-
1
-
-
84994235308
-
Type 1 diabetes prevention: a goal dependent on accepting a diagnosis of an asymptomatic disease
-
Ziegler, AG, Bonifacio, E, Powers, AC, Todd, JA, Harrison, LC, Atkinson, MA, Type 1 diabetes prevention: a goal dependent on accepting a diagnosis of an asymptomatic disease. Diabetes 65 (2016), 3233–3239.
-
(2016)
Diabetes
, vol.65
, pp. 3233-3239
-
-
Ziegler, A.G.1
Bonifacio, E.2
Powers, A.C.3
Todd, J.A.4
Harrison, L.C.5
Atkinson, M.A.6
-
2
-
-
0023601936
-
Effects of cyclosporine in recent-onset juvenile type 1 diabetes: impact of age and duration of disease
-
Stiller, CR, Dupre, J, Gent, M, et al. Effects of cyclosporine in recent-onset juvenile type 1 diabetes: impact of age and duration of disease. J Pediatr 111 (1987), 1069–1072.
-
(1987)
J Pediatr
, vol.111
, pp. 1069-1072
-
-
Stiller, C.R.1
Dupre, J.2
Gent, M.3
-
3
-
-
0025105268
-
Cyclosporine A for the treatment of new-onset insulin-dependent diabetes mellitus
-
Chase, HP, Butler-Simon, N, Garg, SK, et al. Cyclosporine A for the treatment of new-onset insulin-dependent diabetes mellitus. Pediatrics 85 (1990), 241–245.
-
(1990)
Pediatrics
, vol.85
, pp. 241-245
-
-
Chase, H.P.1
Butler-Simon, N.2
Garg, S.K.3
-
4
-
-
0024813410
-
Double-blind controlled trial of azathioprine in children with newly diagnosed type I diabetes
-
Cook, JJ, Hudson, I, Harrison, LC, et al. Double-blind controlled trial of azathioprine in children with newly diagnosed type I diabetes. Diabetes 38 (1989), 779–783.
-
(1989)
Diabetes
, vol.38
, pp. 779-783
-
-
Cook, J.J.1
Hudson, I.2
Harrison, L.C.3
-
5
-
-
77955653658
-
Cyclosporin and methotrexate therapy induces remission in type 1 diabetes mellitus
-
Sobel, DO, Henzke, A, Abbassi, V, Cyclosporin and methotrexate therapy induces remission in type 1 diabetes mellitus. Acta Diabetol 47 (2010), 243–250.
-
(2010)
Acta Diabetol
, vol.47
, pp. 243-250
-
-
Sobel, D.O.1
Henzke, A.2
Abbassi, V.3
-
6
-
-
85058921914
-
Antigen-based immune modulation therapy for type 1 diabetes: the era of precision medicine
-
published online Oct 24.
-
Roep, BO, Wheeler, DCS, Peakman, M, Antigen-based immune modulation therapy for type 1 diabetes: the era of precision medicine. Lancet Diabetes Endocrinol, 2018 published online Oct 24. http://dx.doi.org/10.1016/S2213-8587(18)30109-8.
-
(2018)
Lancet Diabetes Endocrinol
-
-
Roep, B.O.1
Wheeler, D.C.S.2
Peakman, M.3
-
7
-
-
0037198420
-
Anti-CD3 monoclonal antibody in new-onset type 1 diabetes
-
Herold, KC, Hagopian, W, Auger, JA, et al. Anti-CD3 monoclonal antibody in new-onset type 1 diabetes. N Engl J Med 346 (2002), 1692–1698.
-
(2002)
N Engl J Med
, vol.346
, pp. 1692-1698
-
-
Herold, K.C.1
Hagopian, W.2
Auger, J.A.3
-
8
-
-
20544443927
-
Insulin needs after CD3-antibody therapy in new-onset type 1 diabetes
-
Keymeulen, B, Vandemeulebroucke, E, Ziegler, AG, et al. Insulin needs after CD3-antibody therapy in new-onset type 1 diabetes. N Engl J Med 352 (2005), 2598–2608.
-
(2005)
N Engl J Med
, vol.352
, pp. 2598-2608
-
-
Keymeulen, B.1
Vandemeulebroucke, E.2
Ziegler, A.G.3
-
9
-
-
70449480577
-
Rituximab, B-lymphocyte depletion, and preservation of beta-cell function
-
Pescovitz, MD, Greenbaum, CJ, Krause-Steinrauf, H, et al. Rituximab, B-lymphocyte depletion, and preservation of beta-cell function. N Engl J Med 361 (2009), 2143–2152.
-
(2009)
N Engl J Med
, vol.361
, pp. 2143-2152
-
-
Pescovitz, M.D.1
Greenbaum, C.J.2
Krause-Steinrauf, H.3
-
10
-
-
84939218518
-
Alefacept provides sustained clinical and immunological effects in new-onset type 1 diabetes patients
-
Rigby, MR, Harris, KM, Pinckney, A, et al. Alefacept provides sustained clinical and immunological effects in new-onset type 1 diabetes patients. J Clin Invest 125 (2015), 3285–3296.
-
(2015)
J Clin Invest
, vol.125
, pp. 3285-3296
-
-
Rigby, M.R.1
Harris, K.M.2
Pinckney, A.3
-
11
-
-
84907487451
-
Reduction in CD4 central memory T-cell subset in costimulation modulator abatacept-treated patients with recent-onset type 1 diabetes is associated with slower C-peptide decline
-
Orban, T, Beam, CA, Xu, P, et al. Reduction in CD4 central memory T-cell subset in costimulation modulator abatacept-treated patients with recent-onset type 1 diabetes is associated with slower C-peptide decline. Diabetes 63 (2014), 3449–3457.
-
(2014)
Diabetes
, vol.63
, pp. 3449-3457
-
-
Orban, T.1
Beam, C.A.2
Xu, P.3
-
12
-
-
84962673275
-
Antithymocyte globulin therapy for patients with recent-onset type 1 diabetes: 2 year results of a randomised trial
-
Gitelman, SE, Gottlieb, PA, Felner, EI, et al. Antithymocyte globulin therapy for patients with recent-onset type 1 diabetes: 2 year results of a randomised trial. Diabetologia 59 (2016), 1153–1161.
-
(2016)
Diabetologia
, vol.59
, pp. 1153-1161
-
-
Gitelman, S.E.1
Gottlieb, P.A.2
Felner, E.I.3
-
13
-
-
77950636402
-
Failure to preserve β-cell function with mycophenolate mofetil and daclizumab combined therapy in patients with new-onset type 1 diabetes
-
Gottlieb, PA, Quinlan, S, Krause-Steinrauf, H, et al. Failure to preserve β-cell function with mycophenolate mofetil and daclizumab combined therapy in patients with new-onset type 1 diabetes. Diabetes Care 33 (2010), 826–832.
-
(2010)
Diabetes Care
, vol.33
, pp. 826-832
-
-
Gottlieb, P.A.1
Quinlan, S.2
Krause-Steinrauf, H.3
-
14
-
-
84865478468
-
Rapamycin/IL-2 combination therapy in patients with type 1 diabetes augments Tregs yet transiently impairs β-cell function
-
Long, SA, Rieck, M, Sanda, S, et al. Rapamycin/IL-2 combination therapy in patients with type 1 diabetes augments Tregs yet transiently impairs β-cell function. Diabetes 61 (2012), 2340–2348.
-
(2012)
Diabetes
, vol.61
, pp. 2340-2348
-
-
Long, S.A.1
Rieck, M.2
Sanda, S.3
-
15
-
-
84887625676
-
Low-dose interleukin 2 in patients with type 1 diabetes: a phase 1/2 randomised, double-blind, placebo-controlled trial
-
Hartemann, A, Bensimon, G, Payan, CA, et al. Low-dose interleukin 2 in patients with type 1 diabetes: a phase 1/2 randomised, double-blind, placebo-controlled trial. Lancet Diabetes Endocrinol 1 (2013), 295–305.
-
(2013)
Lancet Diabetes Endocrinol
, vol.1
, pp. 295-305
-
-
Hartemann, A.1
Bensimon, G.2
Payan, C.A.3
-
16
-
-
84928589620
-
Low-dose interleukin-2 fosters a dose-dependent regulatory T cell tuned milieu in T1D patients
-
Rosenzwajg, M, Churlaud, G, Mallone, R, et al. Low-dose interleukin-2 fosters a dose-dependent regulatory T cell tuned milieu in T1D patients. J Autoimmun 58 (2015), 48–58.
-
(2015)
J Autoimmun
, vol.58
, pp. 48-58
-
-
Rosenzwajg, M.1
Churlaud, G.2
Mallone, R.3
-
17
-
-
84928586624
-
Selective IL-2 responsiveness of regulatory T cells through multiple intrinsic mechanisms supports the use of low-dose IL-2 therapy in type 1 diabetes
-
Yu, A, Snowhite, I, Vendrame, F, et al. Selective IL-2 responsiveness of regulatory T cells through multiple intrinsic mechanisms supports the use of low-dose IL-2 therapy in type 1 diabetes. Diabetes 64 (2015), 2172–2183.
-
(2015)
Diabetes
, vol.64
, pp. 2172-2183
-
-
Yu, A.1
Snowhite, I.2
Vendrame, F.3
-
18
-
-
84960414830
-
Protocol of the adaptive study of IL-2 dose frequency on regulatory T cells in type 1 diabetes (DILfrequency): a mechanistic, non-randomised, repeat dose, open-label, response-adaptive study
-
Truman, LA, Pekalski, ML, Kareclas, P, et al. Protocol of the adaptive study of IL-2 dose frequency on regulatory T cells in type 1 diabetes (DILfrequency): a mechanistic, non-randomised, repeat dose, open-label, response-adaptive study. BMJ Open, 5, 2015, e009799.
-
(2015)
BMJ Open
, vol.5
, pp. e009799
-
-
Truman, L.A.1
Pekalski, M.L.2
Kareclas, P.3
-
19
-
-
84994226769
-
Regulatory T cell responses in participants with type 1 diabetes after a single dose of interleukin-2: a non-randomised, open label, adaptive dose-finding trial
-
Todd, JA, Evangelou, M, Cutler, AJ, et al. Regulatory T cell responses in participants with type 1 diabetes after a single dose of interleukin-2: a non-randomised, open label, adaptive dose-finding trial. PLoS Med, 13, 2016, e1002139.
-
(2016)
PLoS Med
, vol.13
, pp. e1002139
-
-
Todd, J.A.1
Evangelou, M.2
Cutler, A.J.3
-
20
-
-
85062702714
-
Partial exhaustion of CD8 T cells and clinical response to teplizumab in new-onset type 1 diabetes
-
Long, SA, Thorpe, J, DeBerg, HA, et al. Partial exhaustion of CD8 T cells and clinical response to teplizumab in new-onset type 1 diabetes. Sci Immunol, 1, 2016, eaai7793.
-
(2016)
Sci Immunol
, vol.1
, pp. eaai7793
-
-
Long, S.A.1
Thorpe, J.2
DeBerg, H.A.3
-
21
-
-
84962430639
-
Staging presymptomatic type 1 diabetes: a scientific statement of JDRF, the Endocrine Society, and the American Diabetes Association
-
Insel, RA, Dunne, JL, Atkinson, MA, et al. Staging presymptomatic type 1 diabetes: a scientific statement of JDRF, the Endocrine Society, and the American Diabetes Association. Diabetes Care 38 (2015), 1964–1974.
-
(2015)
Diabetes Care
, vol.38
, pp. 1964-1974
-
-
Insel, R.A.1
Dunne, J.L.2
Atkinson, M.A.3
-
22
-
-
85041590399
-
Safety of biologic agents for psoriasis in patients with viral hepatitis
-
published online Feb 1.
-
AlMutairi, N, Abouzaid, HA, Safety of biologic agents for psoriasis in patients with viral hepatitis. J Dermatolog Treat, 2018 published online Feb 1. DOI:10.1080/09546634.2018.1430301.
-
(2018)
J Dermatolog Treat
-
-
AlMutairi, N.1
Abouzaid, H.A.2
-
23
-
-
85040669431
-
Biosimilarity and interchangeability: principles and evidence: a systematic review
-
McKinnon, RA, Cook, M, Liauw, W, et al. Biosimilarity and interchangeability: principles and evidence: a systematic review. BioDrugs 32 (2018), 27–52.
-
(2018)
BioDrugs
, vol.32
, pp. 27-52
-
-
McKinnon, R.A.1
Cook, M.2
Liauw, W.3
-
24
-
-
85039943711
-
A regulatory perspective on testing of biological activity of complex biologics
-
Saldanha, M, Dandekar, P, Jain, R, A regulatory perspective on testing of biological activity of complex biologics. Trends Biotechnol 36 (2018), 231–234.
-
(2018)
Trends Biotechnol
, vol.36
, pp. 231-234
-
-
Saldanha, M.1
Dandekar, P.2
Jain, R.3
-
25
-
-
85033498305
-
Adverse reactions to biologics in psoriasis
-
Lockwood, SJ, Prens, LM, Kimball, AB, Adverse reactions to biologics in psoriasis. Curr Probl Dermatol 53 (2018), 1–14.
-
(2018)
Curr Probl Dermatol
, vol.53
, pp. 1-14
-
-
Lockwood, S.J.1
Prens, L.M.2
Kimball, A.B.3
-
26
-
-
84856825977
-
Demonstration of islet-autoreactive CD8 T cells in insulitic lesions from recent onset and long-term type 1 diabetes patients
-
Coppieters, KT, Dotta, F, Amirian, N, et al. Demonstration of islet-autoreactive CD8 T cells in insulitic lesions from recent onset and long-term type 1 diabetes patients. J Exp Med 209 (2012), 51–60.
-
(2012)
J Exp Med
, vol.209
, pp. 51-60
-
-
Coppieters, K.T.1
Dotta, F.2
Amirian, N.3
-
27
-
-
84964661224
-
Differential insulitic profiles determine the extent of β-cell destruction and the age at onset of type 1 diabetes
-
Leete, P, Willcox, A, Krogvold, L, et al. Differential insulitic profiles determine the extent of β-cell destruction and the age at onset of type 1 diabetes. Diabetes 65 (2016), 1362–1369.
-
(2016)
Diabetes
, vol.65
, pp. 1362-1369
-
-
Leete, P.1
Willcox, A.2
Krogvold, L.3
-
28
-
-
84990208383
-
Histology of type 1 diabetes pancreas
-
Willcox, A, Gillespie, KM, Histology of type 1 diabetes pancreas. Methods Mol Biol 1433 (2016), 105–117.
-
(2016)
Methods Mol Biol
, vol.1433
, pp. 105-117
-
-
Willcox, A.1
Gillespie, K.M.2
-
29
-
-
77955559432
-
Evidence of increased islet cell proliferation in patients with recent-onset type 1 diabetes
-
Willcox, A, Richardson, SJ, Bone, AJ, Foulis, AK, Morgan, NG, Evidence of increased islet cell proliferation in patients with recent-onset type 1 diabetes. Diabetologia 53 (2010), 2020–2028.
-
(2010)
Diabetologia
, vol.53
, pp. 2020-2028
-
-
Willcox, A.1
Richardson, S.J.2
Bone, A.J.3
Foulis, A.K.4
Morgan, N.G.5
-
30
-
-
58149299735
-
Analysis of islet inflammation in human type 1 diabetes
-
Willcox, A, Richardson, SJ, Bone, AJ, Foulis, AK, Morgan, NG, Analysis of islet inflammation in human type 1 diabetes. Clin Exp Immunol 155 (2009), 173–181.
-
(2009)
Clin Exp Immunol
, vol.155
, pp. 173-181
-
-
Willcox, A.1
Richardson, S.J.2
Bone, A.J.3
Foulis, A.K.4
Morgan, N.G.5
-
31
-
-
0033001488
-
The NOD mouse model of type 1 diabetes: as good as it gets?
-
Atkinson, MA, Leiter, EH, The NOD mouse model of type 1 diabetes: as good as it gets?. Nat Med 5 (1999), 601–614.
-
(1999)
Nat Med
, vol.5
, pp. 601-614
-
-
Atkinson, M.A.1
Leiter, E.H.2
-
32
-
-
10244255039
-
Satisfaction (not) guaranteed: re-evaluating the use of animal models of type 1 diabetes
-
Roep, BO, Atkinson, M, von Herrath, M, Satisfaction (not) guaranteed: re-evaluating the use of animal models of type 1 diabetes. Nat Rev Immunol 4 (2004), 989–997.
-
(2004)
Nat Rev Immunol
, vol.4
, pp. 989-997
-
-
Roep, B.O.1
Atkinson, M.2
von Herrath, M.3
-
33
-
-
80051837898
-
Evaluating preclinical efficacy
-
Atkinson, MA, Evaluating preclinical efficacy. Sci Transl Med, 3, 2011, 96cm22.
-
(2011)
Sci Transl Med
, vol.3
, pp. 96cm22
-
-
Atkinson, M.A.1
-
34
-
-
84873666112
-
Transient B-cell depletion with anti-CD20 in combination with proinsulin DNA vaccine or oral insulin: immunologic effects and efficacy in NOD mice
-
Sarikonda, G, Sachithanantham, S, Manenkova, Y, et al. Transient B-cell depletion with anti-CD20 in combination with proinsulin DNA vaccine or oral insulin: immunologic effects and efficacy in NOD mice. PLoS One, 8, 2013, e54712.
-
(2013)
PLoS One
, vol.8
, pp. e54712
-
-
Sarikonda, G.1
Sachithanantham, S.2
Manenkova, Y.3
-
35
-
-
84964681152
-
A preclinical consortium approach for assessing the efficacy of combined anti-CD3 plus IL-1 blockade in reversing new-onset autoimmune diabetes in NOD mice
-
Gill, RG, Pagni, PP, Kupfer, T, et al. A preclinical consortium approach for assessing the efficacy of combined anti-CD3 plus IL-1 blockade in reversing new-onset autoimmune diabetes in NOD mice. Diabetes 65 (2016), 1310–1316.
-
(2016)
Diabetes
, vol.65
, pp. 1310-1316
-
-
Gill, R.G.1
Pagni, P.P.2
Kupfer, T.3
-
36
-
-
0027958044
-
Anti-CD3 antibody induces long-term remission of overt autoimmunity in nonobese diabetic mice
-
Chatenoud, L, Thervet, E, Primo, J, Bach, JF, Anti-CD3 antibody induces long-term remission of overt autoimmunity in nonobese diabetic mice. Proc Natl Acad Sci USA 91 (1994), 123–127.
-
(1994)
Proc Natl Acad Sci USA
, vol.91
, pp. 123-127
-
-
Chatenoud, L.1
Thervet, E.2
Primo, J.3
Bach, J.F.4
-
37
-
-
0031569177
-
CD3 antibody-induced dominant self tolerance in overtly diabetic NOD mice
-
Chatenoud, L, Primo, J, Bach, JF, CD3 antibody-induced dominant self tolerance in overtly diabetic NOD mice. J Immunol 158 (1997), 2947–2954.
-
(1997)
J Immunol
, vol.158
, pp. 2947-2954
-
-
Chatenoud, L.1
Primo, J.2
Bach, J.F.3
-
38
-
-
80855124117
-
Preservation of recall immunity in anti-CD3-treated recent onset type 1 diabetes patients
-
Alkemade, GM, Hilbrands, R, Vandemeulebroucke, E, et al. Preservation of recall immunity in anti-CD3-treated recent onset type 1 diabetes patients. Diabetes Metab Res Rev 27 (2011), 925–927.
-
(2011)
Diabetes Metab Res Rev
, vol.27
, pp. 925-927
-
-
Alkemade, G.M.1
Hilbrands, R.2
Vandemeulebroucke, E.3
-
39
-
-
84937763351
-
Animal models of rheumatoid arthritis: how informative are they?
-
McNamee, K, Williams, R, Seed, M, Animal models of rheumatoid arthritis: how informative are they?. Eur J Pharmacol 759 (2015), 278–286.
-
(2015)
Eur J Pharmacol
, vol.759
, pp. 278-286
-
-
McNamee, K.1
Williams, R.2
Seed, M.3
-
40
-
-
85032211977
-
Isogenic cellular systems model the impact of genetic risk variants in the pathogenesis of type 1 diabetes
-
Wallet, MA, Santostefano, KE, Terada, N, Brusko, TM, Isogenic cellular systems model the impact of genetic risk variants in the pathogenesis of type 1 diabetes. Front Endocrinol (Lausanne), 8, 2017, 276.
-
(2017)
Front Endocrinol (Lausanne)
, vol.8
, pp. 276
-
-
Wallet, M.A.1
Santostefano, K.E.2
Terada, N.3
Brusko, T.M.4
-
41
-
-
85030766826
-
Type 1 diabetes induction in humanized mice
-
Tan, S, Li, Y, Xia, J, et al. Type 1 diabetes induction in humanized mice. Proc Natl Acad Sci USA 114 (2017), 10954–10959.
-
(2017)
Proc Natl Acad Sci USA
, vol.114
, pp. 10954-10959
-
-
Tan, S.1
Li, Y.2
Xia, J.3
-
42
-
-
85018466835
-
Incidence trends of type 1 and type 2 diabetes among youths, 2002–2012
-
Mayer-Davis, EJ, Lawrence, JM, Dabelea, D, et al. Incidence trends of type 1 and type 2 diabetes among youths, 2002–2012. N Engl J Med 376 (2017), 1419–1429.
-
(2017)
N Engl J Med
, vol.376
, pp. 1419-1429
-
-
Mayer-Davis, E.J.1
Lawrence, J.M.2
Dabelea, D.3
-
43
-
-
85035361972
-
Frequency and phenotype of type 1 diabetes in the first six decades of life: a cross-sectional, genetically stratified survival analysis from UK Biobank
-
Thomas, NJ, Jones, SE, Weedon, MN, Shields, BM, Oram, RA, Hattersley, AT, Frequency and phenotype of type 1 diabetes in the first six decades of life: a cross-sectional, genetically stratified survival analysis from UK Biobank. Lancet Diabetes Endocrinol 6 (2018), 122–129.
-
(2018)
Lancet Diabetes Endocrinol
, vol.6
, pp. 122-129
-
-
Thomas, N.J.1
Jones, S.E.2
Weedon, M.N.3
Shields, B.M.4
Oram, R.A.5
Hattersley, A.T.6
-
44
-
-
85019597731
-
Analysis of diabetes incidence against type 1 diabetes genetic risk score in 150,000 shows autoimmune diabetes presents as often between 30–60 years as before 30 years
-
Oram, RA, Thomas, NM, Jones, SE, Weedon, MN, Hattersley, AT, Analysis of diabetes incidence against type 1 diabetes genetic risk score in 150,000 shows autoimmune diabetes presents as often between 30–60 years as before 30 years. Diabetes, 65(suppl 1), 2016, A413.
-
(2016)
Diabetes
, vol.65
, pp. A413
-
-
Oram, R.A.1
Thomas, N.M.2
Jones, S.E.3
Weedon, M.N.4
Hattersley, A.T.5
-
45
-
-
84973345544
-
Capillary blood islet autoantibody screening for identifying pre-type 1 diabetes in the general population: design and initial results of the Fr1da study
-
Raab, J, Haupt, F, Scholz, M, et al. Capillary blood islet autoantibody screening for identifying pre-type 1 diabetes in the general population: design and initial results of the Fr1da study. BMJ Open, 6, 2016, e011144.
-
(2016)
BMJ Open
, vol.6
, pp. e011144
-
-
Raab, J.1
Haupt, F.2
Scholz, M.3
-
46
-
-
84856236241
-
Prediction model for the incidence and prevalence of type 1 diabetes in childhood and adolescence: evidence for a cohort-dependent increase within the next two decades in Germany
-
Ehehalt, S, Dietz, K, Willasch, AM, Neu, A, Prediction model for the incidence and prevalence of type 1 diabetes in childhood and adolescence: evidence for a cohort-dependent increase within the next two decades in Germany. Pediatr Diabetes 13 (2012), 15–20.
-
(2012)
Pediatr Diabetes
, vol.13
, pp. 15-20
-
-
Ehehalt, S.1
Dietz, K.2
Willasch, A.M.3
Neu, A.4
-
47
-
-
84908218494
-
Low-dose otelixizumab anti-CD3 monoclonal antibody DEFEND-1 study: results of the randomized phase III study in recent-onset human type 1 diabetes
-
Aronson, R, Gottlieb, PA, Christiansen, JS, et al. Low-dose otelixizumab anti-CD3 monoclonal antibody DEFEND-1 study: results of the randomized phase III study in recent-onset human type 1 diabetes. Diabetes Care 37 (2014), 2746–2754.
-
(2014)
Diabetes Care
, vol.37
, pp. 2746-2754
-
-
Aronson, R.1
Gottlieb, P.A.2
Christiansen, J.S.3
-
48
-
-
84896116224
-
Efficacy and safety of low-dose otelixizumab anti-CD3 monoclonal antibody in preserving C-peptide secretion in adolescent type 1 diabetes: DEFEND-2, a randomized, placebo-controlled, double-blind, multi-centre study
-
Ambery, P, Donner, TW, Biswas, N, Donaldson, J, Parkin, J, Dayan, CM, Efficacy and safety of low-dose otelixizumab anti-CD3 monoclonal antibody in preserving C-peptide secretion in adolescent type 1 diabetes: DEFEND-2, a randomized, placebo-controlled, double-blind, multi-centre study. Diabet Med 31 (2014), 399–402.
-
(2014)
Diabet Med
, vol.31
, pp. 399-402
-
-
Ambery, P.1
Donner, T.W.2
Biswas, N.3
Donaldson, J.4
Parkin, J.5
Dayan, C.M.6
-
49
-
-
77949266510
-
Four-year metabolic outcome of a randomised controlled CD3-antibody trial in recent-onset type 1 diabetic patients depends on their age and baseline residual beta cell mass
-
Keymeulen, B, Walter, M, Mathieu, C, et al. Four-year metabolic outcome of a randomised controlled CD3-antibody trial in recent-onset type 1 diabetic patients depends on their age and baseline residual beta cell mass. Diabetologia 53 (2010), 614–623.
-
(2010)
Diabetologia
, vol.53
, pp. 614-623
-
-
Keymeulen, B.1
Walter, M.2
Mathieu, C.3
-
50
-
-
84887025288
-
Anti-CD3 clinical trials in type 1 diabetes mellitus
-
Daifotis, AG, Koenig, S, Chatenoud, L, Herold, KC, Anti-CD3 clinical trials in type 1 diabetes mellitus. Clin Immunol 149 (2013), 268–278.
-
(2013)
Clin Immunol
, vol.149
, pp. 268-278
-
-
Daifotis, A.G.1
Koenig, S.2
Chatenoud, L.3
Herold, K.C.4
-
51
-
-
85059321927
-
Amevive (alefacept) voluntarily discontinued in the US
-
(Accessed 30 May 2018)
-
National Psoriasis Foundation. Amevive (alefacept) voluntarily discontinued in the US. https://www.psoriasis.org/media/press-releases/amevive-alefacept-voluntarily-discontinued-us, 2011. (Accessed 30 May 2018)
-
(2011)
-
-
-
52
-
-
84887621720
-
Targeting of memory T cells with alefacept in new-onset type 1 diabetes (T1DAL study): 12 month results of a randomised, double-blind, placebo-controlled phase 2 trial
-
Rigby, MR, DiMeglio, LA, Rendell, MS, et al. Targeting of memory T cells with alefacept in new-onset type 1 diabetes (T1DAL study): 12 month results of a randomised, double-blind, placebo-controlled phase 2 trial. Lancet Diabetes Endocrinol 1 (2013), 284–294.
-
(2013)
Lancet Diabetes Endocrinol
, vol.1
, pp. 284-294
-
-
Rigby, M.R.1
DiMeglio, L.A.2
Rendell, M.S.3
-
53
-
-
84879533278
-
From markers to molecular mechanisms: type 1 diabetes in the post-GWAS era
-
Baxter, AG, Jordan, MA, From markers to molecular mechanisms: type 1 diabetes in the post-GWAS era. Rev Diabet Stud 9 (2012), 201–223.
-
(2012)
Rev Diabet Stud
, vol.9
, pp. 201-223
-
-
Baxter, A.G.1
Jordan, M.A.2
-
54
-
-
84891812006
-
Acceleration of the loss of the first-phase insulin response during the progression to type 1 diabetes in Diabetes Prevention Trial–Type 1 participants
-
Sosenko, JM, Skyler, JS, Beam, CA, et al. Acceleration of the loss of the first-phase insulin response during the progression to type 1 diabetes in Diabetes Prevention Trial–Type 1 participants. Diabetes 62 (2013), 4179–4183.
-
(2013)
Diabetes
, vol.62
, pp. 4179-4183
-
-
Sosenko, J.M.1
Skyler, J.S.2
Beam, C.A.3
-
55
-
-
84864381301
-
Fall in C-peptide during first 2 years from diagnosis: evidence of at least two distinct phases from composite Type 1 Diabetes TrialNet data
-
Greenbaum, CJ, Beam, CA, Boulware, D, et al. Fall in C-peptide during first 2 years from diagnosis: evidence of at least two distinct phases from composite Type 1 Diabetes TrialNet data. Diabetes 61 (2012), 2066–2073.
-
(2012)
Diabetes
, vol.61
, pp. 2066-2073
-
-
Greenbaum, C.J.1
Beam, C.A.2
Boulware, D.3
-
56
-
-
84924022501
-
β cell death and dysfunction during type 1 diabetes development in at-risk individuals
-
Herold, KC, Usmani-Brown, S, Ghazi, T, et al. β cell death and dysfunction during type 1 diabetes development in at-risk individuals. J Clin Invest 125 (2015), 1163–1173.
-
(2015)
J Clin Invest
, vol.125
, pp. 1163-1173
-
-
Herold, K.C.1
Usmani-Brown, S.2
Ghazi, T.3
-
57
-
-
84983517618
-
Biomarkers of β-cell stress and death in type 1 diabetes
-
Mirmira, RG, Sims, EK, Syed, F, Evans-Molina, C, Biomarkers of β-cell stress and death in type 1 diabetes. Curr Diabetes Rep, 16, 2016, 95.
-
(2016)
Curr Diabetes Rep
, vol.16
, pp. 95
-
-
Mirmira, R.G.1
Sims, E.K.2
Syed, F.3
Evans-Molina, C.4
-
58
-
-
84962407100
-
Identification of tissue-specific cell death using methylation patterns of circulating DNA
-
Lehmann-Werman, R, Neiman, D, Zemmour, H, et al. Identification of tissue-specific cell death using methylation patterns of circulating DNA. Proc Natl Acad Sci USA 113 (2016), E1826–E1834.
-
(2016)
Proc Natl Acad Sci USA
, vol.113
, pp. E1826-E1834
-
-
Lehmann-Werman, R.1
Neiman, D.2
Zemmour, H.3
-
59
-
-
0020461362
-
Abnormal proinsulin/C-peptide ratio in juvenile diabetes
-
Ludvigsson, J, Heding, L, Abnormal proinsulin/C-peptide ratio in juvenile diabetes. Acta Diabetol Lat 19 (1982), 351–358.
-
(1982)
Acta Diabetol Lat
, vol.19
, pp. 351-358
-
-
Ludvigsson, J.1
Heding, L.2
-
60
-
-
84973595170
-
β-cell specific T-lymphocyte response has a distinct inflammatory phenotype in children with type 1 diabetes compared with adults
-
Arif, S, Gibson, VB, Nguyen, V, et al. β-cell specific T-lymphocyte response has a distinct inflammatory phenotype in children with type 1 diabetes compared with adults. Diabet Med 34 (2017), 419–425.
-
(2017)
Diabet Med
, vol.34
, pp. 419-425
-
-
Arif, S.1
Gibson, V.B.2
Nguyen, V.3
-
61
-
-
84856564903
-
GAD65 antigen therapy in recently diagnosed type 1 diabetes mellitus
-
Ludvigsson, J, Krisky, D, Casas, R, et al. GAD65 antigen therapy in recently diagnosed type 1 diabetes mellitus. N Engl J Med 366 (2012), 433–442.
-
(2012)
N Engl J Med
, vol.366
, pp. 433-442
-
-
Ludvigsson, J.1
Krisky, D.2
Casas, R.3
-
62
-
-
84923923735
-
Impact of disease heterogeneity on treatment efficacy of immunotherapy in type 1 diabetes: different shades of gray
-
Woittiez, NJ, Roep, BO, Impact of disease heterogeneity on treatment efficacy of immunotherapy in type 1 diabetes: different shades of gray. Immunotherapy 7 (2015), 163–174.
-
(2015)
Immunotherapy
, vol.7
, pp. 163-174
-
-
Woittiez, N.J.1
Roep, B.O.2
-
63
-
-
84962406567
-
Defining pathways for development of disease-modifying therapies in children with type 1 diabetes: a consensus report
-
Wherrett, DK, Chiang, JL, Delamater, AM, et al. Defining pathways for development of disease-modifying therapies in children with type 1 diabetes: a consensus report. Diabetes Care 38 (2015), 1975–1985.
-
(2015)
Diabetes Care
, vol.38
, pp. 1975-1985
-
-
Wherrett, D.K.1
Chiang, J.L.2
Delamater, A.M.3
-
64
-
-
84901807842
-
TNF inhibitor therapy for rheumatoid arthritis
-
Ma, X, Xu, S, TNF inhibitor therapy for rheumatoid arthritis. Biomed Rep Eng 2013 (2013), 177–184.
-
(2013)
Biomed Rep Eng
, vol.2013
, pp. 177-184
-
-
Ma, X.1
Xu, S.2
-
65
-
-
0022574058
-
Lawrence lecture. Death of a beta cell: homicide or suicide?
-
Bottazzo, GF, Lawrence lecture. Death of a beta cell: homicide or suicide?. Diabet Med 3 (1986), 119–130.
-
(1986)
Diabet Med
, vol.3
, pp. 119-130
-
-
Bottazzo, G.F.1
-
66
-
-
79959386535
-
How does type 1 diabetes develop? The notion of homicide or β-cell suicide revisited
-
Atkinson, MA, Bluestone, JA, Eisenbarth, GS, et al. How does type 1 diabetes develop? The notion of homicide or β-cell suicide revisited. Diabetes 60 (2011), 1370–1379.
-
(2011)
Diabetes
, vol.60
, pp. 1370-1379
-
-
Atkinson, M.A.1
Bluestone, J.A.2
Eisenbarth, G.S.3
-
67
-
-
84962422694
-
Insulitis and β-cell mass in the natural history of type 1 diabetes
-
Campbell-Thompson, M, Fu, A, Kaddis, JS, et al. Insulitis and β-cell mass in the natural history of type 1 diabetes. Diabetes 65 (2016), 719–731.
-
(2016)
Diabetes
, vol.65
, pp. 719-731
-
-
Campbell-Thompson, M.1
Fu, A.2
Kaddis, J.S.3
-
68
-
-
84890999355
-
The majority of patients with long-duration type 1 diabetes are insulin microsecretors and have functioning beta cells
-
Oram, RA, Jones, AG, Besser, RE, et al. The majority of patients with long-duration type 1 diabetes are insulin microsecretors and have functioning beta cells. Diabetologia 57 (2014), 187–191.
-
(2014)
Diabetologia
, vol.57
, pp. 187-191
-
-
Oram, R.A.1
Jones, A.G.2
Besser, R.E.3
-
69
-
-
85028648374
-
Persistence of pancreatic insulin mRNA expression and proinsulin protein in type 1 diabetes pancreata
-
75.e3
-
Wasserfall, C, Nick, HS, Campbell-Thompson, M, et al. Persistence of pancreatic insulin mRNA expression and proinsulin protein in type 1 diabetes pancreata. Cell Metab, 26, 2017, 568 75.e3.
-
(2017)
Cell Metab
, vol.26
, pp. 568
-
-
Wasserfall, C.1
Nick, H.S.2
Campbell-Thompson, M.3
-
70
-
-
85012885799
-
β cells that resist immunological attack develop during progression of autoimmune diabetes in NOD mice
-
Rui, J, Deng, S, Arazi, A, Perdigoto, AL, Liu, Z, Herold, KC, β cells that resist immunological attack develop during progression of autoimmune diabetes in NOD mice. Cell Metab 25 (2017), 727–738.
-
(2017)
Cell Metab
, vol.25
, pp. 727-738
-
-
Rui, J.1
Deng, S.2
Arazi, A.3
Perdigoto, A.L.4
Liu, Z.5
Herold, K.C.6
-
71
-
-
84992372038
-
Rebranding asymptomatic type 1 diabetes: the case for autoimmune beta cell disorder as a pathological and diagnostic entity
-
Bonifacio, E, Mathieu, C, Nepom, GT, et al. Rebranding asymptomatic type 1 diabetes: the case for autoimmune beta cell disorder as a pathological and diagnostic entity. Diabetologia 60 (2017), 35–38.
-
(2017)
Diabetologia
, vol.60
, pp. 35-38
-
-
Bonifacio, E.1
Mathieu, C.2
Nepom, G.T.3
-
72
-
-
84962422694
-
Insulitis and β-cell mass in the natural history of type 1 diabetes
-
Campbell-Thompson, M, Fu, A, Kaddis, JS, et al. Insulitis and β-cell mass in the natural history of type 1 diabetes. Diabetes 65 (2016), 719–731.
-
(2016)
Diabetes
, vol.65
, pp. 719-731
-
-
Campbell-Thompson, M.1
Fu, A.2
Kaddis, J.S.3
-
73
-
-
85051139305
-
Autoreactive T effector memory differentiation mirrors β cell function in type 1 diabetes
-
Yeo, L, Woodwyk, A, Sood, S, et al. Autoreactive T effector memory differentiation mirrors β cell function in type 1 diabetes. J Clin Invest 128 (2018), 3460–3474.
-
(2018)
J Clin Invest
, vol.128
, pp. 3460-3474
-
-
Yeo, L.1
Woodwyk, A.2
Sood, S.3
-
74
-
-
0032880017
-
Autoreactive T cell responses in insulin-dependent (type 1) diabetes mellitus. Report of the First International Workshop for Standardization of T Cell Assays
-
Roep, BO, Atkinson, MA, van Endert, PM, Gottlieb, PA, Wilson, SB, Sachs, JA, Autoreactive T cell responses in insulin-dependent (type 1) diabetes mellitus. Report of the First International Workshop for Standardization of T Cell Assays. J Autoimmun 13 (1999), 267–282.
-
(1999)
J Autoimmun
, vol.13
, pp. 267-282
-
-
Roep, B.O.1
Atkinson, M.A.2
van Endert, P.M.3
Gottlieb, P.A.4
Wilson, S.B.5
Sachs, J.A.6
-
75
-
-
84920024469
-
Proinsulin-specific, HLA-DQ8, and HLA-DQ8-transdimer-restricted CD4+ T cells infiltrate islets in type 1 diabetes
-
Pathiraja, V, Kuehlich, JP, Campbell, PD, et al. Proinsulin-specific, HLA-DQ8, and HLA-DQ8-transdimer-restricted CD4+ T cells infiltrate islets in type 1 diabetes. Diabetes 64 (2015), 172–182.
-
(2015)
Diabetes
, vol.64
, pp. 172-182
-
-
Pathiraja, V.1
Kuehlich, J.P.2
Campbell, P.D.3
-
76
-
-
84992699812
-
Analysis of self-antigen specificity of islet-infiltrating T cells from human donors with type 1 diabetes
-
Babon, JA, DeNicola, ME, Blodgett, DM, et al. Analysis of self-antigen specificity of islet-infiltrating T cells from human donors with type 1 diabetes. Nat Med 22 (2016), 1482–1487.
-
(2016)
Nat Med
, vol.22
, pp. 1482-1487
-
-
Babon, J.A.1
DeNicola, M.E.2
Blodgett, D.M.3
-
77
-
-
85018742541
-
Islet-derived CD4 T cells targeting proinsulin in human autoimmune diabetes
-
Michels, AW, Landry, LG, McDaniel, KA, et al. Islet-derived CD4 T cells targeting proinsulin in human autoimmune diabetes. Diabetes 66 (2017), 722–734.
-
(2017)
Diabetes
, vol.66
, pp. 722-734
-
-
Michels, A.W.1
Landry, L.G.2
McDaniel, K.A.3
-
78
-
-
85055601298
-
Tissue distribution and clonal diversity of the T and B cell repertoire in type 1 diabetes
-
Seay, HR, Yusko, E, Rothweiler, SJ, et al. Tissue distribution and clonal diversity of the T and B cell repertoire in type 1 diabetes. JCI Insight, 1, 2016, e88242.
-
(2016)
JCI Insight
, vol.1
, pp. e88242
-
-
Seay, H.R.1
Yusko, E.2
Rothweiler, S.J.3
-
79
-
-
85035317900
-
T cell receptor β-chains display abnormal shortening and repertoire sharing in type 1 diabetes
-
Gomez-Tourino, I, Kamra, Y, Baptista, R, Lorenc, A, Peakman, M, T cell receptor β-chains display abnormal shortening and repertoire sharing in type 1 diabetes. Nat Commun, 8, 2017, 1792.
-
(2017)
Nat Commun
, vol.8
, pp. 1792
-
-
Gomez-Tourino, I.1
Kamra, Y.2
Baptista, R.3
Lorenc, A.4
Peakman, M.5
-
80
-
-
85018252086
-
High throughput single cell counting in droplet-based microfluidics
-
Lu, H, Caen, O, Vrignon, J, et al. High throughput single cell counting in droplet-based microfluidics. Sci Rep, 7, 2017, 1366.
-
(2017)
Sci Rep
, vol.7
, pp. 1366
-
-
Lu, H.1
Caen, O.2
Vrignon, J.3
-
81
-
-
85031429533
-
T cell receptor profiling in type 1 diabetes
-
Jacobsen, LM, Posgai, A, Seay, HR, Haller, MJ, Brusko, TM, T cell receptor profiling in type 1 diabetes. Curr Diabetes Rep, 17, 2017, 118.
-
(2017)
Curr Diabetes Rep
, vol.17
, pp. 118
-
-
Jacobsen, L.M.1
Posgai, A.2
Seay, H.R.3
Haller, M.J.4
Brusko, T.M.5
-
82
-
-
70349635504
-
Differences in baseline lymphocyte counts and autoreactivity are associated with differences in outcome of islet cell transplantation in type 1 diabetic patients
-
Hilbrands, R, Huurman, VA, Gillard, P, et al. Differences in baseline lymphocyte counts and autoreactivity are associated with differences in outcome of islet cell transplantation in type 1 diabetic patients. Diabetes 58 (2009), 2267–2276.
-
(2009)
Diabetes
, vol.58
, pp. 2267-2276
-
-
Hilbrands, R.1
Huurman, V.A.2
Gillard, P.3
-
83
-
-
43049150180
-
Cellular islet autoimmunity associates with clinical outcome of islet cell transplantation
-
Huurman, VA, Hilbrands, R, Pinkse, GG, et al. Cellular islet autoimmunity associates with clinical outcome of islet cell transplantation. PLoS One, 3, 2008, e2435.
-
(2008)
PLoS One
, vol.3
, pp. e2435
-
-
Huurman, V.A.1
Hilbrands, R.2
Pinkse, G.G.3
-
84
-
-
77951983004
-
Simultaneous detection of circulating autoreactive CD8+ T-cells specific for different islet cell-associated epitopes using combinatorial MHC multimers
-
Velthuis, JH, Unger, WW, Abreu, JR, et al. Simultaneous detection of circulating autoreactive CD8+ T-cells specific for different islet cell-associated epitopes using combinatorial MHC multimers. Diabetes 59 (2010), 1721–1730.
-
(2010)
Diabetes
, vol.59
, pp. 1721-1730
-
-
Velthuis, J.H.1
Unger, W.W.2
Abreu, J.R.3
-
85
-
-
85014313309
-
Immunological balance is associated with clinical outcome after autologous hematopoietic stem cell transplantation in type 1 diabetes
-
Malmegrim, KC, de Azevedo, JT, Arruda, LC, et al. Immunological balance is associated with clinical outcome after autologous hematopoietic stem cell transplantation in type 1 diabetes. Front Immunol, 8, 2017, 167.
-
(2017)
Front Immunol
, vol.8
, pp. 167
-
-
Malmegrim, K.C.1
de Azevedo, J.T.2
Arruda, L.C.3
-
86
-
-
84990829763
-
GAD vaccine reduces insulin loss in recently diagnosed type 1 diabetes: findings from a Bayesian meta-analysis
-
Beam, CA, MacCallum, C, Herold, KC, Wherrett, DK, Palmer, J, Ludvigsson, J, GAD vaccine reduces insulin loss in recently diagnosed type 1 diabetes: findings from a Bayesian meta-analysis. Diabetologia 60 (2017), 43–49.
-
(2017)
Diabetologia
, vol.60
, pp. 43-49
-
-
Beam, C.A.1
MacCallum, C.2
Herold, K.C.3
Wherrett, D.K.4
Palmer, J.5
Ludvigsson, J.6
-
87
-
-
84906657317
-
Recommendations for the definition of clinical responder in insulin preservation studies
-
Beam, CA, Gitelman, SE, Palmer, JP, Recommendations for the definition of clinical responder in insulin preservation studies. Diabetes 63 (2014), 3120–3127.
-
(2014)
Diabetes
, vol.63
, pp. 3120-3127
-
-
Beam, C.A.1
Gitelman, S.E.2
Palmer, J.P.3
-
88
-
-
84908632192
-
Blood and islet phenotypes indicate immunological heterogeneity in type 1 diabetes
-
Arif, S, Leete, P, Nguyen, V, et al. Blood and islet phenotypes indicate immunological heterogeneity in type 1 diabetes. Diabetes 63 (2014), 3835–3845.
-
(2014)
Diabetes
, vol.63
, pp. 3835-3845
-
-
Arif, S.1
Leete, P.2
Nguyen, V.3
-
89
-
-
85028889973
-
Beyond glycaemic control: a crossover, double-blinded, 24-week intervention with liraglutide in type 1 diabetes
-
Dubé, MC, D'Amours, M, Weisnagel, SJ, Beyond glycaemic control: a crossover, double-blinded, 24-week intervention with liraglutide in type 1 diabetes. Diabetes Obes Metab 20 (2018), 178–184.
-
(2018)
Diabetes Obes Metab
, vol.20
, pp. 178-184
-
-
Dubé, M.C.1
D'Amours, M.2
Weisnagel, S.J.3
-
90
-
-
85018995962
-
Use of sitagliptin with closed-loop technology to decrease postprandial blood glucose in type 1 diabetes
-
Underland, LJ, Ilkowitz, JT, Katikaneni, R, Dowd, A, Heptulla, RA, Use of sitagliptin with closed-loop technology to decrease postprandial blood glucose in type 1 diabetes. J Diabetes Sci Technol 11 (2017), 602–610.
-
(2017)
J Diabetes Sci Technol
, vol.11
, pp. 602-610
-
-
Underland, L.J.1
Ilkowitz, J.T.2
Katikaneni, R.3
Dowd, A.4
Heptulla, R.A.5
-
91
-
-
85020470639
-
Optimizing the analysis strategy for the CANVAS Program: a prespecified plan for the integrated analyses of the CANVAS and CANVAS-R trials
-
Neal, B, Perkovic, V, Mahaffey, KW, et al. Optimizing the analysis strategy for the CANVAS Program: a prespecified plan for the integrated analyses of the CANVAS and CANVAS-R trials. Diabetes Obes Metab 19 (2017), 915–925.
-
(2017)
Diabetes Obes Metab
, vol.19
, pp. 915-925
-
-
Neal, B.1
Perkovic, V.2
Mahaffey, K.W.3
-
92
-
-
84959567309
-
β cell ER stress and the implications for immunogenicity in type 1 diabetes
-
Marré, ML, James, EA, Piganelli, JD, β cell ER stress and the implications for immunogenicity in type 1 diabetes. Front Cell Dev Biol, 3, 2015, 67.
-
(2015)
Front Cell Dev Biol
, vol.3
, pp. 67
-
-
Marré, M.L.1
James, E.A.2
Piganelli, J.D.3
-
93
-
-
85044183266
-
Carbamazepine, a beta-cell protecting drug, reduces type 1 diabetes incidence in NOD mice
-
Lee, JTC, Shanina, I, Chu, YN, Horwitz, MS, Johnson, JD, Carbamazepine, a beta-cell protecting drug, reduces type 1 diabetes incidence in NOD mice. Nat Sci Rep, 8, 2018, 4588.
-
(2018)
Nat Sci Rep
, vol.8
, pp. 4588
-
-
Lee, J.T.C.1
Shanina, I.2
Chu, Y.N.3
Horwitz, M.S.4
Johnson, J.D.5
-
94
-
-
84942755473
-
Current state of type 1 diabetes treatment in the US: updated data from the T1D Exchange clinic registry
-
Miller, KM, Foster, NC, Beck, RW, et al. Current state of type 1 diabetes treatment in the US: updated data from the T1D Exchange clinic registry. Diabetes Care 38 (2015), 971–978.
-
(2015)
Diabetes Care
, vol.38
, pp. 971-978
-
-
Miller, K.M.1
Foster, N.C.2
Beck, R.W.3
-
95
-
-
85028331021
-
Remodeling T cell compartments during anti-CD3 immunotherapy of type 1 diabetes
-
Long, SA, Thorpe, J, Herold, KC, et al. Remodeling T cell compartments during anti-CD3 immunotherapy of type 1 diabetes. Cell Immunol 319 (2017), 3–9.
-
(2017)
Cell Immunol
, vol.319
, pp. 3-9
-
-
Long, S.A.1
Thorpe, J.2
Herold, K.C.3
|