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Volumn 38, Issue 10, 2015, Pages 1964-1974

Staging presymptomatic type 1 diabetes: A scientific statement of jdrf, the endocrine society, and the American diabetes association

(16)  Insel, Richard A a   Dunne, Jessica L a   Atkinson, Mark A b   Chiang, Jane L c   Dabelea, Dana d   Gottlieb, Peter A e   Greenbaum, Carla J f   Herold, Kevan C g   Krischer, Jeffrey P h   Lernmark, Ake i   Ratner, Robert E c   Rewers, Marian J e   Schatz, Desmond A b   Skyler, Jay S j   Sosenko, Jay M j   Ziegler, Anette G k  


Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; ASYMPTOMATIC DISEASE; AUTOIMMUNITY; DISEASE ASSOCIATION; ENDOCRINE SOCIETY; ENVIRONMENTAL FACTOR; GENETIC RISK; GENETIC SUSCEPTIBILITY; HEREDITY; HUMAN; INSULIN DEPENDENT DIABETES MELLITUS; LONGITUDINAL STUDY; MEDICAL SOCIETY; PANCREAS ISLET BETA CELL; PROSPECTIVE STUDY; REIMBURSEMENT; RISK BENEFIT ANALYSIS; SYMPTOMATOLOGY; CLASSIFICATION; DIABETES MELLITUS, TYPE 1; DISEASE COURSE; EARLY DIAGNOSIS; GENETIC PREDISPOSITION; IMMUNOLOGY; PREDIABETIC STATE; UNITED STATES;

EID: 84962430639     PISSN: 01495992     EISSN: 19355548     Source Type: Journal    
DOI: 10.2337/dc15-1419     Document Type: Article
Times cited : (689)

References (131)
  • 1
    • 0022617990 scopus 로고
    • Type I diabetes mellitus. A chronic autoimmune disease
    • Eisenbarth GS. Type I diabetes mellitus. A chronic autoimmune disease. N Engl J Med 1986;314:1360-1368.
    • (1986) N Engl J Med , vol.314 , pp. 1360-1368
    • Eisenbarth, G.S.1
  • 2
    • 0035928391 scopus 로고    scopus 로고
    • Type 1 diabetes: New perspectives on disease pathogenesis and treatment
    • Atkinson MA, Eisenbarth GS. Type 1 diabetes: new perspectives on disease pathogenesis and treatment. Lancet 2001;358:221-229.
    • (2001) Lancet , vol.358 , pp. 221-229
    • Atkinson, M.A.1    Eisenbarth, G.S.2
  • 4
    • 0037198427 scopus 로고    scopus 로고
    • Effect of insulin in relatives of patients with type 1 diabetes mellitus
    • Diabetes Prevention Trial-Type 1 Diabetes Study Group
    • Diabetes Prevention Trial-Type 1 Diabetes Study Group. Effect of insulin in relatives of patients with type 1 diabetes mellitus. N Engl J Med 2002;346:1685-1691.
    • (2002) N Engl J Med , vol.346 , pp. 1685-1691
  • 5
    • 33845701367 scopus 로고    scopus 로고
    • TEDDYd The environmental determinants of diabetes in the young: An observational clinical trial
    • Hagopian WA, Lernmark A, Rewers MJ, et al. TEDDYdThe Environmental Determinants of Diabetes in the Young: An observational clinical trial. Ann N Y Acad Sci 2006;1079:320-326.
    • (2006) Ann N Y Acad, Sci , vol.1079 , pp. 320-326
    • Hagopian, W.A.1    Lernmark, A.2    Rewers, M.J.3
  • 6
    • 57749176852 scopus 로고    scopus 로고
    • Type 1 diabetes trial netdan international collaborative clinical trials network
    • Type 1 Diabetes TrialNet Study Group
    • Skyler JS, Greenbaum CJ, Lachin JM, et al.; Type 1 Diabetes TrialNet Study Group. Type 1 Diabetes TrialNetdan international collaborative clinical trials network. Ann N Y Acad Sci 2008;1150:14-24.
    • (2008) Ann N Y Acad Sci , vol.1150 , pp. 14-24
    • Skyler, J.S.1    Greenbaum, C.J.2    Lachin, J.M.3
  • 7
    • 84879114358 scopus 로고    scopus 로고
    • Seroconversion to multiple islet autoantibodies and risk of progression to diabetes in children
    • Ziegler AG, Rewers M, Simell O, et al. Seroconversion to multiple islet autoantibodies and risk of progression to diabetes in children. JAMA 2013;309:2473-2479.
    • (2013) JAMA , vol.309 , pp. 2473-2479
    • Ziegler, A.G.1    Rewers, M.2    Simell, O.3
  • 8
    • 72249122333 scopus 로고    scopus 로고
    • Pancreatic islet autoantibodies as predictors of type 1 diabetes in the Diabetes Prevention Trial-Type 1
    • Diabetes Prevention Trial-Type 1 Study Group
    • Orban T, Sosenko JM, Cuthbertson D, et al.; Diabetes Prevention Trial-Type 1 Study Group. Pancreatic islet autoantibodies as predictors of type 1 diabetes in the Diabetes Prevention Trial-Type 1. Diabetes Care 2009;32:2269-2274.
    • (2009) Diabetes Care , vol.32 , pp. 2269-2274
    • Orban, T.1    Sosenko, J.M.2    Cuthbertson, D.3
  • 9
    • 84928811876 scopus 로고    scopus 로고
    • Predictors of progression from the appearance of islet autoantibodies to early childhood diabetes: The Environmental Determinants of Diabetes in the Young (TEDDY)
    • TEDDY Study Group
    • Steck AK, Vehik K, Bonifacio E, et al.; TEDDY Study Group. Predictors of progression from the appearance of islet autoantibodies to early childhood diabetes: The Environmental Determinants of Diabetes in the Young (TEDDY). Diabetes Care 2015;38:808-813.
    • (2015) Diabetes Care , vol.38 , pp. 808-813
    • Steck, A.K.1    Vehik, K.2    Bonifacio, E.3
  • 10
    • 84881614660 scopus 로고    scopus 로고
    • The use of intermediate endpoints in the design of type 1 diabetes prevention trials
    • Type 1 Diabetes TrialNet Study Group
    • Krischer JP; Type 1 Diabetes TrialNet Study Group. The use of intermediate endpoints in the design of type 1 diabetes prevention trials. Diabetologia 2013;56:1919-1924.
    • (2013) Diabetologia , vol.56 , pp. 1919-1924
    • Krischer, J.P.1
  • 11
    • 0029953008 scopus 로고    scopus 로고
    • The role of HLA class II genes in insulin-dependent diabetes mellitus: Molecular analysis of 180 Caucasian, multiplex families
    • Noble JA, Valdes AM, Cook M, Klitz W, Thomson G, Erlich HA. The role of HLA class II genes in insulin-dependent diabetes mellitus: molecular analysis of 180 Caucasian, multiplex families. Am J Hum Genet 1996;59:1134-1148.
    • (1996) Am J Hum Genet , vol.59 , pp. 1134-1148
    • Noble, J.A.1    Valdes, A.M.2    Cook, M.3    Klitz, W.4    Thomson, G.5    Erlich, H.A.6
  • 12
    • 67049159857 scopus 로고    scopus 로고
    • Incidence trends for childhood type 1 diabetes in Europe during 1989-2003 and predicted new cases 2005-20: A multicentre prospective registration study
    • EURODIAB Study Group
    • Patterson CC, Dahlquist GG, Gyürüs E, Green A, Soltész G; EURODIAB Study Group. Incidence trends for childhood type 1 diabetes in Europe during 1989-2003 and predicted new cases 2005-20: A multicentre prospective registration study. Lancet 2009;373:2027-2033.
    • (2009) Lancet , vol.373 , pp. 2027-2033
    • Patterson, C.C.1    Dahlquist, G.G.2    Gyürüs, E.3    Green, A.4    Soltész, G.5
  • 13
    • 43849096855 scopus 로고    scopus 로고
    • Time trends in the incidence of type 1 diabetes in Finnish children: A cohort study
    • Harjutsalo V, Sjöberg L, Tuomilehto J. Time trends in the incidence of type 1 diabetes in Finnish children: A cohort study. Lancet 2008;371:1777-1782.
    • (2008) Lancet , vol.371 , pp. 1777-1782
    • Harjutsalo, V.1    Sjöberg, L.2    Tuomilehto, J.3
  • 14
    • 33847657143 scopus 로고    scopus 로고
    • Increasing incidence of type 1 diabetes in 0- To 17-year-old Colorado youth
    • Vehik K, Hamman RF, Lezotte D, et al. Increasing incidence of type 1 diabetes in 0- To 17-year-old Colorado youth. Diabetes Care 2007;30:503-509.
    • (2007) Diabetes Care , vol.30 , pp. 503-509
    • Vehik, K.1    Hamman, R.F.2    Lezotte, D.3
  • 15
    • 79952384694 scopus 로고    scopus 로고
    • Stepwise or linear decrease in penetrance of type 1 diabetes with lower-risk HLA genotypes over the past 40, years
    • Type 1 Diabetes Genetics Consortium
    • Steck AK, Armstrong TK, Babu SR, Eisenbarth GS; Type 1 Diabetes Genetics Consortium. Stepwise or linear decrease in penetrance of type 1 diabetes with lower-risk HLA genotypes over the past 40 years. Diabetes 2011;60:1045-1049.
    • (2011) Diabetes , vol.60 , pp. 1045-1049
    • Steck, A.K.1    Armstrong, T.K.2    Babu, S.R.3    Eisenbarth, G.S.4
  • 16
    • 49649119940 scopus 로고    scopus 로고
    • Trends in high-risk HLA susceptibility genes among Colorado youth with type 1 diabetes
    • Vehik K, Hamman RF, Lezotte D, et al. Trends in high-risk HLA susceptibility genes among Colorado youth with type 1 diabetes. Diabetes Care 2008;31:1392-1396.
    • (2008) Diabetes Care , vol.31 , pp. 1392-1396
    • Vehik, K.1    Hamman, R.F.2    Lezotte, D.3
  • 18
    • 0036688819 scopus 로고    scopus 로고
    • Genetics of type 1 diabetes mellitus
    • Pociot F, McDermott MF. Genetics of type 1 diabetes mellitus. Genes Immun 2002;3:235-249.
    • (2002) Genes Immun , vol.3 , pp. 235-249
    • Pociot, F.1    McDermott, M.F.2
  • 19
    • 84883533518 scopus 로고    scopus 로고
    • Candidate genes for type 1 diabetes modulate pancreatic islet inflammation and b-cell apoptosis
    • Santin I, Eizirik DL. Candidate genes for type 1 diabetes modulate pancreatic islet inflammation and b-cell apoptosis. Diabetes Obes Metab 2013;15(Suppl.3):71-81.
    • (2013) Diabetes Obes Metab , vol.15 , pp. 71-81
    • Santin, I.1    Eizirik, D.L.2
  • 20
    • 78650057803 scopus 로고    scopus 로고
    • Effect of HLA class I and class II alleles on progression from autoantibody positivity to overt type 1 diabetes in children with risk-associated class II genotypes
    • Lipponen K, Gombos Z, Kiviniemi M, et al. Effect of HLA class I and class II alleles on progression from autoantibody positivity to overt type 1 diabetes in children with risk-associated class II genotypes. Diabetes 2010;59:3253-3256.
    • (2010) Diabetes , vol.59 , pp. 3253-3256
    • Lipponen, K.1    Gombos, Z.2    Kiviniemi, M.3
  • 21
    • 84878847275 scopus 로고    scopus 로고
    • Characteristics of rapid vs slow progression to type 1 diabetes in multiple islet autoantibody-positive children
    • Achenbach P, Hummel M, Thümer L, Boerschmann H, Höfelmann D, Ziegler AG. Characteristics of rapid vs slow progression to type 1 diabetes in multiple islet autoantibody-positive children. Diabetologia 2013;56:1615-1622.
    • (2013) Diabetologia , vol.56 , pp. 1615-1622
    • Achenbach, P.1    Hummel, M.2    Thümer, L.3    Boerschmann, H.4    Höfelmann, D.5    Ziegler, A.G.6
  • 22
    • 84867741377 scopus 로고    scopus 로고
    • A strategy for combining minor genetic susceptibility genes to improve prediction of disease in type 1 diabetes
    • Winkler C, Krumsiek J, Lempainen J, et al. A strategy for combining minor genetic susceptibility genes to improve prediction of disease in type 1 diabetes. Genes Immun 2012;13:549-555.
    • (2012) Genes Immun , vol.13 , pp. 549-555
    • Winkler, C.1    Krumsiek, J.2    Lempainen, J.3
  • 23
    • 84926665363 scopus 로고    scopus 로고
    • Feature ranking of type 1 diabetes susceptibility genes improves prediction of type 1 diabetes
    • Winkler C, Krumsiek J, Buettner F, et al. Feature ranking of type 1 diabetes susceptibility genes improves prediction of type 1 diabetes. Diabetologia 2014;57:2521-2529.
    • (2014) Diabetologia , vol.57 , pp. 2521-2529
    • Winkler, C.1    Krumsiek, J.2    Buettner, F.3
  • 24
    • 84872734510 scopus 로고    scopus 로고
    • The environment and the origins of islet autoimmunity and type 1 diabetes
    • Eringsmark Regnell S, Lernmark A. The environment and the origins of islet autoimmunity and type 1 diabetes. Diabet Med 2013;30:155-160.
    • (2013) Diabet Med , vol.30 , pp. 155-160
    • Eringsmark Regnell, S.1    Lernmark, A.2
  • 26
    • 84881613172 scopus 로고    scopus 로고
    • The prenatal environment and type 1 diabetes
    • Stene LC, Gale EA. The prenatal environment and type 1 diabetes. Diabetologia 2013; 56:1888-1897.
    • (2013) Diabetologia , vol.56 , pp. 1888-1897
    • Stene, L.C.1    Gale, E.A.2
  • 27
    • 34548783929 scopus 로고    scopus 로고
    • The environmental determinants of diabetes in the young (TEDDY) study: Study design
    • TEDDY Study Group
    • TEDDY Study Group. The Environmental Determinants of Diabetes in the Young (TEDDY) study: study design. Pediatr Diabetes 2007;8:286-298.
    • (2007) Pediatr Diabetes , vol.8 , pp. 286-298
  • 29
    • 0035076548 scopus 로고    scopus 로고
    • Heterogeneity of type I diabetes: Analysis of monozygotic twins in Great Britain and the United States
    • Redondo MJ, Yu L, Hawa M, et al. Heterogeneity of type I diabetes: Analysis of monozygotic twins in Great Britain and the United States. Diabetologia 2001;44:354-362.
    • (2001) Diabetologia , vol.44 , pp. 354-362
    • Redondo, M.J.1    Yu, L.2    Hawa, M.3
  • 30
    • 33749012255 scopus 로고    scopus 로고
    • Extreme genetic risk for type 1A diabetes
    • Aly TA, Ide A, Jahromi MM, et al. Extreme genetic risk for type 1A diabetes. Proc Natl Acad Sci U S A 2006;103:14074-14079.
    • (2006) Proc Natl Acad Sci U S A , vol.103 , pp. 14074-14079
    • Aly, T.A.1    Ide, A.2    Jahromi, M.M.3
  • 31
    • 84894441964 scopus 로고    scopus 로고
    • Early onset of diabetes in the proband is the major determinant of risk in HLA DR3-DQ2/DR4-DQ8 siblings
    • Gillespie KM, Aitken RJ, Wilson I, Williams AJ, Bingley PJ. Early onset of diabetes in the proband is the major determinant of risk in HLA DR3-DQ2/DR4-DQ8 siblings. Diabetes 2014;63:1041-1047.
    • (2014) Diabetes , vol.63 , pp. 1041-1047
    • Gillespie, K.M.1    Aitken, R.J.2    Wilson, I.3    Williams, A.J.4    Bingley, P.J.5
  • 32
    • 18144391496 scopus 로고    scopus 로고
    • Effects of oral insulin in relatives of patients with type 1 diabetes: The diabetes prevention trial- Type 1
    • Skyler JS, Krischer JP, Wolfsdorf J, et al. Effects of oral insulin in relatives of patients with type 1 diabetes: The Diabetes Prevention Trial- Type 1. Diabetes Care 2005;28:1068-1076.
    • (2005) Diabetes Care , vol.28 , pp. 1068-1076
    • Skyler, J.S.1    Krischer, J.P.2    Wolfsdorf, J.3
  • 33
    • 61549136296 scopus 로고    scopus 로고
    • The Trial- Net natural history study of the development of type 1 Diabetes: Objectives, design, and initial results
    • TrialNet Natural History Committee; Type 1 Diabetes TrialNet Study Group
    • Mahon JL, Sosenko JM, Rafkin-Mervis L, et al.; TrialNet Natural History Committee; Type 1 Diabetes TrialNet Study Group. The Trial- Net Natural History Study of the Development of Type 1 Diabetes: objectives, design, and initial results. Pediatr Diabetes 2009;10:97-104.
    • (2009) Pediatr Diabetes , vol.10 , pp. 97-104
    • Mahon, J.L.1    Sosenko, J.M.2    Rafkin-Mervis, L.3
  • 34
    • 84903552407 scopus 로고    scopus 로고
    • Type 1 diabetes sourcebook authors. Type 1 diabetes through the life span: A position statement of the American Diabetes Association
    • Chiang JL, Kirkman MS, Laffel LM, Peters AL; Type 1 Diabetes Sourcebook Authors. Type 1 diabetes through the life span: A position statement of the American Diabetes Association. Diabetes Care 2014;37:2034-2054.
    • (2014) Diabetes Care , vol.37 , pp. 2034-2054
    • Chiang, J.L.1    Kirkman, M.S.2    Laffel, L.M.3    Peters, A.L.4
  • 35
    • 0026603981 scopus 로고
    • Incidence of insulin-dependent diabetes mellitus in Colorado
    • Kostraba JN, Gay EC, Cai Y, et al. Incidence of insulin-dependent diabetes mellitus in Colorado. Epidemiology 1992;3:232-238.
    • (1992) Epidemiology , vol.3 , pp. 232-238
    • Kostraba, J.N.1    Gay, E.C.2    Cai, Y.3
  • 36
    • 0031782989 scopus 로고    scopus 로고
    • Familial risk of type I diabetes in European children
    • The EURODIAB ACE Study Group and the EURODIAB ACE Substudy 2 Study Group
    • The EURODIAB ACE Study Group and the EURODIAB ACE Substudy 2 Study Group. Familial risk of type I diabetes in European children. Diabetologia 1998;41:1151-1156.
    • (1998) Diabetologia , vol.41 , pp. 1151-1156
  • 37
    • 80053036722 scopus 로고    scopus 로고
    • The environmental determinants of diabetes in the young (TEDDY): Genetic criteria and international diabetes risk screening of 421 000 infants
    • TEDDY Study Group
    • Hagopian WA, Erlich H, Lernmark A, et al.; TEDDY Study Group. The Environmental Determinants of Diabetes in the Young (TEDDY): genetic criteria and international diabetes risk screening of 421 000 infants. Pediatr Diabetes 2011;12:733-743.
    • (2011) Pediatr Diabetes , vol.12 , pp. 733-743
    • Hagopian, W.A.1    Erlich, H.2    Lernmark, A.3
  • 38
    • 0242364727 scopus 로고    scopus 로고
    • A comprehensive guide to antibody and T-cell responses in type 1 diabetes
    • Lieberman SM, DiLorenzo TP. A comprehensive guide to antibody and T-cell responses in type 1 diabetes. Tissue Antigens 2003;62: 359-377.
    • (2003) Tissue Antigens , vol.62 , pp. 359-377
    • Lieberman, S.M.1    DiLorenzo, T.P.2
  • 39
    • 84862302663 scopus 로고    scopus 로고
    • Antigen targets of type 1 diabetes autoimmunity
    • Roep BO, Peakman M. Antigen targets of type 1 diabetes autoimmunity. Cold Spring Harb Perspect Med 2012;2:a007781.
    • (2012) Cold Spring Harb Perspect Med , vol.2 , pp. a007781
    • Roep, B.O.1    Peakman, M.2
  • 40
    • 84866394974 scopus 로고    scopus 로고
    • Age-related islet autoantibody incidence in offspring of patients with type 1 diabetes
    • BABYDIAB-BABYDIET Study Group
    • Ziegler AG, Bonifacio E; BABYDIAB-BABYDIET Study Group. Age-related islet autoantibody incidence in offspring of patients with type 1 diabetes. Diabetologia 2012;55:1937-1943.
    • (2012) Diabetologia , vol.55 , pp. 1937-1943
    • Ziegler, A.G.1    Bonifacio, E.2
  • 41
    • 84866382555 scopus 로고    scopus 로고
    • Early seroconversion and rapidly increasing autoantibody concentrations predict prepubertal manifestation of type 1 diabetes in children at genetic risk
    • Parikka V, Nanẗo-Salonen K, Saarinen M, et al. Early seroconversion and rapidly increasing autoantibody concentrations predict prepubertal manifestation of type 1 diabetes in children at genetic risk. Diabetologia 2012;55: 1926-1936.
    • (2012) Diabetologia , vol.55 , pp. 1926-1936
    • Parikka, V.1    Nanẗo-Salonen, K.2    Saarinen, M.3
  • 42
    • 84939961476 scopus 로고    scopus 로고
    • The 6 year incidence of diabetesassociated autoantibodies in genetically at-risk children: The TEDDY study
    • TEDDY Study Group
    • Krischer JP, Lynch KF, Schatz DA, et al.; TEDDY Study Group. The 6 year incidence of diabetesassociated autoantibodies in genetically at-risk children: The TEDDY study. Diabetologia 2015; 58:980-987.
    • (2015) Diabetologia , vol.58 , pp. 980-987
    • Krischer, J.P.1    Lynch, K.F.2    Schatz, D.A.3
  • 43
    • 0033016840 scopus 로고    scopus 로고
    • Autoantibody appearance and risk for development of childhood diabetes in offspring of parents with type 1 diabetes: The 2- year analysis of the German BABYDIAB Study
    • Ziegler AG, Hummel M, Schenker M, Bonifacio E. Autoantibody appearance and risk for development of childhood diabetes in offspring of parents with type 1 diabetes: The 2- year analysis of the German BABYDIAB Study. Diabetes 1999;48:460-468.
    • (1999) Diabetes , vol.48 , pp. 460-468
    • Ziegler, A.G.1    Hummel, M.2    Schenker, M.3    Bonifacio, E.4
  • 44
    • 2542505445 scopus 로고    scopus 로고
    • Brief communication: Early appearance of islet autoantibodies predicts childhood type 1 diabetes in offspring of diabetic parents
    • Hummel M, Bonifacio E, Schmid S, Walter M, Knopff A, Ziegler AG. Brief communication: early appearance of islet autoantibodies predicts childhood type 1 diabetes in offspring of diabetic parents. Ann Intern Med 2004;140: 882-886.
    • (2004) Ann Intern Med , vol.140 , pp. 882-886
    • Hummel, M.1    Bonifacio, E.2    Schmid, S.3    Walter, M.4    Knopff, A.5    Ziegler, A.G.6
  • 45
    • 84925503990 scopus 로고    scopus 로고
    • Progression from single to multiple islet autoantibodies often occurs soon after seroconversion: Implications for early screening
    • Chmiel R, Giannopoulou EZ, Winkler C, Achenbach P, Ziegler AG, Bonifacio E. Progression from single to multiple islet autoantibodies often occurs soon after seroconversion: implications for early screening. Diabetologia 2015; 58:411-413.
    • (2015) Diabetologia , vol.58 , pp. 411-413
    • Chmiel, R.1    Giannopoulou, E.Z.2    Winkler, C.3    Achenbach, P.4    Ziegler, A.G.5    Bonifacio, E.6
  • 46
    • 0025899032 scopus 로고
    • HLA-associated insulin autoantibody formation in newly diagnosed type I diabetic patients
    • Ziegler AG, Standl E, Albert E, Mehnert H. HLA-associated insulin autoantibody formation in newly diagnosed type I diabetic patients. Diabetes 1991;40:1146-1149.
    • (1991) Diabetes , vol.40 , pp. 1146-1149
    • Ziegler, A.G.1    Standl, E.2    Albert, E.3    Mehnert, H.4
  • 47
    • 0036319041 scopus 로고    scopus 로고
    • Genetic effects on age-dependent onset and islet cell autoantibody markers in type 1 diabetes
    • Diabetes Incidence in Sweden Study Group; Swedish Childhood Diabetes Study Group
    • Graham J, Hagopian WA, Kockum I, et al.; Diabetes Incidence in Sweden Study Group; Swedish Childhood Diabetes Study Group. Genetic effects on age-dependent onset and islet cell autoantibody markers in type 1 diabetes. Diabetes 2002;51:1346-1355.
    • (2002) Diabetes , vol.51 , pp. 1346-1355
    • Graham, J.1    Hagopian, W.A.2    Kockum, I.3
  • 48
    • 84866596750 scopus 로고    scopus 로고
    • Zinctransporter 8 autoantibodies and their association with SLC30A8 and HLA-DQ genes differ between immigrant and Swedish patients with newly diagnosed type 1 diabetes in the Better Diabetes Diagnosis study
    • Better Diabetes Diagnosis Study Group
    • Delli AJ, Vaziri-Sani F, Lindblad B, et al.; Better Diabetes Diagnosis Study Group. Zinctransporter 8 autoantibodies and their association with SLC30A8 and HLA-DQ genes differ between immigrant and Swedish patients with newly diagnosed type 1 diabetes in the Better Diabetes Diagnosis study. Diabetes 2012;61:2556-2564.
    • (2012) Diabetes , vol.61 , pp. 2556-2564
    • Delli, A.J.1    Vaziri-Sani, F.2    Lindblad, B.3
  • 49
    • 79951713180 scopus 로고    scopus 로고
    • Islet autoantibody seroconversion in the DPT-1 study: Justification for repeat screening throughout childhood
    • DPT-1 Study Group
    • Vehik K, Haller MJ, Beam CA, et al.; DPT-1 Study Group. Islet autoantibody seroconversion in the DPT-1 study: justification for repeat screening throughout childhood. Diabetes Care 2011;34:358-362.
    • (2011) Diabetes Care , vol.34 , pp. 358-362
    • Vehik, K.1    Haller, M.J.2    Beam, C.A.3
  • 50
    • 84856689949 scopus 로고    scopus 로고
    • Development of autoantibodies in the TrialNet Natural History Study
    • TrialNet Natural History Study Group
    • Vehik K, Beam CA, Mahon JL, et al.; TrialNet Natural History Study Group. Development of autoantibodies in the TrialNet Natural History Study. Diabetes Care 2011;34:1897-1901.
    • (2011) Diabetes Care , vol.34 , pp. 1897-1901
    • Vehik, K.1    Beam, C.A.2    Mahon, J.L.3
  • 51
    • 84937774881 scopus 로고    scopus 로고
    • General population screening for type 1 diabetes: Has its time come?
    • Insel R, Dunne J, Ziegler A. General population screening for type 1 diabetes: has its time come? Curr Opin Endocrinol Diabetes Obes 2015;22:270-276.
    • (2015) Curr Opin Endocrinol Diabetes Obes , vol.22 , pp. 270-276
    • Insel, R.1    Dunne, J.2    Ziegler, A.3
  • 52
    • 0842288452 scopus 로고    scopus 로고
    • Stratification of type 1 diabetes risk on the basis of islet autoantibody characteristics
    • Achenbach P, Warncke K, Reiter J, et al. Stratification of type 1 diabetes risk on the basis of islet autoantibody characteristics. Diabetes 2004;53:384-392.
    • (2004) Diabetes , vol.53 , pp. 384-392
    • Achenbach, P.1    Warncke, K.2    Reiter, J.3
  • 54
    • 80051979794 scopus 로고    scopus 로고
    • Age of islet autoantibody appearance and mean levels of insulin, but not GAD or IA-2 autoantibodies, predict age of diagnosis of type 1 diabetes: Diabetes autoimmunity study in the young
    • Steck AK, Johnson K, Barriga KJ, et al. Age of islet autoantibody appearance and mean levels of insulin, but not GAD or IA-2 autoantibodies, predict age of diagnosis of type 1 diabetes: diabetes autoimmunity study in the young. Diabetes Care 2011;34:1397-1399.
    • (2011) Diabetes Care , vol.34 , pp. 1397-1399
    • Steck, A.K.1    Johnson, K.2    Barriga, K.J.3
  • 55
    • 4344690190 scopus 로고    scopus 로고
    • Mature high-affinity immune responses to (pro)insulin anticipate the autoimmune cascade that leads to type 1 diabetes
    • Achenbach P, Koczwara K, Knopff A, Naserke H, Ziegler AG, Bonifacio E. Mature high-affinity immune responses to (pro)insulin anticipate the autoimmune cascade that leads to type 1 diabetes. J Clin Invest 2004;114:589- 597.
    • (2004) J Clin Invest , vol.114 , pp. 589-597
    • Achenbach, P.1    Koczwara, K.2    Knopff, A.3    Naserke, H.4    Ziegler, A.G.5    Bonifacio, E.6
  • 56
    • 84886055195 scopus 로고    scopus 로고
    • Proinsulin/insulin autoantibodies measured with electrochemiluminescent assay are the earliest indicator of prediabetic islet autoimmunity
    • Yu L, Dong F, Miao D, Fouts AR, Wenzlau JM, Steck AK. Proinsulin/insulin autoantibodies measured with electrochemiluminescent assay are the earliest indicator of prediabetic islet autoimmunity. Diabetes Care 2013;36:2266-2270.
    • (2013) Diabetes Care , vol.36 , pp. 2266-2270
    • Yu, L.1    Dong, F.2    Miao, D.3    Fouts, A.R.4    Wenzlau, J.M.5    Steck, A.K.6
  • 57
    • 77949273351 scopus 로고    scopus 로고
    • Predictive power of screening for antibodies against insulinomaassociated protein 2 beta (IA-2beta) and zinc transporter-8 to select first-degree relatives of type 1 diabetic patients with risk of rapid progression to clinical onset of the disease: Implications for prevention trials
    • Belgian Diabetes Registry
    • De Grijse J, Asanghanwa M, Nouthe B, et al.; Belgian Diabetes Registry. Predictive power of screening for antibodies against insulinomaassociated protein 2 beta (IA-2beta) and zinc transporter-8 to select first-degree relatives of type 1 diabetic patients with risk of rapid progression to clinical onset of the disease: implications for prevention trials. Diabetologia 2010;53: 517-524.
    • (2010) Diabetologia , vol.53 , pp. 517-524
    • De Grijse, J.1    Asanghanwa, M.2    Nouthe, B.3
  • 58
    • 84870442527 scopus 로고    scopus 로고
    • Screening for insulinoma antigen 2 and zinc transporter 8 autoantibodies: A cost-effective and age-independent strategy to identify rapid progressors to clinical onset among relatives of type 1 diabetic patients
    • Belgian Diabetes Registry
    • Gorus FK, Balti EV, Vermeulen I, et al.; Belgian Diabetes Registry. Screening for insulinoma antigen 2 and zinc transporter 8 autoantibodies: A cost-effective and age-independent strategy to identify rapid progressors to clinical onset among relatives of type 1 diabetic patients. Clin Exp Immunol 2013;171:82-90.
    • (2013) Clin Exp Immunol , vol.171 , pp. 82-90
    • Gorus, F.K.1    Balti, E.V.2    Vermeulen, I.3
  • 59
    • 84922463345 scopus 로고    scopus 로고
    • Electrochemiluminescence assays for insulin and glutamic acid decarboxylase autoantibodies improve prediction of type 1 diabetes risk
    • Type 1 Diabetes TrialNet Study Group
    • Miao D, Steck AK, Zhang L, et al.; Type 1 Diabetes TrialNet Study Group. Electrochemiluminescence assays for insulin and glutamic acid decarboxylase autoantibodies improve prediction of type 1 diabetes risk. Diabetes Technol Ther 2015;17:119-127.
    • (2015) Diabetes Technol Ther , vol.17 , pp. 119-127
    • Miao, D.1    Steck, A.K.2    Zhang, L.3
  • 60
    • 84891767179 scopus 로고    scopus 로고
    • Islet autoantibody testing: An end to the trials and tribulations?
    • Bingley PJ, Williams AJ. Islet autoantibody testing: An end to the trials and tribulations? Diabetes 2013;62:4009-4011.
    • (2013) Diabetes , vol.62 , pp. 4009-4011
    • Bingley, P.J.1    Williams, A.J.2
  • 61
    • 84555186979 scopus 로고    scopus 로고
    • Distinguishing persistent insulin autoantibodies with differential risk: Nonradioactive bivalent proinsulin/insulin autoantibody assay
    • Yu L, Miao D, Scrimgeour L, Johnson K, Rewers M, Eisenbarth GS. Distinguishing persistent insulin autoantibodies with differential risk: nonradioactive bivalent proinsulin/insulin autoantibody assay. Diabetes 2012;61:179- 186.
    • (2012) Diabetes , vol.61 , pp. 179-186
    • Yu, L.1    Miao, D.2    Scrimgeour, L.3    Johnson, K.4    Rewers, M.5    Eisenbarth, G.S.6
  • 62
    • 84891821090 scopus 로고    scopus 로고
    • GAD65 autoantibodies detected by electrochemiluminescence assay identify high risk for type 1 diabetes
    • Miao D, Guyer KM, Dong F, et al. GAD65 autoantibodies detected by electrochemiluminescence assay identify high risk for type 1 diabetes. Diabetes 2013;62:4174-4178.
    • (2013) Diabetes , vol.62 , pp. 4174-4178
    • Miao, D.1    Guyer, K.M.2    Dong, F.3
  • 63
    • 69549089992 scopus 로고    scopus 로고
    • Incident dysglycemia and progression to type 1 diabetes among participants in the diabetes prevention Trial-Type 1
    • Diabetes Prevention Trial-Type 1 Study Group
    • Sosenko JM, Palmer JP, Rafkin-Mervis L, et al.; Diabetes Prevention Trial-Type 1 Study Group. Incident dysglycemia and progression to type 1 diabetes among participants in the Diabetes Prevention Trial-Type 1. Diabetes Care 2009;32:1603-1607.
    • (2009) Diabetes Care , vol.32 , pp. 1603-1607
    • Sosenko, J.M.1    Palmer, J.P.2    Rafkin-Mervis, L.3
  • 64
    • 84926338262 scopus 로고    scopus 로고
    • Standards of medical care in diabetesd 2015
    • American Diabetes Association. Classification and diagnosis of diabetes. Sec. 2
    • American Diabetes Association. Classification and diagnosis of diabetes. Sec. 2. In Standards of Medical Care in Diabetesd2015. Diabetes Care 2015;38(Suppl.1):S8-S16.
    • (2015) Diabetes Care , vol.38 , pp. S8-S16
  • 65
    • 84930841315 scopus 로고    scopus 로고
    • American association of clinical endocrinologists and American college of endocrinologydclinical practice guidelines for developing a diabetes mellitus comprehensive care pland2015
    • Handelsman Y, Bloomgarden ZT, Grunberger G, et al. American Association of Clinical Endocrinologists and American College of Endocrinologydclinical practice guidelines for developing a diabetes mellitus comprehensive care pland2015. Endocr Pract 2015; 21(Suppl.1):1-87.
    • (2015) Endocr Pract , vol.21 , pp. 1-87
    • Handelsman, Y.1    Bloomgarden, Z.T.2    Grunberger, G.3
  • 66
    • 80052572136 scopus 로고    scopus 로고
    • Metabolic tests to determine risk for type 1 diabetes in clinical trials
    • Diabetes Prevention Trial, Type 1 Diabetes (DPT-1) Study Group
    • Greenbaum CJ, Buckingham B, Chase HP, Krischer J; Diabetes Prevention Trial, Type 1 Diabetes (DPT-1) Study Group. Metabolic tests to determine risk for type 1 diabetes in clinical trials. Diabetes Metab Res Rev 2011;27:584-589.
    • (2011) Diabetes Metab Res, Rev , vol.27 , pp. 584-589
    • Greenbaum, C.J.1    Buckingham, B.2    Chase, H.P.3    Krischer, J.4
  • 67
    • 84861868035 scopus 로고    scopus 로고
    • The metabolic progression to type 1 diabetes as indicated by serial oral glucose tolerance testing in the diabetes prevention trial-Type 1
    • Type 1 Diabetes TrialNet and Diabetes Prevention Trial-Type 1 Study Groups
    • Sosenko JM, Skyler JS, Herold KC, Palmer JP; Type 1 Diabetes TrialNet and Diabetes Prevention Trial-Type 1 Study Groups. The metabolic progression to type 1 diabetes as indicated by serial oral glucose tolerance testing in the Diabetes Prevention Trial-Type 1. Diabetes 2012; 61:1331-1337.
    • (2012) Diabetes , vol.61 , pp. 1331-1337
    • Sosenko, J.M.1    Skyler, J.S.2    Herold, K.C.3    Palmer, J.P.4
  • 68
    • 84891812006 scopus 로고    scopus 로고
    • Acceleration of the loss of the first-phase insulin response during the progression to type 1 diabetes in diabetes prevention Trial-Type 1 participants
    • Type 1 Diabetes TrialNet and Diabetes Prevention Trial- Type 1 Study Groups
    • Sosenko JM, Skyler JS, Beam CA, et al.; Type 1 Diabetes TrialNet and Diabetes Prevention Trial- Type 1 Study Groups. Acceleration of the loss of the first-phase insulin response during the progression to type 1 diabetes in Diabetes Prevention Trial-Type 1 participants. Diabetes 2013;62: 4179-4183.
    • (2013) Diabetes , vol.62 , pp. 4179-4183
    • Sosenko, J.M.1    Skyler, J.S.2    Beam, C.A.3
  • 69
    • 0026022192 scopus 로고
    • Predictive value of intravenous glucose tolerance test insulin secretion less than or greater than the first percentile in islet cell antibody positive relatives of type 1 (insulin-dependent) diabetic patients
    • Vardi P, Crisa L, Jackson RA. Predictive value of intravenous glucose tolerance test insulin secretion less than or greater than the first percentile in islet cell antibody positive relatives of type 1 (insulin-dependent) diabetic patients. Diabetologia 1991;34:93-102.
    • (1991) Diabetologia , vol.34 , pp. 93-102
    • Vardi, P.1    Crisa, L.2    Jackson, R.A.3
  • 70
    • 33744995996 scopus 로고    scopus 로고
    • Patterns of metabolic progression to type 1 diabetes in the Diabetes Prevention Trial-Type 1
    • Sosenko JM, Palmer JP, Greenbaum CJ, et al. Patterns of metabolic progression to type 1 diabetes in the Diabetes Prevention Trial-Type 1. Diabetes Care 2006;29:643-649.
    • (2006) Diabetes Care , vol.29 , pp. 643-649
    • Sosenko, J.M.1    Palmer, J.P.2    Greenbaum, C.J.3
  • 71
    • 79951710703 scopus 로고    scopus 로고
    • Prognostic performance of metabolic indexes in predicting onset of type 1 diabetes
    • Diabetes Prevention Trial-Type 1 (DPT-1) Study Group
    • Xu P, Wu Y, Zhu Y, et al.; Diabetes Prevention Trial-Type 1 (DPT-1) Study Group. Prognostic performance of metabolic indexes in predicting onset of type 1 diabetes. Diabetes Care 2010;33:2508-2513.
    • (2010) Diabetes Care , vol.33 , pp. 2508-2513
    • Xu, P.1    Wu, Y.2    Zhu, Y.3
  • 72
    • 77950356610 scopus 로고    scopus 로고
    • Progression to diabetes in relatives of type 1 diabetic patients: Mechanisms and mode of onset
    • DPT-1 Study Group
    • Ferrannini E, Mari A, Nofrate V, Sosenko JM, Skyler JS; DPT-1 Study Group. Progression to diabetes in relatives of type 1 diabetic patients: mechanisms and mode of onset. Diabetes 2010;59:679-685.
    • (2010) Diabetes , vol.59 , pp. 679-685
    • Ferrannini, E.1    Mari, A.2    Nofrate, V.3    Sosenko, J.M.4    Skyler, J.S.5
  • 73
    • 28444472424 scopus 로고    scopus 로고
    • Impaired beta cell glucose sensitivity and whole-body insulin sensitivity as predictors of hyperglycaemia in non-diabetic subjects
    • Walker M, Mari A, Jayapaul MK, Bennett SM, Ferrannini E. Impaired beta cell glucose sensitivity and whole-body insulin sensitivity as predictors of hyperglycaemia in non-diabetic subjects. Diabetologia 2005;48:2470-2476.
    • (2005) Diabetologia , vol.48 , pp. 2470-2476
    • Walker, M.1    Mari, A.2    Jayapaul, M.K.3    Bennett, S.M.4    Ferrannini, E.5
  • 74
    • 33847636157 scopus 로고    scopus 로고
    • Progressive loss of beta-cell function leads to worsening glucose tolerance in first-degree relatives of subjects with type 2 diabetes
    • Cnop M, Vidal J, Hull RL, et al. Progressive loss of beta-cell function leads to worsening glucose tolerance in first-degree relatives of subjects with type 2 diabetes. Diabetes Care 2007;30:677-682.
    • (2007) Diabetes Care , vol.30 , pp. 677-682
    • Cnop, M.1    Vidal, J.2    Hull, R.L.3
  • 75
    • 77957564957 scopus 로고    scopus 로고
    • Glucose excursions between states of glycemia with progression to type 1 diabetes in the Diabetes Prevention Trial-Type 1 (DPT-1)
    • Diabetes Prevention Trial-Type 1 Study Group
    • Sosenko JM, Skyler JS, Krischer JP, et al.; Diabetes Prevention Trial-Type 1 Study Group. Glucose excursions between states of glycemia with progression to type 1 diabetes in the Diabetes Prevention Trial-Type 1 (DPT-1). Diabetes 2010;59:2386-2389.
    • (2010) Diabetes , vol.59 , pp. 2386-2389
    • Sosenko, J.M.1    Skyler, J.S.2    Krischer, J.P.3
  • 76
    • 56649115489 scopus 로고    scopus 로고
    • Glucose and C-peptide changes in the perionset period of type 1 diabetes in the Diabetes Prevention Trial-Type 1
    • Sosenko JM, Palmer JP, Rafkin-Mervis L, et al. Glucose and C-peptide changes in the perionset period of type 1 diabetes in the Diabetes Prevention Trial-Type 1. Diabetes Care 2008;31: 2188-2192.
    • (2008) Diabetes Care , vol.31 , pp. 2188-2192
    • Sosenko, J.M.1    Palmer, J.P.2    Rafkin-Mervis, L.3
  • 78
    • 34548431028 scopus 로고    scopus 로고
    • Role of insulin resistance in predicting progression to type 1 diabetes
    • Diabetes Prevention Trial-Type 1 Study Group
    • Xu P, Cuthbertson D, Greenbaum C, Palmer JP, Krischer JP; Diabetes Prevention Trial-Type 1 Study Group. Role of insulin resistance in predicting progression to type 1 diabetes. Diabetes Care 2007;30:2314-2320.
    • (2007) Diabetes Care , vol.30 , pp. 2314-2320
    • Xu, P.1    Cuthbertson, D.2    Greenbaum, C.3    Palmer, J.P.4    Krischer, J.P.5
  • 79
    • 38149011472 scopus 로고    scopus 로고
    • Insulin resistance and progression to type 1 diabetes in the European Nicotinamide Diabetes Intervention Trial (ENDIT)
    • European Nicotinamide Diabetes Intervention Trial Group
    • Bingley PJ, Mahon JL, Gale EA; European Nicotinamide Diabetes Intervention Trial Group. Insulin resistance and progression to type 1 diabetes in the European Nicotinamide Diabetes Intervention Trial (ENDIT). Diabetes Care 2008;31:146-150.
    • (2008) Diabetes Care , vol.31 , pp. 146-150
    • Bingley, P.J.1    Mahon, J.L.2    Gale, E.A.3
  • 80
    • 84865471364 scopus 로고    scopus 로고
    • Performance of HbA1c as an early diagnostic indicator of type 1 diabetes in children and youth
    • TEDDY, TRIGR, Diabetes Prevention Trial-Type 1, and Type 1 Diabetes TrialNet Natural History Study Groups
    • Vehik K, Cuthbertson D, Boulware D, et al.; TEDDY, TRIGR, Diabetes Prevention Trial-Type 1, and Type 1 Diabetes TrialNet Natural History Study Groups. Performance of HbA1c as an early diagnostic indicator of type 1 diabetes in children and youth. Diabetes Care 2012;35:1821- 1825.
    • (2012) Diabetes Care , vol.35 , pp. 1821-1825
    • Vehik, K.1    Cuthbertson, D.2    Boulware, D.3
  • 81
    • 33750140236 scopus 로고    scopus 로고
    • Normal but increasing hemoglobin A1c levels predict progression from islet autoimmunity to overt type 1 diabetes: Diabetes Autoimmunity Study in the Young (DAISY)
    • Stene LC, Barriga K, Hoffman M, et al. Normal but increasing hemoglobin A1c levels predict progression from islet autoimmunity to overt type 1 diabetes: Diabetes Autoimmunity Study in the Young (DAISY). Pediatr Diabetes 2006;7:247-253.
    • (2006) Pediatr Diabetes , vol.7 , pp. 247-253
    • Stene, L.C.1    Barriga, K.2    Hoffman, M.3
  • 82
    • 84933519614 scopus 로고    scopus 로고
    • HbA1c predicts time to diagnosis of type 1 diabetes in children at risk
    • Helminen O, Aspholm S, Pokka T, et al. HbA1c predicts time to diagnosis of type 1 diabetes in children at risk. Diabetes 2015;64: 1719-1727.
    • (2015) Diabetes , vol.64 , pp. 1719-1727
    • Helminen, O.1    Aspholm, S.2    Pokka, T.3
  • 83
    • 2542484935 scopus 로고    scopus 로고
    • Clinical characteristics of children diagnosed with type 1 diabetes through intensive screening and follow-up
    • DAISY Study
    • Barker JM, Goehrig SH, Barriga K, et al.; DAISY Study. Clinical characteristics of children diagnosed with type 1 diabetes through intensive screening and follow-up. Diabetes Care 2004;27:1399-1404.
    • (2004) Diabetes Care , vol.27 , pp. 1399-1404
    • Barker, J.M.1    Goehrig, S.H.2    Barriga, K.3
  • 84
    • 84857073801 scopus 로고    scopus 로고
    • Reduced prevalence of diabetic ketoacidosis at diagnosis of type 1 diabetes in young children participating in longitudinal follow-up
    • TEDDY Study Group; SEARCH Study Group; Swediabkids Study Group; DPV Study Group; Finnish Diabetes Registry Study Group
    • Elding Larsson H, Vehik K, Bell R, et al.; TEDDY Study Group; SEARCH Study Group; Swediabkids Study Group; DPV Study Group; Finnish Diabetes Registry Study Group. Reduced prevalence of diabetic ketoacidosis at diagnosis of type 1 diabetes in young children participating in longitudinal follow-up. Diabetes Care 2011;34:2347-2352.
    • (2011) Diabetes Care , vol.34 , pp. 2347-2352
    • Elding Larsson, H.1    Vehik, K.2    Bell, R.3
  • 85
    • 84861711458 scopus 로고    scopus 로고
    • Markedly reduced rate of diabetic ketoacidosis at onset of type 1 diabetes in relatives screened for islet autoantibodies
    • Winkler C, Schober E, Ziegler AG, Holl RW. Markedly reduced rate of diabetic ketoacidosis at onset of type 1 diabetes in relatives screened for islet autoantibodies. Pediatr Diabetes 2012; 13:308-313.
    • (2012) Pediatr Diabetes , vol.13 , pp. 308-313
    • Winkler, C.1    Schober, E.2    Ziegler, A.G.3    Holl, R.W.4
  • 86
    • 65949083333 scopus 로고    scopus 로고
    • Diabetic subjects diagnosed through the Diabetes Prevention Trial-Type 1 (DPT-1) are often asymptomatic with normal A1C at diabetes onset
    • DPT-1 Study Group
    • Triolo TM, Chase HP, Barker JM; DPT-1 Study Group. Diabetic subjects diagnosed through the Diabetes Prevention Trial-Type 1 (DPT-1) are often asymptomatic with normal A1C at diabetes onset. Diabetes Care 2009;32: 769-773.
    • (2009) Diabetes, Care , vol.32 , pp. 769-773
    • Triolo, T.M.1    Chase, H.P.2    Barker, J.M.3
  • 87
    • 84898745025 scopus 로고    scopus 로고
    • Trends in the prevalence of ketoacidosis at diabetes diagnosis: The SEARCH for Diabetes in Youth study
    • SEARCH for Diabetes in Youth Study Group
    • Dabelea D, Rewers A, Stafford JM, et al.; SEARCH for Diabetes in Youth Study Group. Trends in the prevalence of ketoacidosis at diabetes diagnosis: The SEARCH for Diabetes in Youth study. Pediatrics 2014;133:e938-e945.
    • (2014) Pediatrics , vol.133 , pp. e938-e945
    • Dabelea, D.1    Rewers, A.2    Stafford, J.M.3
  • 88
    • 84928403771 scopus 로고    scopus 로고
    • Incidence of diabetic ketoacidosis at diagnosis of type 1 diabetes in Colorado youth, 1998-2012
    • Rewers A, Dong F, Slover RH, Klingensmith GJ, Rewers M. Incidence of diabetic ketoacidosis at diagnosis of type 1 diabetes in Colorado youth, 1998-2012. JAMA 2015;313:1570-1572.
    • (2015) JAMA , vol.313 , pp. 1570-1572
    • Rewers, A.1    Dong, F.2    Slover, R.H.3    Klingensmith, G.J.4    Rewers, M.5
  • 89
    • 0029831007 scopus 로고    scopus 로고
    • Ketoacidosis at diagnosis is predictive of lower residual beta-cell function and poor metabolic control in type 1 diabetes
    • Fernandez Castañer M, Montaña E, Camps I, et al. Ketoacidosis at diagnosis is predictive of lower residual beta-cell function and poor metabolic control in type 1 diabetes. Diabetes Metab 1996;22:349-355.
    • (1996) Diabetes Metab , vol.22 , pp. 349-355
    • Fernandez, C.M.1    Montaña, E.2    Camps, I.3
  • 90
    • 44649164537 scopus 로고    scopus 로고
    • Young children (, 5 yr) and adolescents (.12 yr) with type 1 diabetes mellitus have low rate of partial remission: Diabetic ketoacidosis is an important risk factor
    • Bowden SA, Duck MM, Hoffman RP. Young children (, 5 yr) and adolescents (.12 yr) with type 1 diabetes mellitus have low rate of partial remission: diabetic ketoacidosis is an important risk factor. Pediatr Diabetes 2008;9:197-201.
    • (2008) Pediatr Diabetes , vol.9 , pp. 197-201
    • Bowden, S.A.1    Duck, M.M.2    Hoffman, R.P.3
  • 91
    • 84901478265 scopus 로고    scopus 로고
    • Neurological consequences of diabetic ketoacidosis at initial presentation of type 1 diabetes in a prospective cohort study of children
    • DKA Brain Injury Study Group
    • Cameron FJ, Scratch SE, Nadebaum C, et al.; DKA Brain Injury Study Group. Neurological consequences of diabetic ketoacidosis at initial presentation of type 1 diabetes in a prospective cohort study of children. Diabetes Care 2014; 37:1554-1562.
    • (2014) Diabetes Care , vol.37 , pp. 1554-1562
    • Cameron, F.J.1    Scratch, S.E.2    Nadebaum, C.3
  • 92
    • 0032055459 scopus 로고    scopus 로고
    • Effect of intensive therapy on residual beta-cell function in patients with type 1 diabetes in the diabetes control and complications trial. A randomized, controlled trial
    • The Diabetes Control and Complications Trial Research Group
    • The Diabetes Control and Complications Trial Research Group. Effect of intensive therapy on residual beta-cell function in patients with type 1 diabetes in the diabetes control and complications trial. A randomized, controlled trial. Ann Intern Med 1998;128:517-523.
    • (1998) Ann Intern Med , vol.128 , pp. 517-523
  • 93
    • 0041666293 scopus 로고    scopus 로고
    • Beta-cell function and the development of diabetes-related complications in the diabetes control and complications trial
    • Steffes MW, Sibley S, Jackson M, Thomas W. Beta-cell function and the development of diabetes-related complications in the diabetes control and complications trial. Diabetes Care 2003;26:832-836.
    • (2003) Diabetes Care , vol.26 , pp. 832-836
    • Steffes, M.W.1    Sibley, S.2    Jackson, M.3    Thomas, W.4
  • 94
    • 0017740757 scopus 로고
    • C-peptide in juvenile diabetics beyond the postinitial remission period. Relation to clinical manifestations at onset of diabetes, remission and diabetic control
    • Ludvigsson J, Heding LG, Larsson Y, Leander E. C-peptide in juvenile diabetics beyond the postinitial remission period. Relation to clinical manifestations at onset of diabetes, remission and diabetic control. Acta Paediatr Scand 1977;66:177-184.
    • (1977) Acta Paediatr Scand , vol.66 , pp. 177-184
    • Ludvigsson, J.1    Heding, L.G.2    Larsson, Y.3    Leander, E.4
  • 95
    • 84920538565 scopus 로고    scopus 로고
    • Association between 7 years of intensive treatment of type 1 diabetes and long-term mortality
    • Writing Group for the DCCT/EDIC Research Group
    • Orchard TJ, Nathan DM, Zinman B, et al.; Writing Group for the DCCT/EDIC Research Group. Association between 7 years of intensive treatment of type 1 diabetes and long-term mortality. JAMA 2015;313:45-53.
    • (2015) JAMA , vol.313 , pp. 45-53
    • Orchard, T.J.1    Nathan, D.M.2    Zinman, B.3
  • 96
    • 84907952499 scopus 로고    scopus 로고
    • Reduced mortality at diagnosis and improved glycemic control in children previously enrolled in DiPiS follow-up
    • DiPiS Study Group
    • Lundgren M, Sahlin A, Svensson C, et al.; DiPiS Study Group. Reduced mortality at diagnosis and improved glycemic control in children previously enrolled in DiPiS follow-up. Pediatr Diabetes 2014;15:494-501.
    • (2014) Pediatr Diabetes , vol.15 , pp. 494-501
    • Lundgren, M.1    Sahlin, A.2    Svensson, C.3
  • 97
    • 84879274635 scopus 로고    scopus 로고
    • Most youth with type 1 diabetes in the T1D Exchange clinic registry do not meet American Diabetes association or international society for pediatric and adolescent diabetes clinical guidelines
    • T1D Exchange Clinic Network
    • Wood JR, Miller KM, Maahs DM, et al.; T1D Exchange Clinic Network. Most youth with type 1 diabetes in the T1D Exchange clinic registry do not meet American Diabetes Association or International Society for Pediatric and Adolescent Diabetes clinical guidelines. Diabetes Care 2013; 36:2035-2037.
    • (2013) Diabetes Care , vol.36 , pp. 2035-2037
    • Wood, J.R.1    Miller, K.M.2    Maahs, D.M.3
  • 98
    • 84901497575 scopus 로고    scopus 로고
    • Longitudinal associations between sex, diabetes self-care, and health-related quality of life among youth with type 1 or type 2 diabetes mellitus
    • SEARCH for Diabetes in Youth Study Group., e1
    • Naughton MJ, Yi-Frazier JP, Morgan TM, et al.; SEARCH for Diabetes in Youth Study Group. Longitudinal associations between sex, diabetes self-care, and health-related quality of life among youth with type 1 or type 2 diabetes mellitus. J Pediatr 2014;164:1376-1383.e1.
    • (2014) J Pediatr , vol.164 , pp. 1376-1383
    • Naughton, M.J.1    Yi-Frazier, J.P.2    Morgan, T.M.3
  • 99
    • 84920509071 scopus 로고    scopus 로고
    • Estimated life expectancy in a Scottish cohort with type 1 diabetes, 2008-2010
    • Scottish Diabetes Research Network Epidemiology Group; Scottish Renal Registry
    • Livingstone SJ, Levin D, Looker HC, et al.; Scottish Diabetes Research Network Epidemiology Group; Scottish Renal Registry. Estimated life expectancy in a Scottish cohort with type 1 diabetes, 2008-2010. JAMA 2015;313:37-44.
    • (2015) JAMA , vol.313 , pp. 37-44
    • Livingstone, S.J.1    Levin, D.2    Looker, H.C.3
  • 100
    • 84911375963 scopus 로고    scopus 로고
    • Glycemic control and excess mortality in type 1 diabetes
    • Lind M, Svensson AM, Kosiborod M, et al. Glycemic control and excess mortality in type 1 diabetes. N Engl J Med 2014;371:1972-1982.
    • (2014) N Engl J Med , vol.371 , pp. 1972-1982
    • Lind, M.1    Svensson, A.M.2    Kosiborod, M.3
  • 101
    • 59649105735 scopus 로고    scopus 로고
    • Dysregulation of lipid and amino acid metabolism precedes islet autoimmunity in children who later progress to type 1 diabetes
    • Oresic M, Simell S, Sysi-Aho M, et al. Dysregulation of lipid and amino acid metabolism precedes islet autoimmunity in children who later progress to type 1 diabetes. J Exp Med 2008;205:2975-2984.
    • (2008) J Exp Med , vol.205 , pp. 2975-2984
    • Oresic, M.1    Simell, S.2    Sysi-Aho, M.3
  • 102
    • 84883230213 scopus 로고    scopus 로고
    • Cord serum lipidome in prediction of islet autoimmunity and type 1 diabetes
    • Oresic M, Gopalacharyulu P, Mykkänen J, et al. Cord serum lipidome in prediction of islet autoimmunity and type 1 diabetes. Diabetes 2013;62:3268-3274.
    • (2013) Diabetes , vol.62 , pp. 3268-3274
    • Oresic, M.1    Gopalacharyulu, P.2    Mykkänen, J.3
  • 103
    • 84890747164 scopus 로고    scopus 로고
    • Decreased cordblood phospholipids in young age-at-onset type 1 diabetes
    • DiPiS Study Group
    • La Torre D, Seppänen-Laakso T, Larsson HE, et al.; DiPiS Study Group. Decreased cordblood phospholipids in young age-at-onset type 1 diabetes. Diabetes 2013;62:3951-3956.
    • (2013) Diabetes , vol.62 , pp. 3951-3956
    • La Torre, D.1    Seppänen-Laakso, T.2    Larsson, H.E.3
  • 104
    • 84879520258 scopus 로고    scopus 로고
    • Metabolomics in the studies of islet autoimmunity and type 1 diabetes
    • Oresic M. Metabolomics in the studies of islet autoimmunity and type 1 diabetes. Rev Diabet Stud 2012;9:236-247.
    • (2012) Rev Diabet Stud , vol.9 , pp. 236-247
    • Oresic, M.1
  • 105
    • 84903691108 scopus 로고    scopus 로고
    • Biomarker discovery study design for type 1 diabetes in The Environmental Determinants of Diabetes in the Young (TEDDY) study
    • TEDDY Study Group
    • Lee HS, Burkhardt BR, McLeod W, et al.; TEDDY Study Group. Biomarker discovery study design for type 1 diabetes in The Environmental Determinants of Diabetes in the Young (TEDDY) study. Diabetes Metab Res Rev 2014;30:424-434.
    • (2014) Diabetes Metab Res Rev , vol.30 , pp. 424-434
    • Lee, H.S.1    Burkhardt, B.R.2    McLeod, W.3
  • 106
    • 84904241519 scopus 로고    scopus 로고
    • The intestinal microbiome in type 1 diabetes
    • Dunne JL, Triplett EW, Gevers D, et al. The intestinal microbiome in type 1 diabetes. Clin Exp Immunol 2014;177:30-37.
    • (2014) Clin Exp Immunol , vol.177 , pp. 30-37
    • Dunne, J.L.1    Triplett, E.W.2    Gevers, D.3
  • 107
    • 78650616947 scopus 로고    scopus 로고
    • Toward defining the autoimmune microbiome for type 1 diabetes
    • Giongo A, Gano KA, Crabb DB, et al. Toward defining the autoimmune microbiome for type 1 diabetes. ISME J 2011;5:82-91.
    • (2011) ISME J , vol.5 , pp. 82-91
    • Giongo, A.1    Gano, K.A.2    Crabb, D.B.3
  • 108
    • 84904741913 scopus 로고    scopus 로고
    • Aberrant gut microbiota composition at the onset of type 1 diabetes in young children
    • de Goffau MC, Fuentes S, van den Bogert B, et al. Aberrant gut microbiota composition at the onset of type 1 diabetes in young children. Diabwetologia 2014;57:1569-1577.
    • (2014) Diabwetologia , vol.57 , pp. 1569-1577
    • De Goffau, M.C.1    Fuentes, S.2    Van Den Bogert, B.3
  • 109
    • 84901330157 scopus 로고    scopus 로고
    • Compromised gut microbiota networks in children with anti-islet cell autoimmunity
    • Endesfelder D, zu Castell W, Ardissone A, et al. Compromised gut microbiota networks in children with anti-islet cell autoimmunity. Diabetes 2014;63:2006-2014.
    • (2014) Diabetes , vol.63 , pp. 2006-2014
    • Endesfelder, D.1    Zu Castell, W.2    Ardissone, A.3
  • 110
    • 84922941772 scopus 로고    scopus 로고
    • The dynamics of the human infant gut microbiome in development and in progression toward type 1 diabetes
    • DIABIMMUNE Study Group
    • Kostic AD, Gevers D, Siljander H, et al.; DIABIMMUNE Study Group. The dynamics of the human infant gut microbiome in development and in progression toward type 1 diabetes. Cell Host Microbe 2015;17:260-273.
    • (2015) Cell Host Microbe , vol.17 , pp. 260-273
    • Kostic, A.D.1    Gevers, D.2    Siljander, H.3
  • 111
    • 84870911405 scopus 로고    scopus 로고
    • Transcriptional signatures as a disease-specific and predictive inflammatory biomarker for type 1 diabetes
    • Levy H, Wang X, Kaldunski M, et al. Transcriptional signatures as a disease-specific and predictive inflammatory biomarker for type 1 diabetes. Genes Immun 2012;13:593-604.
    • (2012) Genes Immun , vol.13 , pp. 593-604
    • Levy, H.1    Wang, X.2    Kaldunski, M.3
  • 112
    • 84906086651 scopus 로고    scopus 로고
    • Molecular signatures differentiate immune states in type 1 diabetic families
    • Chen YG, Cabrera SM, Jia S, et al. Molecular signatures differentiate immune states in type 1 diabetic families. Diabetes 2014;63: 3960-3973.
    • (2014) Diabetes , vol.63 , pp. 3960-3973
    • Chen, Y.G.1    Cabrera, S.M.2    Jia, S.3
  • 113
    • 84903188015 scopus 로고    scopus 로고
    • A type I interferon transcriptional signature precedes autoimmunity in children genetically at risk for type 1 diabetes
    • Ferreira RC, Guo H, Coulson RM, et al. A type I interferon transcriptional signature precedes autoimmunity in children genetically at risk for type 1 diabetes. Diabetes 2014;63: 2538-2550.
    • (2014) Diabetes , vol.63 , pp. 2538-2550
    • Ferreira, R.C.1    Guo, H.2    Coulson, R.M.3
  • 114
    • 84903184518 scopus 로고    scopus 로고
    • Innate immune activity is detected prior to seroconversion in children with HLA-conferred type 1 diabetes susceptibility
    • Kallionpää H, Elo LL, Laajala E, et al. Innate immune activity is detected prior to seroconversion in children with HLA-conferred type 1 diabetes susceptibility. Diabetes 2014;63: 2402-2414.
    • (2014) Diabetes , vol.63 , pp. 2402-2414
    • Kallionpää, H.1    Elo, L.L.2    Laajala, E.3
  • 115
    • 84923172399 scopus 로고    scopus 로고
    • Noninvasive mapping of pancreatic inflammation in recent-onset type-1 diabetes patients
    • Gaglia JL, Harisinghani M, Aganj I, et al. Noninvasive mapping of pancreatic inflammation in recent-onset type-1 diabetes patients. Proc Natl Acad Sci U S A 2015;112:2139-2144.
    • (2015) Proc Natl Acad Sci U S A , vol.112 , pp. 2139-2144
    • Gaglia, J.L.1    Harisinghani, M.2    Aganj, I.3
  • 116
    • 82755197361 scopus 로고    scopus 로고
    • Detection of b cell death in diabetes using differentially methylated circulating DNA
    • Akirav EM, Lebastchi J, Galvan EM, et al. Detection of b cell death in diabetes using differentially methylated circulating DNA. Proc Natl Acad Sci U S A 2011;108:19018-19023.
    • (2011) Proc Natl Acad Sci U S A , vol.108 , pp. 19018-19023
    • Akirav, E.M.1    Lebastchi, J.2    Galvan, E.M.3
  • 117
    • 84868113134 scopus 로고    scopus 로고
    • Development of a quantitative methylation-specific polymerase chain reaction method for monitoring beta cell death in type 1 diabetes
    • Husseiny MI, Kuroda A, Kaye AN, Nair I, Kandeel F, Ferreri K. Development of a quantitative methylation-specific polymerase chain reaction method for monitoring beta cell death in type 1 diabetes. PLoS One 2012;7:e47942.
    • (2012) PLoS One , vol.7 , pp. e47942
    • Husseiny, M.I.1    Kuroda, A.2    Kaye, A.N.3    Nair, I.4    Kandeel, F.5    Ferreri, K.6
  • 119
    • 84883174104 scopus 로고    scopus 로고
    • Detection of islet b-cell death in vivo by multiplex PCR analysis of differentially methylated DNA
    • Fisher MM, Perez Chumbiauca CN, Mather KJ, Mirmira RG, Tersey SA. Detection of islet b-cell death in vivo by multiplex PCR analysis of differentially methylated DNA. Endocrinology 2013;154:3476-3481.
    • (2013) Endocrinology , vol.154 , pp. 3476-3481
    • Fisher, M.M.1    Perez Chumbiauca, C.N.2    Mather, K.J.3    Mirmira, R.G.4    Tersey, S.A.5
  • 120
    • 84924022501 scopus 로고    scopus 로고
    • B Cell death and dysfunction during type 1 diabetes development in at-risk individuals
    • Type 1 Diabetes TrialNet Study Group
    • Herold KC, Usmani-Brown S, Ghazi T, et al.; Type 1 Diabetes TrialNet Study Group. b Cell death and dysfunction during type 1 diabetes development in at-risk individuals. J Clin Invest 2015;125:1163-1173.
    • (2015) J Clin Invest , vol.125 , pp. 1163-1173
    • Herold, K.C.1    Usmani-Brown, S.2    Ghazi, T.3
  • 121
    • 44349193971 scopus 로고    scopus 로고
    • A risk score for type 1 diabetes derived from autoantibody-positive participants in the diabetes prevention Trial-Type 1
    • Diabetes Prevention Trial-Type 1 Study Group
    • Sosenko JM, Krischer JP, Palmer JP, et al.; Diabetes Prevention Trial-Type 1 Study Group. A risk score for type 1 diabetes derived from autoantibody-positive participants in the Diabetes Prevention Trial-Type 1. Diabetes Care 2008;31:528-533.
    • (2008) Diabetes Care , vol.31 , pp. 528-533
    • Sosenko, J.M.1    Krischer, J.P.2    Palmer, J.P.3
  • 122
    • 84885862936 scopus 로고    scopus 로고
    • The prediction of type 1 diabetes by multiple autoantibody levels and their incorporation into an autoantibody risk score in relatives of type 1 diabetic patients
    • Type 1 Diabetes TrialNet Study Group; Diabetes Prevention Trial-Type 1 Study Group
    • Sosenko JM, Skyler JS, Palmer JP, et al.; Type 1 Diabetes TrialNet Study Group; Diabetes Prevention Trial-Type 1 Study Group. The prediction of type 1 diabetes by multiple autoantibody levels and their incorporation into an autoantibody risk score in relatives of type 1 diabetic patients. Diabetes Care 2013;36: 2615-2620.
    • (2013) Diabetes Care , vol.36 , pp. 2615-2620
    • Sosenko, J.M.1    Skyler, J.S.2    Palmer, J.P.3
  • 123
    • 84921896148 scopus 로고    scopus 로고
    • A new approach for diagnosing type 1 diabetes in autoantibody-positive individuals based on prediction and natural history
    • Type 1 Diabetes TrialNet Study Group; Diabetes Prevention Trial-Type 1 Study Group
    • Sosenko JM, Skyler JS, DiMeglio LA, et al.; Type 1 Diabetes TrialNet Study Group; Diabetes Prevention Trial-Type 1 Study Group. A new approach for diagnosing type 1 diabetes in autoantibody-positive individuals based on prediction and natural history. Diabetes Care 2015; 38:271-276.
    • (2015) Diabetes Care , vol.38 , pp. 271-276
    • Sosenko, J.M.1    Skyler, J.S.2    DiMeglio, L.A.3
  • 124
    • 10744222979 scopus 로고    scopus 로고
    • IDDM2/insulin VNTR modifies risk conferred by IDDM1/HLA for development of type 1 diabetes and associated autoimmunity
    • Walter M, Albert E, Conrad M, et al. IDDM2/insulin VNTR modifies risk conferred by IDDM1/HLA for development of type 1 diabetes and associated autoimmunity. Diabetologia 2003;46:712-720.
    • (2003) Diabetologia , vol.46 , pp. 712-720
    • Walter, M.1    Albert, E.2    Conrad, M.3
  • 125
    • 0033060864 scopus 로고    scopus 로고
    • Early expression and high prevalence of islet autoantibodies for DR3/4 heterozygous and DR4/4 homozygous offspring of parents with type I diabetes: The German BABYDIAB study
    • Schenker M, Hummel M, Ferber K, et al. Early expression and high prevalence of islet autoantibodies for DR3/4 heterozygous and DR4/4 homozygous offspring of parents with type I diabetes: The German BABYDIAB study. Diabetologia 1999;42:671-677.
    • (1999) Diabetologia , vol.42 , pp. 671-677
    • Schenker, M.1    Hummel, M.2    Ferber, K.3
  • 126
    • 7444253875 scopus 로고    scopus 로고
    • IDDM1 and multiple family history of type 1 diabetes combine to identify neonates at high risk for type 1 diabetes
    • Bonifacio E, Hummel M, Walter M, Schmid S, Ziegler AG. IDDM1 and multiple family history of type 1 diabetes combine to identify neonates at high risk for type 1 diabetes. Diabetes Care 2004;27:2695-2700.
    • (2004) Diabetes Care , vol.27 , pp. 2695-2700
    • Bonifacio, E.1    Hummel, M.2    Walter, M.3    Schmid, S.4    Ziegler, A.G.5
  • 127
    • 0031860075 scopus 로고    scopus 로고
    • The deutsche nicotinamide intervention study: An attempt to prevent type 1 diabetes
    • DENIS Group
    • Lampeter EF, Klinghammer A, Scherbaum WA, et al.; DENIS Group. The Deutsche Nicotinamide Intervention Study: An attempt to prevent type 1 diabetes. Diabetes 1998;47: 980-984.
    • (1998) Diabetes , vol.47 , pp. 980-984
    • Lampeter, E.F.1    Klinghammer, A.2    Scherbaum, W.A.3
  • 128
    • 1642277657 scopus 로고    scopus 로고
    • European Nicotinamide Diabetes Intervention Trial (ENDIT): A randomised controlled trial of intervention before the onset of type 1 diabetes
    • European Nicotinamide Diabetes Intervention Trial (ENDIT) Group
    • Gale EA, Bingley PJ, Emmett CL, Collier T; European Nicotinamide Diabetes Intervention Trial (ENDIT) Group. European Nicotinamide Diabetes Intervention Trial (ENDIT): A randomised controlled trial of intervention before the onset of type 1 diabetes. Lancet 2004;363:925-931.
    • (2004) Lancet , vol.363 , pp. 925-931
    • Gale, E.A.1    Bingley, P.J.2    Emmett, C.L.3    Collier, T.4
  • 129
    • 55749104546 scopus 로고    scopus 로고
    • Nasal insulin to prevent type 1 diabetes in children with HLA genotypes and autoantibodies conferring increased risk of disease: A doubleblind, randomised controlled trial
    • Näntö-Salonen K, Kuplia A, Simell S, et al. Nasal insulin to prevent type 1 diabetes in children with HLA genotypes and autoantibodies conferring increased risk of disease: A doubleblind, randomised controlled trial. Lancet 2008; 372:1746-1755.
    • (2008) Lancet , vol.372 , pp. 1746-1755
    • Näntö-Salonen, K.1    Kuplia, A.2    Simell, S.3
  • 130
    • 70349257206 scopus 로고    scopus 로고
    • Belgian diabetes registry. Insulin treatment in IA-2A-positive relatives of type 1 diabetic patients
    • Vandemeulebroucke E, Gorus FK, Decochez K, et al.; Belgian Diabetes Registry. Insulin treatment in IA-2A-positive relatives of type 1 diabetic patients. Diabetes Metab 2009; 35:319-327.
    • (2009) Diabetes Metab , vol.35 , pp. 319-327
    • Vandemeulebroucke, E.1    Gorus, F.K.2    Decochez, K.3
  • 131
    • 84881021878 scopus 로고    scopus 로고
    • Glucose tolerance and beta-cell function in islet autoantibody-positive children recruited to a secondary prevention study
    • Di- APREV-IT Study Group
    • Andersson C, Carlsson A, Cilio C, et al.; Di- APREV-IT Study Group. Glucose tolerance and beta-cell function in islet autoantibody-positive children recruited to a secondary prevention study. Pediatr Diabetes 2013;14:341-349.
    • (2013) Pediatr Diabetes , vol.14 , pp. 341-349
    • Andersson, C.1    Carlsson, A.2    Cilio, C.3


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