Persistence of Pancreatic Insulin mRNA Expression and Proinsulin Protein in Type 1 Diabetes Pancreata

Cell Metabolism

Volumn 26, Issue 3, 2017, Pages 568-575.e3

  Wasserfall, Clive ^a   Nick, Harry S ^b   Campbell Thompson, Martha ^a   Beachy, Dawn ^b   Haataja, Leena ^c   Kusmartseva, Irina ^a   Posgai, Amanda ^a   Beery, Maria ^a   Rhodes, Christopher ^d   Bonifacio, Ezio ^e   Arvan, Peter ^c   Atkinson, Mark ^a  

^a UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF FLORIDA   (United States)

^c UNIVERSITY OF MICHIGAN HEALTH SYSTEM   (United States)

^d Dresden University of Technology ^*  (United States)

^e DRESDEN UNIVERSITY OF TECHNOLOGY   (Germany)

Author keywords

insulin mRNA; insulin promoter; insulin positive single cells; pancreas; PCSK1; PCSK2; proconvertases; proinsulin; type 1 diabetes

Indexed keywords

AMYLIN; AUTOANTIBODY; C PEPTIDE; CALMODULIN 1; CHYMOTRYPSIN; CHYMOTRYPSIN C; CYCLOPHILIN A; GAMMA INTERFERON; GLUCAGON; HETEROGENEOUS NUCLEAR RNA; INSULIN; INTERLEUKIN 1BETA; MESSENGER RNA; PCSK1 PROTEIN; PROINSULIN; SERINE PROTEASE INHIBITOR KAZAL TYPE 1; SERINE PROTEINASE; SERINE PROTEINASE INHIBITOR; SOMATOMEDIN B; TUMOR NECROSIS FACTOR; UNCLASSIFIED DRUG; PCSK1 PROTEIN, HUMAN; PROPROTEIN CONVERTASE 1;

ADULT; AGED; ARTICLE; CASE CONTROL STUDY; CHILD; COHORT ANALYSIS; COMPARATIVE STUDY; CONTROLLED STUDY; DIABETIC PATIENT; DISEASE DURATION; FEMALE; GENE EXPRESSION; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; INFANT; INSULIN DEPENDENT DIABETES MELLITUS; INSULIN LEVEL; INSULIN SYNTHESIS; MAJOR CLINICAL STUDY; MALE; NEWBORN; PANCREAS ISLET BETA CELL; PANCREAS TISSUE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; SAMPLE; EXOCRINE PANCREAS; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; PANCREAS; PATHOLOGY; YOUNG ADULT;

ADULT; DIABETES MELLITUS, TYPE 1; FEMALE; GENE EXPRESSION REGULATION; GLUCAGON; HUMANS; INSULIN; MALE; PANCREAS; PANCREAS, EXOCRINE; PROINSULIN; PROPROTEIN CONVERTASE 1; RNA, MESSENGER; YOUNG ADULT;

EID: 85028648374     PISSN: 15504131     EISSN: 19327420     Source Type: Journal    
DOI: 10.1016/j.cmet.2017.08.013     Document Type: Article

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