSN: 00928674     EISSN: 10974172     Source Type: Journal    
DOI: 10.1016/j.cell.2018.03.068     Document Type: Article

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